JPS6323987B2 - - Google Patents

Info

Publication number
JPS6323987B2
JPS6323987B2 JP54000138A JP13879A JPS6323987B2 JP S6323987 B2 JPS6323987 B2 JP S6323987B2 JP 54000138 A JP54000138 A JP 54000138A JP 13879 A JP13879 A JP 13879A JP S6323987 B2 JPS6323987 B2 JP S6323987B2
Authority
JP
Japan
Prior art keywords
formula
hydrogen
group
alkyl
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP54000138A
Other languages
English (en)
Japanese (ja)
Other versions
JPS54109930A (en
Inventor
Guramufusein Kasawara Fuaizura
Jii Heidaa Jon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SANDO AG
Original Assignee
SANDO AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/881,780 external-priority patent/US4229463A/en
Priority claimed from US05/891,298 external-priority patent/US4194002A/en
Application filed by SANDO AG filed Critical SANDO AG
Priority to JP1387979A priority Critical patent/JPS55107257A/ja
Publication of JPS54109930A publication Critical patent/JPS54109930A/ja
Publication of JPS6323987B2 publication Critical patent/JPS6323987B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B22/00—Use of inorganic materials as active ingredients for mortars, concrete or artificial stone, e.g. accelerators or shrinkage compensating agents
    • C04B22/0013—Boron compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
    • C07C243/26—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C243/28—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Ceramic Engineering (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Materials Engineering (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Structural Engineering (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP13879A 1978-01-09 1979-01-08 Long chain fatty acid amides and hydrazides* their cyclopropano analogue* their manufacture and use Granted JPS54109930A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP1387979A JPS55107257A (en) 1979-01-08 1979-02-09 Ohmic electrode

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US86781378A 1978-01-09 1978-01-09
US86782478A 1978-01-09 1978-01-09
US87283678A 1978-01-27 1978-01-27
US88178178A 1978-02-27 1978-02-27
US05/881,780 US4229463A (en) 1978-02-27 1978-02-27 Unsaturated fatty acid hydrazides
US05/891,298 US4194002A (en) 1978-03-29 1978-03-29 Cholesterol ester-reducing amides of hexahydroindolinols

Publications (2)

Publication Number Publication Date
JPS54109930A JPS54109930A (en) 1979-08-29
JPS6323987B2 true JPS6323987B2 (Direct) 1988-05-18

Family

ID=27560330

Family Applications (1)

Application Number Title Priority Date Filing Date
JP13879A Granted JPS54109930A (en) 1978-01-09 1979-01-08 Long chain fatty acid amides and hydrazides* their cyclopropano analogue* their manufacture and use

Country Status (20)

Country Link
JP (1) JPS54109930A (Direct)
AU (1) AU529328B2 (Direct)
CA (1) CA1101871A (Direct)
CH (1) CH644842A5 (Direct)
CY (1) CY1294A (Direct)
DE (1) DE2856856A1 (Direct)
DK (1) DK3079A (Direct)
FI (1) FI790025A7 (Direct)
FR (1) FR2416885A1 (Direct)
GB (1) GB2012261B (Direct)
HK (1) HK80985A (Direct)
IE (1) IE48077B1 (Direct)
IL (1) IL56393A (Direct)
IT (1) IT1110603B (Direct)
KE (1) KE3546A (Direct)
MY (1) MY8500133A (Direct)
NZ (1) NZ189331A (Direct)
PT (1) PT69052A (Direct)
SE (1) SE446093B (Direct)
SG (1) SG42985G (Direct)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2937175A1 (de) * 1978-09-18 1980-03-27 Sandoz Ag Sekundaere amide von 2-alkynoylsaeuren, deren herstellung und deren pharmazeutischen zusammensetzungen
US4297349A (en) 1980-04-15 1981-10-27 Sandoz, Inc. Silicon-bearing carboxylic acids and amides
US4722927A (en) * 1986-04-28 1988-02-02 Warner-Lambert Company Pyrimidine amides of oleic or linoleic acid, composition containing them and their use as inhibitors of acyl-CoA cholesterol acyltransferase
FR2633617B1 (fr) * 1988-07-04 1991-02-08 Adir Nouveaux derives du benzocycloheptene, leur procede de preparation et les compositions pharmaceutiques les renfermant
US5290814A (en) * 1988-11-21 1994-03-01 Burroughs Wellcome Co. Anti-atherosclerotic diaryl compounds
CN102014897B (zh) * 2008-04-21 2015-08-05 西格纳姆生物科学公司 化合物、组合物和其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1814334B2 (de) * 1967-12-21 1973-04-19 Sumitomo Chemical Co Ltd , Osaka (Japan) Fettsaeureamide und diese verbindungen enthaltende arzneimittel
FR2000945A1 (Direct) * 1968-01-30 1969-09-19 Sumitomo Chemical Co
JPS5835505B2 (ja) * 1976-01-09 1983-08-03 エーザイ株式会社 Ｎ−（α−メチル−ベンジル）−脂肪酸アミド

Also Published As

Publication number Publication date
IL56393A (en) 1982-08-31
CY1294A (en) 1985-10-18
IL56393A0 (en) 1979-03-12
IE790031L (en) 1979-07-09
MY8500133A (en) 1985-12-31
JPS54109930A (en) 1979-08-29
NZ189331A (en) 1981-07-13
SE7900142L (sv) 1979-07-10
IT7919059A0 (it) 1979-01-04
CH644842A5 (de) 1984-08-31
SE446093B (sv) 1986-08-11
FR2416885A1 (fr) 1979-09-07
GB2012261B (en) 1982-12-22
KE3546A (en) 1985-07-19
GB2012261A (en) 1979-07-25
DE2856856A1 (de) 1979-07-12
AU4323379A (en) 1979-07-19
AU529328B2 (en) 1983-06-02
PT69052A (fr) 1979-02-01
FI790025A7 (fi) 1979-07-10
SG42985G (en) 1985-12-13
IT1110603B (it) 1985-12-23
IE48077B1 (en) 1984-09-19
HK80985A (en) 1985-10-25
FR2416885B1 (Direct) 1983-04-22
DK3079A (da) 1979-07-10
CA1101871A (en) 1981-05-26

Similar Documents

Publication Publication Date Title
CN1193996C (zh) 可用作抗氧剂和5－脂氧合酶抑制剂及非甾体类抗炎药的抗炎非甾体类羧酸酯和酰胺
KR100202463B1 (ko) 아미노코우마란 유도체, 그들의 제조방법 및 용도
US4448785A (en) N-Unsaturated fatty acid amides of tryptophan ester homologues and anti-cholesteric use thereof
KR20130109103A (ko) 신경변성 질환의 치료 방법
FR2692264A1 (fr) Nouvelles pipérazines 1,4-disubstituées, leur procédé de préparation et les compositions pharmaceutiques les contenant.
FR2873368A1 (fr) Derives de guanidine et leurs utilisations en therapeutique
JPH08505375A (ja) 置換基をもつトリオール類
EP0055588B1 (en) Analgesic and anti-inflammatory agents
JP2001515490A (ja) Ｌｔａ▲下４▼ヒドロラーゼインヒビター
KR900006743B1 (ko) 천식치료제인 치환된 테트랄린, 크로만 및 관련화합물
CA2112678A1 (en) Indoles
US4297349A (en) Silicon-bearing carboxylic acids and amides
CN1025786C (zh) 氨基甲酰基衍生物的制备方法
US4248893A (en) Arterial wall cholesterol ester reducing cyclopropanyl-bearing amides
JPH0597839A (ja) ホスホリパーゼａ２阻害剤としてのテトロン酸誘導体およびチオテトロン酸誘導体
JPH0379336B2 (Direct)
US4420475A (en) Silicon-bearing amides
IE48077B1 (en) Long-chain fatty acid amides and cyclopropano analogues thereof,their production and their use as anti-atherosclerotic agents
US4194002A (en) Cholesterol ester-reducing amides of hexahydroindolinols
US4201785A (en) Cyclopropanyl-bearing hydrazides
US4456619A (en) Amides of 2-alkynoic acids and use for inhibiting accumulation of cholesterol ester in arterial walls
US4611063A (en) Silicon-bearing amides
JPH043377B2 (Direct)
JP2526414B2 (ja) 制ガン剤エステル化合物及びその製造方法
US4296240A (en) Silacycloalkane amides