GB2012261A - Long-chain fatty acid amides and hydrazides and cyclopropano analogues thereof, their production and their use as anti-atherosclerotic agents - Google Patents
Long-chain fatty acid amides and hydrazides and cyclopropano analogues thereof, their production and their use as anti-atherosclerotic agentsInfo
- Publication number
- GB2012261A GB2012261A GB79337A GB7900337A GB2012261A GB 2012261 A GB2012261 A GB 2012261A GB 79337 A GB79337 A GB 79337A GB 7900337 A GB7900337 A GB 7900337A GB 2012261 A GB2012261 A GB 2012261A
- Authority
- GB
- United Kingdom
- Prior art keywords
- cyclopropano
- analogues
- fatty acid
- hydrazides
- production
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B22/00—Use of inorganic materials as active ingredients for mortars, concrete or artificial stone, e.g. accelerators, shrinkage compensating agents
- C04B22/0013—Boron compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
- C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
- C07C243/26—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C243/28—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of a saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Abstract
The invention provides novel anti- atherosclerotic compounds of the type <IMAGE> where A is the residue of a long chain, unsaturated fatty acid or cyclopropano analogues thereof; the -CO-N< moiety forms an amide or hydrazide group or the N atom may be part of a 4-optionally-substituted-styryl- hexahydro-4-indolinol-(1) group. The compounds are made by acylation of amines.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US86782478A | 1978-01-09 | 1978-01-09 | |
US86781378A | 1978-01-09 | 1978-01-09 | |
US87283678A | 1978-01-27 | 1978-01-27 | |
US88178178A | 1978-02-27 | 1978-02-27 | |
US05/881,780 US4229463A (en) | 1978-02-27 | 1978-02-27 | Unsaturated fatty acid hydrazides |
US05/891,298 US4194002A (en) | 1978-03-29 | 1978-03-29 | Cholesterol ester-reducing amides of hexahydroindolinols |
Publications (2)
Publication Number | Publication Date |
---|---|
GB2012261A true GB2012261A (en) | 1979-07-25 |
GB2012261B GB2012261B (en) | 1982-12-22 |
Family
ID=27560330
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB79337A Expired GB2012261B (en) | 1978-01-09 | 1979-01-05 | Fatty acid amide and hydrsazide derivatives their production and use as pharmaceuticals |
Country Status (20)
Country | Link |
---|---|
JP (1) | JPS54109930A (en) |
AU (1) | AU529328B2 (en) |
CA (1) | CA1101871A (en) |
CH (1) | CH644842A5 (en) |
CY (1) | CY1294A (en) |
DE (1) | DE2856856A1 (en) |
DK (1) | DK3079A (en) |
FI (1) | FI790025A (en) |
FR (1) | FR2416885A1 (en) |
GB (1) | GB2012261B (en) |
HK (1) | HK80985A (en) |
IE (1) | IE48077B1 (en) |
IL (1) | IL56393A (en) |
IT (1) | IT1110603B (en) |
KE (1) | KE3546A (en) |
MY (1) | MY8500133A (en) |
NZ (1) | NZ189331A (en) |
PT (1) | PT69052A (en) |
SE (1) | SE446093B (en) |
SG (1) | SG42985G (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4297349A (en) | 1980-04-15 | 1981-10-27 | Sandoz, Inc. | Silicon-bearing carboxylic acids and amides |
EP0245687A1 (en) * | 1986-04-28 | 1987-11-19 | Warner-Lambert Company | Substituted pyrimidine amides of oleic or linoleic acid as inhibitors of acyl-coa cholesterol acyltransferase |
FR2633617A1 (en) * | 1988-07-04 | 1990-01-05 | Adir | NOVEL BENZOCYCLOHEPTENE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME |
US5290814A (en) * | 1988-11-21 | 1994-03-01 | Burroughs Wellcome Co. | Anti-atherosclerotic diaryl compounds |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2937175A1 (en) * | 1978-09-18 | 1980-03-27 | Sandoz Ag | SECOND AMIDES OF 2-ALKYNOYL ACIDS, THEIR PRODUCTION AND THEIR PHARMACEUTICAL COMPOSITIONS |
JP5607025B2 (en) * | 2008-04-21 | 2014-10-15 | シグナム バイオサイエンシーズ, インコーポレイテッド | Compounds, compositions and methods of making them |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1814334B2 (en) * | 1967-12-21 | 1973-04-19 | Sumitomo Chemical Co Ltd , Osaka (Japan) | FATTY ACID AMIDES AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS |
FR2000945A1 (en) * | 1968-01-30 | 1969-09-19 | Sumitomo Chemical Co | |
JPS5835505B2 (en) * | 1976-01-09 | 1983-08-03 | エーザイ株式会社 | N-(α-methyl-benzyl)-fatty acid amide |
-
1978
- 1978-12-30 DE DE19782856856 patent/DE2856856A1/en not_active Ceased
-
1979
- 1979-01-02 CH CH379A patent/CH644842A5/en not_active IP Right Cessation
- 1979-01-03 DK DK3079A patent/DK3079A/en not_active Application Discontinuation
- 1979-01-04 IT IT19059/79A patent/IT1110603B/en active
- 1979-01-04 FI FI790025A patent/FI790025A/en not_active IP Right Cessation
- 1979-01-05 GB GB79337A patent/GB2012261B/en not_active Expired
- 1979-01-05 CY CY1294A patent/CY1294A/en unknown
- 1979-01-08 IE IE31/79A patent/IE48077B1/en unknown
- 1979-01-08 NZ NZ189331A patent/NZ189331A/en unknown
- 1979-01-08 IL IL56393A patent/IL56393A/en unknown
- 1979-01-08 JP JP13879A patent/JPS54109930A/en active Granted
- 1979-01-08 CA CA319,259A patent/CA1101871A/en not_active Expired
- 1979-01-08 SE SE7900142A patent/SE446093B/en not_active IP Right Cessation
- 1979-01-09 FR FR7900438A patent/FR2416885A1/en active Granted
- 1979-01-09 AU AU43233/79A patent/AU529328B2/en not_active Ceased
- 1979-01-09 PT PT69052A patent/PT69052A/en unknown
-
1985
- 1985-06-01 SG SG42985A patent/SG42985G/en unknown
- 1985-06-19 KE KE3546A patent/KE3546A/en unknown
- 1985-10-17 HK HK809/85A patent/HK80985A/en unknown
- 1985-12-30 MY MY133/85A patent/MY8500133A/en unknown
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4297349A (en) | 1980-04-15 | 1981-10-27 | Sandoz, Inc. | Silicon-bearing carboxylic acids and amides |
EP0245687A1 (en) * | 1986-04-28 | 1987-11-19 | Warner-Lambert Company | Substituted pyrimidine amides of oleic or linoleic acid as inhibitors of acyl-coa cholesterol acyltransferase |
FR2633617A1 (en) * | 1988-07-04 | 1990-01-05 | Adir | NOVEL BENZOCYCLOHEPTENE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME |
EP0354078A2 (en) * | 1988-07-04 | 1990-02-07 | Adir Et Compagnie | Derivatives of benzocycloheptene, method for their preparation and pharmaceutical compositions containing same |
EP0354078A3 (en) * | 1988-07-04 | 1990-05-23 | Adir Et Compagnie | Derivatives of benzocycloheptene, method for their preparation and pharmaceutical compositions containing same |
US5290814A (en) * | 1988-11-21 | 1994-03-01 | Burroughs Wellcome Co. | Anti-atherosclerotic diaryl compounds |
Also Published As
Publication number | Publication date |
---|---|
CH644842A5 (en) | 1984-08-31 |
SE7900142L (en) | 1979-07-10 |
CY1294A (en) | 1985-10-18 |
KE3546A (en) | 1985-07-19 |
NZ189331A (en) | 1981-07-13 |
JPS6323987B2 (en) | 1988-05-18 |
IE790031L (en) | 1979-07-09 |
PT69052A (en) | 1979-02-01 |
FI790025A (en) | 1979-07-10 |
IE48077B1 (en) | 1984-09-19 |
IT7919059A0 (en) | 1979-01-04 |
IL56393A (en) | 1982-08-31 |
GB2012261B (en) | 1982-12-22 |
DE2856856A1 (en) | 1979-07-12 |
FR2416885B1 (en) | 1983-04-22 |
AU4323379A (en) | 1979-07-19 |
FR2416885A1 (en) | 1979-09-07 |
MY8500133A (en) | 1985-12-31 |
IT1110603B (en) | 1985-12-23 |
IL56393A0 (en) | 1979-03-12 |
CA1101871A (en) | 1981-05-26 |
JPS54109930A (en) | 1979-08-29 |
DK3079A (en) | 1979-07-10 |
HK80985A (en) | 1985-10-25 |
SE446093B (en) | 1986-08-11 |
SG42985G (en) | 1985-12-13 |
AU529328B2 (en) | 1983-06-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PCNP | Patent ceased through non-payment of renewal fee |