JPS627162B2 - - Google Patents
Info
- Publication number
- JPS627162B2 JPS627162B2 JP4067684A JP4067684A JPS627162B2 JP S627162 B2 JPS627162 B2 JP S627162B2 JP 4067684 A JP4067684 A JP 4067684A JP 4067684 A JP4067684 A JP 4067684A JP S627162 B2 JPS627162 B2 JP S627162B2
- Authority
- JP
- Japan
- Prior art keywords
- skin
- effect
- ester
- aminobutyric acid
- improving
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical class NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 claims description 18
- -1 vitamin E orotate ester Chemical class 0.000 claims description 18
- 239000002537 cosmetic Substances 0.000 claims description 13
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 13
- 229930003427 Vitamin E Natural products 0.000 claims description 12
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 12
- 229940046009 vitamin E Drugs 0.000 claims description 12
- 235000019165 vitamin E Nutrition 0.000 claims description 12
- 239000011709 vitamin E Substances 0.000 claims description 12
- 239000000203 mixture Substances 0.000 claims description 9
- 230000009759 skin aging Effects 0.000 claims description 8
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 125000003342 alkenyl group Chemical group 0.000 claims description 2
- 125000000217 alkyl group Chemical group 0.000 claims description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
- 210000003491 skin Anatomy 0.000 description 42
- 230000000694 effects Effects 0.000 description 37
- 210000004080 milk Anatomy 0.000 description 15
- 235000013336 milk Nutrition 0.000 description 15
- 239000008267 milk Substances 0.000 description 13
- 230000007306 turnover Effects 0.000 description 13
- 238000012360 testing method Methods 0.000 description 12
- 102000011782 Keratins Human genes 0.000 description 11
- 108010076876 Keratins Proteins 0.000 description 11
- 239000006071 cream Substances 0.000 description 9
- 210000000434 stratum corneum Anatomy 0.000 description 9
- 229960003692 gamma aminobutyric acid Drugs 0.000 description 8
- OGNSCSPNOLGXSM-UHFFFAOYSA-N (+/-)-DABA Natural products NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 description 7
- 230000037303 wrinkles Effects 0.000 description 7
- 238000010998 test method Methods 0.000 description 6
- 238000009499 grossing Methods 0.000 description 5
- 206010040844 Skin exfoliation Diseases 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- 210000002510 keratinocyte Anatomy 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- XPDXVDYUQZHFPV-UHFFFAOYSA-N Dansyl Chloride Chemical compound C1=CC=C2C(N(C)C)=CC=CC2=C1S(Cl)(=O)=O XPDXVDYUQZHFPV-UHFFFAOYSA-N 0.000 description 3
- 230000003712 anti-aging effect Effects 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 230000003020 moisturizing effect Effects 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 230000002265 prevention Effects 0.000 description 3
- 230000036620 skin dryness Effects 0.000 description 3
- AOKCDAVWJLOAHG-UHFFFAOYSA-N 4-(methylamino)butyric acid Chemical compound C[NH2+]CCCC([O-])=O AOKCDAVWJLOAHG-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 230000032683 aging Effects 0.000 description 2
- 229940124277 aminobutyric acid Drugs 0.000 description 2
- 230000000916 dilatatory effect Effects 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000006210 lotion Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000002674 ointment Substances 0.000 description 2
- 210000005259 peripheral blood Anatomy 0.000 description 2
- 239000011886 peripheral blood Substances 0.000 description 2
- 230000004215 skin function Effects 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- NPSJHQMIVNJLNN-UHFFFAOYSA-N 2-ethylhexyl 4-nitrobenzoate Chemical compound CCCCC(CC)COC(=O)C1=CC=C([N+]([O-])=O)C=C1 NPSJHQMIVNJLNN-UHFFFAOYSA-N 0.000 description 1
- 239000004808 2-ethylhexylester Substances 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- DCXXMTOCNZCJGO-UHFFFAOYSA-N Glycerol trioctadecanoate Natural products CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 description 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 125000004494 ethyl ester group Chemical group 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000004299 exfoliation Methods 0.000 description 1
- 239000007850 fluorescent dye Substances 0.000 description 1
- 210000000245 forearm Anatomy 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 150000004702 methyl esters Chemical class 0.000 description 1
- 239000007764 o/w emulsion Substances 0.000 description 1
- 235000014593 oils and fats Nutrition 0.000 description 1
- PXQPEWDEAKTCGB-UHFFFAOYSA-N orotic acid Chemical compound OC(=O)C1=CC(=O)NC(=O)N1 PXQPEWDEAKTCGB-UHFFFAOYSA-N 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 230000002250 progressing effect Effects 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- 239000003871 white petrolatum Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4067684A JPS60184005A (ja) | 1984-03-02 | 1984-03-02 | 皮膚老化防止用化粧料 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4067684A JPS60184005A (ja) | 1984-03-02 | 1984-03-02 | 皮膚老化防止用化粧料 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS60184005A JPS60184005A (ja) | 1985-09-19 |
| JPS627162B2 true JPS627162B2 (enrdf_load_stackoverflow) | 1987-02-16 |
Family
ID=12587128
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP4067684A Granted JPS60184005A (ja) | 1984-03-02 | 1984-03-02 | 皮膚老化防止用化粧料 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS60184005A (enrdf_load_stackoverflow) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6287506A (ja) * | 1985-10-15 | 1987-04-22 | Kanebo Ltd | 皮膚老化防止化粧料 |
| JPS63150209A (ja) * | 1986-12-15 | 1988-06-22 | Kanebo Ltd | 皮膚化粧料 |
| JP3256369B2 (ja) * | 1994-03-03 | 2002-02-12 | カネボウ株式会社 | 皮膚化粧料 |
| UA10208A (uk) * | 1994-08-03 | 1996-12-25 | Жанна Прокопівна Гудзенко | Дерматологічний косметичний засіб |
| DE69529043T2 (de) * | 1994-09-30 | 2003-05-08 | L'oreal S.A., Paris | Verwendung von einem Agonisten eines mit einem Chloridkanal assozierten Rezeptors zur Behandlung von Hautfalten |
| JPH08264272A (ja) * | 1995-03-27 | 1996-10-11 | Seta Giken:Kk | 電磁誘導加熱装置 |
| FR2909280B1 (fr) * | 2006-11-30 | 2015-04-17 | Marcel Georges Cohen | Utilisation de l'acide gamma-aminobutyrique en tant qu'agent depigmentant |
| JP5297631B2 (ja) * | 2007-11-13 | 2013-09-25 | 花王株式会社 | 皮膚外用組成物 |
-
1984
- 1984-03-02 JP JP4067684A patent/JPS60184005A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS60184005A (ja) | 1985-09-19 |
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