JPS6248393A - Ｌ−グルタミン酸の製造法 - Google Patents
Ｌ−グルタミン酸の製造法Info
- Publication number
- JPS6248393A JPS6248393A JP18645285A JP18645285A JPS6248393A JP S6248393 A JPS6248393 A JP S6248393A JP 18645285 A JP18645285 A JP 18645285A JP 18645285 A JP18645285 A JP 18645285A JP S6248393 A JPS6248393 A JP S6248393A
- Authority
- JP
- Japan
- Prior art keywords
- glutamic acid
- arthrobacter
- bacterium
- medium
- genus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 title claims abstract description 66
- 229960002989 glutamic acid Drugs 0.000 title claims abstract description 33
- 238000004519 manufacturing process Methods 0.000 title claims description 15
- 241000186063 Arthrobacter Species 0.000 claims abstract description 11
- 241000193830 Bacillus <bacterium> Species 0.000 claims abstract description 11
- 239000007788 liquid Substances 0.000 claims abstract description 6
- 229930182555 Penicillin Natural products 0.000 claims abstract description 4
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 claims abstract description 4
- 229940049954 penicillin Drugs 0.000 claims abstract description 4
- 244000005700 microbiome Species 0.000 claims description 11
- 238000012258 culturing Methods 0.000 claims description 6
- 239000004094 surface-active agent Substances 0.000 claims description 6
- 241000894006 Bacteria Species 0.000 abstract description 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract description 4
- 238000001816 cooling Methods 0.000 abstract description 4
- 229920002472 Starch Polymers 0.000 abstract description 3
- 229940024606 amino acid Drugs 0.000 abstract description 3
- 235000001014 amino acid Nutrition 0.000 abstract description 3
- 150000001413 amino acids Chemical class 0.000 abstract description 3
- 239000008107 starch Substances 0.000 abstract description 3
- 235000019698 starch Nutrition 0.000 abstract description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract description 2
- 241000866060 Terrabacter tumescens Species 0.000 abstract description 2
- 229910052799 carbon Inorganic materials 0.000 abstract description 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract description 2
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- 241000193764 Brevibacillus brevis Species 0.000 abstract 1
- 229910017053 inorganic salt Inorganic materials 0.000 abstract 1
- 239000002609 medium Substances 0.000 description 10
- 238000000855 fermentation Methods 0.000 description 9
- 230000004151 fermentation Effects 0.000 description 9
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 4
- 239000008103 glucose Substances 0.000 description 4
- 239000002826 coolant Substances 0.000 description 3
- 239000000284 extract Substances 0.000 description 3
- 235000013372 meat Nutrition 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000003507 refrigerant Substances 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
- 239000001888 Peptone Substances 0.000 description 2
- 108010080698 Peptones Proteins 0.000 description 2
- 108010073771 Soybean Proteins Proteins 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 235000019319 peptone Nutrition 0.000 description 2
- 239000003531 protein hydrolysate Substances 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 238000011218 seed culture Methods 0.000 description 2
- 235000019710 soybean protein Nutrition 0.000 description 2
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 1
- ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 description 1
- PAWQVTBBRAZDMG-UHFFFAOYSA-N 2-(3-bromo-2-fluorophenyl)acetic acid Chemical compound OC(=O)CC1=CC=CC(Br)=C1F PAWQVTBBRAZDMG-UHFFFAOYSA-N 0.000 description 1
- XZIIFPSPUDAGJM-UHFFFAOYSA-N 6-chloro-2-n,2-n-diethylpyrimidine-2,4-diamine Chemical compound CCN(CC)C1=NC(N)=CC(Cl)=N1 XZIIFPSPUDAGJM-UHFFFAOYSA-N 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- 241000185996 Arthrobacter citreus Species 0.000 description 1
- 241000194107 Bacillus megaterium Species 0.000 description 1
- 241000186146 Brevibacterium Species 0.000 description 1
- 241000186216 Corynebacterium Species 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
- -1 Oxyethylene sorbitan monostearate Chemical compound 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- 241000635201 Pumilus Species 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 238000005273 aeration Methods 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 235000019270 ammonium chloride Nutrition 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 1
- 235000011130 ammonium sulphate Nutrition 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 235000012041 food component Nutrition 0.000 description 1
- 239000001530 fumaric acid Substances 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 159000000014 iron salts Chemical class 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 159000000003 magnesium salts Chemical class 0.000 description 1
- 150000002696 manganese Chemical class 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 description 1
- 235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 229940035044 sorbitan monolaurate Drugs 0.000 description 1
- 239000001593 sorbitan monooleate Substances 0.000 description 1
- 235000011069 sorbitan monooleate Nutrition 0.000 description 1
- 229940035049 sorbitan monooleate Drugs 0.000 description 1
- 239000001587 sorbitan monostearate Substances 0.000 description 1
- 235000011076 sorbitan monostearate Nutrition 0.000 description 1
- 229940035048 sorbitan monostearate Drugs 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP18645285A JPS6248393A (ja) | 1985-08-24 | 1985-08-24 | Ｌ−グルタミン酸の製造法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP18645285A JPS6248393A (ja) | 1985-08-24 | 1985-08-24 | Ｌ−グルタミン酸の製造法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6248393A true JPS6248393A (ja) | 1987-03-03 |
| JPH0528112B2 JPH0528112B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1993-04-23 |
Family
ID=16188703
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP18645285A Granted JPS6248393A (ja) | 1985-08-24 | 1985-08-24 | Ｌ−グルタミン酸の製造法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6248393A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2612937A1 (fr) * | 1987-03-27 | 1988-09-30 | Ajinomoto Kk | Nouveaux micro-organismes et procede pour la production d'acide glutamique utilisant ces micro-organismes |
| US5250434A (en) * | 1987-03-27 | 1993-10-05 | Ajinomoto Co., Inc. | Microorganisms for production of glutamic acid |
| US6083728A (en) * | 1997-10-17 | 2000-07-04 | Regents Of The University Of Minnesota | Production of glutamate using wild type Bacillus methanolicus |
| JP2011217671A (ja) * | 2010-04-09 | 2011-11-04 | Sanyo Chem Ind Ltd | 有用物質製造方法 |
| JP2011217670A (ja) * | 2010-04-09 | 2011-11-04 | Sanyo Chem Ind Ltd | 有用物質製造方法 |
| JP2012005456A (ja) * | 2010-06-28 | 2012-01-12 | Sanyo Chem Ind Ltd | 有用物質生産方法 |
| JP2012005457A (ja) * | 2010-06-28 | 2012-01-12 | Sanyo Chem Ind Ltd | 有用物質生産方法 |
-
1985
- 1985-08-24 JP JP18645285A patent/JPS6248393A/ja active Granted
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2612937A1 (fr) * | 1987-03-27 | 1988-09-30 | Ajinomoto Kk | Nouveaux micro-organismes et procede pour la production d'acide glutamique utilisant ces micro-organismes |
| US5250434A (en) * | 1987-03-27 | 1993-10-05 | Ajinomoto Co., Inc. | Microorganisms for production of glutamic acid |
| US6083728A (en) * | 1997-10-17 | 2000-07-04 | Regents Of The University Of Minnesota | Production of glutamate using wild type Bacillus methanolicus |
| JP2011217671A (ja) * | 2010-04-09 | 2011-11-04 | Sanyo Chem Ind Ltd | 有用物質製造方法 |
| JP2011217670A (ja) * | 2010-04-09 | 2011-11-04 | Sanyo Chem Ind Ltd | 有用物質製造方法 |
| JP2012005456A (ja) * | 2010-06-28 | 2012-01-12 | Sanyo Chem Ind Ltd | 有用物質生産方法 |
| JP2012005457A (ja) * | 2010-06-28 | 2012-01-12 | Sanyo Chem Ind Ltd | 有用物質生産方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0528112B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1993-04-23 |
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