JPS6134426B2 - - Google Patents

Info

Publication number
JPS6134426B2
JPS6134426B2 JP52059295A JP5929577A JPS6134426B2 JP S6134426 B2 JPS6134426 B2 JP S6134426B2 JP 52059295 A JP52059295 A JP 52059295A JP 5929577 A JP5929577 A JP 5929577A JP S6134426 B2 JPS6134426 B2 JP S6134426B2
Authority
JP
Japan
Prior art keywords
cis
trans
methyl
compounds
hexahydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP52059295A
Other languages
English (en)
Japanese (ja)
Other versions
JPS532465A (en
Inventor
Yakobu Fuan Deru Burugu Uiremu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzo NV
Original Assignee
Akzo NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo NV filed Critical Akzo NV
Publication of JPS532465A publication Critical patent/JPS532465A/ja
Publication of JPS6134426B2 publication Critical patent/JPS6134426B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/18—Ring systems of four or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
JP5929577A 1976-05-24 1977-05-20 Novel tetracyclic derivative* its preparation and formulations containing same Granted JPS532465A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL7605526A NL7605526A (nl) 1976-05-24 1976-05-24 Nieuwe tetracyclische derivaten.

Publications (2)

Publication Number Publication Date
JPS532465A JPS532465A (en) 1978-01-11
JPS6134426B2 true JPS6134426B2 (en:Method) 1986-08-07

Family

ID=19826245

Family Applications (2)

Application Number Title Priority Date Filing Date
JP5929577A Granted JPS532465A (en) 1976-05-24 1977-05-20 Novel tetracyclic derivative* its preparation and formulations containing same
JP61007790A Granted JPS61178965A (ja) 1976-05-24 1986-01-17 新規な四環式誘導体

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP61007790A Granted JPS61178965A (ja) 1976-05-24 1986-01-17 新規な四環式誘導体

Country Status (18)

Country Link
US (1) US4145434A (en:Method)
JP (2) JPS532465A (en:Method)
AU (1) AU509073B2 (en:Method)
BE (1) BE854915A (en:Method)
CA (1) CA1122976A (en:Method)
CH (2) CH633536A5 (en:Method)
DE (2) DE2723209A1 (en:Method)
DK (1) DK157868C (en:Method)
ES (3) ES459024A1 (en:Method)
FI (1) FI65238C (en:Method)
FR (1) FR2352800A1 (en:Method)
GB (1) GB1567862A (en:Method)
HU (1) HU173795B (en:Method)
IE (1) IE45419B1 (en:Method)
LU (1) LU77387A1 (en:Method)
NL (1) NL7605526A (en:Method)
SE (1) SE436202B (en:Method)
ZA (1) ZA772752B (en:Method)

Families Citing this family (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0007450A1 (de) * 1978-07-07 1980-02-06 Ciba-Geigy Ag Azatetracyclische Carbonitrile, ihre Herstellung, pharmazeutische Präparate, die diese enthalten und deren Verwendung
DE3069086D1 (de) * 1979-12-10 1984-10-04 Ciba Geigy Ag Azatetracyclic carbonitriles
FR2504140A1 (fr) * 1981-04-16 1982-10-22 Centre Nat Rech Scient Nouveaux derives tetracycliques de la dibenzazepine, leur procede de preparation et les compositions pharmaceutiques en renfermant
IL68711A (en) * 1982-05-18 1986-12-31 Sparamedica Ag Dihydro-8-halo-6-phenylpyrrolo-(3,4-d)(2)benzazepin derivatives,their preparation and pharmaceutical compositions containing them
JPS62101941U (en:Method) * 1985-12-16 1987-06-29
IE62754B1 (en) * 1988-08-26 1995-02-22 Akzo Nv Tetracyclic antidepressants
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PT690863E (pt) * 1993-04-06 2003-07-31 Abbott Lab Compostos tetraciclicos como agonistas da dopamina
PL180465B1 (pl) * 1994-03-02 2001-02-28 Akzo Nobel Nv Kompozycja farmaceutyczna zawierajaca trans-5-chloro-2-metylo-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oksepino[4,5-c]pirol PL PL PL
JP3274579B2 (ja) * 1995-01-12 2002-04-15 住友製薬株式会社 脳血管障害に伴う精神症候治療剤
HUP9901613A3 (en) * 1996-04-12 2001-08-28 Janssen Pharmaceutica Nv Substituted tetracyclic fused furanamine derivatives, process for their preparation, use thereof and pharmaceutical compositions containing them
CA2290070A1 (en) * 1997-05-26 1998-12-03 Akzo Nobel Nv Salts of aromatic sulphonic acids
HRP20020305A8 (en) * 2002-04-10 2009-03-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. 2-thia-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof
HRP20020441A2 (en) * 2002-05-21 2003-12-31 Pliva D D 1-oxa-dibenzoazulen as inhibitor of production of tumor necrosis factors and intermediate for preparation thereof
HRP20030160A2 (en) * 2003-03-06 2005-04-30 Pliva-Istra�iva�ki institut d.o.o. 1-thiadibenzoazulene derivatives and biological action thereof
KR20060011873A (ko) * 2003-05-16 2006-02-03 화이자 프로덕츠 인코포레이티드 비정형 항정신약과 ｇａｂａ 조절제, 항경련성 약물 또는 벤조다이아제핀의 치료 혼합물
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HRP20030958A2 (en) * 2003-11-21 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 1,3-DIAZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
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HRP20030956A2 (en) * 2003-11-21 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 1,2-DIAZA-DIBENZO[e,h]AZULENES FOR THE MANU
HRP20030954A2 (en) * 2003-11-21 2005-08-31 Pliva D.D. USE OF 1-AZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20030955A2 (en) * 2003-11-21 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 1-OXADIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20030957A2 (en) * 2003-11-21 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 1-THIA-3-AZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20030959A2 (en:Method) * 2003-11-21 2005-10-31 Pliva-Istra�iva�ki institut d.o.o.
HRP20040104A2 (en) * 2004-01-30 2005-10-31 Pliva-Istra�iva�ki institut d.o.o. Use of benzonaphthoazulenes for the manufacture of pharmaceutical formulations for the treatment and prevention of central nervous system diseases and disorders
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EP1753460A2 (en) * 2004-05-11 2007-02-21 Pfizer Products Inc. Combination of atypical antipsychotics and 5-ht1b receptor antagonists
BRPI0516000A (pt) * 2004-10-15 2008-05-06 Pfizer uso de um composto ou de um sal, solvato, hidrato ou isÈmero óptico farmaceuticamente aceitável do mesmo, método para tratar distúrbio bipolar em um mamìfero em necessidade do mesmo, e, kit para uso no tratamento de distúrbios bipolares
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CN103772401A (zh) * 2014-01-07 2014-05-07 万特制药(海南)有限公司 11-氯-2,3,3a,12b-四氢-2-甲基-1H-二苯并[2,3:6,7]氧杂卓并[4,5-c]吡咯-1-酮的一种新精制方法
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Also Published As

Publication number Publication date
LU77387A1 (en:Method) 1977-08-29
ZA772752B (en) 1978-04-26
CH637382A5 (de) 1983-07-29
FI65238C (fi) 1984-04-10
DE2760372C2 (en:Method) 1991-05-29
DE2723209A1 (de) 1977-12-15
DK157868B (da) 1990-02-26
HU173795B (hu) 1979-08-28
JPS6238348B2 (en:Method) 1987-08-17
JPS61178965A (ja) 1986-08-11
DK157868C (da) 1990-07-30
BE854915A (fr) 1977-11-23
SE436202B (sv) 1984-11-19
AU509073B2 (en) 1980-04-17
FI771635A7 (en:Method) 1977-11-25
JPS532465A (en) 1978-01-11
IE45419L (en) 1977-11-24
SE7705957L (sv) 1977-11-25
CH633536A5 (de) 1982-12-15
ES470408A1 (es) 1979-01-01
AU2533177A (en) 1978-11-23
FI65238B (fi) 1983-12-30
FR2352800B1 (en:Method) 1980-02-01
NL7605526A (nl) 1977-11-28
FR2352800A1 (fr) 1977-12-23
GB1567862A (en) 1980-05-21
CA1122976A (en) 1982-05-04
US4145434A (en) 1979-03-20
DK227477A (da) 1977-11-25
ES470407A1 (es) 1979-01-01
IE45419B1 (en) 1982-08-25
ES459024A1 (es) 1978-11-01

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