JPS6125687B2 - - Google Patents
Info
- Publication number
- JPS6125687B2 JPS6125687B2 JP57011299A JP1129982A JPS6125687B2 JP S6125687 B2 JPS6125687 B2 JP S6125687B2 JP 57011299 A JP57011299 A JP 57011299A JP 1129982 A JP1129982 A JP 1129982A JP S6125687 B2 JPS6125687 B2 JP S6125687B2
- Authority
- JP
- Japan
- Prior art keywords
- water
- pharmaceutically acceptable
- group
- soluble
- material layer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 25
- 239000002861 polymer material Substances 0.000 claims description 23
- 238000002360 preparation method Methods 0.000 claims description 19
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 16
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 12
- 239000000126 substance Substances 0.000 claims description 12
- 239000004014 plasticizer Substances 0.000 claims description 10
- 239000000463 material Substances 0.000 claims description 9
- 229920003169 water-soluble polymer Polymers 0.000 claims description 9
- 235000011187 glycerol Nutrition 0.000 claims description 8
- 150000003839 salts Chemical class 0.000 claims description 8
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 7
- 210000004400 mucous membrane Anatomy 0.000 claims description 7
- 235000010413 sodium alginate Nutrition 0.000 claims description 7
- 239000000661 sodium alginate Substances 0.000 claims description 7
- 229940005550 sodium alginate Drugs 0.000 claims description 7
- 238000004132 cross linking Methods 0.000 claims description 6
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 5
- 229920002125 Sokalan® Polymers 0.000 claims description 5
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 5
- 239000004584 polyacrylic acid Substances 0.000 claims description 5
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 4
- 229910021645 metal ion Inorganic materials 0.000 claims description 4
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 3
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 3
- -1 carboxymethylulose Substances 0.000 claims 1
- 230000001747 exhibiting effect Effects 0.000 claims 1
- 235000002639 sodium chloride Nutrition 0.000 claims 1
- 229940079593 drug Drugs 0.000 description 19
- 239000003814 drug Substances 0.000 description 19
- 239000000203 mixture Substances 0.000 description 8
- 230000001070 adhesive effect Effects 0.000 description 7
- 238000001035 drying Methods 0.000 description 5
- 238000009472 formulation Methods 0.000 description 5
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 4
- 239000001110 calcium chloride Substances 0.000 description 4
- 229910001628 calcium chloride Inorganic materials 0.000 description 4
- 230000003111 delayed effect Effects 0.000 description 4
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 4
- 229920006267 polyester film Polymers 0.000 description 4
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 4
- 239000004372 Polyvinyl alcohol Substances 0.000 description 3
- 239000000853 adhesive Substances 0.000 description 3
- 239000002585 base Substances 0.000 description 3
- 239000011248 coating agent Substances 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 238000004090 dissolution Methods 0.000 description 3
- 239000000499 gel Substances 0.000 description 3
- 239000011259 mixed solution Substances 0.000 description 3
- 229920002451 polyvinyl alcohol Polymers 0.000 description 3
- 238000006467 substitution reaction Methods 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 239000001856 Ethyl cellulose Substances 0.000 description 2
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 2
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 2
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 230000008602 contraction Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 235000019325 ethyl cellulose Nutrition 0.000 description 2
- 229920001249 ethyl cellulose Polymers 0.000 description 2
- 229960002089 ferrous chloride Drugs 0.000 description 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 2
- NMCUIPGRVMDVDB-UHFFFAOYSA-L iron dichloride Chemical compound Cl[Fe]Cl NMCUIPGRVMDVDB-UHFFFAOYSA-L 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 210000004379 membrane Anatomy 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 210000000214 mouth Anatomy 0.000 description 2
- 210000002200 mouth mucosa Anatomy 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 229920002126 Acrylic acid copolymer Polymers 0.000 description 1
- 229920000856 Amylose Polymers 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 239000004373 Pullulan Substances 0.000 description 1
- 229920001218 Pullulan Polymers 0.000 description 1
- 241000978776 Senegalia senegal Species 0.000 description 1
- JAWMENYCRQKKJY-UHFFFAOYSA-N [3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-ylmethyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-en-8-yl]-[2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidin-5-yl]methanone Chemical compound N1N=NC=2CN(CCC=21)CC1=NOC2(C1)CCN(CC2)C(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F JAWMENYCRQKKJY-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 239000011243 crosslinked material Substances 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 235000019441 ethanol Nutrition 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 238000001879 gelation Methods 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229910001629 magnesium chloride Inorganic materials 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 235000019423 pullulan Nutrition 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1129982A JPS58128314A (ja) | 1982-01-26 | 1982-01-26 | 粘膜製剤 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1129982A JPS58128314A (ja) | 1982-01-26 | 1982-01-26 | 粘膜製剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS58128314A JPS58128314A (ja) | 1983-07-30 |
| JPS6125687B2 true JPS6125687B2 (xx) | 1986-06-17 |
Family
ID=11774109
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1129982A Granted JPS58128314A (ja) | 1982-01-26 | 1982-01-26 | 粘膜製剤 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS58128314A (xx) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60116630A (ja) * | 1983-11-29 | 1985-06-24 | Nitto Electric Ind Co Ltd | 口腔内製剤 |
| JPS60116631A (ja) * | 1983-11-29 | 1985-06-24 | Nitto Electric Ind Co Ltd | 口腔内製剤 |
| JPS60215622A (ja) * | 1984-04-09 | 1985-10-29 | Toyobo Co Ltd | 口腔粘膜適用徐放性製剤 |
| JPS60248609A (ja) * | 1984-05-23 | 1985-12-09 | Toyobo Co Ltd | 口腔粘膜適用徐放性製剤 |
| JPS6185315A (ja) * | 1984-10-04 | 1986-04-30 | Teikoku Seiyaku Kk | シ−ト状製剤 |
| JPS61280423A (ja) * | 1985-06-05 | 1986-12-11 | Kiyuukiyuu Yakuhin Kogyo Kk | 口腔内粘膜貼付剤 |
| JPH07553B2 (ja) * | 1985-12-09 | 1995-01-11 | 佐藤製薬株式会社 | フイルム状製剤 |
| JPS63310818A (ja) * | 1987-06-12 | 1988-12-19 | Sato Seiyaku Kk | シ−ト状口腔粘膜付着製剤 |
| JP2776837B2 (ja) * | 1988-08-11 | 1998-07-16 | 日本レダリー株式会社 | 消化性潰瘍治療剤 |
| US5039699A (en) * | 1989-03-27 | 1991-08-13 | Lederle (Japan), Ltd. | Anti-peptic ulcer agent |
| US5525351A (en) * | 1989-11-07 | 1996-06-11 | Dam; Anders | Nicotine containing stimulant unit |
| DK615689A (da) * | 1989-11-07 | 1991-05-08 | Anders Dam | Rygesupplement eller rygeerstatningsprodukt |
| JP2791317B2 (ja) * | 1995-12-26 | 1998-08-27 | 株式会社三和化学研究所 | 多層フィルム製剤 |
| DE10358747A1 (de) * | 2003-12-12 | 2005-07-07 | Lts Lohmann Therapie-Systeme Ag | Darreichungsform basierend auf vernetzten hydrophilen Polymeren |
| US10987321B2 (en) * | 2018-09-04 | 2021-04-27 | Babak Ghalili | Cannabinoid and anesthetic compositions and methods |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS502006A (xx) * | 1973-05-09 | 1975-01-10 | ||
| JPS5282715A (en) * | 1975-12-29 | 1977-07-11 | Sanyo Chem Ind Ltd | Long acting drug composition |
| JPS5315413A (en) * | 1976-07-28 | 1978-02-13 | Daikiyou Yakuhin Kougiyou Kk | Pap agent |
| JPS5492618A (en) * | 1977-12-30 | 1979-07-23 | Japan Synthetic Rubber Co Ltd | Poultice |
| JPS555488A (en) * | 1978-06-16 | 1980-01-16 | Bbc Brown Boveri & Cie | Operation method of gas turbine apparatus |
| JPS5562012A (en) * | 1978-11-06 | 1980-05-10 | Teijin Ltd | Slow-releasing preparation |
| JPS5584166A (en) * | 1978-12-20 | 1980-06-25 | Lion Hamigaki Kk | Band for spongy medicine |
| JPS5584167A (en) * | 1978-12-20 | 1980-06-25 | Lion Hamigaki Kk | Band for spongy medicine |
| JPS5758615A (en) * | 1980-09-26 | 1982-04-08 | Nippon Soda Co Ltd | Film agnent and its preparation |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5937253Y2 (ja) * | 1978-12-20 | 1984-10-15 | ライオン株式会社 | 口腔用バンド |
-
1982
- 1982-01-26 JP JP1129982A patent/JPS58128314A/ja active Granted
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS502006A (xx) * | 1973-05-09 | 1975-01-10 | ||
| JPS5282715A (en) * | 1975-12-29 | 1977-07-11 | Sanyo Chem Ind Ltd | Long acting drug composition |
| JPS5315413A (en) * | 1976-07-28 | 1978-02-13 | Daikiyou Yakuhin Kougiyou Kk | Pap agent |
| JPS5492618A (en) * | 1977-12-30 | 1979-07-23 | Japan Synthetic Rubber Co Ltd | Poultice |
| JPS555488A (en) * | 1978-06-16 | 1980-01-16 | Bbc Brown Boveri & Cie | Operation method of gas turbine apparatus |
| JPS5562012A (en) * | 1978-11-06 | 1980-05-10 | Teijin Ltd | Slow-releasing preparation |
| JPS5584166A (en) * | 1978-12-20 | 1980-06-25 | Lion Hamigaki Kk | Band for spongy medicine |
| JPS5584167A (en) * | 1978-12-20 | 1980-06-25 | Lion Hamigaki Kk | Band for spongy medicine |
| JPS5758615A (en) * | 1980-09-26 | 1982-04-08 | Nippon Soda Co Ltd | Film agnent and its preparation |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS58128314A (ja) | 1983-07-30 |
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