JPS6089414A - リポソ−ム組成物の製造法 - Google Patents
リポソ−ム組成物の製造法Info
- Publication number
- JPS6089414A JPS6089414A JP59170982A JP17098284A JPS6089414A JP S6089414 A JPS6089414 A JP S6089414A JP 59170982 A JP59170982 A JP 59170982A JP 17098284 A JP17098284 A JP 17098284A JP S6089414 A JPS6089414 A JP S6089414A
- Authority
- JP
- Japan
- Prior art keywords
- component
- propellant
- manufacturing
- chambers
- chamber
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims description 67
- 238000004519 manufacturing process Methods 0.000 title claims description 28
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical group CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 116
- 238000002156 mixing Methods 0.000 claims description 88
- 239000003380 propellant Substances 0.000 claims description 76
- 239000000443 aerosol Substances 0.000 claims description 68
- 239000000243 solution Substances 0.000 claims description 68
- 239000004338 Dichlorodifluoromethane Substances 0.000 claims description 54
- PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 claims description 54
- 235000019404 dichlorodifluoromethane Nutrition 0.000 claims description 54
- 239000002502 liposome Substances 0.000 claims description 48
- 150000001875 compounds Chemical class 0.000 claims description 47
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 37
- 238000000034 method Methods 0.000 claims description 34
- 150000002632 lipids Chemical class 0.000 claims description 28
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 28
- 239000013543 active substance Substances 0.000 claims description 25
- 235000012000 cholesterol Nutrition 0.000 claims description 18
- 239000000126 substance Substances 0.000 claims description 14
- 238000011282 treatment Methods 0.000 claims description 13
- DDMOUSALMHHKOS-UHFFFAOYSA-N 1,2-dichloro-1,1,2,2-tetrafluoroethane Chemical compound FC(F)(Cl)C(F)(F)Cl DDMOUSALMHHKOS-UHFFFAOYSA-N 0.000 claims description 12
- 229940087091 dichlorotetrafluoroethane Drugs 0.000 claims description 12
- 150000003904 phospholipids Chemical class 0.000 claims description 12
- PORPENFLTBBHSG-MGBGTMOVSA-N 1,2-dihexadecanoyl-sn-glycerol-3-phosphate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(O)=O)OC(=O)CCCCCCCCCCCCCCC PORPENFLTBBHSG-MGBGTMOVSA-N 0.000 claims description 8
- 239000007788 liquid Substances 0.000 claims description 8
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical group CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims description 8
- 239000007921 spray Substances 0.000 claims description 8
- 241001465754 Metazoa Species 0.000 claims description 7
- REYJJPSVUYRZGE-UHFFFAOYSA-N Octadecylamine Chemical compound CCCCCCCCCCCCCCCCCCN REYJJPSVUYRZGE-UHFFFAOYSA-N 0.000 claims description 6
- RNPXCFINMKSQPQ-UHFFFAOYSA-N dicetyl hydrogen phosphate Chemical compound CCCCCCCCCCCCCCCCOP(O)(=O)OCCCCCCCCCCCCCCCC RNPXCFINMKSQPQ-UHFFFAOYSA-N 0.000 claims description 6
- 229940093541 dicetylphosphate Drugs 0.000 claims description 6
- 238000005507 spraying Methods 0.000 claims description 6
- 229960004620 bitolterol Drugs 0.000 claims description 5
- FZGVEKPRDOIXJY-UHFFFAOYSA-N bitolterol Chemical group C1=CC(C)=CC=C1C(=O)OC1=CC=C(C(O)CNC(C)(C)C)C=C1OC(=O)C1=CC=C(C)C=C1 FZGVEKPRDOIXJY-UHFFFAOYSA-N 0.000 claims description 5
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 4
- KILNVBDSWZSGLL-KXQOOQHDSA-N 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine Chemical group CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC KILNVBDSWZSGLL-KXQOOQHDSA-N 0.000 claims description 3
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 3
- 239000002260 anti-inflammatory agent Substances 0.000 claims description 3
- 229940121363 anti-inflammatory agent Drugs 0.000 claims description 3
- 150000008282 halocarbons Chemical class 0.000 claims description 3
- 239000004615 ingredient Substances 0.000 claims description 3
- 239000000787 lecithin Substances 0.000 claims description 3
- 229940067606 lecithin Drugs 0.000 claims description 3
- 235000010445 lecithin Nutrition 0.000 claims description 3
- 230000007935 neutral effect Effects 0.000 claims description 3
- 239000003960 organic solvent Substances 0.000 claims description 3
- 239000004033 plastic Substances 0.000 claims description 3
- JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 claims description 2
- 239000000427 antigen Substances 0.000 claims description 2
- 102000036639 antigens Human genes 0.000 claims description 2
- 108091007433 antigens Proteins 0.000 claims description 2
- 239000002246 antineoplastic agent Substances 0.000 claims description 2
- 229940124630 bronchodilator Drugs 0.000 claims description 2
- 239000000872 buffer Substances 0.000 claims description 2
- 239000007853 buffer solution Substances 0.000 claims description 2
- 235000016709 nutrition Nutrition 0.000 claims description 2
- 150000008104 phosphatidylethanolamines Chemical class 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 claims description 2
- 229940042935 dichlorodifluoromethane Drugs 0.000 claims 3
- 239000000470 constituent Substances 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- ZAFNJMIOTHYJRJ-UHFFFAOYSA-N Diisopropyl ether Chemical group CC(C)OC(C)C ZAFNJMIOTHYJRJ-UHFFFAOYSA-N 0.000 claims 1
- 229960000265 cromoglicic acid Drugs 0.000 claims 1
- IMZMKUWMOSJXDT-UHFFFAOYSA-N cromoglycic acid Chemical compound O1C(C(O)=O)=CC(=O)C2=C1C=CC=C2OCC(O)COC1=CC=CC2=C1C(=O)C=C(C(O)=O)O2 IMZMKUWMOSJXDT-UHFFFAOYSA-N 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 125000001095 phosphatidyl group Chemical group 0.000 claims 1
- 230000035935 pregnancy Effects 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 150000003431 steroids Chemical class 0.000 claims 1
- 235000019441 ethanol Nutrition 0.000 description 53
- 239000011521 glass Substances 0.000 description 28
- JQWAHKMIYCERGA-UHFFFAOYSA-N (2-nonanoyloxy-3-octadeca-9,12-dienoyloxypropoxy)-[2-(trimethylazaniumyl)ethyl]phosphinate Chemical compound CCCCCCCCC(=O)OC(COP([O-])(=O)CC[N+](C)(C)C)COC(=O)CCCCCCCC=CCC=CCCCCC JQWAHKMIYCERGA-UHFFFAOYSA-N 0.000 description 27
- 238000012546 transfer Methods 0.000 description 25
- APUPEJJSWDHEBO-UHFFFAOYSA-P ammonium molybdate Chemical compound [NH4+].[NH4+].[O-][Mo]([O-])(=O)=O APUPEJJSWDHEBO-UHFFFAOYSA-P 0.000 description 18
- 239000011609 ammonium molybdate Substances 0.000 description 18
- 229940010552 ammonium molybdate Drugs 0.000 description 18
- 235000018660 ammonium molybdate Nutrition 0.000 description 18
- 239000008367 deionised water Substances 0.000 description 18
- 229910021641 deionized water Inorganic materials 0.000 description 18
- 239000000463 material Substances 0.000 description 15
- LKAJKIOFIWVMDJ-IYRCEVNGSA-N Stanazolol Chemical compound C([C@@H]1CC[C@H]2[C@@H]3CC[C@@]([C@]3(CC[C@@H]2[C@@]1(C)C1)C)(O)C)C2=C1C=NN2 LKAJKIOFIWVMDJ-IYRCEVNGSA-N 0.000 description 13
- 229960000912 stanozolol Drugs 0.000 description 13
- 239000007864 aqueous solution Substances 0.000 description 8
- 230000000694 effects Effects 0.000 description 8
- 239000001488 sodium phosphate Substances 0.000 description 8
- 229910000162 sodium phosphate Inorganic materials 0.000 description 8
- 235000011008 sodium phosphates Nutrition 0.000 description 8
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 8
- 239000003795 chemical substances by application Substances 0.000 description 7
- 239000002356 single layer Substances 0.000 description 7
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 6
- 229910052782 aluminium Inorganic materials 0.000 description 6
- 239000012298 atmosphere Substances 0.000 description 6
- 229960000585 bitolterol mesylate Drugs 0.000 description 6
- HODFCFXCOMKRCG-UHFFFAOYSA-N bitolterol mesylate Chemical compound CS([O-])(=O)=O.C1=CC(C)=CC=C1C(=O)OC1=CC=C(C(O)C[NH2+]C(C)(C)C)C=C1OC(=O)C1=CC=C(C)C=C1 HODFCFXCOMKRCG-UHFFFAOYSA-N 0.000 description 6
- 238000009472 formulation Methods 0.000 description 6
- 239000000725 suspension Substances 0.000 description 6
- 229910019142 PO4 Inorganic materials 0.000 description 5
- UMNKXPULIDJLSU-UHFFFAOYSA-N dichlorofluoromethane Chemical compound FC(Cl)Cl UMNKXPULIDJLSU-UHFFFAOYSA-N 0.000 description 5
- 229940099364 dichlorofluoromethane Drugs 0.000 description 5
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 5
- 239000010452 phosphate Substances 0.000 description 5
- 229920000642 polymer Polymers 0.000 description 5
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 239000004480 active ingredient Substances 0.000 description 4
- 239000000969 carrier Substances 0.000 description 4
- 229910052708 sodium Inorganic materials 0.000 description 4
- 239000011734 sodium Substances 0.000 description 4
- 102000002322 Egg Proteins Human genes 0.000 description 3
- 108010000912 Egg Proteins Proteins 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 239000000853 adhesive Substances 0.000 description 3
- 230000001070 adhesive effect Effects 0.000 description 3
- 238000012387 aerosolization Methods 0.000 description 3
- 239000002537 cosmetic Substances 0.000 description 3
- 235000013345 egg yolk Nutrition 0.000 description 3
- 210000002969 egg yolk Anatomy 0.000 description 3
- 239000010410 layer Substances 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 239000003595 mist Substances 0.000 description 3
- 238000001556 precipitation Methods 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical compound O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 description 2
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- -1 Salbutamol Catecholamines Chemical class 0.000 description 2
- 229960002537 betamethasone Drugs 0.000 description 2
- UREBDLICKHMUKA-DVTGEIKXSA-N betamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-DVTGEIKXSA-N 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- NBVXSUQYWXRMNV-UHFFFAOYSA-N fluoromethane Chemical compound FC NBVXSUQYWXRMNV-UHFFFAOYSA-N 0.000 description 2
- 238000010348 incorporation Methods 0.000 description 2
- 238000002664 inhalation therapy Methods 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 238000004537 pulping Methods 0.000 description 2
- 229960002052 salbutamol Drugs 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 238000013268 sustained release Methods 0.000 description 2
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 description 1
- POAOYUHQDCAZBD-UHFFFAOYSA-N 2-butoxyethanol Chemical compound CCCCOCCO POAOYUHQDCAZBD-UHFFFAOYSA-N 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- 241000972773 Aulopiformes Species 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 208000001840 Dandruff Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 206010024612 Lipoma Diseases 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- 241000238814 Orthoptera Species 0.000 description 1
- 206010038687 Respiratory distress Diseases 0.000 description 1
- RYMZZMVNJRMUDD-UHFFFAOYSA-N SJ000286063 Natural products C12C(OC(=O)C(C)(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 RYMZZMVNJRMUDD-UHFFFAOYSA-N 0.000 description 1
- 206010039792 Seborrhoea Diseases 0.000 description 1
- 206010072170 Skin wound Diseases 0.000 description 1
- 208000010040 Sprains and Strains Diseases 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 description 1
- 239000003263 anabolic agent Substances 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000001166 anti-perspirative effect Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000003213 antiperspirant Substances 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 239000007900 aqueous suspension Substances 0.000 description 1
- 239000003212 astringent agent Substances 0.000 description 1
- 229960004311 betamethasone valerate Drugs 0.000 description 1
- SNHRLVCMMWUAJD-SUYDQAKGSA-N betamethasone valerate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(OC(=O)CCCC)[C@@]1(C)C[C@@H]2O SNHRLVCMMWUAJD-SUYDQAKGSA-N 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000007844 bleaching agent Substances 0.000 description 1
- 238000009534 blood test Methods 0.000 description 1
- 210000000621 bronchi Anatomy 0.000 description 1
- 241001233037 catfish Species 0.000 description 1
- 239000003638 chemical reducing agent Substances 0.000 description 1
- KNHUKKLJHYUCFP-UHFFFAOYSA-N clofibrate Chemical compound CCOC(=O)C(C)(C)OC1=CC=C(Cl)C=C1 KNHUKKLJHYUCFP-UHFFFAOYSA-N 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 229940124558 contraceptive agent Drugs 0.000 description 1
- 239000003433 contraceptive agent Substances 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 239000002781 deodorant agent Substances 0.000 description 1
- 229940061607 dibasic sodium phosphate Drugs 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 238000001493 electron microscopy Methods 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- 238000007429 general method Methods 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
- 229940047135 glycate Drugs 0.000 description 1
- 239000000118 hair dye Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 239000003410 keratolytic agent Substances 0.000 description 1
- 239000003580 lung surfactant Substances 0.000 description 1
- 239000006166 lysate Substances 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- 229940045641 monobasic sodium phosphate Drugs 0.000 description 1
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 1
- 235000019799 monosodium phosphate Nutrition 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 150000008105 phosphatidylcholines Chemical class 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol Chemical compound C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 235000019515 salmon Nutrition 0.000 description 1
- 208000008742 seborrheic dermatitis Diseases 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000002884 skin cream Substances 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- 239000012064 sodium phosphate buffer Substances 0.000 description 1
- 230000000475 sunscreen effect Effects 0.000 description 1
- 239000000516 sunscreening agent Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940075420 xanthine Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1277—Preparation processes; Proliposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Otolaryngology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8322178 | 1983-08-17 | ||
| GB838322178A GB8322178D0 (en) | 1983-08-17 | 1983-08-17 | Preparing aerosol compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS6089414A true JPS6089414A (ja) | 1985-05-20 |
Family
ID=10547457
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP59170982A Pending JPS6089414A (ja) | 1983-08-17 | 1984-08-16 | リポソ−ム組成物の製造法 |
Country Status (22)
| Country | Link |
|---|---|
| JP (1) | JPS6089414A (en, 2012) |
| KR (1) | KR850001689A (en, 2012) |
| AT (1) | AT389993B (en, 2012) |
| AU (1) | AU569314B2 (en, 2012) |
| BE (1) | BE900375A (en, 2012) |
| CH (1) | CH667384B (en, 2012) |
| DE (1) | DE3430385A1 (en, 2012) |
| DK (1) | DK163479C (en, 2012) |
| ES (1) | ES535163A0 (en, 2012) |
| FI (1) | FI85214C (en, 2012) |
| FR (1) | FR2550706B1 (en, 2012) |
| GB (2) | GB8322178D0 (en, 2012) |
| GR (1) | GR80127B (en, 2012) |
| IE (1) | IE57537B1 (en, 2012) |
| IL (1) | IL72590A (en, 2012) |
| IT (1) | IT1175612B (en, 2012) |
| LU (1) | LU85512A1 (en, 2012) |
| NL (1) | NL8402514A (en, 2012) |
| NZ (1) | NZ209112A (en, 2012) |
| PT (1) | PT79104B (en, 2012) |
| SE (1) | SE459471B (en, 2012) |
| ZA (1) | ZA846064B (en, 2012) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63211223A (ja) * | 1986-11-06 | 1988-09-02 | リサーチ デベロップメント ファウンデイション | 医療用のリポソームおよび薬物含有リポソームのエアゾールの小粒子 |
| JPS63287711A (ja) * | 1987-05-18 | 1988-11-24 | Hiroaki Konishi | 化粧料 |
| JPH03193714A (ja) * | 1989-12-25 | 1991-08-23 | Kobayashi Kose Co Ltd | エアゾール型化粧料 |
| WO1998055104A1 (fr) * | 1997-06-06 | 1998-12-10 | Shionogi & Co., Ltd. | Perfectionnement d'un systeme d'administration de medicament |
| WO2000000178A1 (fr) * | 1998-06-30 | 2000-01-06 | Rohto Pharmaceutical Co., Ltd. | Compositions contenant des liposomes et/ou des emulsions et leur procede de preparation |
| JP2002529393A (ja) * | 1998-11-12 | 2002-09-10 | フランク ジー． ピルキーウィッツ， | 吸入システム |
| WO2007117023A1 (ja) * | 2006-04-11 | 2007-10-18 | Wingturf Co., Ltd. | リポソーム分散液の製造方法ならびに製造装置 |
| JP2019043929A (ja) * | 2017-08-31 | 2019-03-22 | クラシエホームプロダクツ株式会社 | 皮膚化粧料 |
Families Citing this family (41)
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| DE3585967D1 (de) * | 1984-03-08 | 1992-06-11 | Phares Pharma Holland | Liposombildende zusammensetzung. |
| GB8423436D0 (en) * | 1984-09-17 | 1984-10-24 | Riker Laboratories Inc | Preparation of liposomes |
| CA1260393A (en) * | 1984-10-16 | 1989-09-26 | Lajos Tarcsay | Liposomes of synthetic lipids |
| GB8502892D0 (en) * | 1985-02-05 | 1985-03-06 | Sterwin Ag | Aerosol composition |
| WO1986006959A1 (en) * | 1985-05-22 | 1986-12-04 | Liposome Technology, Inc. | Liposome inhalation method and system |
| US5192528A (en) | 1985-05-22 | 1993-03-09 | Liposome Technology, Inc. | Corticosteroid inhalation treatment method |
| US5340587A (en) * | 1985-05-22 | 1994-08-23 | Liposome Technology, Inc. | Liposome/bronchodilator method & System |
| GB8522964D0 (en) * | 1985-09-17 | 1985-10-23 | Biocompatibles Ltd | Aerosol |
| JPS62270531A (ja) * | 1985-11-01 | 1987-11-24 | サントル ナシヨナ−ル ド ラ ルシエルシユ シヤンテイフイ−ク（セ−・エン・エル・エス） | 生体内でのイメ−ジング及び治療用の新規エアロゾル組成物 |
| US4897256A (en) * | 1986-11-25 | 1990-01-30 | Abbott Laboratories | LHRH analog formulations |
| US5030442A (en) * | 1987-03-30 | 1991-07-09 | Liposome Technology, Inc. | Non-crystalline minoxidil composition |
| US4828837A (en) * | 1987-03-30 | 1989-05-09 | Liposome Technology, Inc. | Non-crystalline minoxidil composition, its production and application |
| FR2638639A1 (fr) * | 1988-11-08 | 1990-05-11 | Parincos Parfumerie Cosmet Int | Composition et procede d'obtention de liposomes oligolamellaires en vue d'une application en cosmetologie et dermatologie topique |
| DE4203306A1 (de) * | 1992-02-06 | 1993-08-12 | Ig Spruehtechnik Gmbh | Asthma oder pulmonal-aerosolzubereitungen mit lecithin |
| ATE166573T1 (de) * | 1993-03-24 | 1998-06-15 | Ciba Geigy Ag | Verfahren zur herstellung einer liposomendispersion im hochdruckbereich |
| AU689786B2 (en) * | 1993-06-30 | 1998-04-09 | Genentech Inc. | Method for preparing liposomes |
| GB9409763D0 (en) * | 1994-05-16 | 1994-07-06 | Phares Pharma Holland | Liposome forming compositions |
| ES2111488B1 (es) * | 1996-01-17 | 1998-11-01 | Lucas Meyer S A | Utilizacion de composiciones proliposomas en la tintura, blanqueo y suavizado de la industrial textil y procedimiento para la preparacion de banos de tintura a partir de dichas composiciones proliposomas. |
| EP1839648A3 (en) * | 1998-11-12 | 2007-11-21 | Transave, Inc. | An inhalation system |
| US7879351B2 (en) | 2002-10-29 | 2011-02-01 | Transave, Inc. | High delivery rates for lipid based drug formulations, and methods of treatment thereof |
| ES2539591T3 (es) | 2002-10-29 | 2015-07-02 | Insmed Incorporated | Liberación sostenida de antiinfectantes |
| US7718189B2 (en) | 2002-10-29 | 2010-05-18 | Transave, Inc. | Sustained release of antiinfectives |
| EP1954243A2 (en) * | 2005-10-26 | 2008-08-13 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | A method for preparing liposomes and uses thereof |
| ES2798263T3 (es) | 2005-12-08 | 2020-12-10 | Insmed Inc | Composiciones a base de lípidos de antiinfecciosos para tratar infecciones pulmonares |
| WO2008137717A1 (en) | 2007-05-04 | 2008-11-13 | Transave, Inc. | Compositions of multicationic drugs for reducing interactions with polyanionic biomolecules and methods and uses thereof |
| US9333214B2 (en) | 2007-05-07 | 2016-05-10 | Insmed Incorporated | Method for treating pulmonary disorders with liposomal amikacin formulations |
| US9114081B2 (en) | 2007-05-07 | 2015-08-25 | Insmed Incorporated | Methods of treating pulmonary disorders with liposomal amikacin formulations |
| US9119783B2 (en) | 2007-05-07 | 2015-09-01 | Insmed Incorporated | Method of treating pulmonary disorders with liposomal amikacin formulations |
| CN102307557B (zh) * | 2008-12-29 | 2014-10-22 | 叶夫根尼·彼得罗维奇·格列比翁尼科夫 | 脂质体药物的制备方法和脂质体制备装置 |
| RU2470624C1 (ru) * | 2011-08-25 | 2012-12-27 | Евгений Петрович Гребенников | Устройство для получения липосомальных препаратов |
| ES2905368T3 (es) | 2012-05-21 | 2022-04-08 | Insmed Inc | Sistemas para el tratamiento de infecciones pulmonares |
| WO2014085526A1 (en) | 2012-11-29 | 2014-06-05 | Insmed Incorporated | Stabilized vancomycin formulations |
| EP3104854B1 (en) | 2014-02-10 | 2020-04-08 | Respivant Sciences GmbH | Mast cell stabilizers for lung disease treatment |
| WO2015120389A1 (en) | 2014-02-10 | 2015-08-13 | Patara Pharma, LLC | Mast cell stabilizers treatment for systemic disorders |
| ES2755941T3 (es) | 2014-05-15 | 2020-04-24 | Insmed Inc | Métodos para tratar infecciones pulmonares micobacterianas no tuberculosas |
| US10265296B2 (en) | 2015-08-07 | 2019-04-23 | Respivant Sciences Gmbh | Methods for the treatment of systemic disorders treatable with mast cell stabilizers, including mast cell related disorders |
| WO2017027387A1 (en) | 2015-08-07 | 2017-02-16 | Patara Pharma, LLC | Methods for the treatment of mast cell related disorders with mast cell stabilizers |
| JP2019528320A (ja) | 2016-08-31 | 2019-10-10 | レシュピファント サイエンシス ゲゼルシャフト ミット ベシュレンクター ハフトゥングＲｅｓｐｉｖａｎｔ Ｓｃｉｅｎｃｅｓ Ｇｍｂｈ | 特発性肺線維症による慢性咳の治療のためのクロモリン組成物 |
| EP3522983A4 (en) | 2016-10-07 | 2020-06-03 | Respivant Sciences GmbH | CROMOLYNE-BASED COMPOSITIONS FOR THE TREATMENT OF PULMONARY FIBROSIS |
| WO2019191627A1 (en) | 2018-03-30 | 2019-10-03 | Insmed Incorporated | Methods for continuous manufacture of liposomal drug products |
| JP7269378B2 (ja) * | 2020-07-17 | 2023-05-08 | ケーティー アンド ジー コーポレイション | エアロゾル生成物品用加圧装置及びそれを含むエアロゾル生成システム |
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| GB780885A (en) * | 1955-05-03 | 1957-08-07 | Innoxa England Ltd | Foundation cream |
| GB993702A (en) * | 1961-11-10 | 1965-06-02 | Takeda Chemical Industries Ltd | An aerosol dispersing agent |
| DE1277210B (de) * | 1965-09-24 | 1968-09-12 | Revlon | Selbsttreibende Gemische |
| US3326416A (en) * | 1966-01-14 | 1967-06-20 | Du Pont | Apparatus for codispensing a plurality of liquids |
| US3325056A (en) * | 1966-02-23 | 1967-06-13 | Du Pont | Apparatus for codispensing a plurality of liquids |
| US3338479A (en) * | 1966-04-04 | 1967-08-29 | Leonard L Marraffino | Mixing head with secondary fluid adapted for connection with discharge means of primary fluid container |
| GB1287470A (en) * | 1968-11-25 | 1972-08-31 | Gillette Co | Pressurised dispensing package |
| US3594476A (en) * | 1969-05-12 | 1971-07-20 | Massachusetts Inst Technology | Submicron aqueous aerosols containing lecithin |
| NL7012832A (en, 2012) * | 1970-08-29 | 1972-03-02 | ||
| US3637114A (en) * | 1970-09-03 | 1972-01-25 | Philip Meshberg | Device for codispensing two materials |
| GB1372721A (en) * | 1971-01-16 | 1974-11-06 | Wilkinson Sword Ltd | Containers of antiseptics for the treatment of burns and scalds |
| DE2115926C3 (de) * | 1971-04-01 | 1978-05-03 | C.H. Boehringer Sohn, 6507 Ingelheim | 1 -(4-Hydroxy-3-dimethylaminosuIfamidophenyI)-2-aminoäthanderivate, Verfahren zu ihrer Herstellung und diese enthaltende Mittel |
| US3997467A (en) * | 1971-11-26 | 1976-12-14 | Pharmacia Aktiebolag | Foam forming composition |
| DE2346730C3 (de) * | 1973-09-17 | 1980-10-16 | Carl Heyer Gmbh, Inhalationstechnik, 5427 Bad Ems | Einrichtung zur Aerosolbehandlung von Menschen, Tieren, Gegenständen, Stoffen u.dgl. in einem Behandlungsraum |
| LU70720A1 (en, 2012) * | 1974-08-12 | 1976-08-19 | ||
| US4073412A (en) * | 1976-06-03 | 1978-02-14 | Blue Cross Laboratories, Inc. | Emulsified cookware lubricant having freeze-thaw stability |
| GB1575343A (en) * | 1977-05-10 | 1980-09-17 | Ici Ltd | Method for preparing liposome compositions containing biologically active compounds |
| GB2001334B (en) * | 1977-07-19 | 1982-03-03 | Fisons Ltd | Pressurised aerosol formulation |
| FR2416008A1 (fr) * | 1978-02-02 | 1979-08-31 | Oreal | Lyophilisats de liposomes |
| CH646390A5 (de) * | 1980-05-12 | 1984-11-30 | Polyfill Ag | Druckdose. |
| DE3207289A1 (de) * | 1982-03-01 | 1983-09-15 | Perfect-Valois Ventil GmbH, 4600 Dortmund | Abgabeventil fuer aerosoldosen |
| EP0100964A3 (de) * | 1982-07-31 | 1984-06-13 | Reifenrath, Rainer, Dr. | Pharmazeutisches Erzeugnis zur Behandlung und Prophylaxe von Infektionen sowie von Husten und obstruktiven Atemwegserkrankungen sowie Verfahren zu seiner Herstellung |
| FR2543018B1 (fr) * | 1983-03-22 | 1985-07-26 | Oreal | Procede de preparation de vesicules lipidiques par vaporisation de solvants |
| CH664943A5 (de) * | 1983-08-16 | 1988-04-15 | Sterwin Ag | Zweikomponentenpackung. |
-
1983
- 1983-08-17 GB GB838322178A patent/GB8322178D0/en active Pending
-
1984
- 1984-08-03 NZ NZ209112A patent/NZ209112A/xx unknown
- 1984-08-06 ZA ZA846064A patent/ZA846064B/xx unknown
- 1984-08-06 IL IL72590A patent/IL72590A/xx unknown
- 1984-08-10 AU AU31786/84A patent/AU569314B2/en not_active Ceased
- 1984-08-14 ES ES535163A patent/ES535163A0/es active Granted
- 1984-08-15 DE DE19843430385 patent/DE3430385A1/de not_active Withdrawn
- 1984-08-15 FI FI843223A patent/FI85214C/fi not_active IP Right Cessation
- 1984-08-16 IE IE2121/84A patent/IE57537B1/en not_active IP Right Cessation
- 1984-08-16 SE SE8404118A patent/SE459471B/sv not_active IP Right Cessation
- 1984-08-16 CH CH395884A patent/CH667384B/xx not_active IP Right Cessation
- 1984-08-16 KR KR1019840004923A patent/KR850001689A/ko not_active Withdrawn
- 1984-08-16 GR GR80127A patent/GR80127B/el unknown
- 1984-08-16 DK DK392884A patent/DK163479C/da not_active IP Right Cessation
- 1984-08-16 NL NL8402514A patent/NL8402514A/nl not_active Application Discontinuation
- 1984-08-16 GB GB08420850A patent/GB2145107B/en not_active Expired
- 1984-08-16 JP JP59170982A patent/JPS6089414A/ja active Pending
- 1984-08-16 AT AT0263684A patent/AT389993B/de not_active IP Right Cessation
- 1984-08-17 PT PT79104A patent/PT79104B/pt not_active IP Right Cessation
- 1984-08-17 IT IT22357/84A patent/IT1175612B/it active
- 1984-08-17 FR FR8412930A patent/FR2550706B1/fr not_active Expired
- 1984-08-17 LU LU85512A patent/LU85512A1/fr unknown
- 1984-08-17 BE BE0/213504A patent/BE900375A/fr not_active IP Right Cessation
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63211223A (ja) * | 1986-11-06 | 1988-09-02 | リサーチ デベロップメント ファウンデイション | 医療用のリポソームおよび薬物含有リポソームのエアゾールの小粒子 |
| JPS63287711A (ja) * | 1987-05-18 | 1988-11-24 | Hiroaki Konishi | 化粧料 |
| JPH03193714A (ja) * | 1989-12-25 | 1991-08-23 | Kobayashi Kose Co Ltd | エアゾール型化粧料 |
| WO1998055104A1 (fr) * | 1997-06-06 | 1998-12-10 | Shionogi & Co., Ltd. | Perfectionnement d'un systeme d'administration de medicament |
| WO2000000178A1 (fr) * | 1998-06-30 | 2000-01-06 | Rohto Pharmaceutical Co., Ltd. | Compositions contenant des liposomes et/ou des emulsions et leur procede de preparation |
| JP2002529393A (ja) * | 1998-11-12 | 2002-09-10 | フランク ジー． ピルキーウィッツ， | 吸入システム |
| WO2007117023A1 (ja) * | 2006-04-11 | 2007-10-18 | Wingturf Co., Ltd. | リポソーム分散液の製造方法ならびに製造装置 |
| JP2019043929A (ja) * | 2017-08-31 | 2019-03-22 | クラシエホームプロダクツ株式会社 | 皮膚化粧料 |
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