JPS6052157B2 - スピロ−多環式イミダゾリジンジオン誘導体 - Google Patents

スピロ−多環式イミダゾリジンジオン誘導体

Info

Publication number
JPS6052157B2
JPS6052157B2 JP54147592A JP14759279A JPS6052157B2 JP S6052157 B2 JPS6052157 B2 JP S6052157B2 JP 54147592 A JP54147592 A JP 54147592A JP 14759279 A JP14759279 A JP 14759279A JP S6052157 B2 JPS6052157 B2 JP S6052157B2
Authority
JP
Japan
Prior art keywords
naphtho
imidazolidinedione
spiro polycyclic
derivative
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP54147592A
Other languages
English (en)
Japanese (ja)
Other versions
JPS5589268A (en
Inventor
レインハ−ド・サ−ジエス
ジヨン・エル・ベルテイア
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp Belgium
Original Assignee
Pfizer Corp Belgium
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp Belgium filed Critical Pfizer Corp Belgium
Publication of JPS5589268A publication Critical patent/JPS5589268A/ja
Publication of JPS6052157B2 publication Critical patent/JPS6052157B2/ja
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP54147592A 1978-11-16 1979-11-14 スピロ−多環式イミダゾリジンジオン誘導体 Expired JPS6052157B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/961,335 US4181728A (en) 1978-11-16 1978-11-16 Spiro-polycyclicimidazolidinedione derivatives
US961335 1978-11-16

Publications (2)

Publication Number Publication Date
JPS5589268A JPS5589268A (en) 1980-07-05
JPS6052157B2 true JPS6052157B2 (ja) 1985-11-18

Family

ID=25504341

Family Applications (2)

Application Number Title Priority Date Filing Date
JP54147592A Expired JPS6052157B2 (ja) 1978-11-16 1979-11-14 スピロ−多環式イミダゾリジンジオン誘導体
JP59222857A Granted JPS60120870A (ja) 1978-11-16 1984-10-23 スピロ−多環式イミダゾリジンジオン誘導体

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP59222857A Granted JPS60120870A (ja) 1978-11-16 1984-10-23 スピロ−多環式イミダゾリジンジオン誘導体

Country Status (23)

Country Link
US (1) US4181728A (en, 2012)
JP (2) JPS6052157B2 (en, 2012)
AR (1) AR222052A1 (en, 2012)
AT (1) AT369742B (en, 2012)
AU (1) AU515301B2 (en, 2012)
BE (1) BE880065A (en, 2012)
CA (1) CA1125294A (en, 2012)
CH (1) CH642358A5 (en, 2012)
DE (1) DE2946037A1 (en, 2012)
DK (1) DK484479A (en, 2012)
ES (1) ES486007A1 (en, 2012)
FI (1) FI66385C (en, 2012)
FR (1) FR2441627A1 (en, 2012)
GB (1) GB2038315B (en, 2012)
IE (1) IE49116B1 (en, 2012)
IL (1) IL58730A (en, 2012)
IT (1) IT1127231B (en, 2012)
LU (1) LU81890A1 (en, 2012)
NL (1) NL177689C (en, 2012)
PH (1) PH15672A (en, 2012)
PT (1) PT70452A (en, 2012)
SE (1) SE447731B (en, 2012)
YU (1) YU41678B (en, 2012)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6372140U (en, 2012) * 1986-10-29 1988-05-14
JPS63119451U (en, 2012) * 1987-01-30 1988-08-02

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU532110B2 (en) * 1979-11-13 1983-09-15 Ici Ltd. Spiro(imidazolidine-4,3:-indoline)-2,2:5-trione derivatives
DE3261684D1 (en) * 1981-05-12 1985-02-07 Ici Plc Pyrrole derivatives
JPS59500618A (ja) * 1982-04-15 1984-04-12 アルコン・ラボラトリ−ズ・インコ−ポレ−テッド スピロ―フルオロフルオレン化合物、その製造法およびアルド―スレダクターゼ活性を阻害する組成物
US4464385A (en) * 1982-04-15 1984-08-07 Alcon Laboratories, Inc. Treatment of diabetic complications with hydantoins
IL68314A0 (en) * 1982-04-15 1983-07-31 Alcon Lab Inc Method and composition for inhibiting aldose reductase activity and process for preparing spirofluorofluoren and spiro-difluorofluoren compounds
US4540700A (en) * 1982-04-15 1985-09-10 Alcon Laboratories, Inc. Treatment of diabetic complications with certain spiro-imidazolidine-diones
US4438272A (en) 1982-04-15 1984-03-20 Alcon Laboratories, Inc. Spiro-(fluoren-9,4'-imidazolidine)-2',5'-diones
US4436745A (en) 1982-04-15 1984-03-13 Alcon Laboratories, Inc. Method of inhibiting aldose reductase activity
DE3342933A1 (de) * 1983-11-26 1985-06-05 Horst G. 5190 Stolberg Schumann Regalfoerderzeug
US4600717A (en) * 1984-04-11 1986-07-15 Alcon Laboratories, Inc. Aldose reductase inhibitors useful in ophthalmic wound healing
US4717725A (en) * 1984-04-11 1988-01-05 Alcon Laboratories, Inc. Ophthalmic wound healing with aldose reductase inhibitors
US4609663A (en) * 1984-09-11 1986-09-02 Alcon Laboratories, Inc. Aldose reductase inhibitors useful in glaucoma therapy
US4576143A (en) * 1984-10-05 1986-03-18 Clark Iii William T Method of immune modification by means of extracorporeal irradiation of the blood
US5340829A (en) * 1984-11-20 1994-08-23 Washington Research Foundation Immunoregulatory agents
US4966911A (en) * 1984-11-20 1990-10-30 Washington Research Foundation Immunoregulatory agents
EP0536119A4 (en) * 1989-02-10 1993-08-04 Washington Research Foundation Immunoregulatory agents

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2683718A (en) * 1952-01-11 1954-07-13 Searle & Co Spiro-[xanthene-9, 4'-imidazolidine]-2, 5-dione
DE1032257B (de) * 1954-05-27 1958-06-19 Cutter Lab Verfahren zur Herstellung neuer Hydantoine
GB796069A (en) * 1955-12-23 1958-06-04 Ici Ltd Substituted hydantoins
GB818724A (en) * 1956-10-18 1959-08-19 Ici Ltd Hydantoin derivatives
US3532744A (en) * 1967-07-28 1970-10-06 American Home Prod 1- and 2-amino substituted indane and tetralene carboxylic acids
US3821383A (en) * 1972-07-10 1974-06-28 Ayerst Mckenna & Harrison Compositions for and a method of treating diabetic complications
US4078064A (en) * 1976-08-18 1978-03-07 E. R. Squibb & Sons, Inc. 8H-Pyrazolo[4',3':5,6]pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidines
CA1088945A (en) * 1976-10-18 1980-11-04 Pfizer Limited Hydantoin derivatives as therapeutic agents
US4117230A (en) * 1976-10-18 1978-09-26 Pfizer Inc. Hydantoin derivatives as therapeutic agents
US4130714A (en) * 1977-05-23 1978-12-19 Pfizer Inc. Hydantoin therapeutic agents
US4127665A (en) * 1978-01-18 1978-11-28 Pfizer Inc. Thienohydantoin derivatives

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6372140U (en, 2012) * 1986-10-29 1988-05-14
JPS63119451U (en, 2012) * 1987-01-30 1988-08-02

Also Published As

Publication number Publication date
LU81890A1 (fr) 1980-06-05
NL177689B (nl) 1985-06-03
SE7909439L (sv) 1980-05-17
DK484479A (da) 1980-05-17
IL58730A0 (en) 1980-02-29
ES486007A1 (es) 1980-09-01
IE49116B1 (en) 1985-08-07
YU41678B (en) 1987-12-31
ATA729779A (de) 1982-06-15
AR222052A1 (es) 1981-04-15
NL7908352A (nl) 1980-05-20
IT1127231B (it) 1986-05-21
PH15672A (en) 1983-03-11
FI793586A7 (fi) 1980-05-17
PT70452A (en) 1979-12-01
JPS60120870A (ja) 1985-06-28
US4181728A (en) 1980-01-01
AT369742B (de) 1983-01-25
FI66385C (fi) 1984-10-10
FI66385B (fi) 1984-06-29
JPS5589268A (en) 1980-07-05
YU277379A (en) 1983-01-21
IE792184L (en) 1980-05-16
SE447731B (sv) 1986-12-08
FR2441627B1 (en, 2012) 1983-06-03
AU5288079A (en) 1980-05-22
CA1125294A (en) 1982-06-08
AU515301B2 (en) 1981-03-26
GB2038315A (en) 1980-07-23
JPS6144868B2 (en, 2012) 1986-10-04
NL177689C (nl) 1985-11-01
IL58730A (en) 1984-01-31
IT7927311A0 (it) 1979-11-15
DE2946037A1 (de) 1980-05-22
CH642358A5 (fr) 1984-04-13
GB2038315B (en) 1982-08-11
FR2441627A1 (fr) 1980-06-13
BE880065A (fr) 1980-05-16

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