NL177689B - Farmaceutisch preparaat voor het behandelen van gevolgen van diabetes, alsmede imidazolidine-2,5-dion-spiro-(zesledige ring)-verbinding. - Google Patents
Farmaceutisch preparaat voor het behandelen van gevolgen van diabetes, alsmede imidazolidine-2,5-dion-spiro-(zesledige ring)-verbinding.Info
- Publication number
- NL177689B NL177689B NLAANVRAGE7908352,A NL7908352A NL177689B NL 177689 B NL177689 B NL 177689B NL 7908352 A NL7908352 A NL 7908352A NL 177689 B NL177689 B NL 177689B
- Authority
- NL
- Netherlands
- Prior art keywords
- ring
- dion
- imidazolidine
- spiro
- diabetes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Ophthalmology & Optometry (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US05/961,335 US4181728A (en) | 1978-11-16 | 1978-11-16 | Spiro-polycyclicimidazolidinedione derivatives |
US96133578 | 1978-11-16 |
Publications (3)
Publication Number | Publication Date |
---|---|
NL7908352A NL7908352A (nl) | 1980-05-20 |
NL177689B true NL177689B (nl) | 1985-06-03 |
NL177689C NL177689C (nl) | 1985-11-01 |
Family
ID=25504341
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NLAANVRAGE7908352,A NL177689C (nl) | 1978-11-16 | 1979-11-15 | Farmaceutisch preparaat voor het behandelen van gevolgen van diabetes, alsmede imidazolidine-2,5-dion-spiro-(zesledige ring)-verbinding. |
Country Status (23)
Country | Link |
---|---|
US (1) | US4181728A (nl) |
JP (2) | JPS6052157B2 (nl) |
AR (1) | AR222052A1 (nl) |
AT (1) | AT369742B (nl) |
AU (1) | AU515301B2 (nl) |
BE (1) | BE880065A (nl) |
CA (1) | CA1125294A (nl) |
CH (1) | CH642358A5 (nl) |
DE (1) | DE2946037A1 (nl) |
DK (1) | DK484479A (nl) |
ES (1) | ES486007A1 (nl) |
FI (1) | FI66385C (nl) |
FR (1) | FR2441627A1 (nl) |
GB (1) | GB2038315B (nl) |
IE (1) | IE49116B1 (nl) |
IL (1) | IL58730A (nl) |
IT (1) | IT1127231B (nl) |
LU (1) | LU81890A1 (nl) |
NL (1) | NL177689C (nl) |
PH (1) | PH15672A (nl) |
PT (1) | PT70452A (nl) |
SE (1) | SE447731B (nl) |
YU (1) | YU41678B (nl) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4490381A (en) * | 1979-11-13 | 1984-12-25 | Imperial Chemical Industries Plc | 1'-Substituted spiro[imidazolidine-4,3'-indoline]2,2',5-triones |
EP0065393B1 (en) * | 1981-05-12 | 1984-12-27 | Imperial Chemical Industries Plc | Pyrrole derivatives |
US4438272A (en) | 1982-04-15 | 1984-03-20 | Alcon Laboratories, Inc. | Spiro-(fluoren-9,4'-imidazolidine)-2',5'-diones |
JPS59500618A (ja) * | 1982-04-15 | 1984-04-12 | アルコン・ラボラトリ−ズ・インコ−ポレ−テッド | スピロ―フルオロフルオレン化合物、その製造法およびアルド―スレダクターゼ活性を阻害する組成物 |
US4464385A (en) * | 1982-04-15 | 1984-08-07 | Alcon Laboratories, Inc. | Treatment of diabetic complications with hydantoins |
IL68314A0 (en) * | 1982-04-15 | 1983-07-31 | Alcon Lab Inc | Method and composition for inhibiting aldose reductase activity and process for preparing spirofluorofluoren and spiro-difluorofluoren compounds |
US4436745A (en) | 1982-04-15 | 1984-03-13 | Alcon Laboratories, Inc. | Method of inhibiting aldose reductase activity |
US4540700A (en) * | 1982-04-15 | 1985-09-10 | Alcon Laboratories, Inc. | Treatment of diabetic complications with certain spiro-imidazolidine-diones |
DE3342933A1 (de) * | 1983-11-26 | 1985-06-05 | Horst G. 5190 Stolberg Schumann | Regalfoerderzeug |
US4717725A (en) * | 1984-04-11 | 1988-01-05 | Alcon Laboratories, Inc. | Ophthalmic wound healing with aldose reductase inhibitors |
US4600717A (en) * | 1984-04-11 | 1986-07-15 | Alcon Laboratories, Inc. | Aldose reductase inhibitors useful in ophthalmic wound healing |
US4609663A (en) * | 1984-09-11 | 1986-09-02 | Alcon Laboratories, Inc. | Aldose reductase inhibitors useful in glaucoma therapy |
US4576143A (en) * | 1984-10-05 | 1986-03-18 | Clark Iii William T | Method of immune modification by means of extracorporeal irradiation of the blood |
US4966911A (en) * | 1984-11-20 | 1990-10-30 | Washington Research Foundation | Immunoregulatory agents |
US5340829A (en) * | 1984-11-20 | 1994-08-23 | Washington Research Foundation | Immunoregulatory agents |
JPS6372140U (nl) * | 1986-10-29 | 1988-05-14 | ||
JPS63119451U (nl) * | 1987-01-30 | 1988-08-02 | ||
EP0536119A4 (en) * | 1989-02-10 | 1993-08-04 | Washington Research Foundation | Immunoregulatory agents |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2683718A (en) * | 1952-01-11 | 1954-07-13 | Searle & Co | Spiro-[xanthene-9, 4'-imidazolidine]-2, 5-dione |
DE1032257B (de) * | 1954-05-27 | 1958-06-19 | Cutter Lab | Verfahren zur Herstellung neuer Hydantoine |
GB796069A (en) * | 1955-12-23 | 1958-06-04 | Ici Ltd | Substituted hydantoins |
GB818724A (en) * | 1956-10-18 | 1959-08-19 | Ici Ltd | Hydantoin derivatives |
US3532744A (en) * | 1967-07-28 | 1970-10-06 | American Home Prod | 1- and 2-amino substituted indane and tetralene carboxylic acids |
US3821383A (en) * | 1972-07-10 | 1974-06-28 | Ayerst Mckenna & Harrison | Compositions for and a method of treating diabetic complications |
US4078064A (en) * | 1976-08-18 | 1978-03-07 | E. R. Squibb & Sons, Inc. | 8H-Pyrazolo[4',3':5,6]pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidines |
CA1088945A (en) * | 1976-10-18 | 1980-11-04 | Pfizer Limited | Hydantoin derivatives as therapeutic agents |
US4117230A (en) * | 1976-10-18 | 1978-09-26 | Pfizer Inc. | Hydantoin derivatives as therapeutic agents |
US4130714A (en) * | 1977-05-23 | 1978-12-19 | Pfizer Inc. | Hydantoin therapeutic agents |
US4127665A (en) * | 1978-01-18 | 1978-11-28 | Pfizer Inc. | Thienohydantoin derivatives |
-
1978
- 1978-11-16 US US05/961,335 patent/US4181728A/en not_active Expired - Lifetime
-
1979
- 1979-11-12 YU YU2773/79A patent/YU41678B/xx unknown
- 1979-11-13 GB GB7939211A patent/GB2038315B/en not_active Expired
- 1979-11-14 JP JP54147592A patent/JPS6052157B2/ja not_active Expired
- 1979-11-14 DE DE19792946037 patent/DE2946037A1/de not_active Ceased
- 1979-11-14 PT PT70452A patent/PT70452A/pt unknown
- 1979-11-14 IE IE2184/79A patent/IE49116B1/en not_active IP Right Cessation
- 1979-11-14 PH PH23277A patent/PH15672A/en unknown
- 1979-11-15 IL IL58730A patent/IL58730A/xx not_active IP Right Cessation
- 1979-11-15 FR FR7928234A patent/FR2441627A1/fr active Granted
- 1979-11-15 IT IT27311/79A patent/IT1127231B/it active
- 1979-11-15 AT AT0729779A patent/AT369742B/de not_active IP Right Cessation
- 1979-11-15 SE SE7909439A patent/SE447731B/sv not_active IP Right Cessation
- 1979-11-15 CH CH1021479A patent/CH642358A5/fr not_active IP Right Cessation
- 1979-11-15 ES ES486007A patent/ES486007A1/es not_active Expired
- 1979-11-15 NL NLAANVRAGE7908352,A patent/NL177689C/nl not_active IP Right Cessation
- 1979-11-15 AR AR278904A patent/AR222052A1/es active
- 1979-11-15 FI FI793586A patent/FI66385C/fi not_active IP Right Cessation
- 1979-11-15 DK DK484479A patent/DK484479A/da not_active Application Discontinuation
- 1979-11-15 LU LU81890A patent/LU81890A1/fr unknown
- 1979-11-15 AU AU52880/79A patent/AU515301B2/en not_active Ceased
- 1979-11-16 CA CA340,068A patent/CA1125294A/en not_active Expired
- 1979-11-16 BE BE0/198129A patent/BE880065A/fr not_active IP Right Cessation
-
1984
- 1984-10-23 JP JP59222857A patent/JPS60120870A/ja active Granted
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
A1A | A request for search or an international-type search has been filed | ||
BB | A search report has been drawn up | ||
BC | A request for examination has been filed | ||
A85 | Still pending on 85-01-01 | ||
V1 | Lapsed because of non-payment of the annual fee |