JPS60243068A - Ｎ，３―ジ置換２―オキシンドール―１―カルボキサミド - Google Patents

Ｎ，３―ジ置換２―オキシンドール―１―カルボキサミド

Info

Publication number
JPS60243068A
JPS60243068A JP60095275A JP9527585A JPS60243068A JP S60243068 A JPS60243068 A JP S60243068A JP 60095275 A JP60095275 A JP 60095275A JP 9527585 A JP9527585 A JP 9527585A JP S60243068 A JPS60243068 A JP S60243068A
Authority
JP
Japan
Prior art keywords
group
carbon atoms
chloro
alkyl
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP60095275A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0335315B2 (is
Inventor
サウル・バーナード・カデイン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of JPS60243068A publication Critical patent/JPS60243068A/ja
Publication of JPH0335315B2 publication Critical patent/JPH0335315B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP60095275A 1984-05-04 1985-05-02 Ｎ，３―ジ置換２―オキシンドール―１―カルボキサミド Granted JPS60243068A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US60735684A 1984-05-04 1984-05-04
US607356 1984-05-04
US714012 1985-03-22

Publications (2)

Publication Number Publication Date
JPS60243068A true JPS60243068A (ja) 1985-12-03
JPH0335315B2 JPH0335315B2 (is) 1991-05-27

Family

ID=24431933

Family Applications (1)

Application Number Title Priority Date Filing Date
JP60095275A Granted JPS60243068A (ja) 1984-05-04 1985-05-02 Ｎ，３―ジ置換２―オキシンドール―１―カルボキサミド

Country Status (25)

Country Link
JP (1) JPS60243068A (is)
KR (1) KR870000497B1 (is)
AR (1) AR241159A1 (is)
BG (2) BG60208B2 (is)
CS (1) CS252828B2 (is)
DD (1) DD232916A5 (is)
EG (1) EG17193A (is)
ES (2) ES8609248A1 (is)
FI (1) FI80016C (is)
HU (1) HU196057B (is)
IE (1) IE851103L (is)
IN (1) IN161509B (is)
MA (1) MA20424A1 (is)
MW (1) MW1685A1 (is)
MX (1) MX5839A (is)
NO (1) NO163132C (is)
OA (1) OA08098A (is)
PL (2) PL145416B1 (is)
PT (1) PT80375B (is)
RO (2) RO94455B (is)
RU (1) RU2017729C1 (is)
SU (1) SU1468413A3 (is)
YU (1) YU44998B (is)
ZA (1) ZA853324B (is)
ZW (1) ZW7885A1 (is)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02292258A (ja) * 1989-04-18 1990-12-03 Pfizer Inc ３―置換―２―オキシインドール誘導体
JPH03133929A (ja) * 1989-10-13 1991-06-07 Pfizer Inc インターロイキン―１生合成の阻止剤としての３―置換―２―オキシインドール誘導体

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02292258A (ja) * 1989-04-18 1990-12-03 Pfizer Inc ３―置換―２―オキシインドール誘導体
JPH03133929A (ja) * 1989-10-13 1991-06-07 Pfizer Inc インターロイキン―１生合成の阻止剤としての３―置換―２―オキシインドール誘導体

Also Published As

Publication number Publication date
ES551275A0 (es) 1987-07-16
MA20424A1 (fr) 1985-12-31
FI80016C (fi) 1990-04-10
FI851756A0 (fi) 1985-05-03
KR850008154A (ko) 1985-12-13
SU1468413A3 (ru) 1989-03-23
PL257892A1 (en) 1986-10-07
CS252828B2 (en) 1987-10-15
RO94455A (ro) 1988-06-30
JPH0335315B2 (is) 1991-05-27
PL147508B1 (en) 1989-06-30
ZA853324B (en) 1986-12-30
BG60207B2 (en) 1993-12-30
FI851756L (fi) 1985-11-05
RO91141B (ro) 1987-07-03
RU2017729C1 (ru) 1994-08-15
FI80016B (fi) 1989-12-29
BG60208B2 (en) 1993-12-30
IE851103L (en) 1985-11-04
HU196057B (en) 1988-09-28
YU73085A (en) 1988-04-30
PT80375A (en) 1985-05-01
HUT37754A (en) 1986-02-28
ES542813A0 (es) 1986-07-16
OA08098A (fr) 1987-03-31
PL145416B1 (en) 1988-09-30
IN161509B (is) 1987-12-19
ES8707182A1 (es) 1987-07-16
NO163132C (no) 1990-04-11
ES8609248A1 (es) 1986-07-16
CS320285A2 (en) 1987-03-12
DD232916A5 (de) 1986-02-12
PL253203A1 (en) 1986-06-17
AR241159A1 (es) 1991-12-30
KR870000497B1 (ko) 1987-03-12
MW1685A1 (en) 1986-09-10
RO91141A (ro) 1987-06-30
MX5839A (es) 1993-11-01
NO851774L (no) 1985-11-05
RO94455B (ro) 1988-07-01
AR241159A2 (es) 1991-12-30
ZW7885A1 (en) 1985-07-24
EG17193A (en) 1990-08-30
YU44998B (en) 1991-06-30
PT80375B (pt) 1987-09-30
NO163132B (no) 1990-01-02

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