BG60208B2 - Process for preparingn-substituted 3-acyl-2-oxindole-1-carboxamides - Google Patents

Process for preparingn-substituted 3-acyl-2-oxindole-1-carboxamides

Info

Publication number
BG60208B2
BG60208B2 BG070071A BG7007185A BG60208B2 BG 60208 B2 BG60208 B2 BG 60208B2 BG 070071 A BG070071 A BG 070071A BG 7007185 A BG7007185 A BG 7007185A BG 60208 B2 BG60208 B2 BG 60208B2
Authority
BG
Bulgaria
Prior art keywords
preparingn
oxindole
carboxamides
acyl
substituted
Prior art date
Application number
BG070071A
Other languages
Bulgarian (bg)
Inventor
Saul Kadin
Original Assignee
Pfizer Inc., a corporation organized аnd existing under the laws of the State of Delaware
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc., a corporation organized аnd existing under the laws of the State of Delaware filed Critical Pfizer Inc., a corporation organized аnd existing under the laws of the State of Delaware
Publication of BG60208B2 publication Critical patent/BG60208B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The obtained compounds are used as analgetic and anti-inflammatory agents. According to the method, a compound of the formula wherein X is on the fifth or sixth place and means hydrogen, fluorine, chlorine or trifluoromethyl, Y is hydrogen, and R2 is alkyl having 2 to 4 hydrogen atoms, cyclohexyl, benzyl, phenyl, fluorophenyl, 2,4 - difluorophenyl, chlorophenyl or methoxyphenyl reacts with an activated derivative of the carboxylic acid in an inert solvent in the presence of alkaline agent.
BG070071A 1984-05-04 1985-05-03 Process for preparingn-substituted 3-acyl-2-oxindole-1-carboxamides BG60208B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US60735684A 1984-05-04 1984-05-04

Publications (1)

Publication Number Publication Date
BG60208B2 true BG60208B2 (en) 1993-12-30

Family

ID=24431933

Family Applications (2)

Application Number Title Priority Date Filing Date
BG070071A BG60208B2 (en) 1984-05-04 1985-05-03 Process for preparingn-substituted 3-acyl-2-oxindole-1-carboxamides
BG096583A BG60207B2 (en) 1984-05-04 1992-07-08 Process for preparing n-substituted 3-acyl-2-oxindole-1-carboxamides

Family Applications After (1)

Application Number Title Priority Date Filing Date
BG096583A BG60207B2 (en) 1984-05-04 1992-07-08 Process for preparing n-substituted 3-acyl-2-oxindole-1-carboxamides

Country Status (25)

Country Link
JP (1) JPS60243068A (en)
KR (1) KR870000497B1 (en)
AR (1) AR241159A1 (en)
BG (2) BG60208B2 (en)
CS (1) CS252828B2 (en)
DD (1) DD232916A5 (en)
EG (1) EG17193A (en)
ES (2) ES8609248A1 (en)
FI (1) FI80016C (en)
HU (1) HU196057B (en)
IE (1) IE851103L (en)
IN (1) IN161509B (en)
MA (1) MA20424A1 (en)
MW (1) MW1685A1 (en)
MX (1) MX5839A (en)
NO (1) NO163132C (en)
OA (1) OA08098A (en)
PL (2) PL145416B1 (en)
PT (1) PT80375B (en)
RO (2) RO94455B (en)
RU (1) RU2017729C1 (en)
SU (1) SU1468413A3 (en)
YU (1) YU44998B (en)
ZA (1) ZA853324B (en)
ZW (1) ZW7885A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5047554A (en) * 1989-04-18 1991-09-10 Pfizer Inc. 3-substituted-2-oxindole derivatives
IL95880A (en) * 1989-10-13 1995-12-31 Pfizer Use of 3-substituted-2-oxindole derivatives for the preparation of a pharmaceutical preparation for inhibiting interleukin-1 biosynthesis

Also Published As

Publication number Publication date
ES551275A0 (en) 1987-07-16
MA20424A1 (en) 1985-12-31
JPS60243068A (en) 1985-12-03
FI80016C (en) 1990-04-10
FI851756A0 (en) 1985-05-03
KR850008154A (en) 1985-12-13
SU1468413A3 (en) 1989-03-23
PL257892A1 (en) 1986-10-07
CS252828B2 (en) 1987-10-15
RO94455A (en) 1988-06-30
JPH0335315B2 (en) 1991-05-27
PL147508B1 (en) 1989-06-30
ZA853324B (en) 1986-12-30
BG60207B2 (en) 1993-12-30
FI851756L (en) 1985-11-05
RO91141B (en) 1987-07-03
RU2017729C1 (en) 1994-08-15
FI80016B (en) 1989-12-29
IE851103L (en) 1985-11-04
HU196057B (en) 1988-09-28
YU73085A (en) 1988-04-30
PT80375A (en) 1985-05-01
HUT37754A (en) 1986-02-28
ES542813A0 (en) 1986-07-16
OA08098A (en) 1987-03-31
PL145416B1 (en) 1988-09-30
IN161509B (en) 1987-12-19
ES8707182A1 (en) 1987-07-16
NO163132C (en) 1990-04-11
ES8609248A1 (en) 1986-07-16
CS320285A2 (en) 1987-03-12
DD232916A5 (en) 1986-02-12
PL253203A1 (en) 1986-06-17
AR241159A1 (en) 1991-12-30
KR870000497B1 (en) 1987-03-12
MW1685A1 (en) 1986-09-10
RO91141A (en) 1987-06-30
MX5839A (en) 1993-11-01
NO851774L (en) 1985-11-05
RO94455B (en) 1988-07-01
AR241159A2 (en) 1991-12-30
ZW7885A1 (en) 1985-07-24
EG17193A (en) 1990-08-30
YU44998B (en) 1991-06-30
PT80375B (en) 1987-09-30
NO163132B (en) 1990-01-02

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