BG60208B2 - Process for preparingn-substituted 3-acyl-2-oxindole-1-carboxamides - Google Patents
Process for preparingn-substituted 3-acyl-2-oxindole-1-carboxamidesInfo
- Publication number
- BG60208B2 BG60208B2 BG70071A BG7007185A BG60208B2 BG 60208 B2 BG60208 B2 BG 60208B2 BG 70071 A BG70071 A BG 70071A BG 7007185 A BG7007185 A BG 7007185A BG 60208 B2 BG60208 B2 BG 60208B2
- Authority
- BG
- Bulgaria
- Prior art keywords
- preparingn
- oxindole
- carboxamides
- acyl
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Abstract
The obtained compounds are used as analgetic and anti-inflammatory agents. According to the method, a compound of the formula wherein X is on the fifth or sixth place and means hydrogen, fluorine, chlorine or trifluoromethyl, Y is hydrogen, and R2 is alkyl having 2 to 4 hydrogen atoms, cyclohexyl, benzyl, phenyl, fluorophenyl, 2,4 - difluorophenyl, chlorophenyl or methoxyphenyl reacts with an activated derivative of the carboxylic acid in an inert solvent in the presence of alkaline agent.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US60735684A | 1984-05-04 | 1984-05-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
BG60208B2 true BG60208B2 (en) | 1993-12-30 |
Family
ID=24431933
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BG70071A BG60208B2 (en) | 1984-05-04 | 1985-05-03 | Process for preparingn-substituted 3-acyl-2-oxindole-1-carboxamides |
BG96583A BG60207B2 (en) | 1984-05-04 | 1992-07-08 | Process for preparing n-substituted 3-acyl-2-oxindole-1-carboxamides |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BG96583A BG60207B2 (en) | 1984-05-04 | 1992-07-08 | Process for preparing n-substituted 3-acyl-2-oxindole-1-carboxamides |
Country Status (25)
Country | Link |
---|---|
JP (1) | JPS60243068A (en) |
KR (1) | KR870000497B1 (en) |
AR (1) | AR241159A1 (en) |
BG (2) | BG60208B2 (en) |
CS (1) | CS252828B2 (en) |
DD (1) | DD232916A5 (en) |
EG (1) | EG17193A (en) |
ES (2) | ES8609248A1 (en) |
FI (1) | FI80016C (en) |
HU (1) | HU196057B (en) |
IE (1) | IE851103L (en) |
IN (1) | IN161509B (en) |
MA (1) | MA20424A1 (en) |
MW (1) | MW1685A1 (en) |
MX (1) | MX5839A (en) |
NO (1) | NO163132C (en) |
OA (1) | OA08098A (en) |
PL (2) | PL145416B1 (en) |
PT (1) | PT80375B (en) |
RO (2) | RO94455B (en) |
RU (1) | RU2017729C1 (en) |
SU (1) | SU1468413A3 (en) |
YU (1) | YU44998B (en) |
ZA (1) | ZA853324B (en) |
ZW (1) | ZW7885A1 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5047554A (en) * | 1989-04-18 | 1991-09-10 | Pfizer Inc. | 3-substituted-2-oxindole derivatives |
IL95880A (en) * | 1989-10-13 | 1995-12-31 | Pfizer | Use of 3-substituted-2-oxindole derivatives for the preparation of a pharmaceutical preparation for inhibiting interleukin-1 biosynthesis |
-
1985
- 1985-04-08 IN IN288/DEL/85A patent/IN161509B/en unknown
- 1985-04-30 PT PT80375A patent/PT80375B/en unknown
- 1985-04-30 YU YU730/85A patent/YU44998B/en unknown
- 1985-05-02 DD DD85275898A patent/DD232916A5/en not_active IP Right Cessation
- 1985-05-02 AR AR300259A patent/AR241159A1/en active
- 1985-05-02 JP JP60095275A patent/JPS60243068A/en active Granted
- 1985-05-02 EG EG275/85A patent/EG17193A/en active
- 1985-05-02 IE IE851103A patent/IE851103L/en unknown
- 1985-05-03 MW MW16/85A patent/MW1685A1/en unknown
- 1985-05-03 ES ES542813A patent/ES8609248A1/en not_active Expired
- 1985-05-03 OA OA58583A patent/OA08098A/en unknown
- 1985-05-03 ZA ZA853324A patent/ZA853324B/en unknown
- 1985-05-03 RO RO123678A patent/RO94455B/en unknown
- 1985-05-03 BG BG70071A patent/BG60208B2/en unknown
- 1985-05-03 KR KR1019850003013A patent/KR870000497B1/en not_active IP Right Cessation
- 1985-05-03 PL PL1985253203A patent/PL145416B1/en unknown
- 1985-05-03 NO NO851774A patent/NO163132C/en not_active IP Right Cessation
- 1985-05-03 RO RO118604A patent/RO91141B/en unknown
- 1985-05-03 FI FI851756A patent/FI80016C/en not_active IP Right Cessation
- 1985-05-03 PL PL1985257892A patent/PL147508B1/en unknown
- 1985-05-03 MA MA20648A patent/MA20424A1/en unknown
- 1985-05-03 MX MX583985A patent/MX5839A/en unknown
- 1985-05-03 ZW ZW78/85A patent/ZW7885A1/en unknown
- 1985-05-04 CS CS853202A patent/CS252828B2/en not_active IP Right Cessation
- 1985-05-04 RU SU853891002A patent/RU2017729C1/en active
- 1985-05-31 HU HU851693A patent/HU196057B/en unknown
-
1986
- 1986-01-27 ES ES551275A patent/ES8707182A1/en not_active Expired
- 1986-05-12 SU SU864027453A patent/SU1468413A3/en active
-
1992
- 1992-07-08 BG BG96583A patent/BG60207B2/en unknown
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