ES8707182A1 - N,3-disubstituted 2-oxyindole-1-carboxamide as analgesic andantiinflammatory - Google Patents

N,3-disubstituted 2-oxyindole-1-carboxamide as analgesic andantiinflammatory

Info

Publication number
ES8707182A1
ES8707182A1 ES551275A ES551275A ES8707182A1 ES 8707182 A1 ES8707182 A1 ES 8707182A1 ES 551275 A ES551275 A ES 551275A ES 551275 A ES551275 A ES 551275A ES 8707182 A1 ES8707182 A1 ES 8707182A1
Authority
ES
Spain
Prior art keywords
analgesic
carboxamide
compound
formula
andantiinflammatory
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES551275A
Other languages
Spanish (es)
Other versions
ES551275A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of ES551275A0 publication Critical patent/ES551275A0/en
Publication of ES8707182A1 publication Critical patent/ES8707182A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

PROCEDURE FOR THE PREPARATION OF A COMPOUND OF 2-OXINDOL-1-CARBOXAMIDE. IT CONSISTS OF REACTIONING A COMPOUND OF FORMULA (II) WITH A CARBOXYLIC ACTIVE DERIVATIVE OF FORMULA R1-C (F) -OH, IN AN INERT SOLVENT AND AT A TEMPERATURE BETWEEN C10 AND 25ºC, TO OBTAIN A COMPOUND OF 2-OXINDOL-1-CARBOXIDE FROM FORMULA (I) WHERE X IS H, FLUORINE, CHLORINE, BROMINE, CYCLOALKYL FROM C 3 TO 7 AND OTHERS; Y IS H, FLUORINE, CHLORINE, BROMINE, ALKYL FROM C 1 TO 4 AND OTHERS; R1 IS ALKYL FROM C 1 TO 6, CYCLLOALKYL WITH C 4 TO 7, PHENYL AND OTHERS; AND R2 IS RENT OF C 1 TO 6, FURILO, BENCILO AND OTHERS. IT HAS PHARMACEUTICAL APPLICATIONS AS AN ANALGESIC IN POSTOPERATIVE STATES AND IN RHEUMATIC DISEASES. (Machine-translation by Google Translate, not legally binding)
ES551275A 1984-05-04 1986-01-27 N,3-disubstituted 2-oxyindole-1-carboxamide as analgesic andantiinflammatory Expired ES8707182A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US60735684A 1984-05-04 1984-05-04

Publications (2)

Publication Number Publication Date
ES551275A0 ES551275A0 (en) 1987-07-16
ES8707182A1 true ES8707182A1 (en) 1987-07-16

Family

ID=24431933

Family Applications (2)

Application Number Title Priority Date Filing Date
ES542813A Expired ES8609248A1 (en) 1984-05-04 1985-05-03 N,3-disubstituted 2-oxyindole-1-carboxamide as analgesic andantiinflammatory
ES551275A Expired ES8707182A1 (en) 1984-05-04 1986-01-27 N,3-disubstituted 2-oxyindole-1-carboxamide as analgesic andantiinflammatory

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES542813A Expired ES8609248A1 (en) 1984-05-04 1985-05-03 N,3-disubstituted 2-oxyindole-1-carboxamide as analgesic andantiinflammatory

Country Status (25)

Country Link
JP (1) JPS60243068A (en)
KR (1) KR870000497B1 (en)
AR (1) AR241159A1 (en)
BG (2) BG60208B2 (en)
CS (1) CS252828B2 (en)
DD (1) DD232916A5 (en)
EG (1) EG17193A (en)
ES (2) ES8609248A1 (en)
FI (1) FI80016C (en)
HU (1) HU196057B (en)
IE (1) IE851103L (en)
IN (1) IN161509B (en)
MA (1) MA20424A1 (en)
MW (1) MW1685A1 (en)
MX (1) MX5839A (en)
NO (1) NO163132C (en)
OA (1) OA08098A (en)
PL (2) PL145416B1 (en)
PT (1) PT80375B (en)
RO (2) RO94455B (en)
RU (1) RU2017729C1 (en)
SU (1) SU1468413A3 (en)
YU (1) YU44998B (en)
ZA (1) ZA853324B (en)
ZW (1) ZW7885A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5047554A (en) * 1989-04-18 1991-09-10 Pfizer Inc. 3-substituted-2-oxindole derivatives
IL95880A (en) * 1989-10-13 1995-12-31 Pfizer Use of 3-substituted-2-oxindole derivatives for the preparation of a pharmaceutical preparation for inhibiting interleukin-1 biosynthesis

Also Published As

Publication number Publication date
MA20424A1 (en) 1985-12-31
PL145416B1 (en) 1988-09-30
ZW7885A1 (en) 1985-07-24
OA08098A (en) 1987-03-31
KR850008154A (en) 1985-12-13
RU2017729C1 (en) 1994-08-15
NO163132C (en) 1990-04-11
PL257892A1 (en) 1986-10-07
RO94455B (en) 1988-07-01
AR241159A2 (en) 1991-12-30
FI80016C (en) 1990-04-10
IE851103L (en) 1985-11-04
RO94455A (en) 1988-06-30
ES551275A0 (en) 1987-07-16
IN161509B (en) 1987-12-19
BG60208B2 (en) 1993-12-30
FI851756L (en) 1985-11-05
DD232916A5 (en) 1986-02-12
CS320285A2 (en) 1987-03-12
YU44998B (en) 1991-06-30
RO91141A (en) 1987-06-30
AR241159A1 (en) 1991-12-30
ES8609248A1 (en) 1986-07-16
HU196057B (en) 1988-09-28
ES542813A0 (en) 1986-07-16
BG60207B2 (en) 1993-12-30
RO91141B (en) 1987-07-03
ZA853324B (en) 1986-12-30
JPS60243068A (en) 1985-12-03
MW1685A1 (en) 1986-09-10
YU73085A (en) 1988-04-30
NO851774L (en) 1985-11-05
CS252828B2 (en) 1987-10-15
KR870000497B1 (en) 1987-03-12
PL253203A1 (en) 1986-06-17
PT80375B (en) 1987-09-30
SU1468413A3 (en) 1989-03-23
EG17193A (en) 1990-08-30
PT80375A (en) 1985-05-01
HUT37754A (en) 1986-02-28
MX5839A (en) 1993-11-01
JPH0335315B2 (en) 1991-05-27
PL147508B1 (en) 1989-06-30
FI851756A0 (en) 1985-05-03
NO163132B (en) 1990-01-02
FI80016B (en) 1989-12-29

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20060128