JPS60226814A - 骨形成因子 - Google Patents
骨形成因子Info
- Publication number
- JPS60226814A JPS60226814A JP60000078A JP7885A JPS60226814A JP S60226814 A JPS60226814 A JP S60226814A JP 60000078 A JP60000078 A JP 60000078A JP 7885 A JP7885 A JP 7885A JP S60226814 A JPS60226814 A JP S60226814A
- Authority
- JP
- Japan
- Prior art keywords
- protein
- bone
- osteogenic
- proteins
- calf
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- 239000003324 growth hormone secretagogue Substances 0.000 description 1
- PJJJBBJSCAKJQF-UHFFFAOYSA-N guanidinium chloride Chemical compound [Cl-].NC(N)=[NH2+] PJJJBBJSCAKJQF-UHFFFAOYSA-N 0.000 description 1
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- 238000010438 heat treatment Methods 0.000 description 1
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- 239000005556 hormone Substances 0.000 description 1
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- 230000010874 maintenance of protein location Effects 0.000 description 1
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- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
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- 210000003205 muscle Anatomy 0.000 description 1
- ZIUHHBKFKCYYJD-UHFFFAOYSA-N n,n'-methylenebisacrylamide Chemical compound C=CC(=O)NCNC(=O)C=C ZIUHHBKFKCYYJD-UHFFFAOYSA-N 0.000 description 1
- 210000002184 nasal cartilage Anatomy 0.000 description 1
- ZHCAAFJSYLFLPX-UHFFFAOYSA-N nitrocyclohexatriene Chemical group [O-][N+](=O)C1=CC=C=C[CH]1 ZHCAAFJSYLFLPX-UHFFFAOYSA-N 0.000 description 1
- 230000004819 osteoinduction Effects 0.000 description 1
- 201000008968 osteosarcoma Diseases 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 238000012540 peak fractionation analysis Methods 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
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- 239000008279 sol Substances 0.000 description 1
- 238000002798 spectrophotometry method Methods 0.000 description 1
- LXMSZDCAJNLERA-ZHYRCANASA-N spironolactone Chemical compound C([C@@H]1[C@]2(C)CC[C@@H]3[C@@]4(C)CCC(=O)C=C4C[C@H]([C@@H]13)SC(=O)C)C[C@@]21CCC(=O)O1 LXMSZDCAJNLERA-ZHYRCANASA-N 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
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- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- 210000002303 tibia Anatomy 0.000 description 1
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- 229950003937 tolonium Drugs 0.000 description 1
- HNONEKILPDHFOL-UHFFFAOYSA-M tolonium chloride Chemical compound [Cl-].C1=C(C)C(N)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 HNONEKILPDHFOL-UHFFFAOYSA-M 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000000844 transformation Methods 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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- 238000000108 ultra-filtration Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Toxicology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Materials For Medical Uses (AREA)
- Saccharide Compounds (AREA)
- Magnetic Heads (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56816784A | 1984-01-04 | 1984-01-04 | |
| US568167 | 1984-01-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS60226814A true JPS60226814A (ja) | 1985-11-12 |
Family
ID=24270176
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP60000078A Pending JPS60226814A (ja) | 1984-01-04 | 1985-01-04 | 骨形成因子 |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP0148155B1 (enExample) |
| JP (1) | JPS60226814A (enExample) |
| AT (1) | ATE42309T1 (enExample) |
| AU (1) | AU580975B2 (enExample) |
| CA (1) | CA1241641A (enExample) |
| DE (1) | DE3569542D1 (enExample) |
| DK (1) | DK161524C (enExample) |
| GR (1) | GR850006B (enExample) |
| IE (1) | IE57966B1 (enExample) |
| NZ (1) | NZ210699A (enExample) |
| ZA (1) | ZA8547B (enExample) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62135431A (ja) * | 1985-12-07 | 1987-06-18 | Katsuyuki Fujii | 液状骨形成剤からなる注射液 |
| JPS6344527A (ja) * | 1986-08-05 | 1988-02-25 | ロ−バフアルム アクチエンゲゼルシヤフト | 軟骨細胞および骨芽細胞を刺激する組成物、オセインヒドロキシアパタイトコンパウンド、その製法、および前記組成物を含む製剤生成物 |
| JPH02500241A (ja) * | 1986-07-01 | 1990-02-01 | ジェネテイックス・インスティテュート・インコーポレイテッド | 新規骨誘導組成物 |
| JPH0285300A (ja) * | 1988-06-27 | 1990-03-26 | Yissum Res Dev Co Of Hebrew Univ Of Jerusalem | 再生骨髄から得られる骨形成生長因子 |
| JPH04502336A (ja) * | 1989-10-17 | 1992-04-23 | ストライカー・コーポレーション | 骨形成具 |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4795804A (en) * | 1983-08-16 | 1989-01-03 | The Regents Of The University Of California | Bone morphogenetic agents |
| US4627982A (en) * | 1984-07-16 | 1986-12-09 | Collagen Corporation | Partially purified bone-inducing factor |
| US6150328A (en) | 1986-07-01 | 2000-11-21 | Genetics Institute, Inc. | BMP products |
| US6432919B1 (en) | 1986-07-01 | 2002-08-13 | Genetics Institute, Inc. | Bone morphogenetic protein-3 and compositions |
| US4877864A (en) * | 1987-03-26 | 1989-10-31 | Genetics Institute, Inc. | Osteoinductive factors |
| US5154931A (en) * | 1986-10-22 | 1992-10-13 | Gesellschaft Fur Biotechnologische Forschung Mbh (Gbf) | Growth-stimulating material derived from porcine bone therefor and a manufacturing process |
| WO1989009605A1 (en) * | 1988-04-06 | 1989-10-19 | Collagen Corporation | Bone-inducing protein |
| US5162114A (en) * | 1989-02-23 | 1992-11-10 | Stryker Corporation | Bone collagen matrix for xenogenic implants |
| US5266683A (en) | 1988-04-08 | 1993-11-30 | Stryker Corporation | Osteogenic proteins |
| US5324819A (en) * | 1988-04-08 | 1994-06-28 | Stryker Corporation | Osteogenic proteins |
| US5250302A (en) * | 1988-04-08 | 1993-10-05 | Stryker Corporation | Osteogenic devices |
| US4968590A (en) * | 1988-04-08 | 1990-11-06 | Stryker Corporation | Osteogenic proteins and polypeptides |
| EP1225225A3 (en) | 1988-04-08 | 2003-01-08 | Stryker Corporation | Osteogenic devices |
| US5354557A (en) * | 1988-04-08 | 1994-10-11 | Stryker Corporation | Osteogenic devices |
| US6919308B2 (en) | 1988-04-08 | 2005-07-19 | Stryker Corporation | Osteogenic devices |
| US5108753A (en) * | 1988-04-08 | 1992-04-28 | Creative Biomolecules | Osteogenic devices |
| US4975526A (en) * | 1989-02-23 | 1990-12-04 | Creative Biomolecules, Inc. | Bone collagen matrix for zenogenic implants |
| US5258494A (en) * | 1988-04-08 | 1993-11-02 | Stryker Corporation | Osteogenic proteins |
| US5670336A (en) * | 1988-04-08 | 1997-09-23 | Stryker Corporation | Method for recombinant production of osteogenic protein |
| US6586388B2 (en) | 1988-04-08 | 2003-07-01 | Stryker Corporation | Method of using recombinant osteogenic protein to repair bone or cartilage defects |
| US5106626A (en) * | 1988-10-11 | 1992-04-21 | International Genetic Engineering, Inc. | Osteogenic factors |
| PT94241A (pt) * | 1989-06-02 | 1991-02-08 | Chiron Corp | Processo para a preparacao de factor calcificacao ossea e de composicoes farmaceuticas que os contem |
| CA2020729A1 (en) * | 1989-07-19 | 1991-01-20 | Michael C. Kiefer | Bone morphogenetic protein |
| US5645591A (en) * | 1990-05-29 | 1997-07-08 | Stryker Corporation | Synthetic bone matrix |
| US6090776A (en) * | 1991-03-11 | 2000-07-18 | Creative Bio Molecules, Inc. | Morphogen treatment of organ implants |
| US5674844A (en) * | 1991-03-11 | 1997-10-07 | Creative Biomolecules, Inc. | Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases |
| US6800603B2 (en) | 1991-03-11 | 2004-10-05 | Curis, Inc. | Morphogen-induced neural cell adhesion |
| US5849686A (en) * | 1991-03-11 | 1998-12-15 | Creative Biomolecules, Inc. | Morphogen-induced liver regeneration |
| US6495513B1 (en) | 1991-03-11 | 2002-12-17 | Curis, Inc. | Morphogen-enhanced survival and repair of neural cells |
| US6077823A (en) * | 1991-03-11 | 2000-06-20 | Creative Biomolecules, Inc. | Method for reducing tissue damage associated with ischemia-reperfusion or hypoxia injury |
| US7056882B2 (en) | 1991-03-11 | 2006-06-06 | Curis, Inc. | Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases |
| US5739107A (en) * | 1991-03-11 | 1998-04-14 | Creative Biomolecules, Inc. | Morphogen treatment of gastrointestinal ulcers |
| US5656593A (en) * | 1991-03-11 | 1997-08-12 | Creative Biomolecules, Inc. | Morphogen induced periodontal tissue regeneration |
| US5972884A (en) * | 1991-03-11 | 1999-10-26 | Creative Biomolecules, Inc. | Morphogen treatment of gastrointestinal ulcers |
| US5652337A (en) * | 1991-03-11 | 1997-07-29 | Creative Biomolecules, Inc. | OP-3-induced morphogenesis |
| US5652118A (en) * | 1991-03-11 | 1997-07-29 | Creative Biomolecules, Inc. | Nucleic acid encoding a novel morphogenic protein, OP-3 |
| US6949505B1 (en) | 1991-03-11 | 2005-09-27 | Curis, Inc. | Morphogen-induced dendritic growth |
| CA2104678C (en) | 1991-03-11 | 2002-05-14 | Charles M. Cohen | Protein-induced morphogenesis |
| US5693615A (en) * | 1991-06-05 | 1997-12-02 | The Procter & Gamble Company | Therapeutic compositions for osteoinduction |
| US6022853A (en) * | 1991-08-30 | 2000-02-08 | Creative Biomolecules, Inc. | Morphogen-enriched dietary composition |
| KR100259827B1 (ko) | 1991-11-04 | 2000-06-15 | 브루스 엠. 에이센, 토마스 제이 데스로저 | 재조합 골형태 형성 단백질 헤테로다이머, 그 조성물 및 사용방법 |
| PT698094E (pt) | 1993-05-12 | 2004-05-31 | Inst Genetics Llc | Composicoes de bmp-11 |
| US6291206B1 (en) | 1993-09-17 | 2001-09-18 | Genetics Institute, Inc. | BMP receptor proteins |
| DK0733109T3 (da) | 1993-12-07 | 2006-07-03 | Genetics Inst Llc | BMP-12, BMP-13 og seneinducerende præparater dermed |
| US5928940A (en) * | 1996-09-24 | 1999-07-27 | Creative Biomolecules, Inc. | Morphogen-responsive signal transducer and methods of use thereof |
| US6727224B1 (en) | 1999-02-01 | 2004-04-27 | Genetics Institute, Llc. | Methods and compositions for healing and repair of articular cartilage |
| DE19906096A1 (de) | 1999-02-13 | 2000-08-17 | Walter Sebald | Protein mit einem Heparin-bindenden Epitop |
| US7189392B1 (en) | 1999-10-15 | 2007-03-13 | Genetics Institute, Llc | Injectable carrier formulations of hyaluronic acid derivatives for delivery of osteogenic proteins |
| TW200526779A (en) | 2001-02-08 | 2005-08-16 | Wyeth Corp | Modified and stabilized GDF propeptides and uses thereof |
| ATE469916T1 (de) | 2002-06-20 | 2010-06-15 | Altis Biolog Pty Ltd | Osteoinduktive biomaterialien |
| JP5392981B2 (ja) | 2003-09-12 | 2014-01-22 | ワイス・エルエルシー | 骨形成蛋白の送達のための注入可能なリン酸カルシウム固体ロッドおよびペースト |
| US8734525B2 (en) | 2003-12-31 | 2014-05-27 | Warsaw Orthopedic, Inc. | Osteoinductive demineralized cancellous bone |
| WO2005065396A2 (en) | 2003-12-31 | 2005-07-21 | Osteotech, Inc. | Improved bone matrix compositions and methods |
| ES2551852T3 (es) | 2004-07-23 | 2015-11-24 | Acceleron Pharma Inc. | Polipéptidos del receptor ActRII |
| US8992965B2 (en) | 2005-11-01 | 2015-03-31 | Warsaw Orthopedic, Inc. | Bone matrix compositions and methods |
| TWI782836B (zh) | 2007-02-02 | 2022-11-01 | 美商艾瑟勒朗法瑪公司 | 衍生自ActRIIB的變體與其用途 |
| US8642061B2 (en) | 2007-06-15 | 2014-02-04 | Warsaw Orthopedic, Inc. | Method of treating bone tissue |
| AU2008265850B2 (en) | 2007-06-15 | 2014-06-26 | Warsaw Orthopedic, Inc. | Bone matrix compositions and methods |
| US9554920B2 (en) | 2007-06-15 | 2017-01-31 | Warsaw Orthopedic, Inc. | Bone matrix compositions having nanoscale textured surfaces |
| WO2009009688A1 (en) | 2007-07-10 | 2009-01-15 | Osteotech, Inc. | Delivery system |
| ES2446544T3 (es) | 2007-10-19 | 2014-03-10 | Warsaw Orthopedic, Inc. | Composiciones de matrices óseas desmineralizadas y métodos |
| US9101475B2 (en) | 2009-02-12 | 2015-08-11 | Warsaw Orthopedic, Inc. | Segmented delivery system |
| ES2658292T3 (es) | 2009-11-17 | 2018-03-09 | Acceleron Pharma, Inc. | Proteínas ActRIIB y variantes y usos de las mismas con respecto a la inducción de la utrofina para el tratamiento de la distrofia muscular |
| WO2018067874A1 (en) | 2016-10-05 | 2018-04-12 | Acceleron Pharma Inc. | Variant actriib proteins and uses thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4294753A (en) * | 1980-08-04 | 1981-10-13 | The Regents Of The University Of California | Bone morphogenetic protein process |
| US4608199A (en) * | 1984-03-20 | 1986-08-26 | Arnold Caplan | Bone protein purification process |
-
1984
- 1984-12-21 NZ NZ210699A patent/NZ210699A/xx unknown
- 1984-12-28 AU AU37221/84A patent/AU580975B2/en not_active Expired
-
1985
- 1985-01-02 AT AT85100047T patent/ATE42309T1/de not_active IP Right Cessation
- 1985-01-02 DE DE8585100047T patent/DE3569542D1/de not_active Expired
- 1985-01-02 GR GR850006A patent/GR850006B/el unknown
- 1985-01-02 DK DK002285A patent/DK161524C/da not_active IP Right Cessation
- 1985-01-02 EP EP85100047A patent/EP0148155B1/en not_active Expired
- 1985-01-03 CA CA000471370A patent/CA1241641A/en not_active Expired
- 1985-01-03 IE IE10/85A patent/IE57966B1/en not_active IP Right Cessation
- 1985-01-03 ZA ZA8547A patent/ZA8547B/xx unknown
- 1985-01-04 JP JP60000078A patent/JPS60226814A/ja active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62135431A (ja) * | 1985-12-07 | 1987-06-18 | Katsuyuki Fujii | 液状骨形成剤からなる注射液 |
| JPH02500241A (ja) * | 1986-07-01 | 1990-02-01 | ジェネテイックス・インスティテュート・インコーポレイテッド | 新規骨誘導組成物 |
| JPH06298800A (ja) * | 1986-07-01 | 1994-10-25 | Genetics Inst Inc | 新規骨誘導組成物 |
| JPS6344527A (ja) * | 1986-08-05 | 1988-02-25 | ロ−バフアルム アクチエンゲゼルシヤフト | 軟骨細胞および骨芽細胞を刺激する組成物、オセインヒドロキシアパタイトコンパウンド、その製法、および前記組成物を含む製剤生成物 |
| JPH0285300A (ja) * | 1988-06-27 | 1990-03-26 | Yissum Res Dev Co Of Hebrew Univ Of Jerusalem | 再生骨髄から得られる骨形成生長因子 |
| JPH04502336A (ja) * | 1989-10-17 | 1992-04-23 | ストライカー・コーポレーション | 骨形成具 |
Also Published As
| Publication number | Publication date |
|---|---|
| DE3569542D1 (en) | 1989-05-24 |
| EP0148155A2 (en) | 1985-07-10 |
| GR850006B (enExample) | 1985-05-03 |
| EP0148155B1 (en) | 1989-04-19 |
| ATE42309T1 (de) | 1989-05-15 |
| IE57966B1 (en) | 1993-06-02 |
| DK2285D0 (da) | 1985-01-02 |
| NZ210699A (en) | 1989-06-28 |
| DK161524C (da) | 1991-12-23 |
| CA1241641A (en) | 1988-09-06 |
| EP0148155A3 (en) | 1986-08-13 |
| DK2285A (da) | 1985-07-05 |
| ZA8547B (en) | 1986-09-24 |
| IE850010L (en) | 1985-07-04 |
| AU3722184A (en) | 1985-07-11 |
| DK161524B (da) | 1991-07-15 |
| AU580975B2 (en) | 1989-02-09 |
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