DE3569542D1 - Osteogenic factors - Google Patents

Osteogenic factors

Info

Publication number
DE3569542D1
DE3569542D1 DE8585100047T DE3569542T DE3569542D1 DE 3569542 D1 DE3569542 D1 DE 3569542D1 DE 8585100047 T DE8585100047 T DE 8585100047T DE 3569542 T DE3569542 T DE 3569542T DE 3569542 D1 DE3569542 D1 DE 3569542D1
Authority
DE
Germany
Prior art keywords
protein
bone
osteogenic factors
inducing
purification
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8585100047T
Other languages
German (de)
English (en)
Inventor
Arup Sen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
International Genetic Engineering Inc
Original Assignee
International Genetic Engineering Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by International Genetic Engineering Inc filed Critical International Genetic Engineering Inc
Application granted granted Critical
Publication of DE3569542D1 publication Critical patent/DE3569542D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Materials For Medical Uses (AREA)
  • Saccharide Compounds (AREA)
  • Magnetic Heads (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE8585100047T 1984-01-04 1985-01-02 Osteogenic factors Expired DE3569542D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US56816784A 1984-01-04 1984-01-04

Publications (1)

Publication Number Publication Date
DE3569542D1 true DE3569542D1 (en) 1989-05-24

Family

ID=24270176

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8585100047T Expired DE3569542D1 (en) 1984-01-04 1985-01-02 Osteogenic factors

Country Status (11)

Country Link
EP (1) EP0148155B1 (enExample)
JP (1) JPS60226814A (enExample)
AT (1) ATE42309T1 (enExample)
AU (1) AU580975B2 (enExample)
CA (1) CA1241641A (enExample)
DE (1) DE3569542D1 (enExample)
DK (1) DK161524C (enExample)
GR (1) GR850006B (enExample)
IE (1) IE57966B1 (enExample)
NZ (1) NZ210699A (enExample)
ZA (1) ZA8547B (enExample)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4795804A (en) * 1983-08-16 1989-01-03 The Regents Of The University Of California Bone morphogenetic agents
US4627982A (en) * 1984-07-16 1986-12-09 Collagen Corporation Partially purified bone-inducing factor
JPH0723322B2 (ja) * 1985-12-07 1995-03-15 克之 藤井 液状骨形成剤からなる注射液
US6150328A (en) 1986-07-01 2000-11-21 Genetics Institute, Inc. BMP products
IL83003A (en) * 1986-07-01 1995-07-31 Genetics Inst Osteoinductive factors
US6432919B1 (en) 1986-07-01 2002-08-13 Genetics Institute, Inc. Bone morphogenetic protein-3 and compositions
US4877864A (en) * 1987-03-26 1989-10-31 Genetics Institute, Inc. Osteoinductive factors
DE3626414C2 (de) * 1986-08-05 1994-11-10 Robapharm Ag Präparat zur Stimulierung von Chondrocyten und Osteoblasten (Ossein-Hydroxyapatit-Komplex), Verfahren zu seiner Herstellung und dieses enthaltende Arzneimittel
US5154931A (en) * 1986-10-22 1992-10-13 Gesellschaft Fur Biotechnologische Forschung Mbh (Gbf) Growth-stimulating material derived from porcine bone therefor and a manufacturing process
WO1989009605A1 (en) * 1988-04-06 1989-10-19 Collagen Corporation Bone-inducing protein
US5162114A (en) * 1989-02-23 1992-11-10 Stryker Corporation Bone collagen matrix for xenogenic implants
US5266683A (en) 1988-04-08 1993-11-30 Stryker Corporation Osteogenic proteins
US5324819A (en) * 1988-04-08 1994-06-28 Stryker Corporation Osteogenic proteins
US5250302A (en) * 1988-04-08 1993-10-05 Stryker Corporation Osteogenic devices
US4968590A (en) * 1988-04-08 1990-11-06 Stryker Corporation Osteogenic proteins and polypeptides
EP1225225A3 (en) 1988-04-08 2003-01-08 Stryker Corporation Osteogenic devices
US5354557A (en) * 1988-04-08 1994-10-11 Stryker Corporation Osteogenic devices
US6919308B2 (en) 1988-04-08 2005-07-19 Stryker Corporation Osteogenic devices
US5108753A (en) * 1988-04-08 1992-04-28 Creative Biomolecules Osteogenic devices
US4975526A (en) * 1989-02-23 1990-12-04 Creative Biomolecules, Inc. Bone collagen matrix for zenogenic implants
US5258494A (en) * 1988-04-08 1993-11-02 Stryker Corporation Osteogenic proteins
US5670336A (en) * 1988-04-08 1997-09-23 Stryker Corporation Method for recombinant production of osteogenic protein
US6586388B2 (en) 1988-04-08 2003-07-01 Stryker Corporation Method of using recombinant osteogenic protein to repair bone or cartilage defects
IL90683A0 (en) * 1988-06-27 1990-01-18 Yissum Res Dev Co Osteogenic growth factors derived from regenerating bone marrow
US5106626A (en) * 1988-10-11 1992-04-21 International Genetic Engineering, Inc. Osteogenic factors
PT94241A (pt) * 1989-06-02 1991-02-08 Chiron Corp Processo para a preparacao de factor calcificacao ossea e de composicoes farmaceuticas que os contem
CA2020729A1 (en) * 1989-07-19 1991-01-20 Michael C. Kiefer Bone morphogenetic protein
CA2042577A1 (en) * 1989-10-17 1991-04-18 Hermann Oppermann Osteogenic devices
US5645591A (en) * 1990-05-29 1997-07-08 Stryker Corporation Synthetic bone matrix
US6090776A (en) * 1991-03-11 2000-07-18 Creative Bio Molecules, Inc. Morphogen treatment of organ implants
US5674844A (en) * 1991-03-11 1997-10-07 Creative Biomolecules, Inc. Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases
US6800603B2 (en) 1991-03-11 2004-10-05 Curis, Inc. Morphogen-induced neural cell adhesion
US5849686A (en) * 1991-03-11 1998-12-15 Creative Biomolecules, Inc. Morphogen-induced liver regeneration
US6495513B1 (en) 1991-03-11 2002-12-17 Curis, Inc. Morphogen-enhanced survival and repair of neural cells
US6077823A (en) * 1991-03-11 2000-06-20 Creative Biomolecules, Inc. Method for reducing tissue damage associated with ischemia-reperfusion or hypoxia injury
US7056882B2 (en) 1991-03-11 2006-06-06 Curis, Inc. Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases
US5739107A (en) * 1991-03-11 1998-04-14 Creative Biomolecules, Inc. Morphogen treatment of gastrointestinal ulcers
US5656593A (en) * 1991-03-11 1997-08-12 Creative Biomolecules, Inc. Morphogen induced periodontal tissue regeneration
US5972884A (en) * 1991-03-11 1999-10-26 Creative Biomolecules, Inc. Morphogen treatment of gastrointestinal ulcers
US5652337A (en) * 1991-03-11 1997-07-29 Creative Biomolecules, Inc. OP-3-induced morphogenesis
US5652118A (en) * 1991-03-11 1997-07-29 Creative Biomolecules, Inc. Nucleic acid encoding a novel morphogenic protein, OP-3
US6949505B1 (en) 1991-03-11 2005-09-27 Curis, Inc. Morphogen-induced dendritic growth
CA2104678C (en) 1991-03-11 2002-05-14 Charles M. Cohen Protein-induced morphogenesis
US5693615A (en) * 1991-06-05 1997-12-02 The Procter & Gamble Company Therapeutic compositions for osteoinduction
US6022853A (en) * 1991-08-30 2000-02-08 Creative Biomolecules, Inc. Morphogen-enriched dietary composition
KR100259827B1 (ko) 1991-11-04 2000-06-15 브루스 엠. 에이센, 토마스 제이 데스로저 재조합 골형태 형성 단백질 헤테로다이머, 그 조성물 및 사용방법
PT698094E (pt) 1993-05-12 2004-05-31 Inst Genetics Llc Composicoes de bmp-11
US6291206B1 (en) 1993-09-17 2001-09-18 Genetics Institute, Inc. BMP receptor proteins
DK0733109T3 (da) 1993-12-07 2006-07-03 Genetics Inst Llc BMP-12, BMP-13 og seneinducerende præparater dermed
US5928940A (en) * 1996-09-24 1999-07-27 Creative Biomolecules, Inc. Morphogen-responsive signal transducer and methods of use thereof
US6727224B1 (en) 1999-02-01 2004-04-27 Genetics Institute, Llc. Methods and compositions for healing and repair of articular cartilage
DE19906096A1 (de) 1999-02-13 2000-08-17 Walter Sebald Protein mit einem Heparin-bindenden Epitop
US7189392B1 (en) 1999-10-15 2007-03-13 Genetics Institute, Llc Injectable carrier formulations of hyaluronic acid derivatives for delivery of osteogenic proteins
TW200526779A (en) 2001-02-08 2005-08-16 Wyeth Corp Modified and stabilized GDF propeptides and uses thereof
ATE469916T1 (de) 2002-06-20 2010-06-15 Altis Biolog Pty Ltd Osteoinduktive biomaterialien
JP5392981B2 (ja) 2003-09-12 2014-01-22 ワイス・エルエルシー 骨形成蛋白の送達のための注入可能なリン酸カルシウム固体ロッドおよびペースト
US8734525B2 (en) 2003-12-31 2014-05-27 Warsaw Orthopedic, Inc. Osteoinductive demineralized cancellous bone
WO2005065396A2 (en) 2003-12-31 2005-07-21 Osteotech, Inc. Improved bone matrix compositions and methods
ES2551852T3 (es) 2004-07-23 2015-11-24 Acceleron Pharma Inc. Polipéptidos del receptor ActRII
US8992965B2 (en) 2005-11-01 2015-03-31 Warsaw Orthopedic, Inc. Bone matrix compositions and methods
TWI782836B (zh) 2007-02-02 2022-11-01 美商艾瑟勒朗法瑪公司 衍生自ActRIIB的變體與其用途
US8642061B2 (en) 2007-06-15 2014-02-04 Warsaw Orthopedic, Inc. Method of treating bone tissue
AU2008265850B2 (en) 2007-06-15 2014-06-26 Warsaw Orthopedic, Inc. Bone matrix compositions and methods
US9554920B2 (en) 2007-06-15 2017-01-31 Warsaw Orthopedic, Inc. Bone matrix compositions having nanoscale textured surfaces
WO2009009688A1 (en) 2007-07-10 2009-01-15 Osteotech, Inc. Delivery system
ES2446544T3 (es) 2007-10-19 2014-03-10 Warsaw Orthopedic, Inc. Composiciones de matrices óseas desmineralizadas y métodos
US9101475B2 (en) 2009-02-12 2015-08-11 Warsaw Orthopedic, Inc. Segmented delivery system
ES2658292T3 (es) 2009-11-17 2018-03-09 Acceleron Pharma, Inc. Proteínas ActRIIB y variantes y usos de las mismas con respecto a la inducción de la utrofina para el tratamiento de la distrofia muscular
WO2018067874A1 (en) 2016-10-05 2018-04-12 Acceleron Pharma Inc. Variant actriib proteins and uses thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4294753A (en) * 1980-08-04 1981-10-13 The Regents Of The University Of California Bone morphogenetic protein process
US4608199A (en) * 1984-03-20 1986-08-26 Arnold Caplan Bone protein purification process

Also Published As

Publication number Publication date
EP0148155A2 (en) 1985-07-10
JPS60226814A (ja) 1985-11-12
GR850006B (enExample) 1985-05-03
EP0148155B1 (en) 1989-04-19
ATE42309T1 (de) 1989-05-15
IE57966B1 (en) 1993-06-02
DK2285D0 (da) 1985-01-02
NZ210699A (en) 1989-06-28
DK161524C (da) 1991-12-23
CA1241641A (en) 1988-09-06
EP0148155A3 (en) 1986-08-13
DK2285A (da) 1985-07-05
ZA8547B (en) 1986-09-24
IE850010L (en) 1985-07-04
AU3722184A (en) 1985-07-11
DK161524B (da) 1991-07-15
AU580975B2 (en) 1989-02-09

Similar Documents

Publication Publication Date Title
DE3569542D1 (en) Osteogenic factors
HUT51279A (en) Process for producing 2-phosphate-esters of ascorbinic acid and pharmaceutical compositions containing them as active components
HUT46710A (en) Process for producing peptode derivatives and pharmaceutical compositions containing them as active components
HUT47274A (en) Process for producing terciary hydroxy-alkyl-xantines and pharmaceutical compositions containing them as active components
PL275089A1 (en) Method of obtaining novel pharmaceutical compositions
HUT45695A (en) Compositions for determining growth of plants and process for producing 5-acylamino-pyrazol derivatives as active components
HUT45252A (en) Process for producing imidazo-pyridine derivatives and pharmaceutical compositions containing them as active components
HUT37781A (en) Process for producing 1-fluorphenyl-butyl-4-/2-pirimidinyl/-piperazine derivatives and pharmaceutical compositions containing them as active agents
HUT48247A (en) Process for producing aza-bicyclo-octyl-ether derivatives and pharmaceutical compositions containing them as active components
HUT46930A (en) Process for producing aminoglycoside-steroides and pharmaceutical compositions containing them as active components
HUT45540A (en) Process for producing beta-lactame compounds and pharmaceutical compositions containing them as active componenets
HUT46837A (en) Compositions of insectifuge and acarifuge activity containing alpha, omega-amino-alkohol derivatives as active components and process for producing the active components
GB8816096D0 (en) New method & compositions of matter
HUT43573A (en) Process for producing azolyl-cyclopropyl-ethanol derivatives and compositions containing them as active agents
GB8810422D0 (en) Ophthalmological composition of matter
HUT43848A (en) Process for producing pyridinyl-piperazine derivatives and pharmaceutical compositions containing them as active agents
HUT48642A (en) Process for producing amino-acid derivatives and pharmaceutical compositions containing them as active components
HUT39437A (en) Process for producing new morpholinol derivatives and pharmaceutical compositions containing them as active agents
MY103562A (en) Somatic embryogenesis and plant regeneration of cacao
HUT47902A (en) Process for producing anilino-phenyl-thiourea-, -isothiourea- and -carbodiimid derivatives and insecticide compositions containing them as active components
HUT48885A (en) Process for producing nukleotid-analogues and pharmaceutical compositions containing them as active components
HUT40648A (en) Process for producing optically active substituted 1,4-dihydro-pyridines and pharmaceutical compositions containing them as active agents
GB8827831D0 (en) Compositions for reduction of phlebectasiae & process for preparing same
EP0240122A3 (en) Method of producing active antioxidant
GB2210765B (en) Method of plant culture

Legal Events

Date Code Title Description
8364 No opposition during term of opposition