ATE42309T1 - Knockenbildungsfaktoren. - Google Patents

Knockenbildungsfaktoren.

Info

Publication number
ATE42309T1
ATE42309T1 AT85100047T AT85100047T ATE42309T1 AT E42309 T1 ATE42309 T1 AT E42309T1 AT 85100047 T AT85100047 T AT 85100047T AT 85100047 T AT85100047 T AT 85100047T AT E42309 T1 ATE42309 T1 AT E42309T1
Authority
AT
Austria
Prior art keywords
protein
bone
nucking
factors
inducing
Prior art date
Application number
AT85100047T
Other languages
English (en)
Inventor
Arup Sen
Original Assignee
Int Genetic Eng
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Int Genetic Eng filed Critical Int Genetic Eng
Application granted granted Critical
Publication of ATE42309T1 publication Critical patent/ATE42309T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Materials For Medical Uses (AREA)
  • Saccharide Compounds (AREA)
  • Magnetic Heads (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT85100047T 1984-01-04 1985-01-02 Knockenbildungsfaktoren. ATE42309T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56816784A 1984-01-04 1984-01-04
EP85100047A EP0148155B1 (de) 1984-01-04 1985-01-02 Knockenbildungsfaktoren

Publications (1)

Publication Number Publication Date
ATE42309T1 true ATE42309T1 (de) 1989-05-15

Family

ID=24270176

Family Applications (1)

Application Number Title Priority Date Filing Date
AT85100047T ATE42309T1 (de) 1984-01-04 1985-01-02 Knockenbildungsfaktoren.

Country Status (11)

Country Link
EP (1) EP0148155B1 (de)
JP (1) JPS60226814A (de)
AT (1) ATE42309T1 (de)
AU (1) AU580975B2 (de)
CA (1) CA1241641A (de)
DE (1) DE3569542D1 (de)
DK (1) DK161524C (de)
GR (1) GR850006B (de)
IE (1) IE57966B1 (de)
NZ (1) NZ210699A (de)
ZA (1) ZA8547B (de)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4795804A (en) * 1983-08-16 1989-01-03 The Regents Of The University Of California Bone morphogenetic agents
US4627982A (en) * 1984-07-16 1986-12-09 Collagen Corporation Partially purified bone-inducing factor
JPH0723322B2 (ja) * 1985-12-07 1995-03-15 克之 藤井 液状骨形成剤からなる注射液
IL83003A (en) * 1986-07-01 1995-07-31 Genetics Inst Osteoinductive factors
US6432919B1 (en) 1986-07-01 2002-08-13 Genetics Institute, Inc. Bone morphogenetic protein-3 and compositions
US6150328A (en) 1986-07-01 2000-11-21 Genetics Institute, Inc. BMP products
US4877864A (en) * 1987-03-26 1989-10-31 Genetics Institute, Inc. Osteoinductive factors
DE3626414C2 (de) * 1986-08-05 1994-11-10 Robapharm Ag Präparat zur Stimulierung von Chondrocyten und Osteoblasten (Ossein-Hydroxyapatit-Komplex), Verfahren zu seiner Herstellung und dieses enthaltende Arzneimittel
WO1993012803A1 (de) * 1986-10-22 1993-07-08 Krueger Wolfgang Wachstumstimulierendes material, herstellungsverfahren und therapeutische zusammensetzung
PT90216A (pt) * 1988-04-06 1989-11-10 Processo para a preparacao de polipeptidos com actividade osteogenica
US4975526A (en) * 1989-02-23 1990-12-04 Creative Biomolecules, Inc. Bone collagen matrix for zenogenic implants
US5324819A (en) * 1988-04-08 1994-06-28 Stryker Corporation Osteogenic proteins
US5162114A (en) * 1989-02-23 1992-11-10 Stryker Corporation Bone collagen matrix for xenogenic implants
US5258494A (en) 1988-04-08 1993-11-02 Stryker Corporation Osteogenic proteins
US5250302A (en) * 1988-04-08 1993-10-05 Stryker Corporation Osteogenic devices
US4968590A (en) * 1988-04-08 1990-11-06 Stryker Corporation Osteogenic proteins and polypeptides
US6919308B2 (en) 1988-04-08 2005-07-19 Stryker Corporation Osteogenic devices
US5108753A (en) * 1988-04-08 1992-04-28 Creative Biomolecules Osteogenic devices
US6586388B2 (en) 1988-04-08 2003-07-01 Stryker Corporation Method of using recombinant osteogenic protein to repair bone or cartilage defects
EP1225225A3 (de) 1988-04-08 2003-01-08 Stryker Corporation Osteogene Vorrichtungen
US5670336A (en) * 1988-04-08 1997-09-23 Stryker Corporation Method for recombinant production of osteogenic protein
US5354557A (en) * 1988-04-08 1994-10-11 Stryker Corporation Osteogenic devices
US5266683A (en) 1988-04-08 1993-11-30 Stryker Corporation Osteogenic proteins
EP0349048A3 (de) * 1988-06-27 1990-07-11 Yissum Research Development Company Of The Hebrew University Of Jerusalem Osteogenische Wachstumsfaktoren, die aus Knochenmark gewonnen werden
US5106626A (en) * 1988-10-11 1992-04-21 International Genetic Engineering, Inc. Osteogenic factors
JPH03151877A (ja) * 1989-06-02 1991-06-28 Chiron Corp 骨カルシウム沈着因子
CA2020729A1 (en) * 1989-07-19 1991-01-20 Michael C. Kiefer Bone morphogenetic protein
ATE167486T1 (de) * 1989-10-17 1998-07-15 Stryker Corp Osteogene vorrichtungen
US5645591A (en) * 1990-05-29 1997-07-08 Stryker Corporation Synthetic bone matrix
US6949505B1 (en) 1991-03-11 2005-09-27 Curis, Inc. Morphogen-induced dendritic growth
CA2363965C (en) 1991-03-11 2010-05-18 Curis, Inc. Protein-induced morphogenesis
US5652118A (en) * 1991-03-11 1997-07-29 Creative Biomolecules, Inc. Nucleic acid encoding a novel morphogenic protein, OP-3
US5656593A (en) * 1991-03-11 1997-08-12 Creative Biomolecules, Inc. Morphogen induced periodontal tissue regeneration
US5652337A (en) * 1991-03-11 1997-07-29 Creative Biomolecules, Inc. OP-3-induced morphogenesis
US5674844A (en) * 1991-03-11 1997-10-07 Creative Biomolecules, Inc. Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases
US6077823A (en) * 1991-03-11 2000-06-20 Creative Biomolecules, Inc. Method for reducing tissue damage associated with ischemia-reperfusion or hypoxia injury
US6399569B1 (en) 1991-03-11 2002-06-04 Curis, Inc. Morphogen treatments for limiting proliferation of epithelial cells
US6090776A (en) * 1991-03-11 2000-07-18 Creative Bio Molecules, Inc. Morphogen treatment of organ implants
US5972884A (en) * 1991-03-11 1999-10-26 Creative Biomolecules, Inc. Morphogen treatment of gastrointestinal ulcers
US7056882B2 (en) 1991-03-11 2006-06-06 Curis, Inc. Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases
US6495513B1 (en) 1991-03-11 2002-12-17 Curis, Inc. Morphogen-enhanced survival and repair of neural cells
US5849686A (en) * 1991-03-11 1998-12-15 Creative Biomolecules, Inc. Morphogen-induced liver regeneration
US6800603B2 (en) 1991-03-11 2004-10-05 Curis, Inc. Morphogen-induced neural cell adhesion
US5693615A (en) * 1991-06-05 1997-12-02 The Procter & Gamble Company Therapeutic compositions for osteoinduction
US6022853A (en) * 1991-08-30 2000-02-08 Creative Biomolecules, Inc. Morphogen-enriched dietary composition
AU674500B2 (en) 1991-11-04 1997-01-02 Genetics Institute, Llc Recombinant bone morphogenetic protein heterodimers, compositions and methods of use
BR9406715A (pt) 1993-05-12 1996-02-06 Genetics Inst Molécula de DNA isolada célula hospedeira vetor método para produzir uma proteina (BMP-11) polipeptideo de proteina-11 morfogenética de osso purificada (BMP-11) e molécula de DNA quimérica
US6291206B1 (en) 1993-09-17 2001-09-18 Genetics Institute, Inc. BMP receptor proteins
ES2255059T3 (es) 1993-12-07 2006-06-16 Genetics Institute, Llc Bmp-12, bmp-13 y composiciones suyas inductoras de tendon.
US5928940A (en) * 1996-09-24 1999-07-27 Creative Biomolecules, Inc. Morphogen-responsive signal transducer and methods of use thereof
US6727224B1 (en) 1999-02-01 2004-04-27 Genetics Institute, Llc. Methods and compositions for healing and repair of articular cartilage
DE19906096A1 (de) 1999-02-13 2000-08-17 Walter Sebald Protein mit einem Heparin-bindenden Epitop
CA2386408A1 (en) 1999-10-15 2001-04-26 Genetics Institute, Inc. Formulations of hyaluronic acid for delivery of osteogenic proteins
TW200526779A (en) 2001-02-08 2005-08-16 Wyeth Corp Modified and stabilized GDF propeptides and uses thereof
CN1678631A (zh) 2002-06-20 2005-10-05 尼古拉斯·杜内斯 骨诱导性生物材料
CN101897974B (zh) 2003-09-12 2013-09-25 惠氏公司 用于递送成骨蛋白的注射型磷酸钙固体小棒剂和糊剂
WO2005065396A2 (en) 2003-12-31 2005-07-21 Osteotech, Inc. Improved bone matrix compositions and methods
CA2891010C (en) 2004-07-23 2022-09-20 Acceleron Pharma Inc. Actrii receptor polypeptides, methods and compositions
CA2627907C (en) 2005-11-01 2014-06-17 Osteotech, Inc. Osteoinductive composition comprising osteoinductive factors recovered from mineralized bone and a carrier
TW202021980A (zh) 2007-02-02 2020-06-16 美商艾瑟勒朗法瑪公司 衍生自ActRIIB的變體與其用途
EP3207948B1 (de) 2007-06-15 2020-02-26 Warsaw Orthopedic, Inc. Knochenmatrixzusammensetzungen und verfahren
WO2008157492A2 (en) 2007-06-15 2008-12-24 Osteotech, Inc. Osteoinductive demineralized cancellous bone
US9554920B2 (en) 2007-06-15 2017-01-31 Warsaw Orthopedic, Inc. Bone matrix compositions having nanoscale textured surfaces
WO2008157497A2 (en) 2007-06-15 2008-12-24 Osteotech, Inc. Method of treating tissue
US9492278B2 (en) 2007-07-10 2016-11-15 Warsaw Orthopedic, Inc. Delivery system
CA2702499A1 (en) 2007-10-19 2009-04-23 Osteotech, Inc. Demineralized bone matrix compositions and methods
US9011537B2 (en) 2009-02-12 2015-04-21 Warsaw Orthopedic, Inc. Delivery system cartridge
JP6267425B2 (ja) 2009-11-17 2018-01-24 アクセルロン ファーマ， インコーポレイテッド 筋ジストロフィー治療のためのユートロフィン誘導に関するａｃｔｒｉｉｂタンパク質およびその改変体およびその使用
BR112019006918A2 (pt) 2016-10-05 2019-06-25 Acceleron Pharma Inc proteínas actriib variantes e usos das mesmas

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4294753A (en) * 1980-08-04 1981-10-13 The Regents Of The University Of California Bone morphogenetic protein process
US4608199A (en) * 1984-03-20 1986-08-26 Arnold Caplan Bone protein purification process

Also Published As

Publication number Publication date
DK161524B (da) 1991-07-15
DK2285A (da) 1985-07-05
CA1241641A (en) 1988-09-06
EP0148155B1 (de) 1989-04-19
JPS60226814A (ja) 1985-11-12
AU580975B2 (en) 1989-02-09
DE3569542D1 (en) 1989-05-24
AU3722184A (en) 1985-07-11
DK2285D0 (da) 1985-01-02
EP0148155A3 (en) 1986-08-13
IE850010L (en) 1985-07-04
DK161524C (da) 1991-12-23
EP0148155A2 (de) 1985-07-10
IE57966B1 (en) 1993-06-02
ZA8547B (en) 1986-09-24
NZ210699A (en) 1989-06-28
GR850006B (de) 1985-05-03

Similar Documents

Publication Publication Date Title
ATE42309T1 (de) Knockenbildungsfaktoren.
PT87492A (pt) Process for the preparation of benzo ]b" pyrrans and pyranopyridines and pharmaceutical compositions containing them
FI861673L (fi) Menetelmä uusien ihmisen kudosplasminogeeniaktivaattorimutanttien valmistamiseksi
HUT47090A (en) Process for producing new thiazol derivatives and pharmaceutical compositions of leukotrinen-antagonistic activity containing them as active components
HUT51279A (en) Process for producing 2-phosphate-esters of ascorbinic acid and pharmaceutical compositions containing them as active components
IT8547835A1 (it) Procedimento di purificazione di proteine ossee
HUT45252A (en) Process for producing imidazo-pyridine derivatives and pharmaceutical compositions containing them as active components
HUT37781A (en) Process for producing 1-fluorphenyl-butyl-4-/2-pirimidinyl/-piperazine derivatives and pharmaceutical compositions containing them as active agents
NZ208831A (en) Imidazolium derivatives and pharmaceutical compositions
HUT48609A (en) Process for producing kumaran derivatives and pharmaceutical compositions comprising same as active ingredient
IT8747583A0 (it) Derivati di diidrobenzofurano - e cromano - carbossammidi, procedimento per prepararli e loro impiegocome neurolettici
GB8729542D0 (en) Upper part of two-part piston for i c engines & process for production thereof
PT80191B (en) Process for preparing substituted benzopyrans useful as medicaments
HUT46837A (en) Compositions of insectifuge and acarifuge activity containing alpha, omega-amino-alkohol derivatives as active components and process for producing the active components
HUT48251A (en) Process for producing new xantin derivatives and pharmaceutical compositions containing them as active components
HUT46930A (en) Process for producing aminoglycoside-steroides and pharmaceutical compositions containing them as active components
BG44379A3 (en) Method for preparing of 9- chlor- 1, 5- benzothiazepine derivatives
HUT43848A (en) Process for producing pyridinyl-piperazine derivatives and pharmaceutical compositions containing them as active agents
HUT39437A (en) Process for producing new morpholinol derivatives and pharmaceutical compositions containing them as active agents
HUT48642A (en) Process for producing amino-acid derivatives and pharmaceutical compositions containing them as active components
FI873701L (fi) Menetelmä kylmäkuivattujen farmaseuttisten fenyylikinoliinikarboksyylihappokoostumusten valmistamiseksi
PT85278A (fr) Procede de preparation d:une fraction immunogene active a liegard des bilharzioses et de compositions immunisantes la contenant
IT1206247B (it) Metodo e composizione per migliorare il regime di crescita di animali
HUT40648A (en) Process for producing optically active substituted 1,4-dihydro-pyridines and pharmaceutical compositions containing them as active agents
FI871479A0 (fi) Menetelmä lääkeaineina käyttökelpoisten perhydrotiatsepiini- ja perhydroatsepiinijohdannaisten valmistamiseksi

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee