JPS60190791A - シアル酸誘導体およびその製造法 - Google Patents

シアル酸誘導体およびその製造法

Info

Publication number
JPS60190791A
JPS60190791A JP59044906A JP4490684A JPS60190791A JP S60190791 A JPS60190791 A JP S60190791A JP 59044906 A JP59044906 A JP 59044906A JP 4490684 A JP4490684 A JP 4490684A JP S60190791 A JPS60190791 A JP S60190791A
Authority
JP
Japan
Prior art keywords
methoxycarbonyl
acid derivative
chromatography
acetyl
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP59044906A
Other languages
English (en)
Japanese (ja)
Other versions
JPS637556B2 (OSRAM
Inventor
Haruo Ogura
小倉　治夫
Kimio Furuhata
古畑　公夫
Toshiaki Osawa
利昭 大沢
Satoshi Toyoshima
豊島　聰
Yoshiyasu Shidori
志鳥　善保
Masayoshi Ito
伊藤　正善
Shoji Yoshimura
吉村　昌治
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KANTO ISHI PHARMA CO Ltd
Original Assignee
KANTO ISHI PHARMA CO Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by KANTO ISHI PHARMA CO Ltd filed Critical KANTO ISHI PHARMA CO Ltd
Priority to JP59044906A priority Critical patent/JPS60190791A/ja
Priority to US06/708,638 priority patent/US4691012A/en
Priority to CA000475959A priority patent/CA1257257A/en
Priority to DE19853508356 priority patent/DE3508356A1/de
Priority to FR8503521A priority patent/FR2560881B1/fr
Priority to GB08506244A priority patent/GB2158433B/en
Publication of JPS60190791A publication Critical patent/JPS60190791A/ja
Publication of JPS637556B2 publication Critical patent/JPS637556B2/ja
Priority to HK276/89A priority patent/HK27689A/xx
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP59044906A 1984-03-09 1984-03-09 シアル酸誘導体およびその製造法 Granted JPS60190791A (ja)

Priority Applications (7)

Application Number Priority Date Filing Date Title
JP59044906A JPS60190791A (ja) 1984-03-09 1984-03-09 シアル酸誘導体およびその製造法
US06/708,638 US4691012A (en) 1984-03-09 1985-03-06 Sialic acid derivative and process for preparing the same
CA000475959A CA1257257A (en) 1984-03-09 1985-03-07 Sialic acid derivative and process for preparing the same
DE19853508356 DE3508356A1 (de) 1984-03-09 1985-03-08 Sialinsaeure-derivate und verfahren zu ihrer herstellung
FR8503521A FR2560881B1 (fr) 1984-03-09 1985-03-11 Derives d'acide sialique, leurs procedes de preparation et leurs applications notamment comme medicament inhibiteur de la metastase des cellules cancereuses
GB08506244A GB2158433B (en) 1984-03-09 1985-03-11 Sialic acid derivatives and process for the preparation thereof
HK276/89A HK27689A (en) 1984-03-09 1989-03-30 Sialic acid derivatives and process for the preparation thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP59044906A JPS60190791A (ja) 1984-03-09 1984-03-09 シアル酸誘導体およびその製造法

Publications (2)

Publication Number Publication Date
JPS60190791A true JPS60190791A (ja) 1985-09-28
JPS637556B2 JPS637556B2 (OSRAM) 1988-02-17

Family

ID=12704508

Family Applications (1)

Application Number Title Priority Date Filing Date
JP59044906A Granted JPS60190791A (ja) 1984-03-09 1984-03-09 シアル酸誘導体およびその製造法

Country Status (7)

Country Link
US (1) US4691012A (OSRAM)
JP (1) JPS60190791A (OSRAM)
CA (1) CA1257257A (OSRAM)
DE (1) DE3508356A1 (OSRAM)
FR (1) FR2560881B1 (OSRAM)
GB (1) GB2158433B (OSRAM)
HK (1) HK27689A (OSRAM)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62267234A (ja) * 1986-05-09 1987-11-19 ゲルハ−ト・プルフェ−ル 悪性腫瘍の転移予防薬
EP0821963A4 (en) * 1996-02-08 1999-07-14 Ngk Insulators Ltd ANTI-CANCER SUBSTANCE INHIBITING THE CANCER METASTATIC PROCESS

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1262130A (en) * 1985-10-11 1989-10-03 Shoji Yoshimura Process for preparing n-glycolylneuraminic acid derivatives
JPS6287598A (ja) * 1985-10-11 1987-04-22 Mect Corp Ｎ−グリコリルノイラミン酸誘導体
WO1987006936A1 (fr) * 1986-05-12 1987-11-19 Mect Corporation Sialosylcholesterol, procede de preparation et medicament contre les troubles du systeme nerveux
JPH0276892A (ja) * 1988-06-16 1990-03-16 Toshio Goto ３−フェニルチオシアル酸誘導体、その製造方法、シアル酸含有オリゴ糖誘導体およびその製造方法
HU205089B (en) * 1989-05-31 1992-03-30 Biogal Gyogyszergyar Process for producing new thymine derivatives and pharmaceutical compositions comprising same
US5138044A (en) * 1990-08-13 1992-08-11 Glycomed, Inc. Synthesis of sialosides
US5438125A (en) * 1991-03-06 1995-08-01 Nippon Zoki Pharmaceutical Co., Ltd. Sialic acid derivatives
JPH0591854U (ja) * 1992-05-20 1993-12-14 アルプス電気株式会社 サ−マルヘッドのクリ−ニング装置

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3501456A (en) * 1967-08-08 1970-03-17 Merck & Co Inc Arabinofuranosyl nucleosides and intermediates
DE3219209A1 (de) * 1981-05-22 1982-12-09 Kanto Ishi Pharmaceutical Co., Ltd., Tokyo N-acetylneuraminsaeure-derivate
JPS6019917B2 (ja) * 1981-05-22 1985-05-18 関東医師製薬株式会社 Ｎ―アセチルノイラミン酸誘導体

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62267234A (ja) * 1986-05-09 1987-11-19 ゲルハ−ト・プルフェ−ル 悪性腫瘍の転移予防薬
EP0821963A4 (en) * 1996-02-08 1999-07-14 Ngk Insulators Ltd ANTI-CANCER SUBSTANCE INHIBITING THE CANCER METASTATIC PROCESS
US6083931A (en) * 1996-02-08 2000-07-04 Ngk Insulators, Ltd. Method of inhibiting cancer metastasis

Also Published As

Publication number Publication date
FR2560881A1 (fr) 1985-09-13
CA1257257A (en) 1989-07-11
JPS637556B2 (OSRAM) 1988-02-17
HK27689A (en) 1989-04-07
DE3508356C2 (OSRAM) 1988-11-17
GB8506244D0 (en) 1985-04-11
FR2560881B1 (fr) 1988-11-25
DE3508356A1 (de) 1985-09-12
GB2158433B (en) 1987-05-13
GB2158433A (en) 1985-11-13
US4691012A (en) 1987-09-01

Similar Documents

Publication Publication Date Title
KR860001283B1 (ko) 디플루오로 항 바이러스제의 제조방법
CA1313661C (en) 2'-deoxy-5-fluorouridine derivatives
IE60328B1 (en) Improvements in the treatment of tumors in mammals
US4950745A (en) Process for synthesis of oligonucleotides and compound for forming polymeric protecting group
JPS60190791A (ja) シアル酸誘導体およびその製造法
JPH0324097A (ja) エトポシドのアシル化誘導体
US5061793A (en) 2-deoxy-2',2'-difluoro-inosine and 5'O-derivatives
Tietze et al. Synthesis of acetal-αḡlucosides. A stereoselective entry into a new class of compounds
KR20010012727A (ko) 신규한 글리코실화 징코라이드 유도체, 의약으로서의이들의 용도 및 제약 조성물
JP2976436B2 (ja) 新規オリゴリボヌクレオチド誘導体及び抗ウイルス剤への使用
GB2168353A (en) Process for preparing steroid-nucleoside conjugates
EP0566162B1 (en) 2'-Methylidenepyrimidine Nucleoside Compounds, their use and method for production thereof
JPH0631298B2 (ja) 新規アンスラサイクリン誘導体，抗腫瘍剤，及び製造法
CN111377988B (zh) 一种卡培他滨中间体
JPS6019917B2 (ja) Ｎ―アセチルノイラミン酸誘導体
Graziani et al. Synthesis of C-glycosidically linked ADP glycero-β-d-manno-heptose analogues
US5773607A (en) Processes for preparing 2'-deoxy-2'-fluorocoformycin and stereoisomers thereof
Jiang et al. Synthesis and stereochemical assignments for 2-(α-and β-D-arabinofuranosyl) thiazole-4-carboxamides
JPS6318590B2 (OSRAM)
JPH03170494A (ja) アルコキシメチリデンエピポドフィロトキシングルコシド
JPS62132895A (ja) 癌転移阻害剤の製造方法
JP3053863B2 (ja) ２―アルキニルアデノシンの合成中間体、該合成中間体の製造法、該合成中間体を利用した２―アルキニルアデノシンの製造法および安定な２―アルキニルアデノシン誘導体
JPS604199A (ja) ヌクレオチド類の製法
BG60756B2 (bg) Дифлуоро противовирусни съединения и техните междинни съединения
EP0643069A1 (en) 2'-deoxy-2'-fluorocoformycin and stereoisomers thereof