JPS5983056A - ジゴキシゲニン免疫原複合体に対する抗体およびそれらを用いるジゴキシン測定免疫試験法 - Google Patents
ジゴキシゲニン免疫原複合体に対する抗体およびそれらを用いるジゴキシン測定免疫試験法Info
- Publication number
- JPS5983056A JPS5983056A JP58174442A JP17444283A JPS5983056A JP S5983056 A JPS5983056 A JP S5983056A JP 58174442 A JP58174442 A JP 58174442A JP 17444283 A JP17444283 A JP 17444283A JP S5983056 A JPS5983056 A JP S5983056A
- Authority
- JP
- Japan
- Prior art keywords
- group
- formula
- complex
- carrier
- amide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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- KKCBUQHMOMHUOY-UHFFFAOYSA-N sodium oxide Chemical compound [O-2].[Na+].[Na+] KKCBUQHMOMHUOY-UHFFFAOYSA-N 0.000 description 1
- 229910001948 sodium oxide Inorganic materials 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 239000012064 sodium phosphate buffer Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000012086 standard solution Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000012956 testing procedure Methods 0.000 description 1
- BJORNXNYWNIWEY-UHFFFAOYSA-N tetrahydrozoline hydrochloride Chemical compound Cl.N1CCN=C1C1C2=CC=CC=C2CCC1 BJORNXNYWNIWEY-UHFFFAOYSA-N 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 239000000052 vinegar Substances 0.000 description 1
- 235000021419 vinegar Nutrition 0.000 description 1
- 229940028445 visine Drugs 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
- G01N33/9453—Cardioregulators, e.g. antihypotensives, antiarrhythmics
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/80—Fluorescent dyes, e.g. rhodamine
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/815—Test for named compound or class of compounds
- Y10S436/817—Steroids or hormones
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/806—Antigenic peptides or proteins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Organic Chemistry (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Cardiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US422217 | 1982-09-23 | ||
| US06/422,217 US4469797A (en) | 1982-09-23 | 1982-09-23 | Digoxigenin immunogens, antibodies, labeled conjugates, and related derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5983056A true JPS5983056A (ja) | 1984-05-14 |
| JPH0231346B2 JPH0231346B2 (enExample) | 1990-07-12 |
Family
ID=23673888
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP58174442A Granted JPS5983056A (ja) | 1982-09-23 | 1983-09-22 | ジゴキシゲニン免疫原複合体に対する抗体およびそれらを用いるジゴキシン測定免疫試験法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4469797A (enExample) |
| EP (1) | EP0104527B1 (enExample) |
| JP (1) | JPS5983056A (enExample) |
| AU (1) | AU541321B2 (enExample) |
| CA (1) | CA1213579A (enExample) |
| DE (1) | DE3369887D1 (enExample) |
| ES (1) | ES8601478A1 (enExample) |
| IL (1) | IL69126A0 (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6111662A (ja) * | 1984-06-15 | 1986-01-20 | シンテツクス（ユー・エス・エイ）インコーポレイテツド | ジゴキシンアツセイ用血清予備処理 |
| JP2014502607A (ja) * | 2011-01-03 | 2014-02-03 | エフ．ホフマン−ラ ロシュ アーゲー | 抗ｄｉｇ抗体およびペプチドと結合体化しているジゴキシゲニンの複合体の薬学的組成物 |
| JP2022500657A (ja) * | 2018-09-20 | 2022-01-04 | ヴェンタナ メディカル システムズ， インク． | クマリン系架橋試薬 |
Families Citing this family (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2551758B1 (fr) * | 1983-08-16 | 1986-01-31 | Anvar | Derives de muramyl-peptides et de steroides ayant des proprietes d'activation des macrophages |
| US4650771A (en) * | 1983-11-04 | 1987-03-17 | Miles Laboratories, Inc. | Immunogens, antibodies, labeled conjugates, and related derivatives for lidocaine and analogs thereof |
| US4595656A (en) * | 1984-01-06 | 1986-06-17 | Becton Dickinson & Company | Coupling agents and products produced therefrom |
| US4767720A (en) * | 1985-08-29 | 1988-08-30 | Hsc Research Development Corporation | Antidigoxin antibodies |
| US5013720A (en) * | 1986-05-06 | 1991-05-07 | Abbott Laboratories | SAP-6-Val proteins and methods |
| FR2601141A1 (fr) * | 1986-07-02 | 1988-01-08 | Centre Nat Rech Scient | Produit de couplage a base d'haptene, utile notamment comme substance immunogene, anticorps correspondants et applications |
| US5034317A (en) * | 1987-01-30 | 1991-07-23 | Polaroid Corporation | Enzyme controlled release system and organic conjugate reactant |
| US6326136B1 (en) * | 1988-04-01 | 2001-12-04 | Digene Corporation | Macromolecular conjugate made using unsaturated aldehydes |
| DE3836656A1 (de) * | 1988-10-27 | 1990-05-03 | Boehringer Mannheim Gmbh | Neue digoxigenin-derivate und ihre verwendung |
| CA2031109C (en) * | 1990-07-27 | 1992-01-28 | Susan J. Danielson | Ligand analogs for immunoassays derived from dicarboxylic acid oxidation products |
| US5650150A (en) * | 1990-11-09 | 1997-07-22 | Gillies; Stephen D. | Recombinant antibody cytokine fusion proteins |
| RU2132553C1 (ru) * | 1996-05-30 | 1999-06-27 | Ивановская Елена Алексеевна | Количественное определение дигоксина в сыворотке крови методом инверсионной вольтамперометрии |
| JP2001514741A (ja) * | 1997-02-18 | 2001-09-11 | オンカー インク． | 緑色蛍光蛋白質およびその蛍光変異体による標的の検出 |
| PT1037927E (pt) | 1997-12-08 | 2004-10-29 | Emd Lexigen Res Ct Corp | Proteinas de fusao heterodimericas uteis para imunoterapia de abordagem selectiva e estimulacao imunologica geral |
| US20030105294A1 (en) * | 1998-02-25 | 2003-06-05 | Stephen Gillies | Enhancing the circulating half life of antibody-based fusion proteins |
| CN1318092C (zh) * | 1998-04-15 | 2007-05-30 | 利思进药品公司 | 含有抗体－细胞因子融合蛋白和血管生成抑制剂的免疫治疗用组合物 |
| PL352332A1 (en) * | 1999-05-19 | 2003-08-11 | Lexigen Pharm Corp | Expression and export of interferon-alpha proteins as fc fusion proteins |
| US7067110B1 (en) | 1999-07-21 | 2006-06-27 | Emd Lexigen Research Center Corp. | Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
| SK782002A3 (en) | 1999-07-21 | 2003-08-05 | Lexigen Pharm Corp | FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
| JP4793971B2 (ja) * | 1999-08-09 | 2011-10-12 | メルク パテント ゲーエムベーハー | 複合サイトカイン−抗体複合体 |
| AU2154401A (en) | 1999-11-12 | 2001-05-30 | Merck Patent Gmbh | Erythropoietin forms with improved properties |
| US20050202538A1 (en) * | 1999-11-12 | 2005-09-15 | Merck Patent Gmbh | Fc-erythropoietin fusion protein with improved pharmacokinetics |
| CA2399832C (en) | 2000-02-11 | 2011-09-20 | Stephen D. Gillies | Enhancing the circulating half-life of antibody-based fusion proteins |
| US7517526B2 (en) | 2000-06-29 | 2009-04-14 | Merck Patent Gmbh | Enhancement of antibody-cytokine fusion protein mediated immune responses by combined treatment with immunocytokine uptake enhancing agents |
| CA2440221C (en) | 2001-03-07 | 2013-02-05 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Expression technology for proteins containing a hybrid isotype antibody moiety |
| WO2002079415A2 (en) * | 2001-03-30 | 2002-10-10 | Lexigen Pharmaceuticals Corp. | Reducing the immunogenicity of fusion proteins |
| PL205352B1 (pl) | 2001-05-03 | 2010-04-30 | Merck Patent Gmbh | Rekombinowane przeciwciało specyficzne dla nowotworu |
| DK1454138T3 (da) * | 2001-12-04 | 2012-02-13 | Merck Patent Gmbh | Immunocytokiner med moduleret selektivitet |
| DE60335428D1 (de) * | 2002-01-31 | 2011-02-03 | Randox Lab Ltd | Immunogene, Antikörper und Konjugate für Ketamin und dessen Metaboliten |
| US7794716B2 (en) | 2002-07-25 | 2010-09-14 | Glenveigh Pharmaceuticals, Llc | Antibody composition and passive immunization against pregnancy-induced hypertension |
| PL211180B1 (pl) * | 2002-12-17 | 2012-04-30 | Merck Patent Gmbh | Białko fuzyjne typu przeciwciało-IL2, wektor zawierający sekwencję kwasów nukleinowych kodujących takie białko, kompozycja farmaceutyczna zawierająca takie białko fuzyjne oraz jego zastosowania do wytwarzania leków |
| US7935539B2 (en) * | 2003-02-14 | 2011-05-03 | Siemens Healthcare Diagnostics, Inc. | Generic method for latex agglutination assays |
| US20050069521A1 (en) * | 2003-08-28 | 2005-03-31 | Emd Lexigen Research Center Corp. | Enhancing the circulating half-life of interleukin-2 proteins |
| JP2005172694A (ja) * | 2003-12-12 | 2005-06-30 | Fuji Photo Film Co Ltd | タンパク質の検出方法 |
| EP1699822B1 (en) * | 2003-12-30 | 2008-04-23 | MERCK PATENT GmbH | Il-7 fusion proteins with antibody portions, their preparation and their use |
| DK1699821T3 (da) * | 2003-12-31 | 2012-07-16 | Merck Patent Gmbh | Fc-ERYTHROPOIETIN-FUSIONSPROTEIN MED FORBEDREDE FARMAKOKINETIKKER |
| AU2005203962C1 (en) * | 2004-01-05 | 2012-11-08 | Antisoma Research Limited | Interleukin-12 targeted to oncofoetal fibronectin |
| US7670595B2 (en) * | 2004-06-28 | 2010-03-02 | Merck Patent Gmbh | Fc-interferon-beta fusion proteins |
| DE602005020837D1 (de) * | 2004-12-09 | 2010-06-02 | Merck Patent Gmbh | Il-7-varianten mit reduzierter immunogenität |
| US20070104689A1 (en) * | 2005-09-27 | 2007-05-10 | Merck Patent Gmbh | Compositions and methods for treating tumors presenting survivin antigens |
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| WO2019055825A1 (en) | 2017-09-15 | 2019-03-21 | The Regents Of The University Of California | INHIBITION OF AMINOACYLASE 3 (AA3) IN THE TREATMENT OF CANCER |
| AU2018341454B2 (en) | 2017-09-26 | 2023-09-28 | The Regents Of The University Of California | Compositions and methods for treating cancer |
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| CA3168337A1 (en) | 2020-02-17 | 2021-08-26 | Marie-Andree Forget | Methods for expansion of tumor infiltrating lymphocytes and use thereof |
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Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3855208A (en) * | 1971-05-24 | 1974-12-17 | Becton Dickinson Co | Derivatives of digoxigenin |
| US3953431A (en) * | 1971-05-24 | 1976-04-27 | Becton, Dickinson & Company | Derivatives of digoxigenin |
| GB1441101A (en) * | 1972-06-22 | 1976-06-30 | Wellcome Found | Reagents for the assay of cardenolide glycosides and aglycones |
| US4064227A (en) * | 1975-03-17 | 1977-12-20 | Mallinckrodt, Inc. | Radioimmunoassay method for the determination of cardiotonic glycosides |
| FR2310766A1 (fr) * | 1975-05-16 | 1976-12-10 | Nativelle Sa Ets | Derives de cardenolides, procede de preparation et application a titre de medicament |
| US4082747A (en) * | 1975-10-01 | 1978-04-04 | Mallinckrodt, Inc. | Chemical process |
| JPS53119873A (en) * | 1977-03-28 | 1978-10-19 | Rohm & Haas | Digoxigenin derivative |
| CA1119163A (en) * | 1977-09-01 | 1982-03-02 | Ravi K. Varma | Digoxigenin derivatives |
-
1982
- 1982-09-23 US US06/422,217 patent/US4469797A/en not_active Expired - Fee Related
-
1983
- 1983-06-30 IL IL69126A patent/IL69126A0/xx unknown
- 1983-06-30 AU AU16416/83A patent/AU541321B2/en not_active Ceased
- 1983-06-30 CA CA000431573A patent/CA1213579A/en not_active Expired
- 1983-09-12 EP EP83108977A patent/EP0104527B1/en not_active Expired
- 1983-09-12 DE DE8383108977T patent/DE3369887D1/de not_active Expired
- 1983-09-22 JP JP58174442A patent/JPS5983056A/ja active Granted
- 1983-09-22 ES ES525861A patent/ES8601478A1/es not_active Expired
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6111662A (ja) * | 1984-06-15 | 1986-01-20 | シンテツクス（ユー・エス・エイ）インコーポレイテツド | ジゴキシンアツセイ用血清予備処理 |
| JP2014502607A (ja) * | 2011-01-03 | 2014-02-03 | エフ．ホフマン−ラ ロシュ アーゲー | 抗ｄｉｇ抗体およびペプチドと結合体化しているジゴキシゲニンの複合体の薬学的組成物 |
| JP2022500657A (ja) * | 2018-09-20 | 2022-01-04 | ヴェンタナ メディカル システムズ， インク． | クマリン系架橋試薬 |
| JP2024096692A (ja) * | 2018-09-20 | 2024-07-17 | ヴェンタナ メディカル システムズ， インク． | クマリン系架橋試薬 |
Also Published As
| Publication number | Publication date |
|---|---|
| AU1641683A (en) | 1984-03-29 |
| ES525861A0 (es) | 1985-11-01 |
| DE3369887D1 (en) | 1987-04-02 |
| IL69126A0 (en) | 1983-10-31 |
| EP0104527A1 (en) | 1984-04-04 |
| ES8601478A1 (es) | 1985-11-01 |
| AU541321B2 (en) | 1985-01-03 |
| US4469797A (en) | 1984-09-04 |
| EP0104527B1 (en) | 1987-02-25 |
| CA1213579A (en) | 1986-11-04 |
| JPH0231346B2 (enExample) | 1990-07-12 |
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