JPS59232094A - 新規な抗腫瘍性抗生物質複合体ｂｂｍ−１６７５ - Google Patents
新規な抗腫瘍性抗生物質複合体ｂｂｍ−１６７５Info
- Publication number
- JPS59232094A JPS59232094A JP59096758A JP9675884A JPS59232094A JP S59232094 A JPS59232094 A JP S59232094A JP 59096758 A JP59096758 A JP 59096758A JP 9675884 A JP9675884 A JP 9675884A JP S59232094 A JPS59232094 A JP S59232094A
- Authority
- JP
- Japan
- Prior art keywords
- bbm
- strain
- methanol
- actinomadeura
- silica gel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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- 239000000126 substance Substances 0.000 title abstract description 9
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- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims abstract description 27
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- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 17
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 claims abstract description 16
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- 241000233866 Fungi Species 0.000 claims 5
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- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
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- 229910052708 sodium Inorganic materials 0.000 description 1
- 235000010344 sodium nitrate Nutrition 0.000 description 1
- 239000004317 sodium nitrate Substances 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 239000008247 solid mixture Substances 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 231100001274 therapeutic index Toxicity 0.000 description 1
- 230000001550 time effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000004454 trace mineral analysis Methods 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- YWYZEGXAUVWDED-UHFFFAOYSA-N triammonium citrate Chemical compound [NH4+].[NH4+].[NH4+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O YWYZEGXAUVWDED-UHFFFAOYSA-N 0.000 description 1
- 239000012137 tryptone Substances 0.000 description 1
- 230000002100 tumorsuppressive effect Effects 0.000 description 1
- 239000006097 ultraviolet radiation absorber Substances 0.000 description 1
- 241001446247 uncultured actinomycete Species 0.000 description 1
- 229910052720 vanadium Inorganic materials 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
- C12P1/02—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using fungi
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
- C12P1/06—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using actinomycetales
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Mycology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49523183A | 1983-05-16 | 1983-05-16 | |
| US495231 | 1990-03-16 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1216009A Division JPH02128693A (ja) | 1983-05-16 | 1989-08-24 | 新規な抗腫瘍性抗生物質複合体ｂｂｍ―１６７５ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS59232094A true JPS59232094A (ja) | 1984-12-26 |
| JPH0229079B2 JPH0229079B2 (fi) | 1990-06-27 |
Family
ID=23967812
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP59096758A Granted JPS59232094A (ja) | 1983-05-16 | 1984-05-16 | 新規な抗腫瘍性抗生物質複合体ｂｂｍ−１６７５ |
| JP1216009A Granted JPH02128693A (ja) | 1983-05-16 | 1989-08-24 | 新規な抗腫瘍性抗生物質複合体ｂｂｍ―１６７５ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1216009A Granted JPH02128693A (ja) | 1983-05-16 | 1989-08-24 | 新規な抗腫瘍性抗生物質複合体ｂｂｍ―１６７５ |
Country Status (28)
| Country | Link |
|---|---|
| JP (2) | JPS59232094A (fi) |
| KR (2) | KR840008817A (fi) |
| AT (1) | AT393691B (fi) |
| AU (1) | AU569294B2 (fi) |
| BE (1) | BE899667A (fi) |
| CA (1) | CA1241282A (fi) |
| CY (1) | CY1465A (fi) |
| DE (1) | DE3418023A1 (fi) |
| DK (1) | DK163127C (fi) |
| ES (1) | ES8700267A1 (fi) |
| FI (1) | FI81114C (fi) |
| FR (1) | FR2547594B1 (fi) |
| GB (1) | GB2141425B (fi) |
| GR (1) | GR81581B (fi) |
| HK (1) | HK9889A (fi) |
| HU (1) | HU193928B (fi) |
| IE (1) | IE57444B1 (fi) |
| IL (1) | IL71824A (fi) |
| IT (1) | IT1175498B (fi) |
| KE (1) | KE3846A (fi) |
| LU (1) | LU85362A1 (fi) |
| NL (1) | NL8401572A (fi) |
| NZ (1) | NZ208013A (fi) |
| PT (1) | PT78590A (fi) |
| SE (1) | SE460364B (fi) |
| SU (1) | SU1344249A3 (fi) |
| YU (1) | YU43846B (fi) |
| ZA (1) | ZA843591B (fi) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GR78648B (fi) * | 1982-07-26 | 1984-09-27 | Bristol Myers Co | |
| IL79519A0 (en) * | 1985-08-27 | 1986-10-31 | Bristol Myers Co | Bbm-1675c and d antitumor antibiotics |
| US4837206A (en) * | 1987-04-29 | 1989-06-06 | Bristol-Myers Company | Esperamicin derivatives |
| US4996305A (en) * | 1988-02-29 | 1991-02-26 | American Cyanamid Company | Process for producing the antibiotic and antitumor agents LL-E33288.epsilon.ε-Br |
| CA2027601A1 (en) * | 1989-11-06 | 1991-05-07 | Koko Sugawara | Antitumor antibiotic bu-3983t |
| CN115380211A (zh) * | 2021-03-17 | 2022-11-22 | 日本水产株式会社 | 精制的方法和经精制的产品 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4195079A (en) * | 1979-01-31 | 1980-03-25 | Pfizer Inc. | New polycyclic ether antibiotic |
| JPS56113791A (en) * | 1980-02-15 | 1981-09-07 | Kaken Pharmaceut Co Ltd | Novel antibiotic and its preparation |
| GR78648B (fi) * | 1982-07-26 | 1984-09-27 | Bristol Myers Co | |
| US4539203A (en) * | 1984-11-13 | 1985-09-03 | Warner-Lambert Company | CL-1577D And CL-1577E antibiotic/antitumor compounds, their production and use |
-
1984
- 1984-05-01 NZ NZ208013A patent/NZ208013A/en unknown
- 1984-05-08 CA CA000453762A patent/CA1241282A/en not_active Expired
- 1984-05-08 AU AU27791/84A patent/AU569294B2/en not_active Ceased
- 1984-05-08 GR GR74646A patent/GR81581B/el unknown
- 1984-05-11 FI FI841906A patent/FI81114C/fi not_active IP Right Cessation
- 1984-05-11 ZA ZA843591A patent/ZA843591B/xx unknown
- 1984-05-14 ES ES532476A patent/ES8700267A1/es not_active Expired
- 1984-05-14 IL IL71824A patent/IL71824A/xx unknown
- 1984-05-15 BE BE0/212942A patent/BE899667A/fr not_active IP Right Cessation
- 1984-05-15 DE DE19843418023 patent/DE3418023A1/de active Granted
- 1984-05-15 SE SE8402619A patent/SE460364B/sv not_active IP Right Cessation
- 1984-05-15 GB GB08412368A patent/GB2141425B/en not_active Expired
- 1984-05-15 DK DK239784A patent/DK163127C/da not_active IP Right Cessation
- 1984-05-15 SU SU843744582A patent/SU1344249A3/ru active
- 1984-05-15 IT IT20928/84A patent/IT1175498B/it active
- 1984-05-15 LU LU85362A patent/LU85362A1/fr unknown
- 1984-05-15 IE IE1200/84A patent/IE57444B1/en not_active IP Right Cessation
- 1984-05-15 HU HU841877A patent/HU193928B/hu not_active IP Right Cessation
- 1984-05-15 FR FR8407477A patent/FR2547594B1/fr not_active Expired
- 1984-05-16 KR KR1019840002636A patent/KR840008817A/ko not_active Application Discontinuation
- 1984-05-16 YU YU849/84A patent/YU43846B/xx unknown
- 1984-05-16 PT PT78590A patent/PT78590A/pt not_active IP Right Cessation
- 1984-05-16 NL NL8401572A patent/NL8401572A/nl not_active Application Discontinuation
- 1984-05-16 AT AT0160984A patent/AT393691B/de not_active IP Right Cessation
- 1984-05-16 JP JP59096758A patent/JPS59232094A/ja active Granted
-
1988
- 1988-11-21 KE KE3846A patent/KE3846A/xx unknown
-
1989
- 1989-02-02 HK HK98/89A patent/HK9889A/xx unknown
- 1989-05-04 KR KR1019890006047A patent/KR920001366B1/ko not_active IP Right Cessation
- 1989-07-21 CY CY1465A patent/CY1465A/xx unknown
- 1989-08-24 JP JP1216009A patent/JPH02128693A/ja active Granted
Also Published As
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