SE460364B - Nytt antibiotiskt antitumoerkomplex och foerfarande foer framstaellning daerav - Google Patents
Nytt antibiotiskt antitumoerkomplex och foerfarande foer framstaellning daeravInfo
- Publication number
- SE460364B SE460364B SE8402619A SE8402619A SE460364B SE 460364 B SE460364 B SE 460364B SE 8402619 A SE8402619 A SE 8402619A SE 8402619 A SE8402619 A SE 8402619A SE 460364 B SE460364 B SE 460364B
- Authority
- SE
- Sweden
- Prior art keywords
- bbm
- methanol
- silica gel
- solvent system
- volume ratio
- Prior art date
Links
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- 238000010791 quenching Methods 0.000 description 1
- 230000000171 quenching effect Effects 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 238000009877 rendering Methods 0.000 description 1
- 238000004366 reverse phase liquid chromatography Methods 0.000 description 1
- 230000005070 ripening Effects 0.000 description 1
- 239000012449 sabouraud dextrose agar Substances 0.000 description 1
- 229940120668 salicin Drugs 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000002784 sclerotic effect Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000010898 silica gel chromatography Methods 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 235000020183 skimmed milk Nutrition 0.000 description 1
- 235000010344 sodium nitrate Nutrition 0.000 description 1
- 239000004317 sodium nitrate Substances 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 239000008247 solid mixture Substances 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 229910052682 stishovite Inorganic materials 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- YWYZEGXAUVWDED-UHFFFAOYSA-N triammonium citrate Chemical compound [NH4+].[NH4+].[NH4+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O YWYZEGXAUVWDED-UHFFFAOYSA-N 0.000 description 1
- 229910052905 tridymite Inorganic materials 0.000 description 1
- UJMBCXLDXJUMFB-UHFFFAOYSA-K trisodium;5-oxo-1-(4-sulfonatophenyl)-4-[(4-sulfonatophenyl)diazenyl]-4h-pyrazole-3-carboxylate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)C1=NN(C=2C=CC(=CC=2)S([O-])(=O)=O)C(=O)C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 UJMBCXLDXJUMFB-UHFFFAOYSA-K 0.000 description 1
- 238000013022 venting Methods 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
- C12P1/02—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using fungi
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
- C12P1/06—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using actinomycetales
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Mycology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49523183A | 1983-05-16 | 1983-05-16 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| SE8402619D0 SE8402619D0 (sv) | 1984-05-15 |
| SE8402619L SE8402619L (sv) | 1984-11-17 |
| SE460364B true SE460364B (sv) | 1989-10-02 |
Family
ID=23967812
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8402619A SE460364B (sv) | 1983-05-16 | 1984-05-15 | Nytt antibiotiskt antitumoerkomplex och foerfarande foer framstaellning daerav |
Country Status (28)
| Country | Link |
|---|---|
| JP (2) | JPS59232094A (fi) |
| KR (2) | KR840008817A (fi) |
| AT (1) | AT393691B (fi) |
| AU (1) | AU569294B2 (fi) |
| BE (1) | BE899667A (fi) |
| CA (1) | CA1241282A (fi) |
| CY (1) | CY1465A (fi) |
| DE (1) | DE3418023A1 (fi) |
| DK (1) | DK163127C (fi) |
| ES (1) | ES8700267A1 (fi) |
| FI (1) | FI81114C (fi) |
| FR (1) | FR2547594B1 (fi) |
| GB (1) | GB2141425B (fi) |
| GR (1) | GR81581B (fi) |
| HK (1) | HK9889A (fi) |
| HU (1) | HU193928B (fi) |
| IE (1) | IE57444B1 (fi) |
| IL (1) | IL71824A (fi) |
| IT (1) | IT1175498B (fi) |
| KE (1) | KE3846A (fi) |
| LU (1) | LU85362A1 (fi) |
| NL (1) | NL8401572A (fi) |
| NZ (1) | NZ208013A (fi) |
| PT (1) | PT78590A (fi) |
| SE (1) | SE460364B (fi) |
| SU (1) | SU1344249A3 (fi) |
| YU (1) | YU43846B (fi) |
| ZA (1) | ZA843591B (fi) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GR78648B (fi) * | 1982-07-26 | 1984-09-27 | Bristol Myers Co | |
| IL79519A0 (en) * | 1985-08-27 | 1986-10-31 | Bristol Myers Co | Bbm-1675c and d antitumor antibiotics |
| US4837206A (en) * | 1987-04-29 | 1989-06-06 | Bristol-Myers Company | Esperamicin derivatives |
| US4996305A (en) * | 1988-02-29 | 1991-02-26 | American Cyanamid Company | Process for producing the antibiotic and antitumor agents LL-E33288.epsilon.ε-Br |
| CA2027601A1 (en) * | 1989-11-06 | 1991-05-07 | Koko Sugawara | Antitumor antibiotic bu-3983t |
| JP7289994B2 (ja) * | 2021-03-17 | 2023-06-12 | 株式会社ニッスイ | 精製の方法および精製された製品 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4195079A (en) * | 1979-01-31 | 1980-03-25 | Pfizer Inc. | New polycyclic ether antibiotic |
| JPS56113791A (en) * | 1980-02-15 | 1981-09-07 | Kaken Pharmaceut Co Ltd | Novel antibiotic and its preparation |
| GR78648B (fi) * | 1982-07-26 | 1984-09-27 | Bristol Myers Co | |
| US4539203A (en) * | 1984-11-13 | 1985-09-03 | Warner-Lambert Company | CL-1577D And CL-1577E antibiotic/antitumor compounds, their production and use |
-
1984
- 1984-05-01 NZ NZ208013A patent/NZ208013A/en unknown
- 1984-05-08 GR GR74646A patent/GR81581B/el unknown
- 1984-05-08 AU AU27791/84A patent/AU569294B2/en not_active Ceased
- 1984-05-08 CA CA000453762A patent/CA1241282A/en not_active Expired
- 1984-05-11 ZA ZA843591A patent/ZA843591B/xx unknown
- 1984-05-11 FI FI841906A patent/FI81114C/fi not_active IP Right Cessation
- 1984-05-14 IL IL71824A patent/IL71824A/xx unknown
- 1984-05-14 ES ES532476A patent/ES8700267A1/es not_active Expired
- 1984-05-15 DK DK239784A patent/DK163127C/da not_active IP Right Cessation
- 1984-05-15 FR FR8407477A patent/FR2547594B1/fr not_active Expired
- 1984-05-15 LU LU85362A patent/LU85362A1/fr unknown
- 1984-05-15 HU HU841877A patent/HU193928B/hu not_active IP Right Cessation
- 1984-05-15 DE DE19843418023 patent/DE3418023A1/de active Granted
- 1984-05-15 GB GB08412368A patent/GB2141425B/en not_active Expired
- 1984-05-15 SU SU843744582A patent/SU1344249A3/ru active
- 1984-05-15 SE SE8402619A patent/SE460364B/sv not_active IP Right Cessation
- 1984-05-15 IT IT20928/84A patent/IT1175498B/it active
- 1984-05-15 BE BE0/212942A patent/BE899667A/fr not_active IP Right Cessation
- 1984-05-15 IE IE1200/84A patent/IE57444B1/en not_active IP Right Cessation
- 1984-05-16 PT PT78590A patent/PT78590A/pt not_active IP Right Cessation
- 1984-05-16 KR KR1019840002636A patent/KR840008817A/ko not_active Application Discontinuation
- 1984-05-16 YU YU849/84A patent/YU43846B/xx unknown
- 1984-05-16 JP JP59096758A patent/JPS59232094A/ja active Granted
- 1984-05-16 NL NL8401572A patent/NL8401572A/nl not_active Application Discontinuation
- 1984-05-16 AT AT0160984A patent/AT393691B/de not_active IP Right Cessation
-
1988
- 1988-11-21 KE KE3846A patent/KE3846A/xx unknown
-
1989
- 1989-02-02 HK HK98/89A patent/HK9889A/xx unknown
- 1989-05-04 KR KR1019890006047A patent/KR920001366B1/ko not_active IP Right Cessation
- 1989-07-21 CY CY1465A patent/CY1465A/xx unknown
- 1989-08-24 JP JP1216009A patent/JPH02128693A/ja active Granted
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