JPS59144755A - ジ置換プロリン誘導体およびそれらの製法 - Google Patents

ジ置換プロリン誘導体およびそれらの製法

Info

Publication number
JPS59144755A
JPS59144755A JP59000375A JP37584A JPS59144755A JP S59144755 A JPS59144755 A JP S59144755A JP 59000375 A JP59000375 A JP 59000375A JP 37584 A JP37584 A JP 37584A JP S59144755 A JPS59144755 A JP S59144755A
Authority
JP
Japan
Prior art keywords
formula
compound
carbon atoms
trans
chain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP59000375A
Other languages
English (en)
Japanese (ja)
Other versions
JPH056542B2 (enExample
Inventor
ライネル・ヘニング
ハンスイエルク・ウルバツハ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of JPS59144755A publication Critical patent/JPS59144755A/ja
Publication of JPH056542B2 publication Critical patent/JPH056542B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
    • C07F3/10—Mercury compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Peptides Or Proteins (AREA)
  • Hydrogenated Pyridines (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Optical Fibers, Optical Fiber Cores, And Optical Fiber Bundles (AREA)
  • Pyrane Compounds (AREA)
JP59000375A 1983-01-07 1984-01-06 ジ置換プロリン誘導体およびそれらの製法 Granted JPS59144755A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3300316.5 1983-01-07
DE19833300316 DE3300316A1 (de) 1983-01-07 1983-01-07 Disubstituierte prolinderivate, verfahren zu ihrer herstellung und ihre verwendung

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP4045560A Division JPH0610190B2 (ja) 1983-01-07 1992-03-03 ジ置換プロリン誘導体の製造方法
JP4045559A Division JPH0570423A (ja) 1983-01-07 1992-03-03 アミド誘導体

Publications (2)

Publication Number Publication Date
JPS59144755A true JPS59144755A (ja) 1984-08-18
JPH056542B2 JPH056542B2 (enExample) 1993-01-26

Family

ID=6187824

Family Applications (3)

Application Number Title Priority Date Filing Date
JP59000375A Granted JPS59144755A (ja) 1983-01-07 1984-01-06 ジ置換プロリン誘導体およびそれらの製法
JP4045560A Expired - Lifetime JPH0610190B2 (ja) 1983-01-07 1992-03-03 ジ置換プロリン誘導体の製造方法
JP4045559A Granted JPH0570423A (ja) 1983-01-07 1992-03-03 アミド誘導体

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP4045560A Expired - Lifetime JPH0610190B2 (ja) 1983-01-07 1992-03-03 ジ置換プロリン誘導体の製造方法
JP4045559A Granted JPH0570423A (ja) 1983-01-07 1992-03-03 アミド誘導体

Country Status (21)

Country Link
US (1) US4684662A (enExample)
EP (1) EP0115639B1 (enExample)
JP (3) JPS59144755A (enExample)
KR (1) KR900007216B1 (enExample)
AT (1) ATE25677T1 (enExample)
AU (1) AU575306B2 (enExample)
CA (1) CA1220213A (enExample)
DE (2) DE3300316A1 (enExample)
DK (2) DK171641B1 (enExample)
ES (2) ES528703A0 (enExample)
FI (1) FI81780C (enExample)
GR (1) GR79462B (enExample)
HU (1) HU190541B (enExample)
IE (1) IE56520B1 (enExample)
IL (1) IL70618A (enExample)
MA (1) MA19996A1 (enExample)
NO (1) NO165921C (enExample)
NZ (1) NZ206733A (enExample)
PH (1) PH19979A (enExample)
PT (1) PT77924B (enExample)
ZA (1) ZA84113B (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3226768A1 (de) * 1981-11-05 1983-05-26 Hoechst Ag, 6230 Frankfurt Derivate der cis, endo-2-azabicyclo-(3.3.0)-octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
IE55867B1 (en) * 1981-12-29 1991-02-14 Hoechst Ag New derivatives of bicyclic aminoacids,processes for their preparation,agents containing these compounds and their use,and new bicyclic aminoacids as intermediates and processes for their preparation
US5175306A (en) * 1983-01-31 1992-12-29 Hoechst Aktiengesellschaft Process for the resolution of racemates of optically active bicyclic imino-α-carboxylic esters
DE3333455A1 (de) * 1983-09-16 1985-04-11 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung n-alkylierter dipeptide und deren estern
DE3413710A1 (de) * 1984-04-12 1985-10-24 Hoechst Ag, 6230 Frankfurt Verfahren zur behandlung der herzinsuffizienz
US5684016A (en) * 1984-04-12 1997-11-04 Hoechst Aktiengesellschaft Method of treating cardiac insufficiency
DE3431541A1 (de) * 1984-08-28 1986-03-06 Hoechst Ag, 6230 Frankfurt Cis,endo-2-azabicycloalkan-3-carbonsaeure-derivate, verfahren zu deren herstellung, deren verwendung sowie zwischenprodukte bei deren herstellung
US5231080A (en) * 1985-10-15 1993-07-27 Hoechst Aktiengesellschaft Method for the treatment of atherosclerosis, thrombosis, and peripheral vessel disease
US5231084A (en) * 1986-03-27 1993-07-27 Hoechst Aktiengesellschaft Compounds having a cognition adjuvant action, agents containing them, and the use thereof for the treatment and prophylaxis of cognitive dysfuncitons
DE3633496A1 (de) * 1986-10-02 1988-04-14 Hoechst Ag Kombination von angiotensin-converting-enzyme-hemmern mit calciumantagonisten sowie deren verwendung in arzneimitteln
DE3639879A1 (de) * 1986-11-21 1988-06-01 Hoechst Ag Verfahren zur herstellung von mono-, bi- und tricyclischen aminosaeuren, zwischenprodukte dieses verfahrens sowie ein verfahren zu deren herstellung
DE3722007A1 (de) * 1987-07-03 1989-01-12 Hoechst Ag Verfahren zur herstellung bicyclischer aminocarbonsaeuren, zwischenprodukte dieses verfahrens und deren verwendung
HU904967D0 (en) * 1988-04-22 1991-01-28 Hoechst Ag Process for producing new azabicyclo(3.3.o)octane-3-carboxylic acid-octylesther derivatives
WO1990012005A1 (fr) * 1989-04-13 1990-10-18 Japan Tobacco Inc. Nouveaux derives aminoacides possedant une activite d'inhibiteur de la prolylendopeptidase
TW492957B (en) * 1996-11-07 2002-07-01 Novartis Ag N-substituted 2-cyanopyrrolidnes
CA2390231A1 (en) * 1999-11-12 2001-05-17 Paul Jackson Dipeptidyl peptidase iv inhibitors and methods of making and using dipeptidyl peptidase iv inhibitors
US20040152745A1 (en) * 1999-11-12 2004-08-05 Guilford Pharmaceuticals, Inc. Dipeptidyl peptidase IV inhibitors and methods of making and using dipeptidyl peptidase IV inhibitors
MXPA05011168A (es) * 2003-04-15 2005-12-14 Warner Lambert Co Derivados de prolina biciclicos [b]-condensados y sus usos para tratar afecciones artriticas.
CA2521364A1 (en) * 2003-04-15 2004-10-28 Warner-Lambert Company Llc [c]-fused bicyclic proline derivatives and their use for treating arthritic conditions
CA2586760A1 (en) * 2004-11-05 2006-05-18 Edward S. Wilson Stabilized ramipril compositions and methods of making

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE315190C (enExample) *
US4350704A (en) * 1980-10-06 1982-09-21 Warner-Lambert Company Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids
US4374847A (en) * 1980-10-27 1983-02-22 Ciba-Geigy Corporation 1-Carboxyalkanoylindoline-2-carboxylic acids
DE3151690A1 (de) * 1981-12-29 1983-07-07 Hoechst Ag, 6230 Frankfurt "neue derivate bicyclischer aminosaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue bicyclische aminosaeuren als zwischenstufen und verfahren zu deren herstellung"

Also Published As

Publication number Publication date
GR79462B (enExample) 1984-10-30
IE56520B1 (en) 1991-08-28
NO165921B (no) 1991-01-21
DK171641B1 (da) 1997-03-03
FI81780C (fi) 1990-12-10
ES8407471A1 (es) 1984-09-16
KR840007583A (ko) 1984-12-08
ATE25677T1 (de) 1987-03-15
ZA84113B (en) 1984-08-29
CA1220213A (en) 1987-04-07
ES8500900A1 (es) 1984-11-01
DE3369980D1 (en) 1987-04-09
IL70618A0 (en) 1984-04-30
AU2314684A (en) 1984-07-12
NO840048L (no) 1984-07-09
JPH0610190B2 (ja) 1994-02-09
DK171642B1 (da) 1997-03-03
JPH0583541B2 (enExample) 1993-11-26
KR900007216B1 (ko) 1990-10-05
IL70618A (en) 1987-10-30
NO165921C (no) 1991-05-02
DE3300316A1 (de) 1984-07-12
EP0115639B1 (de) 1987-03-04
JPH056542B2 (enExample) 1993-01-26
HU190541B (en) 1986-09-29
PT77924A (de) 1984-02-01
EP0115639A1 (de) 1984-08-15
JPH0578312A (ja) 1993-03-30
MA19996A1 (fr) 1984-10-01
ES530311A0 (es) 1984-11-01
JPH0570423A (ja) 1993-03-23
PH19979A (en) 1986-08-26
DK6384D0 (da) 1984-01-06
DK6384A (da) 1984-07-08
FI840027A7 (fi) 1984-07-08
PT77924B (de) 1986-05-30
FI81780B (fi) 1990-08-31
US4684662A (en) 1987-08-04
FI840027A0 (fi) 1984-01-05
DK33196A (da) 1996-03-21
ES528703A0 (es) 1984-09-16
AU575306B2 (en) 1988-07-28
NZ206733A (en) 1988-02-29
IE840023L (en) 1984-07-07

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Legal Events

Date Code Title Description
EXPY Cancellation because of completion of term