JPS59140882A - インターロイキン２活性をもつポリペプチドをコードする遺伝子 - Google Patents

インターロイキン２活性をもつポリペプチドをコードする遺伝子

Info

Publication number
JPS59140882A
JPS59140882A JP57229619A JP22961982A JPS59140882A JP S59140882 A JPS59140882 A JP S59140882A JP 57229619 A JP57229619 A JP 57229619A JP 22961982 A JP22961982 A JP 22961982A JP S59140882 A JPS59140882 A JP S59140882A
Authority
JP
Japan
Prior art keywords
leu
interleukin
lys
glu
thr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP57229619A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0119879B2 (enExample
Inventor
Koretsugu Taniguchi
維紹 谷口
Masami Muramatsu
村松　正美
Haruo Sugano
晴夫 菅野
Yutaka Matsui
裕 松井
Shinichi Kashima
鹿島　信一
Jiyunji Hamuro
淳爾 羽室
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Japanese Foundation for Cancer Research
Original Assignee
Ajinomoto Co Inc
Japanese Foundation for Cancer Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co Inc, Japanese Foundation for Cancer Research filed Critical Ajinomoto Co Inc
Priority to JP57229619A priority Critical patent/JPS59140882A/ja
Priority to EP83101035A priority patent/EP0091539B2/en
Priority to DE8383101035T priority patent/DE3377363D1/de
Priority to US06/463,496 priority patent/US4738927A/en
Priority to CA000424401A priority patent/CA1341562C/en
Priority to AU21472/83A priority patent/AU556353B2/en
Priority to DD25780883A priority patent/DD218632A5/de
Priority to AT435083A priority patent/AT392082B/de
Priority to DK577283A priority patent/DK173788B1/da
Priority to HU426383A priority patent/HU197938B/hu
Priority to KR1019830005952A priority patent/KR940002537B1/ko
Priority to BE0/212058A priority patent/BE898473A/fr
Priority to CA 443333 priority patent/CA1341633C/en
Priority to DE8383112661T priority patent/DE3382383D1/de
Priority to EP83112661A priority patent/EP0118617B1/en
Publication of JPS59140882A publication Critical patent/JPS59140882A/ja
Publication of JPH0119879B2 publication Critical patent/JPH0119879B2/ja
Priority to US07/814,049 priority patent/US5620868A/en
Priority to US08/096,842 priority patent/US5399669A/en
Priority to US08/331,146 priority patent/US5700913A/en
Priority to US08/516,563 priority patent/US5795769A/en
Priority to US08/621,097 priority patent/US5795777A/en
Priority to US09/769,396 priority patent/US20010041362A1/en
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
JP57229619A 1982-03-31 1982-12-24 インターロイキン２活性をもつポリペプチドをコードする遺伝子 Granted JPS59140882A (ja)

Priority Applications (21)

Application Number Priority Date Filing Date Title
JP57229619A JPS59140882A (ja) 1982-12-24 1982-12-24 インターロイキン２活性をもつポリペプチドをコードする遺伝子
EP83101035A EP0091539B2 (en) 1982-03-31 1983-02-03 Gene coding for interleukin-2 polypeptide, recombinant DNA carrying said gene, cell lines possessing the recombinant DNA,and method for producing interleukin-2 using said cells
DE8383101035T DE3377363D1 (en) 1982-03-31 1983-02-03 Gene coding for interleukin-2 polypeptide, recombinant dna carrying said gene, cell lines possessing the recombinant dna,and method for producing interleukin-2 using said cells
US06/463,496 US4738927A (en) 1982-03-31 1983-02-03 Gene coded for interleukin-2 polypeptide, recombinant DNA carrying the said gene, a living cell line possessing the recombinant DNA, and method for producing interleukin-2 using the said cell
CA000424401A CA1341562C (en) 1982-03-31 1983-03-24 Gene coded for interleukin-2 polypeptide, recombinant dna carrying the said gene, a living cell line possessing the recombinant dna, and method for producing interleukin-2 using the said cell
AU21472/83A AU556353B2 (en) 1982-12-15 1983-11-17 Interleukin-2 polypeptide
DD25780883A DD218632A5 (de) 1982-12-15 1983-12-12 Verfahren zur herstellung von interleukin-2
AT435083A AT392082B (de) 1982-12-15 1983-12-14 Das polypeptid interleukin-2 kodierendes gen, rekombinante, dieses gen enthaltende dna, diese rekombinante dna aufweisende zellinien und verfahren zur herstellung von interleukin-2 unter verwendung der genannten zellen
DK577283A DK173788B1 (da) 1982-12-15 1983-12-14 DNA-fragment, som koder for et polypeptid med interleukin-2-aktivitet, rekombinant DNA omfattende dette DNA-fragment, cellelinie transformeret med det rekombinante DNA og fremgangsmåde til fremstilling af interleukin-2 ved anvendelse af denne cellelinie
HU426383A HU197938B (en) 1982-12-15 1983-12-14 Process for producing gene encoding interleukin-2 polypeptide, recombinant dna carrying the gene, living cell line having the recombinant dna and process for producing interleukin-2 with such cells
EP83112661A EP0118617B1 (en) 1982-12-15 1983-12-15 Interleukin-2 polypeptides
KR1019830005952A KR940002537B1 (ko) 1982-12-15 1983-12-15 인터로이킨-2 폴리펩타이드를 코드화하는 dna 서열, 재조합체 dna, 및 인터로이킨-2의 제조방법
BE0/212058A BE898473A (fr) 1982-12-15 1983-12-15 Gène codé pour polypeptide d'interleukine-2, ADN recombinant portant ce gène, cellules vivantes contenant l'ADN recombinant et production d'interleukine-2
CA 443333 CA1341633C (en) 1982-12-15 1983-12-15 Interleukin-2 polypeptides
DE8383112661T DE3382383D1 (en) 1982-12-15 1983-12-15 Interleukin-2-polypeptide.
US07/814,049 US5620868A (en) 1982-03-31 1991-12-26 Gene coded for interleukin-2 polypeptide, recombinant DNA carrying the said gene, a living cell line possessing the recombinant DNA, and method for producing interleukin-2 using the said cell
US08/096,842 US5399669A (en) 1982-03-31 1993-07-26 Interleukin-2 polypeptides
US08/331,146 US5700913A (en) 1982-12-15 1994-10-28 Unglycosylated human interleukin-2 polypeptides
US08/516,563 US5795769A (en) 1982-03-31 1995-08-18 Gene encoding interleukin-2 polypeptide, recombinant DNA carrying the gene, a living cell line possessing the recombinant DNA and method for producing interleukin-2 using the cell
US08/621,097 US5795777A (en) 1982-03-31 1996-03-22 Gene coded for interleukin-2 polypeptide, recombinant DNA carrying the said gene, a living cell line possessing the recombinant DNA, and method for producing interleukin-2 using the said cell
US09/769,396 US20010041362A1 (en) 1982-03-31 2001-01-26 Gene coded for interleukin-2 polypeptide, recombinant DNA carrying the said gene, a living cell line possessing the recombinant DNA, and method for producing interleukin-2 using the said cell

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP57229619A JPS59140882A (ja) 1982-12-24 1982-12-24 インターロイキン２活性をもつポリペプチドをコードする遺伝子

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP63292084A Division JPH0832236B2 (ja) 1988-11-18 1988-11-18 組換えヒトインターロイキン２およびその製造法
JP63292085A Division JPH0832237B2 (ja) 1988-11-18 1988-11-18 ヒトインターロイキン２活性をもつポリペプチドをコードする遺伝子を含有する発現ベクターおよび該ベクターにより形質転換された真核生物

Publications (2)

Publication Number Publication Date
JPS59140882A true JPS59140882A (ja) 1984-08-13
JPH0119879B2 JPH0119879B2 (enExample) 1989-04-13

Family

ID=16895021

Family Applications (1)

Application Number Title Priority Date Filing Date
JP57229619A Granted JPS59140882A (ja) 1982-03-31 1982-12-24 インターロイキン２活性をもつポリペプチドをコードする遺伝子

Country Status (1)

Country Link
JP (1) JPS59140882A (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59220189A (ja) * 1983-02-08 1984-12-11 バイオジェン　ナームローズ　ベンノットシャップ ひとインターロイキン２様ポリペプチドをコードするｄｎａ配列、該ｄｎａ配列を有する発現ベクターおよび該発現ベクターを有する大腸菌
WO1986000334A1 (en) * 1984-06-20 1986-01-16 Takeda Chemical Industries, Ltd. Novel transformant and its use
JPS6158590A (ja) * 1984-08-30 1986-03-25 Ajinomoto Co Inc マウスインターロイキン―２活性を有するポリペプチド及びその製造法
WO1986006405A1 (fr) * 1985-05-02 1986-11-06 Takeda Chemical Industries, Ltd. Nouveau transformateur et son utilisation
JPH029388A (ja) * 1988-03-09 1990-01-12 Ajinomoto Co Inc 生理活性タンパク質の製造法

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59220189A (ja) * 1983-02-08 1984-12-11 バイオジェン　ナームローズ　ベンノットシャップ ひとインターロイキン２様ポリペプチドをコードするｄｎａ配列、該ｄｎａ配列を有する発現ベクターおよび該発現ベクターを有する大腸菌
WO1986000334A1 (en) * 1984-06-20 1986-01-16 Takeda Chemical Industries, Ltd. Novel transformant and its use
JPS6158590A (ja) * 1984-08-30 1986-03-25 Ajinomoto Co Inc マウスインターロイキン―２活性を有するポリペプチド及びその製造法
WO1986006405A1 (fr) * 1985-05-02 1986-11-06 Takeda Chemical Industries, Ltd. Nouveau transformateur et son utilisation
JPH029388A (ja) * 1988-03-09 1990-01-12 Ajinomoto Co Inc 生理活性タンパク質の製造法

Also Published As

Publication number Publication date
JPH0119879B2 (enExample) 1989-04-13

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