JPS5848160B2 - シンキカゴウブツノセイゾウホウ - Google Patents

シンキカゴウブツノセイゾウホウ

Info

Publication number
JPS5848160B2
JPS5848160B2 JP50048517A JP4851775A JPS5848160B2 JP S5848160 B2 JPS5848160 B2 JP S5848160B2 JP 50048517 A JP50048517 A JP 50048517A JP 4851775 A JP4851775 A JP 4851775A JP S5848160 B2 JPS5848160 B2 JP S5848160B2
Authority
JP
Japan
Prior art keywords
erythrobentofuranosyl
deoxy
column
solution
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP50048517A
Other languages
English (en)
Japanese (ja)
Other versions
JPS50145590A (US06373033-20020416-M00071.png
Inventor
ライダー アルバート
デイビツト ハウエルズ ジヨン
ウイン キー ウー ピーター
ウイリアム ダイオン ヘンリー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Parke Davis and Co LLC
Original Assignee
Parke Davis and Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Parke Davis and Co LLC filed Critical Parke Davis and Co LLC
Publication of JPS50145590A publication Critical patent/JPS50145590A/ja
Publication of JPS5848160B2 publication Critical patent/JPS5848160B2/ja
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/38—Nucleosides
    • C12P19/40—Nucleosides having a condensed ring system containing a six-membered ring having two nitrogen atoms in the same ring, e.g. purine nucleosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/052—Imidazole radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/38—Nucleosides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/886—Streptomyces
    • Y10S435/888—Streptomyces antibioticus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
JP50048517A 1974-04-22 1975-04-21 シンキカゴウブツノセイゾウホウ Expired JPS5848160B2 (ja)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US462826A US3923785A (en) 1974-04-22 1974-04-22 (R)-3-(2-deoxy-{62 -D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidazo{8 4,5-d{9 {8 1,3{9 diazepin-8-ol

Publications (2)

Publication Number Publication Date
JPS50145590A JPS50145590A (US06373033-20020416-M00071.png) 1975-11-21
JPS5848160B2 true JPS5848160B2 (ja) 1983-10-26

Family

ID=23837909

Family Applications (1)

Application Number Title Priority Date Filing Date
JP50048517A Expired JPS5848160B2 (ja) 1974-04-22 1975-04-21 シンキカゴウブツノセイゾウホウ

Country Status (8)

Country Link
US (1) US3923785A (US06373033-20020416-M00071.png)
JP (1) JPS5848160B2 (US06373033-20020416-M00071.png)
BE (1) BE828183A (US06373033-20020416-M00071.png)
CA (1) CA1042376A (US06373033-20020416-M00071.png)
DE (1) DE2517596A1 (US06373033-20020416-M00071.png)
FR (1) FR2311552A1 (US06373033-20020416-M00071.png)
GB (1) GB1481927A (US06373033-20020416-M00071.png)
NL (1) NL186868C (US06373033-20020416-M00071.png)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60992B2 (ja) * 1977-03-15 1985-01-11 財団法人微生物化学研究会 コホルマイシンおよび関連物質の分離法
US4195176A (en) * 1977-10-11 1980-03-25 Warner-Lambert Company Imidazole compounds, methods for their production and conversion of said compounds into (R)-3-(2-deoxy-β-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidazol[4,5-d][1,3]diazepin-8-ol
US4117229A (en) * 1977-10-11 1978-09-26 Warner-Lambert Company 2-amino-1-(5-amino-1h-imidazol-4-yl)ethanone and method of preparation
US4163839A (en) * 1977-12-09 1979-08-07 Zaidan Hojin Biselbutsu Kagaku Kenkyu Kai Isocoformycin and a process for the production thereof
US4935505A (en) * 1983-05-03 1990-06-19 Townsend Leroy B Novel azolo [1,3] diazepine-5-ol compounds and their uses
US4713372A (en) * 1984-03-16 1987-12-15 Warner-Lambert Company 2-chloropentostatin compound having adenosine diaminase inhibitory activity
DE3562623D1 (en) * 1984-03-16 1988-06-16 Warner Lambert Co 2'-chloropentostatin, a pharmaceutical composition comprising the compound and a novel microorganism for producing the compound
BR8607124A (pt) * 1986-03-27 1988-04-05 Harry Edward Gruber Um metodo de aumentar a excrecao de adenosina
DK0596943T3 (da) * 1991-07-31 1997-04-21 Warner Lambert Co Fremgangsmåde til rensning af pentostatin
US5773607A (en) * 1991-11-14 1998-06-30 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Processes for preparing 2'-deoxy-2'-fluorocoformycin and stereoisomers thereof
JPH09241294A (ja) * 1996-03-07 1997-09-16 Microbial Chem Res Found ２′−デオキシ−２′−ハロコホルマイシン又はその立体異性体の製造法
US6174873B1 (en) 1998-11-04 2001-01-16 Supergen, Inc. Oral administration of adenosine analogs
US20020086835A1 (en) * 2000-05-22 2002-07-04 Law William R. Use of adenosine deaminase inhibitors to treat systemic inflammatory response syndrome
US7829084B2 (en) 2001-01-17 2010-11-09 Trubion Pharmaceuticals, Inc. Binding constructs and methods for use thereof
US8741858B2 (en) * 2007-09-21 2014-06-03 Zhongxu Ren Oligomer-nucleoside phosphate conjugates
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
EA019295B1 (ru) * 2008-12-23 2014-02-28 Джилид Фармассет, Ллс. Соединения пуриновых нуклеозидов и способ их получения
US8551973B2 (en) * 2008-12-23 2013-10-08 Gilead Pharmasset Llc Nucleoside analogs
EP2376088B1 (en) 2008-12-23 2017-02-22 Gilead Pharmasset LLC 6-O-Substituted-2-amino-purine nucleoside phosphoramidates
CN101792722B (zh) * 2009-02-04 2013-04-10 杭州华东医药集团生物工程研究所有限公司 一种链霉菌及其应用
CN101798330A (zh) * 2009-02-06 2010-08-11 杭州华东医药集团生物工程研究所有限公司 一种喷司他丁的提取纯化方法
US20100261666A1 (en) * 2009-04-14 2010-10-14 The Board Of Trustees Of The University Of Illinois Compositions and methods for the treatment of myocardial dysfunction associated with sirs or sepsis
JP2013527145A (ja) 2010-03-31 2013-06-27 ギリード・ファーマセット・エルエルシー リン含有活性化剤の立体選択的合成
CN102234673B (zh) * 2010-04-29 2014-03-26 上海医药工业研究院 抗生链霉菌发酵生产喷司他丁的发酵培养基以及发酵方法
CN102453065B (zh) * 2010-10-29 2014-12-17 上海医药工业研究院 一种去除喷司他丁发酵液中杂质的方法
CA2972065A1 (en) 2014-12-23 2016-06-30 Intellectual Property Associates, Llc Methods and formulations for transdermal administration
EP3681479B1 (en) 2017-09-15 2024-01-31 Dyve Biosciences, Inc. Sodium bicarbonate for use in the treatment of gout and related disorders
CN108586556B (zh) * 2018-01-17 2021-04-20 浙江海正药业股份有限公司 一种喷司他丁的晶型及其制备方法和用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3616208A (en) * 1967-09-29 1971-10-26 Parke Davis & Co Fermentation process for 9-(beta-d-arabinofuranosyl)adenine
BE756704A (fr) * 1969-09-26 1971-03-01 Parke Davis & Co Procede de production du 5'-phosphate de 9-(beta-d- arabinofuranosyl) adenine et de ses sels
US3792036A (en) * 1970-01-07 1974-02-12 Ciba Geigy Corp Pteridine-glycosides

Also Published As

Publication number Publication date
US3923785A (en) 1975-12-02
BE828183A (fr) 1975-08-18
DE2517596C2 (US06373033-20020416-M00071.png) 1987-05-14
JPS50145590A (US06373033-20020416-M00071.png) 1975-11-21
NL7504710A (nl) 1975-10-24
NL186868B (nl) 1990-10-16
CA1042376A (en) 1978-11-14
GB1481927A (en) 1977-08-03
FR2311552A1 (fr) 1976-12-17
NL186868C (nl) 1991-03-18
DE2517596A1 (de) 1975-10-30
FR2311552B1 (US06373033-20020416-M00071.png) 1979-06-08

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