JPS5822039B2 - チアゾ−ル化合物およびその製造法 - Google Patents

チアゾ−ル化合物およびその製造法

Info

Publication number
JPS5822039B2
JPS5822039B2 JP51067524A JP6752476A JPS5822039B2 JP S5822039 B2 JPS5822039 B2 JP S5822039B2 JP 51067524 A JP51067524 A JP 51067524A JP 6752476 A JP6752476 A JP 6752476A JP S5822039 B2 JPS5822039 B2 JP S5822039B2
Authority
JP
Japan
Prior art keywords
hydrogen
group
water
acid
nuclear magnetic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP51067524A
Other languages
English (en)
Japanese (ja)
Other versions
JPS51149296A (en
Inventor
安芸修躬
岡田泰一
松下義弘
森本明
川喜多健二
落合道彦
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of JPS51149296A publication Critical patent/JPS51149296A/ja
Publication of JPS5822039B2 publication Critical patent/JPS5822039B2/ja
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/40—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP51067524A 1975-06-09 1976-06-08 チアゾ−ル化合物およびその製造法 Expired JPS5822039B2 (ja)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB24611/75A GB1536281A (en) 1975-06-09 1975-06-09 Cephem compounds

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP56087403A Division JPS5858353B2 (ja) 1975-06-09 1981-06-05 セフエムまたはペナム化合物およびその製造法

Publications (2)

Publication Number Publication Date
JPS51149296A JPS51149296A (en) 1976-12-22
JPS5822039B2 true JPS5822039B2 (ja) 1983-05-06

Family

ID=10214399

Family Applications (5)

Application Number Title Priority Date Filing Date
JP51067524A Expired JPS5822039B2 (ja) 1975-06-09 1976-06-08 チアゾ−ル化合物およびその製造法
JP56087403A Expired JPS5858353B2 (ja) 1975-06-09 1981-06-05 セフエムまたはペナム化合物およびその製造法
JP58012560A Granted JPS58185553A (ja) 1975-06-09 1983-01-27 α−保護されたオキシイミノ−β−ケト−γ−ハロゲノ酪酸類
JP58178160A Pending JPS5989686A (ja) 1975-06-09 1983-09-28 セフエムまたはペナム化合物
JP60232072A Granted JPS61143388A (ja) 1975-06-09 1985-10-16 セフェム化合物

Family Applications After (4)

Application Number Title Priority Date Filing Date
JP56087403A Expired JPS5858353B2 (ja) 1975-06-09 1981-06-05 セフエムまたはペナム化合物およびその製造法
JP58012560A Granted JPS58185553A (ja) 1975-06-09 1983-01-27 α−保護されたオキシイミノ−β−ケト−γ−ハロゲノ酪酸類
JP58178160A Pending JPS5989686A (ja) 1975-06-09 1983-09-28 セフエムまたはペナム化合物
JP60232072A Granted JPS61143388A (ja) 1975-06-09 1985-10-16 セフェム化合物

Country Status (7)

Country Link
JP (5) JPS5822039B2 (ru)
AT (2) AT344894B (ru)
GB (1) GB1536281A (ru)
HK (1) HK2282A (ru)
HU (1) HU172304B (ru)
MY (1) MY8200219A (ru)
SE (1) SE444809B (ru)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK154939C (da) * 1974-12-19 1989-06-12 Takeda Chemical Industries Ltd Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf
GB1536281A (en) * 1975-06-09 1978-12-20 Takeda Chemical Industries Ltd Cephem compounds
FR2346014A1 (fr) * 1976-01-23 1977-10-28 Roussel Uclaf Nouvelles oximes derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
SE440655B (sv) * 1976-01-23 1985-08-12 Roussel Uclaf Sett att framstella nya oximderivat av 7-amino-tiazolyl-acetamido-cefalosporansyra
GB1576625A (en) * 1976-04-12 1980-10-08 Fujisawa Pharmaceutical Co Syn isomer 3,7 disubstituted 3 cephem 4 carboxylic acid compounds and processes for the preparation thereof
FI771866A (ru) * 1976-06-28 1977-12-29 Fujisawa Pharmaceutical Co
PH17188A (en) * 1977-03-14 1984-06-14 Fujisawa Pharmaceutical Co New cephem and cepham compounds and their pharmaceutical compositions and method of use
ZA781502B (en) * 1977-03-14 1979-09-26 Fujisawa Pharmaceutical Co New cephem and cepham compounds and processes for preparation thereof
JPS5444695A (en) * 1977-09-13 1979-04-09 Fujisawa Pharmaceut Co Ltd 3,7-disubstituted-3-cephem-4-carboxylic acid and its salt and their preparation
US4370326A (en) * 1977-09-13 1983-01-25 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds and composition
FR2410655A1 (fr) * 1977-12-05 1979-06-29 Roussel Uclaf Nouvelles oximes derivees de l'acide 3-substitue 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
DE2758001A1 (de) * 1977-12-24 1979-07-12 Hoechst Ag Cephalosporinderivate und verfahren zu ihrer herstellung
FR2387235A1 (fr) * 1978-01-23 1978-11-10 Fujisawa Pharmaceutical Co Procede de preparation de composes d'acide 3,7-disubstitue-3-cephem-4-carboxylique et nouveaux produits ainsi obtenus, ayant une forte activite antibacterienne
JPS54106495A (en) * 1978-02-09 1979-08-21 Dai Ichi Seiyaku Co Ltd Cephem derivative
JPS54128594A (en) * 1978-03-27 1979-10-05 Fujisawa Pharmaceut Co Ltd 3,7-disubstituted-3-cephem-4-carboxylic acid derivative
FR2432521A1 (fr) * 1978-03-31 1980-02-29 Roussel Uclaf Nouvelles oximes o-substituees derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
DE2818263A1 (de) * 1978-04-26 1979-11-08 Bayer Ag Beta-lactamantibiotika
US4703046A (en) * 1978-09-08 1987-10-27 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds and processes for preparation thereof
BE878637A (fr) * 1978-09-11 1980-03-06 Fujisawa Pharmaceutical Co Procede de preparation de composes d'acide 3-cephem-4-carboxylique 3,7-disubstitue et de leurs sels pharmaceutiquement acceptables, nouveaux produits ainsi obtenus et leur utilisation pour leurs activites antimicrobiennes
JPS5594354A (en) * 1979-01-12 1980-07-17 Fujisawa Pharmaceut Co Ltd Syn-isomer of 2-substituted imino-3-oxo-4-halobutyric acid, its salt, and their preparation
JPS5543089A (en) * 1978-09-12 1980-03-26 Fujisawa Pharmaceut Co Ltd Preparation of 3-cephem compound
US4409215A (en) * 1979-11-19 1983-10-11 Fujisawa Pharmaceutical Co., Ltd. 7-Acylamino-3-substituted cephalosporanic acid derivatives and processes for the preparation thereof
JPS56125392A (en) * 1980-03-06 1981-10-01 Fujisawa Pharmaceut Co Ltd Cepham and cephem compound and preparation thereof
JPS57154175A (en) * 1981-03-16 1982-09-22 Mitsui Toatsu Chem Inc 2-thiazoleamine derivative, its preparation, and drug composition comprising it
US4457929A (en) * 1982-03-29 1984-07-03 Bristol-Myers Company 3-Quaternary ammonium methyl)-substituted cephalosporin derivatives
JPS5910593A (ja) 1982-06-28 1984-01-20 Bristol Mayers Kenkyusho Kk セフアロスポリン誘導体
IL69246A (en) * 1982-08-07 1986-07-31 Tanabe Seiyaku Co 7-((2-aminothiazolyl-2-pyrrolidonyl or(piperidonyl)-oxyimino)acetamido)cephem carboxylic acid derivatives,their preparation and pharmaceutical compositions containing them
JPS6150973A (ja) * 1983-11-16 1986-03-13 Fujisawa Pharmaceut Co Ltd 置換イミノ酢酸誘導体およびその塩類
IT1180207B (it) * 1984-07-30 1987-09-23 Istituto Biochimico Italiano Procedimento per la preparazione, con resa e purezza elevate, di antibiotici beta-lattamici
JPS60155167A (ja) * 1984-07-31 1985-08-15 Fujisawa Pharmaceut Co Ltd 置換イミノ酢酸誘導体およびその塩類
JPS61121746U (ru) * 1985-01-16 1986-07-31
EP0210815A3 (en) * 1985-07-25 1988-04-20 Beecham Group Plc 6-beta-(alpha-etherified oxyimino)-acylamino penicillanic-acid derivatives, their preparation and use
GB8519606D0 (en) * 1985-08-05 1985-09-11 Fujisawa Pharmaceutical Co 3 7-d substituted-3-cephem compounds
AU1228588A (en) * 1987-02-02 1988-08-24 Teijin Limited Cephalosporin compounds or their salts, process for their preparation, and parmaceutical compositions
AU1228988A (en) * 1987-02-03 1988-08-24 Teijin Limited Cephalosporin compounds or their salts, process for their preparation, and pharmaceutical compositions
JPH02281051A (ja) * 1989-04-21 1990-11-16 Toyo Tire & Rubber Co Ltd タイヤ用トレッドゴム組成物
JPH09110877A (ja) 1995-10-17 1997-04-28 Katayama Seiyakushiyo:Kk セフェム化合物、その製造法及びそれを含有する抗菌剤

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1536281A (en) * 1975-06-09 1978-12-20 Takeda Chemical Industries Ltd Cephem compounds

Also Published As

Publication number Publication date
AT347587B (de) 1979-01-10
JPS5756485A (en) 1982-04-05
MY8200219A (en) 1982-12-31
JPS61143388A (ja) 1986-07-01
JPS5989686A (ja) 1984-05-23
SE444809B (sv) 1986-05-12
JPH0346474B2 (ru) 1991-07-16
SE7713233L (sv) 1977-11-23
JPS51149296A (en) 1976-12-22
HK2282A (en) 1982-01-22
GB1536281A (en) 1978-12-20
HU172304B (hu) 1978-07-28
JPS5858353B2 (ja) 1983-12-24
JPS6155905B2 (ru) 1986-11-29
ATA967775A (de) 1977-12-15
ATA517177A (de) 1978-05-15
JPS58185553A (ja) 1983-10-29
AT344894B (de) 1978-08-10

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