JPS58201719A - 生物学的に活性な多糖類コンセントレ−ト及びその物質を含む組成物の製造方法 - Google Patents
生物学的に活性な多糖類コンセントレ−ト及びその物質を含む組成物の製造方法Info
- Publication number
- JPS58201719A JPS58201719A JP58034690A JP3469083A JPS58201719A JP S58201719 A JPS58201719 A JP S58201719A JP 58034690 A JP58034690 A JP 58034690A JP 3469083 A JP3469083 A JP 3469083A JP S58201719 A JPS58201719 A JP S58201719A
- Authority
- JP
- Japan
- Prior art keywords
- polysaccharide
- water
- separated
- precipitate
- concentrate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920001282 polysaccharide Polymers 0.000 title claims description 89
- 239000005017 polysaccharide Substances 0.000 title claims description 89
- 150000004676 glycans Chemical class 0.000 title claims description 88
- 239000012141 concentrate Substances 0.000 title claims description 56
- 239000000203 mixture Substances 0.000 title claims description 29
- 238000004519 manufacturing process Methods 0.000 title claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 46
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 41
- 230000003110 anti-inflammatory effect Effects 0.000 claims description 27
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 claims description 24
- 239000002244 precipitate Substances 0.000 claims description 24
- 235000000346 sugar Nutrition 0.000 claims description 21
- 238000005119 centrifugation Methods 0.000 claims description 19
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 17
- 238000000034 method Methods 0.000 claims description 17
- 239000007787 solid Substances 0.000 claims description 17
- 241000196324 Embryophyta Species 0.000 claims description 14
- 238000001914 filtration Methods 0.000 claims description 13
- 238000012360 testing method Methods 0.000 claims description 13
- 229960000905 indomethacin Drugs 0.000 claims description 12
- 241000699670 Mus sp. Species 0.000 claims description 11
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 10
- 241000699666 Mus <mouse, genus> Species 0.000 claims description 10
- 206010030113 Oedema Diseases 0.000 claims description 10
- 239000006286 aqueous extract Substances 0.000 claims description 10
- 239000002537 cosmetic Substances 0.000 claims description 10
- 150000008163 sugars Chemical class 0.000 claims description 10
- 241000219122 Cucurbita Species 0.000 claims description 9
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 9
- 239000000679 carrageenan Substances 0.000 claims description 9
- 229920001525 carrageenan Polymers 0.000 claims description 9
- 235000010418 carrageenan Nutrition 0.000 claims description 9
- 229940113118 carrageenan Drugs 0.000 claims description 9
- 239000008103 glucose Substances 0.000 claims description 9
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims description 9
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 claims description 8
- 229930182830 galactose Natural products 0.000 claims description 8
- 239000000463 material Substances 0.000 claims description 8
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims description 7
- 238000005903 acid hydrolysis reaction Methods 0.000 claims description 7
- 239000012528 membrane Substances 0.000 claims description 7
- 229910052698 phosphorus Inorganic materials 0.000 claims description 7
- 239000011574 phosphorus Substances 0.000 claims description 7
- 230000002829 reductive effect Effects 0.000 claims description 7
- 239000006228 supernatant Substances 0.000 claims description 7
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 claims description 6
- 239000002253 acid Substances 0.000 claims description 6
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 claims description 6
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 claims description 6
- 239000000126 substance Substances 0.000 claims description 6
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 5
- 239000000284 extract Substances 0.000 claims description 5
- 229910052757 nitrogen Inorganic materials 0.000 claims description 5
- 230000001376 precipitating effect Effects 0.000 claims description 5
- 238000012545 processing Methods 0.000 claims description 5
- 244000075850 Avena orientalis Species 0.000 claims description 4
- 235000007319 Avena orientalis Nutrition 0.000 claims description 4
- 239000012736 aqueous medium Substances 0.000 claims description 4
- 125000004432 carbon atom Chemical group C* 0.000 claims description 4
- 239000004615 ingredient Substances 0.000 claims description 4
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims description 4
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims description 4
- 235000021533 Beta vulgaris Nutrition 0.000 claims description 3
- 241000335053 Beta vulgaris Species 0.000 claims description 3
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 claims description 3
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 claims description 3
- SHZGCJCMOBCMKK-JFNONXLTSA-N L-rhamnopyranose Chemical compound C[C@@H]1OC(O)[C@H](O)[C@H](O)[C@H]1O SHZGCJCMOBCMKK-JFNONXLTSA-N 0.000 claims description 3
- PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 claims description 3
- 230000002378 acidificating effect Effects 0.000 claims description 3
- 150000007513 acids Chemical class 0.000 claims description 3
- PYMYPHUHKUWMLA-WDCZJNDASA-N arabinose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C=O PYMYPHUHKUWMLA-WDCZJNDASA-N 0.000 claims description 3
- 150000001768 cations Chemical class 0.000 claims description 3
- 239000012452 mother liquor Substances 0.000 claims description 3
- 241000208838 Asteraceae Species 0.000 claims description 2
- 241000871189 Chenopodiaceae Species 0.000 claims description 2
- 241000219104 Cucurbitaceae Species 0.000 claims description 2
- 241000208175 Daucus Species 0.000 claims description 2
- 241000219071 Malvaceae Species 0.000 claims description 2
- 150000001298 alcohols Chemical class 0.000 claims description 2
- 230000007062 hydrolysis Effects 0.000 claims description 2
- 238000006460 hydrolysis reaction Methods 0.000 claims description 2
- 239000003960 organic solvent Substances 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 241000894007 species Species 0.000 claims 5
- 239000003937 drug carrier Substances 0.000 claims 2
- BHEPBYXIRTUNPN-UHFFFAOYSA-N hydridophosphorus(.) (triplet) Chemical compound [PH] BHEPBYXIRTUNPN-UHFFFAOYSA-N 0.000 claims 2
- 239000000419 plant extract Substances 0.000 claims 2
- 240000001980 Cucurbita pepo Species 0.000 claims 1
- 235000009852 Cucurbita pepo Nutrition 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 241000208202 Linaceae Species 0.000 claims 1
- 241001494479 Pecora Species 0.000 claims 1
- 239000004020 conductor Substances 0.000 claims 1
- 230000009089 cytolysis Effects 0.000 claims 1
- 230000001747 exhibiting effect Effects 0.000 claims 1
- MEYZYGMYMLNUHJ-UHFFFAOYSA-N tunicamycin Natural products CC(C)CCCCCCCCCC=CC(=O)NC1C(O)C(O)C(CC(O)C2OC(C(O)C2O)N3C=CC(=O)NC3=O)OC1OC4OC(CO)C(O)C(O)C4NC(=O)C MEYZYGMYMLNUHJ-UHFFFAOYSA-N 0.000 claims 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 78
- 239000000243 solution Substances 0.000 description 19
- 230000000694 effects Effects 0.000 description 16
- 238000003756 stirring Methods 0.000 description 15
- 239000003814 drug Substances 0.000 description 13
- 235000007866 Chamaemelum nobile Nutrition 0.000 description 11
- 244000042664 Matricaria chamomilla Species 0.000 description 11
- 235000007232 Matricaria chamomilla Nutrition 0.000 description 11
- 239000008346 aqueous phase Substances 0.000 description 11
- 241000628997 Flos Species 0.000 description 10
- 239000002260 anti-inflammatory agent Substances 0.000 description 8
- 229940079593 drug Drugs 0.000 description 8
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 8
- 241001312519 Trigonella Species 0.000 description 7
- 238000000605 extraction Methods 0.000 description 7
- 239000007858 starting material Substances 0.000 description 7
- 108090000623 proteins and genes Proteins 0.000 description 6
- 102000004169 proteins and genes Human genes 0.000 description 6
- 241000700159 Rattus Species 0.000 description 5
- 208000025865 Ulcer Diseases 0.000 description 5
- 239000013543 active substance Substances 0.000 description 5
- 229940121363 anti-inflammatory agent Drugs 0.000 description 5
- 210000004379 membrane Anatomy 0.000 description 5
- 238000000746 purification Methods 0.000 description 5
- 239000012153 distilled water Substances 0.000 description 4
- 230000004054 inflammatory process Effects 0.000 description 4
- 235000015110 jellies Nutrition 0.000 description 4
- 239000012071 phase Substances 0.000 description 4
- 238000001556 precipitation Methods 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 239000000839 emulsion Substances 0.000 description 3
- 238000007912 intraperitoneal administration Methods 0.000 description 3
- 239000008274 jelly Substances 0.000 description 3
- 239000003826 tablet Substances 0.000 description 3
- 241000209524 Araceae Species 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 2
- 239000003435 antirheumatic agent Substances 0.000 description 2
- CUFNKYGDVFVPHO-UHFFFAOYSA-N azulene Chemical compound C1=CC=CC2=CC=CC2=C1 CUFNKYGDVFVPHO-UHFFFAOYSA-N 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 241000411851 herbal medicine Species 0.000 description 2
- 230000002757 inflammatory effect Effects 0.000 description 2
- -1 infusion Substances 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 210000004400 mucous membrane Anatomy 0.000 description 2
- 239000002674 ointment Substances 0.000 description 2
- 238000003825 pressing Methods 0.000 description 2
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 210000000582 semen Anatomy 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 description 2
- 229940075582 sorbic acid Drugs 0.000 description 2
- 235000010199 sorbic acid Nutrition 0.000 description 2
- 239000004334 sorbic acid Substances 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 231100000041 toxicology testing Toxicity 0.000 description 2
- 231100000397 ulcer Toxicity 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 206010063409 Acarodermatitis Diseases 0.000 description 1
- 235000006578 Althaea Nutrition 0.000 description 1
- 206010002153 Anal fissure Diseases 0.000 description 1
- 208000016583 Anus disease Diseases 0.000 description 1
- 206010003694 Atrophy Diseases 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- 240000004160 Capsicum annuum Species 0.000 description 1
- 241000207199 Citrus Species 0.000 description 1
- 206010010741 Conjunctivitis Diseases 0.000 description 1
- 241001507921 Cydonia Species 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 208000009531 Fissure in Ano Diseases 0.000 description 1
- 244000130592 Hibiscus syriacus Species 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 102100033292 Leucine-rich repeat-containing protein 7 Human genes 0.000 description 1
- 101710148963 Leucine-rich repeat-containing protein 7 Proteins 0.000 description 1
- 241000208204 Linum Species 0.000 description 1
- ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical class [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 description 1
- 229920000715 Mucilage Polymers 0.000 description 1
- 235000003805 Musa ABB Group Nutrition 0.000 description 1
- 240000008790 Musa x paradisiaca Species 0.000 description 1
- 240000002853 Nelumbo nucifera Species 0.000 description 1
- 235000006508 Nelumbo nucifera Nutrition 0.000 description 1
- 235000006510 Nelumbo pentapetala Nutrition 0.000 description 1
- 206010054107 Nodule Diseases 0.000 description 1
- 235000004347 Perilla Nutrition 0.000 description 1
- 244000124853 Perilla frutescens Species 0.000 description 1
- 201000007100 Pharyngitis Diseases 0.000 description 1
- 235000015266 Plantago major Nutrition 0.000 description 1
- 241000447727 Scabies Species 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 244000061456 Solanum tuberosum Species 0.000 description 1
- 235000002595 Solanum tuberosum Nutrition 0.000 description 1
- SSZBUIDZHHWXNJ-UHFFFAOYSA-N Stearinsaeure-hexadecylester Natural products CCCCCCCCCCCCCCCCCC(=O)OCCCCCCCCCCCCCCCC SSZBUIDZHHWXNJ-UHFFFAOYSA-N 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 241000532784 Thelia <leafhopper> Species 0.000 description 1
- 244000299461 Theobroma cacao Species 0.000 description 1
- 235000005764 Theobroma cacao ssp. cacao Nutrition 0.000 description 1
- 235000005767 Theobroma cacao ssp. sphaerocarpum Nutrition 0.000 description 1
- 244000250129 Trigonella foenum graecum Species 0.000 description 1
- 235000001484 Trigonella foenum graecum Nutrition 0.000 description 1
- 206010046914 Vaginal infection Diseases 0.000 description 1
- 201000008100 Vaginitis Diseases 0.000 description 1
- 229940068372 acetyl salicylate Drugs 0.000 description 1
- 229960001138 acetylsalicylic acid Drugs 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000007059 acute toxicity Effects 0.000 description 1
- 231100000403 acute toxicity Toxicity 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 1
- 235000011130 ammonium sulphate Nutrition 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000003699 antiulcer agent Substances 0.000 description 1
- 206010003246 arthritis Diseases 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000037444 atrophy Effects 0.000 description 1
- RQPZNWPYLFFXCP-UHFFFAOYSA-L barium dihydroxide Chemical compound [OH-].[OH-].[Ba+2] RQPZNWPYLFFXCP-UHFFFAOYSA-L 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 235000001046 cacaotero Nutrition 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 235000020971 citrus fruits Nutrition 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 239000008298 dragée Substances 0.000 description 1
- 210000000613 ear canal Anatomy 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 239000012065 filter cake Substances 0.000 description 1
- 150000002243 furanoses Chemical group 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 208000007565 gingivitis Diseases 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 229960001340 histamine Drugs 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 231100000518 lethal Toxicity 0.000 description 1
- 230000001665 lethal effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 239000000395 magnesium oxide Substances 0.000 description 1
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 1
- 210000001595 mastoid Anatomy 0.000 description 1
- 230000008774 maternal effect Effects 0.000 description 1
- 239000002808 molecular sieve Substances 0.000 description 1
- 229910052750 molybdenum Inorganic materials 0.000 description 1
- 239000011733 molybdenum Substances 0.000 description 1
- 150000002772 monosaccharides Chemical group 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- JVRGQRSHPUQHKJ-UHFFFAOYSA-N octadecanoic acid;propanoic acid Chemical compound CCC(O)=O.CCCCCCCCCCCCCCCCCC(O)=O JVRGQRSHPUQHKJ-UHFFFAOYSA-N 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 239000007971 pharmaceutical suspension Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- OQUKIQWCVTZJAF-UHFFFAOYSA-N phenol;sulfuric acid Chemical compound OS(O)(=O)=O.OC1=CC=CC=C1 OQUKIQWCVTZJAF-UHFFFAOYSA-N 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 238000011403 purification operation Methods 0.000 description 1
- 150000003214 pyranose derivatives Chemical group 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 208000005687 scabies Diseases 0.000 description 1
- 229940076279 serotonin Drugs 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 210000002460 smooth muscle Anatomy 0.000 description 1
- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 1
- 229910001415 sodium ion Inorganic materials 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 235000007586 terpenes Nutrition 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 239000001917 trigonella foenum graecum l. absolute Substances 0.000 description 1
- 235000001019 trigonella foenum-graecum Nutrition 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 208000010484 vulvovaginitis Diseases 0.000 description 1
- 239000003871 white petrolatum Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0216—Solid or semisolid forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Birds (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Polymers & Plastics (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU82660A HU188311B (en) | 1982-03-04 | 1982-03-04 | Process for producing biologically active polisaccharide concentrates and pharmaceutical compositions containing them as active agents |
HU660/82 | 1983-02-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS58201719A true JPS58201719A (ja) | 1983-11-24 |
Family
ID=10950710
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP58034690A Pending JPS58201719A (ja) | 1982-03-04 | 1983-03-04 | 生物学的に活性な多糖類コンセントレ−ト及びその物質を含む組成物の製造方法 |
Country Status (15)
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6023401A (ja) * | 1983-03-09 | 1985-02-06 | Toyo Soda Mfg Co Ltd | 多糖類およびその製造法 |
US4857325A (en) * | 1985-04-24 | 1989-08-15 | Bar-Ilan University | Antioxidant compositions and methods |
US4923697A (en) * | 1985-04-24 | 1990-05-08 | Bar-Ilan University | Antioxidant compositions and methods |
GB8520101D0 (en) * | 1985-08-09 | 1985-09-18 | Unilever Plc | Phase separation |
EP0213099A3 (de) * | 1985-08-23 | 1989-07-19 | Cederroth Nordic Aktiebolag | Mittel mit antiphlogistischer, immunstimulierender und zytoprotektiver Wirkung, ihre Herstellung und pharmazeutische Verwendungen |
DE3541945A1 (de) * | 1985-11-27 | 1987-06-04 | Lomapharm Rudolf Lohman Gmbh K | Immunstimulierend wirkende polysaccharide aus zellkulturen von echinacea purpurea (l.) moench und echinacea angustifolia, d.c. verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zubereitungen |
IL80783A0 (en) * | 1986-10-17 | 1987-02-27 | Univ Bar Ilan | Food supplements |
FR2617848B1 (fr) * | 1987-07-10 | 1990-01-05 | Guyomarch Sa Ets | Polysaccharides extraits, notamment, de vegetaux utiles comme medicaments et additifs alimentaires |
US4986985A (en) * | 1987-11-02 | 1991-01-22 | Bar Ilan University | Method of treating skin virus infections |
US5268467A (en) * | 1988-05-23 | 1993-12-07 | Verbiscar Anthony J | Immunomodulatory polysaccharide fractions from Astragalus plants |
JP2764433B2 (ja) * | 1989-05-12 | 1998-06-11 | 花王株式会社 | 自己免疫疾患治療剤 |
US5696273A (en) * | 1991-02-28 | 1997-12-09 | Parfums Christian Dior | Method for synthesizing cucurbitine |
WO1994001082A1 (en) * | 1992-07-14 | 1994-01-20 | Bozo Tasevski | Bozjo skin treatment mixture |
US5679375A (en) * | 1995-06-07 | 1997-10-21 | C.V. Therapeuctics | Method of treating ulcers with sulfated polysaccharides |
US5864034A (en) * | 1995-07-11 | 1999-01-26 | Shin-Etsu Chemical Co., Ltd. | Process for production of saline-solution soluble xanthan gum |
JPH09175982A (ja) * | 1995-12-28 | 1997-07-08 | Nikka Uisukii Kk | 化粧品 |
US6352845B1 (en) | 1999-02-10 | 2002-03-05 | Eastman Chemical Company | Corn fiber for the production of advanced chemicals and materials: separation of monosaccharides and methods thereof |
WO2002003999A1 (en) * | 2000-07-10 | 2002-01-17 | The University Of Missisippi | High molecular weight polysaccharide fraction from aloe vera with immunostimulatory activity |
ATE311892T1 (de) * | 2000-07-10 | 2005-12-15 | Univ Mississippi | Hochaktive immunstimulierende mittel aus mikroalgen |
RU2177793C1 (ru) * | 2000-07-26 | 2002-01-10 | Дроздова Ирина Леонидовна | Способ получения суммы полисахаридов, обладающей противовоспалительной активностью |
US20020061339A1 (en) * | 2000-09-28 | 2002-05-23 | Martin Stogniew | Compositions and methods for use of extracts of rutaceae plants |
RU2206333C1 (ru) * | 2002-07-22 | 2003-06-20 | Институт общей и экспериментальной биологии СО РАН | Способ получения средства, обладающего противовоспалительной активностью |
RU2232774C1 (ru) * | 2002-12-04 | 2004-07-20 | Курский государственный медицинский университет | Способ получения водорастворимых полисахаридов |
US20060084629A1 (en) * | 2004-10-15 | 2006-04-20 | Alvin Needleman | Immune system activating formula composed of selected long chain polysaccharides from natural sources |
US8378064B2 (en) * | 2006-05-19 | 2013-02-19 | Trustees Of Boston University | Hydrophilic polymers as medical lubricants and gels |
WO2008129457A1 (en) * | 2007-04-18 | 2008-10-30 | Firmenich Sa | Process for preparing sweet juice extract |
CN115010823B (zh) * | 2022-06-16 | 2023-03-24 | 佳木斯大学 | 一种调节肠道菌群的车前子多糖及其制备方法与应用 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE876305C (de) * | 1951-11-13 | 1953-05-11 | Ver Flussspatgruben G M B H | Verfahren zur Gewinnung therapeutisch wirksamer Pflanzenpraeparate |
US2871235A (en) * | 1952-08-29 | 1959-01-27 | Jilovice Vladimir Jan Hlous De | Process for obtaining polysaccharide material from plants of the genus cecropia |
GB878430A (en) * | 1958-10-15 | 1961-09-27 | Ciba Ltd | New polysaccharide material from sassafras plants and process for obtaining it |
US3227616A (en) * | 1961-07-03 | 1966-01-04 | Warner Lambert Pharmaceutical | Emulsions of cactus plant extract |
FR2426M (fr) * | 1962-06-15 | 1964-03-31 | Andre Beaune | Médicament pour le traitement externe des prurits, des dermatoses, des réactions allergiques cutanées et des syndromes inflammatoires en général. |
US3374222A (en) * | 1965-07-06 | 1968-03-19 | Weyerhaeuser Co | Separating levoglucosan and carbohydrate derived acids from aqueous mixtures containing the same by treatment with metal compounds |
US4119435A (en) * | 1976-07-30 | 1978-10-10 | Takeda Chemical Industries, Ltd. | Process of preparing soybean polysaccharides |
ZA786132B (en) * | 1977-11-23 | 1979-12-27 | Roussel Uclaf | New gastric reflux suppressant pharmaceutical compositions |
JPS5943929B2 (ja) * | 1979-08-13 | 1984-10-25 | サッポロビール株式会社 | 多糖体rbs物質,その製法およびそれを有効成分とする抗腫瘍性剤 |
-
1982
- 1982-03-04 HU HU82660A patent/HU188311B/hu not_active IP Right Cessation
-
1983
- 1983-02-28 FI FI830650A patent/FI72735C/fi not_active IP Right Cessation
- 1983-02-28 DK DK104983A patent/DK104983A/da not_active Application Discontinuation
- 1983-03-01 PT PT76314A patent/PT76314B/pt unknown
- 1983-03-03 CS CS831515A patent/CS258450B2/cs unknown
- 1983-03-03 RO RO83110208A patent/RO90536A/ro unknown
- 1983-03-03 NO NO830736A patent/NO158101C/no unknown
- 1983-03-03 PL PL1983240853A patent/PL143397B1/pl unknown
- 1983-03-03 DD DD83248465A patent/DD247567A7/de not_active IP Right Cessation
- 1983-03-04 GR GR70693A patent/GR78464B/el unknown
- 1983-03-04 US US06/472,060 patent/US4511559A/en not_active Expired - Fee Related
- 1983-03-04 DE DE8383102130T patent/DE3377134D1/de not_active Expired
- 1983-03-04 ES ES520334A patent/ES520334A0/es active Granted
- 1983-03-04 EP EP83102130A patent/EP0089529B1/de not_active Expired
- 1983-03-04 JP JP58034690A patent/JPS58201719A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
PT76314A (en) | 1983-04-01 |
US4511559A (en) | 1985-04-16 |
DK104983D0 (da) | 1983-02-28 |
NO158101B (no) | 1988-04-05 |
FI830650A0 (fi) | 1983-02-28 |
NO158101C (no) | 1988-07-13 |
FI72735C (fi) | 1987-07-10 |
RO90536A (ro) | 1986-10-30 |
ES8403930A1 (es) | 1984-04-16 |
FI830650L (fi) | 1983-09-05 |
HU188311B (en) | 1986-04-28 |
NO830736L (no) | 1983-09-05 |
DK104983A (da) | 1983-09-05 |
EP0089529A3 (en) | 1984-10-17 |
ES520334A0 (es) | 1984-04-16 |
EP0089529B1 (de) | 1988-06-22 |
EP0089529A2 (de) | 1983-09-28 |
PL240853A1 (en) | 1986-02-11 |
CS258450B2 (en) | 1988-08-16 |
GR78464B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1984-09-27 |
FI72735B (fi) | 1987-03-31 |
DE3377134D1 (en) | 1988-07-28 |
PL143397B1 (en) | 1988-02-29 |
DD247567A7 (de) | 1987-07-15 |
PT76314B (en) | 1985-11-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JPS58201719A (ja) | 生物学的に活性な多糖類コンセントレ−ト及びその物質を含む組成物の製造方法 | |
US4948785A (en) | Plant polysaccharide fractions inducing prolactin in mammals | |
TW546143B (en) | Comprising vitamin p and a processed product of Pfaffia extract | |
CZ70896A3 (en) | Pharmaceutical preparation and the use of galacturonides for preparing thereof | |
JP2022529085A (ja) | 葛根多糖およびその製作方法並び用途 | |
CN110051801A (zh) | 一种咀嚼片及其制备方法与应用 | |
JPH0539305A (ja) | アストラガルス・メンブラナセウスから抽出した免疫 変調性多糖類及びこれらを含有する薬剤組成物 | |
JPH03285653A (ja) | 脂質代謝改善物及びその製造法 | |
JPH06247861A (ja) | 抗潰瘍剤およびその製造法 | |
JP3966727B2 (ja) | 高齢キキョウ抽出物から製造される薬剤 | |
CN108969580B (zh) | 蓝布正总鞣质的制备方法及应用 | |
WO2007030974A1 (fr) | Utilisation d'heteropolysaccharide de tremella fuciformis ou d'extrait correspondant | |
JPH0245501A (ja) | 竹節ニンジン多糖およびその用途 | |
JP5845526B2 (ja) | 黒生姜を含有する水溶性組成物 | |
CN116874627B (zh) | 对叶百部多糖及其制备方法和应用 | |
CN112168878B (zh) | 一种黄花倒水莲降脂组合物及其制备方法 | |
IL34178A (en) | Extracts from plants of the genus hypoxis and medicinal preparations containing them | |
KR940001730B1 (ko) | 괄루근으로부터 생체활성다당의 제조방법 | |
JPH04273824A (ja) | 酸分泌抑制物質の単離方法 | |
TWI222357B (en) | Anti-ulcer pharmaceutical composition and the preparation and use thereof | |
JPS62428A (ja) | 肥満抑制剤 | |
CN119837963A (zh) | 南瓜提取物组合物、制备方法及其在口服液中的应用 | |
JPS5936888B2 (ja) | 青汁中の血圧降下成分の採取方法及び剤 | |
CN103566053B (zh) | 一种药物组合物及其在制备治疗结核病药物中的应用 | |
CN117838719A (zh) | 一种预防或治疗酒精性胃黏膜损伤的组合物及其制备方法 |