JPS5782390A - Carbostyril derivative - Google Patents
Carbostyril derivativeInfo
- Publication number
- JPS5782390A JPS5782390A JP55159016A JP15901680A JPS5782390A JP S5782390 A JPS5782390 A JP S5782390A JP 55159016 A JP55159016 A JP 55159016A JP 15901680 A JP15901680 A JP 15901680A JP S5782390 A JPS5782390 A JP S5782390A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- halogen
- methyl
- lower alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical class C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 title abstract 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 230000001965 increasing effect Effects 0.000 abstract 2
- FIPPIBNNPHZUIA-UHFFFAOYSA-N 1-methyl-6-(3-methylimidazo[1,2-a]pyridin-2-yl)-3,4-dihydroquinolin-2-one;hydrobromide Chemical compound Br.N1=C2C=CC=CN2C(C)=C1C1=CC=C2N(C)C(=O)CCC2=C1 FIPPIBNNPHZUIA-UHFFFAOYSA-N 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 150000007514 bases Chemical class 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 230000022900 cardiac muscle contraction Effects 0.000 abstract 1
- 239000000496 cardiotonic agent Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 230000009090 positive inotropic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/24—Oxygen atoms attached in position 8
- C07D215/26—Alcohols; Ethers thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/24—Oxygen atoms attached in position 8
- C07D215/26—Alcohols; Ethers thereof
- C07D215/28—Alcohols; Ethers thereof with halogen atoms or nitro radicals in positions 5, 6 or 7
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/24—Oxygen atoms attached in position 8
- C07D215/26—Alcohols; Ethers thereof
- C07D215/32—Esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Priority Applications (22)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP55159016A JPS5782390A (en) | 1980-11-11 | 1980-11-11 | Carbostyril derivative |
| CA000389034A CA1164459A (en) | 1980-11-11 | 1981-10-29 | Process for preparing (imidazo¬1,2-a|pyridine- 2-yl)-carbostyril or -3,4-dihydrocarbostyryl derivatives |
| PT73959A PT73959B (en) | 1980-11-11 | 1981-11-10 | Process for preparing carbostyril compounds and pharmaceutical compositions containing the same |
| PH26478A PH17158A (en) | 1980-11-11 | 1981-11-10 | Imidazo(1,2-a)pyridin-2-yl carbostyril derivatives and compositions containing same |
| ZA817773A ZA817773B (en) | 1980-11-11 | 1981-11-10 | Carbostyril compounds,compositions containing same and processes for preparing same |
| PCT/JP1981/000328 WO1982001706A1 (en) | 1980-11-11 | 1981-11-11 | Carbostyril compounds,composition containing same,and process for their preparation |
| US06/403,582 US4414390A (en) | 1980-11-11 | 1981-11-11 | Carbostyril compounds and compositions containing same |
| DE813152512T DE3152512T1 (de) | 1980-11-11 | 1981-11-11 | Carbostyril compounds,composition containing same,and process for their preparation |
| CH4324/82A CH653684A5 (fr) | 1980-11-11 | 1981-11-11 | Derives de carbostyrile, procede pour leur preparation et compositions les contenant. |
| MX819760U MX6802E (es) | 1980-11-11 | 1981-11-11 | Procedimiento para la preparacion de derivados carboestirilicos |
| EP81305344A EP0052016B1 (en) | 1980-11-11 | 1981-11-11 | Carbostyril compounds, compositions containing same and processes for preparing same |
| ES507545A ES8301967A1 (es) | 1980-11-11 | 1981-11-11 | Procedimiento de preparar compuestos carbostirilicos. |
| NL8120433A NL192040C (nl) | 1980-11-11 | 1981-11-11 | Carbostyrilverbindingen en preparaat dat een dergelijke verbinding bevat. |
| AT0908381A AT382376B (de) | 1980-11-11 | 1981-11-11 | Verfahren zur herstellung von neuen carbostyrilverbindungen und deren pharmazeutisch annehmbaren salzen |
| IT8149680A IT8149680A0 (it) | 1980-11-11 | 1981-11-11 | Composti carbostirilici composizioni che li contengono e procedimenti per prepararli |
| AU78085/81A AU547586B2 (en) | 1980-11-11 | 1981-11-11 | Carbostyril compounds,composition containing same,and processfor their preparation |
| KR1019810004359A KR880001657B1 (ko) | 1980-11-11 | 1981-11-11 | 카보스티릴 화합물의 제조방법 |
| SE8204237A SE440653B (sv) | 1980-11-11 | 1982-07-08 | Karbostyrilforeningar |
| DK307482A DK157193C (da) | 1980-11-11 | 1982-07-08 | Analogifremgangsmaade til fremstilling af carbostyrilforbindelser |
| NO82822391A NO157819C (no) | 1980-11-11 | 1982-07-09 | Analogifremgangsmaate for fremstilling av terapeutisk aktive imidazo (1,2-a)-pyridin-2-yl-karbostyrilforbindelser. |
| SU823466402A SU1215621A3 (ru) | 1980-11-11 | 1982-07-11 | Способ получени карбостирильных производных или их фармацевтически приемлемых солей |
| FI822471A FI71145C (fi) | 1980-11-11 | 1982-07-12 | Foerfarande foer framstaellning av imidazo/1,2-a/-pyridin-2-yl-karbostyrilderivat vilka aer anvaendbara som hjaertmedicin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP55159016A JPS5782390A (en) | 1980-11-11 | 1980-11-11 | Carbostyril derivative |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5782390A true JPS5782390A (en) | 1982-05-22 |
| JPS6411026B2 JPS6411026B2 (enrdf_load_stackoverflow) | 1989-02-23 |
Family
ID=15684401
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP55159016A Granted JPS5782390A (en) | 1980-11-11 | 1980-11-11 | Carbostyril derivative |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JPS5782390A (enrdf_load_stackoverflow) |
| NL (1) | NL192040C (enrdf_load_stackoverflow) |
| ZA (1) | ZA817773B (enrdf_load_stackoverflow) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59186983A (ja) * | 1983-02-25 | 1984-10-23 | Fujisawa Pharmaceut Co Ltd | イミダゾ複素環化合物 |
| JPS63280078A (ja) * | 1987-04-21 | 1988-11-17 | ファイザー・リミテッド | ヘテロニ環式キノロン誘導体 |
-
1980
- 1980-11-11 JP JP55159016A patent/JPS5782390A/ja active Granted
-
1981
- 1981-11-10 ZA ZA817773A patent/ZA817773B/xx unknown
- 1981-11-11 NL NL8120433A patent/NL192040C/nl not_active IP Right Cessation
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59186983A (ja) * | 1983-02-25 | 1984-10-23 | Fujisawa Pharmaceut Co Ltd | イミダゾ複素環化合物 |
| JPS63280078A (ja) * | 1987-04-21 | 1988-11-17 | ファイザー・リミテッド | ヘテロニ環式キノロン誘導体 |
Also Published As
| Publication number | Publication date |
|---|---|
| NL192040C (nl) | 1997-01-07 |
| NL8120433A (nl) | 1982-10-01 |
| ZA817773B (en) | 1982-10-27 |
| NL192040B (nl) | 1996-09-02 |
| JPS6411026B2 (enrdf_load_stackoverflow) | 1989-02-23 |
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