JPS57118578A - Preparation of (r)-(-)-5-trityloxymethyltetrahydrofuran- 2-one - Google Patents
Preparation of (r)-(-)-5-trityloxymethyltetrahydrofuran- 2-oneInfo
- Publication number
- JPS57118578A JPS57118578A JP348381A JP348381A JPS57118578A JP S57118578 A JPS57118578 A JP S57118578A JP 348381 A JP348381 A JP 348381A JP 348381 A JP348381 A JP 348381A JP S57118578 A JPS57118578 A JP S57118578A
- Authority
- JP
- Japan
- Prior art keywords
- substance
- hydroxymethyltetrahydrofuran
- hydrolyzed
- give
- triphenylphosphine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Furan Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
PURPOSE: To obtain the titled substance, by tritylating (S)-(+)-5-hydroxymethyltetrahydrofuran-2-one, hydrolyzing the tritylation product, and reacting the hydrolyzed substance with triphenylphosphine and a dialkyl azodicarboxylate.
CONSTITUTION: (S)-(+)-5-Hydroxymethyltetrahydrofuran-2-one of formulaIderived from natural (S)(+) glutamic acid is tritylated with triphenylmethyl chloride, and the resultant compound is then hydrolyzed in the presence of an alkali, e.g. KOH, to give an oxy acid derivative of formula 3, which is then reacted with and cyclized triphenylphosphine and a dialkyl azodicarboxylate to afford the titled substance. The resultant substance is then hydrolyzed to give (R)-(-)-5- hydroxymethyltetrahydrofuran-2-one of formula 5. The purifying operation is preferably carried out in the respective steps to give a high yield.
EFFECT: A precursor for antitumor agents.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP348381A JPS57118578A (en) | 1981-01-13 | 1981-01-13 | Preparation of (r)-(-)-5-trityloxymethyltetrahydrofuran- 2-one |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP348381A JPS57118578A (en) | 1981-01-13 | 1981-01-13 | Preparation of (r)-(-)-5-trityloxymethyltetrahydrofuran- 2-one |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57118578A true JPS57118578A (en) | 1982-07-23 |
JPH0149709B2 JPH0149709B2 (en) | 1989-10-25 |
Family
ID=11558577
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP348381A Granted JPS57118578A (en) | 1981-01-13 | 1981-01-13 | Preparation of (r)-(-)-5-trityloxymethyltetrahydrofuran- 2-one |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57118578A (en) |
-
1981
- 1981-01-13 JP JP348381A patent/JPS57118578A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPH0149709B2 (en) | 1989-10-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE3260194D1 (en) | 2,3-dialkoxypropyl glyceryl ether and its preparation process as well as cosmetic composition containing same | |
JPS57118578A (en) | Preparation of (r)-(-)-5-trityloxymethyltetrahydrofuran- 2-one | |
JPS5524116A (en) | Preparation of o-(2, 6-dichloroanilino)-phenylacetic acid | |
JPS5668649A (en) | Preparation of gamma-amino-beta-hydroxybutyric acid | |
JPS57128699A (en) | 5-fluorouracil derivative and its medical composition | |
JPS5711981A (en) | Theobromine derivative and its preparation | |
JPS6445392A (en) | Production of estradiol derivative | |
JPS554346A (en) | Preparation of cephapirin sodium | |
JPS53119820A (en) | Preparation of alkali aminodiacetate | |
JPS5711938A (en) | Preparation of 1,1-dialkoxy-3-alkynes | |
JPS57209265A (en) | Preparation of di-lower alkyl ester of naphthalenedisulfonic acid | |
JPS55164674A (en) | Preparation of 4- 3-isopropylamino-2-hydroxy-propoxy indole | |
JPS565458A (en) | Preparation of 1-ethyl-2- 2-methoxy-5- sulfamoylbenzamidemethyl pyrrolidine | |
JPS57146790A (en) | Novel synthesis of organopolysilane | |
JPS56108749A (en) | Preparation of pantothenic ester and pantethine | |
JPS5564596A (en) | Preparation of alkylmethyl-3-dialkoxy-propylphosphinate | |
JPS5543004A (en) | Preparation of alpha-thio-gammadelta-unsaturated carbonyl compound | |
JPS5599073A (en) | Production of artificial antigen containing melatonin residue | |
JPS5626850A (en) | Preparation of 2-aminoacetal | |
JPS5718695A (en) | Preparation of 5-hydroxymethyl-1-beta-d- arabinofuranosyluracil | |
JPS5620556A (en) | Production of alpha-halogeno-beta-alanine | |
JPS56169681A (en) | Preparation of marmelo lactone | |
JPS6419087A (en) | Production of 1,3,4-tri-o-acyl-2-deoxy-beta-d-erythro-pentapyranose | |
JPS5764661A (en) | Preparation of mercaptoamines | |
JPS5576863A (en) | Preparation of 2-chloronicotinic acid |