JPS5718695A - Preparation of 5-hydroxymethyl-1-beta-d- arabinofuranosyluracil - Google Patents
Preparation of 5-hydroxymethyl-1-beta-d- arabinofuranosyluracilInfo
- Publication number
- JPS5718695A JPS5718695A JP9178780A JP9178780A JPS5718695A JP S5718695 A JPS5718695 A JP S5718695A JP 9178780 A JP9178780 A JP 9178780A JP 9178780 A JP9178780 A JP 9178780A JP S5718695 A JPS5718695 A JP S5718695A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound shown
- give
- titled compound
- products
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- Saccharide Compounds (AREA)
Abstract
PURPOSE: To obtain the titled compound useful as an important intermediate for synthesizing an antiviral agent by one process with small amount of by-products in high yield, by hydrolyzing a novel 5-alkoxymethyl-2,2'-cyclouridine as an intermediate.
CONSTITUTION: A novel compound shown by the formula I (R is lower alkyl) is hydrolyzed, to give the titled compound shown by the formula II. The hydrolysis is carried out in an aqueous solution of H2SO4, HCl, etc. at room temperature to about 100°C under refulx. The compound shown by the formula I is obtained by reacting a compound shown by the formula III with a lower alcohol shown by the formula ROH to give a compound shown by the formula IV, which is reacted with a 2,2'-cyclizing agent for pyrimidine nucleoside (e.g., diphenyl carbonate, etc.). The titled compound is obtained only by three processes from the raw material compound shown by the formula III. Having industrially advantageous characteristics, e.g., simple process, small amount of by-products, simple purification and isolation.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9178780A JPS5718695A (en) | 1980-07-07 | 1980-07-07 | Preparation of 5-hydroxymethyl-1-beta-d- arabinofuranosyluracil |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9178780A JPS5718695A (en) | 1980-07-07 | 1980-07-07 | Preparation of 5-hydroxymethyl-1-beta-d- arabinofuranosyluracil |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5718695A true JPS5718695A (en) | 1982-01-30 |
Family
ID=14036307
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP9178780A Pending JPS5718695A (en) | 1980-07-07 | 1980-07-07 | Preparation of 5-hydroxymethyl-1-beta-d- arabinofuranosyluracil |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5718695A (en) |
-
1980
- 1980-07-07 JP JP9178780A patent/JPS5718695A/en active Pending
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