JPS5718695A - Preparation of 5-hydroxymethyl-1-beta-d- arabinofuranosyluracil - Google Patents

Preparation of 5-hydroxymethyl-1-beta-d- arabinofuranosyluracil

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Publication number
JPS5718695A
JPS5718695A JP9178780A JP9178780A JPS5718695A JP S5718695 A JPS5718695 A JP S5718695A JP 9178780 A JP9178780 A JP 9178780A JP 9178780 A JP9178780 A JP 9178780A JP S5718695 A JPS5718695 A JP S5718695A
Authority
JP
Japan
Prior art keywords
formula
compound shown
give
titled compound
products
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP9178780A
Other languages
Japanese (ja)
Inventor
Shinji Sakata
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamasa Shoyu KK
Original Assignee
Yamasa Shoyu KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamasa Shoyu KK filed Critical Yamasa Shoyu KK
Priority to JP9178780A priority Critical patent/JPS5718695A/en
Publication of JPS5718695A publication Critical patent/JPS5718695A/en
Pending legal-status Critical Current

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Abstract

PURPOSE: To obtain the titled compound useful as an important intermediate for synthesizing an antiviral agent by one process with small amount of by-products in high yield, by hydrolyzing a novel 5-alkoxymethyl-2,2'-cyclouridine as an intermediate.
CONSTITUTION: A novel compound shown by the formula I (R is lower alkyl) is hydrolyzed, to give the titled compound shown by the formula II. The hydrolysis is carried out in an aqueous solution of H2SO4, HCl, etc. at room temperature to about 100°C under refulx. The compound shown by the formula I is obtained by reacting a compound shown by the formula III with a lower alcohol shown by the formula ROH to give a compound shown by the formula IV, which is reacted with a 2,2'-cyclizing agent for pyrimidine nucleoside (e.g., diphenyl carbonate, etc.). The titled compound is obtained only by three processes from the raw material compound shown by the formula III. Having industrially advantageous characteristics, e.g., simple process, small amount of by-products, simple purification and isolation.
COPYRIGHT: (C)1982,JPO&Japio
JP9178780A 1980-07-07 1980-07-07 Preparation of 5-hydroxymethyl-1-beta-d- arabinofuranosyluracil Pending JPS5718695A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP9178780A JPS5718695A (en) 1980-07-07 1980-07-07 Preparation of 5-hydroxymethyl-1-beta-d- arabinofuranosyluracil

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9178780A JPS5718695A (en) 1980-07-07 1980-07-07 Preparation of 5-hydroxymethyl-1-beta-d- arabinofuranosyluracil

Publications (1)

Publication Number Publication Date
JPS5718695A true JPS5718695A (en) 1982-01-30

Family

ID=14036307

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9178780A Pending JPS5718695A (en) 1980-07-07 1980-07-07 Preparation of 5-hydroxymethyl-1-beta-d- arabinofuranosyluracil

Country Status (1)

Country Link
JP (1) JPS5718695A (en)

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