JPS5599073A - Production of artificial antigen containing melatonin residue - Google Patents

Production of artificial antigen containing melatonin residue

Info

Publication number
JPS5599073A
JPS5599073A JP610479A JP610479A JPS5599073A JP S5599073 A JPS5599073 A JP S5599073A JP 610479 A JP610479 A JP 610479A JP 610479 A JP610479 A JP 610479A JP S5599073 A JPS5599073 A JP S5599073A
Authority
JP
Japan
Prior art keywords
melatonin
artificial antigen
peptide
residue
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP610479A
Other languages
Japanese (ja)
Other versions
JPS622269B2 (en
Inventor
Koichiro Kawashima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Petrochemical Co Ltd
Original Assignee
Mitsubishi Petrochemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Petrochemical Co Ltd filed Critical Mitsubishi Petrochemical Co Ltd
Priority to JP610479A priority Critical patent/JPS5599073A/en
Publication of JPS5599073A publication Critical patent/JPS5599073A/en
Publication of JPS622269B2 publication Critical patent/JPS622269B2/ja
Granted legal-status Critical Current

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Abstract

PURPOSE: To produce an artificial antigen by reacting a peptide containing a free amino group with a derivative obtained by the reaction of melatonin with a halogenated alkanoic acid ester or the like and to produce an antibody of higher antibody titer using the same.
CONSTITUTION: A peptide, such as ox serum albumin, containing a free amino group is reacted with a compound having a milatonin residue as shown by the formula (where M represents H or alkali metal and n is 2W10) in a phosphate buffer solution at about pH4W7. The reaction is conducted for several hours to several days near room temperature. Then, placed into a dialysis tube, the solution thus produced undergoes dialysis in a large excess of distilled water for one to ten days. The refined aqueous solution of melatonin-peptide combination is freezedried to yield an artificial antigen. The compound of the formula is prepared by hydrolysing a reaction product between melatonin and an ester or an acid chloride of a halogenated alkanoic acid, such as bromobutyric acid.
COPYRIGHT: (C)1980,JPO&Japio
JP610479A 1979-01-24 1979-01-24 Production of artificial antigen containing melatonin residue Granted JPS5599073A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP610479A JPS5599073A (en) 1979-01-24 1979-01-24 Production of artificial antigen containing melatonin residue

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP610479A JPS5599073A (en) 1979-01-24 1979-01-24 Production of artificial antigen containing melatonin residue

Publications (2)

Publication Number Publication Date
JPS5599073A true JPS5599073A (en) 1980-07-28
JPS622269B2 JPS622269B2 (en) 1987-01-19

Family

ID=11629186

Family Applications (1)

Application Number Title Priority Date Filing Date
JP610479A Granted JPS5599073A (en) 1979-01-24 1979-01-24 Production of artificial antigen containing melatonin residue

Country Status (1)

Country Link
JP (1) JPS5599073A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103601662A (en) * 2013-11-21 2014-02-26 深圳市药品检验所 Melatonin hapten and melatonin complete antigen as well as preparation methods and applications thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103601662A (en) * 2013-11-21 2014-02-26 深圳市药品检验所 Melatonin hapten and melatonin complete antigen as well as preparation methods and applications thereof

Also Published As

Publication number Publication date
JPS622269B2 (en) 1987-01-19

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