JPS5599073A - Production of artificial antigen containing melatonin residue - Google Patents
Production of artificial antigen containing melatonin residueInfo
- Publication number
- JPS5599073A JPS5599073A JP610479A JP610479A JPS5599073A JP S5599073 A JPS5599073 A JP S5599073A JP 610479 A JP610479 A JP 610479A JP 610479 A JP610479 A JP 610479A JP S5599073 A JPS5599073 A JP S5599073A
- Authority
- JP
- Japan
- Prior art keywords
- melatonin
- artificial antigen
- peptide
- residue
- reaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Indole Compounds (AREA)
Abstract
PURPOSE: To produce an artificial antigen by reacting a peptide containing a free amino group with a derivative obtained by the reaction of melatonin with a halogenated alkanoic acid ester or the like and to produce an antibody of higher antibody titer using the same.
CONSTITUTION: A peptide, such as ox serum albumin, containing a free amino group is reacted with a compound having a milatonin residue as shown by the formula (where M represents H or alkali metal and n is 2W10) in a phosphate buffer solution at about pH4W7. The reaction is conducted for several hours to several days near room temperature. Then, placed into a dialysis tube, the solution thus produced undergoes dialysis in a large excess of distilled water for one to ten days. The refined aqueous solution of melatonin-peptide combination is freezedried to yield an artificial antigen. The compound of the formula is prepared by hydrolysing a reaction product between melatonin and an ester or an acid chloride of a halogenated alkanoic acid, such as bromobutyric acid.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP610479A JPS5599073A (en) | 1979-01-24 | 1979-01-24 | Production of artificial antigen containing melatonin residue |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP610479A JPS5599073A (en) | 1979-01-24 | 1979-01-24 | Production of artificial antigen containing melatonin residue |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5599073A true JPS5599073A (en) | 1980-07-28 |
JPS622269B2 JPS622269B2 (en) | 1987-01-19 |
Family
ID=11629186
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP610479A Granted JPS5599073A (en) | 1979-01-24 | 1979-01-24 | Production of artificial antigen containing melatonin residue |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5599073A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103601662A (en) * | 2013-11-21 | 2014-02-26 | 深圳市药品检验所 | Melatonin hapten and melatonin complete antigen as well as preparation methods and applications thereof |
-
1979
- 1979-01-24 JP JP610479A patent/JPS5599073A/en active Granted
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103601662A (en) * | 2013-11-21 | 2014-02-26 | 深圳市药品检验所 | Melatonin hapten and melatonin complete antigen as well as preparation methods and applications thereof |
Also Published As
Publication number | Publication date |
---|---|
JPS622269B2 (en) | 1987-01-19 |
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