JPS5668649A - Preparation of gamma-amino-beta-hydroxybutyric acid - Google Patents

Preparation of gamma-amino-beta-hydroxybutyric acid

Info

Publication number
JPS5668649A
JPS5668649A JP14410379A JP14410379A JPS5668649A JP S5668649 A JPS5668649 A JP S5668649A JP 14410379 A JP14410379 A JP 14410379A JP 14410379 A JP14410379 A JP 14410379A JP S5668649 A JPS5668649 A JP S5668649A
Authority
JP
Japan
Prior art keywords
hydroxybutyric acid
amino
ammonia
aqueous solution
chloro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP14410379A
Other languages
Japanese (ja)
Other versions
JPS5945670B2 (en
Inventor
Iwao Kobayashi
Kyoji Aoki
Mitsukuni Ayabe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Denka Co Ltd
Original Assignee
Denki Kagaku Kogyo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Denki Kagaku Kogyo KK filed Critical Denki Kagaku Kogyo KK
Priority to JP14410379A priority Critical patent/JPS5945670B2/en
Publication of JPS5668649A publication Critical patent/JPS5668649A/en
Publication of JPS5945670B2 publication Critical patent/JPS5945670B2/en
Expired legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To prepare the titled compound useful as an antiepileptic agent, easily, in high yield and purity, by reacting a γ-chloro-β-hydroxybutyric acid ester with ammonia, and hydrolyzing the product with an aqueous solution of the hydroxide of alkali metal, etc.
CONSTITUTION: γ-Amino-β-hydroxybutyric acid amide is prepared by reacting a γ-chloro-β-hydroxybutyric acid ester with aqueous ammonia at 0W100°C. The amount of ammonia is 5W100mol/mol of the ester, and the concentration of the aqueous ammonia is pref. 10W40wt%. The acid amide thus produced is hydrolyzed with an aqueous solution of an alkali metal or alkaline earth metal hyroxide at 20W 100°C to obtain the objective γ-amino-β-hydroxybutyric acid. The concentration of the aqueous solution of the hydroxide is 2W50wt%.
EFFECT: The process can be carried out without using highly toxic sodium cyanide nor producing by-products.
COPYRIGHT: (C)1981,JPO&Japio
JP14410379A 1979-11-07 1979-11-07 Production method of γ-amino-β-hydroxybutyric acid Expired JPS5945670B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP14410379A JPS5945670B2 (en) 1979-11-07 1979-11-07 Production method of γ-amino-β-hydroxybutyric acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14410379A JPS5945670B2 (en) 1979-11-07 1979-11-07 Production method of γ-amino-β-hydroxybutyric acid

Publications (2)

Publication Number Publication Date
JPS5668649A true JPS5668649A (en) 1981-06-09
JPS5945670B2 JPS5945670B2 (en) 1984-11-07

Family

ID=15354250

Family Applications (1)

Application Number Title Priority Date Filing Date
JP14410379A Expired JPS5945670B2 (en) 1979-11-07 1979-11-07 Production method of γ-amino-β-hydroxybutyric acid

Country Status (1)

Country Link
JP (1) JPS5945670B2 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57183965A (en) * 1981-05-07 1982-11-12 Mitsubishi Gas Chemical Co Package of deoxidizer
JPS59118093A (en) * 1982-12-06 1984-07-07 シグマ−タウ・インズストリエ・フアルマチエウチケ・リウニテ・エツセ・ピ・ア Production of l-carnitine and chemical intermediate used therein
US4600794A (en) * 1984-07-27 1986-07-15 Sigma Tau Industrie Farmaceutiche Riunite S.P.A. Process for preparing gamma-dimethylamino L-beta hydroxy butyric acid
JPH01287065A (en) * 1988-05-13 1989-11-17 Kanegafuchi Chem Ind Co Ltd Production of carnitine
JP2007246161A (en) * 2006-03-20 2007-09-27 Mitani Valve Co Ltd Container with top cap

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03185588A (en) * 1989-12-15 1991-08-13 Oki Electric Ind Co Ltd Method for issuing ticket in ticket issuing machine

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57183965A (en) * 1981-05-07 1982-11-12 Mitsubishi Gas Chemical Co Package of deoxidizer
JPS6254705B2 (en) * 1981-05-07 1987-11-16 Mitsubishi Gas Chemical Co
JPS59118093A (en) * 1982-12-06 1984-07-07 シグマ−タウ・インズストリエ・フアルマチエウチケ・リウニテ・エツセ・ピ・ア Production of l-carnitine and chemical intermediate used therein
US4600794A (en) * 1984-07-27 1986-07-15 Sigma Tau Industrie Farmaceutiche Riunite S.P.A. Process for preparing gamma-dimethylamino L-beta hydroxy butyric acid
JPH01287065A (en) * 1988-05-13 1989-11-17 Kanegafuchi Chem Ind Co Ltd Production of carnitine
JP2007246161A (en) * 2006-03-20 2007-09-27 Mitani Valve Co Ltd Container with top cap

Also Published As

Publication number Publication date
JPS5945670B2 (en) 1984-11-07

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