JPS5668649A - Preparation of gamma-amino-beta-hydroxybutyric acid - Google Patents
Preparation of gamma-amino-beta-hydroxybutyric acidInfo
- Publication number
- JPS5668649A JPS5668649A JP14410379A JP14410379A JPS5668649A JP S5668649 A JPS5668649 A JP S5668649A JP 14410379 A JP14410379 A JP 14410379A JP 14410379 A JP14410379 A JP 14410379A JP S5668649 A JPS5668649 A JP S5668649A
- Authority
- JP
- Japan
- Prior art keywords
- hydroxybutyric acid
- amino
- ammonia
- aqueous solution
- chloro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To prepare the titled compound useful as an antiepileptic agent, easily, in high yield and purity, by reacting a γ-chloro-β-hydroxybutyric acid ester with ammonia, and hydrolyzing the product with an aqueous solution of the hydroxide of alkali metal, etc.
CONSTITUTION: γ-Amino-β-hydroxybutyric acid amide is prepared by reacting a γ-chloro-β-hydroxybutyric acid ester with aqueous ammonia at 0W100°C. The amount of ammonia is 5W100mol/mol of the ester, and the concentration of the aqueous ammonia is pref. 10W40wt%. The acid amide thus produced is hydrolyzed with an aqueous solution of an alkali metal or alkaline earth metal hyroxide at 20W 100°C to obtain the objective γ-amino-β-hydroxybutyric acid. The concentration of the aqueous solution of the hydroxide is 2W50wt%.
EFFECT: The process can be carried out without using highly toxic sodium cyanide nor producing by-products.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14410379A JPS5945670B2 (en) | 1979-11-07 | 1979-11-07 | Production method of γ-amino-β-hydroxybutyric acid |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14410379A JPS5945670B2 (en) | 1979-11-07 | 1979-11-07 | Production method of γ-amino-β-hydroxybutyric acid |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5668649A true JPS5668649A (en) | 1981-06-09 |
JPS5945670B2 JPS5945670B2 (en) | 1984-11-07 |
Family
ID=15354250
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP14410379A Expired JPS5945670B2 (en) | 1979-11-07 | 1979-11-07 | Production method of γ-amino-β-hydroxybutyric acid |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5945670B2 (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57183965A (en) * | 1981-05-07 | 1982-11-12 | Mitsubishi Gas Chemical Co | Package of deoxidizer |
JPS59118093A (en) * | 1982-12-06 | 1984-07-07 | シグマ−タウ・インズストリエ・フアルマチエウチケ・リウニテ・エツセ・ピ・ア | Production of l-carnitine and chemical intermediate used therein |
US4600794A (en) * | 1984-07-27 | 1986-07-15 | Sigma Tau Industrie Farmaceutiche Riunite S.P.A. | Process for preparing gamma-dimethylamino L-beta hydroxy butyric acid |
JPH01287065A (en) * | 1988-05-13 | 1989-11-17 | Kanegafuchi Chem Ind Co Ltd | Production of carnitine |
JP2007246161A (en) * | 2006-03-20 | 2007-09-27 | Mitani Valve Co Ltd | Container with top cap |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH03185588A (en) * | 1989-12-15 | 1991-08-13 | Oki Electric Ind Co Ltd | Method for issuing ticket in ticket issuing machine |
-
1979
- 1979-11-07 JP JP14410379A patent/JPS5945670B2/en not_active Expired
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57183965A (en) * | 1981-05-07 | 1982-11-12 | Mitsubishi Gas Chemical Co | Package of deoxidizer |
JPS6254705B2 (en) * | 1981-05-07 | 1987-11-16 | Mitsubishi Gas Chemical Co | |
JPS59118093A (en) * | 1982-12-06 | 1984-07-07 | シグマ−タウ・インズストリエ・フアルマチエウチケ・リウニテ・エツセ・ピ・ア | Production of l-carnitine and chemical intermediate used therein |
US4600794A (en) * | 1984-07-27 | 1986-07-15 | Sigma Tau Industrie Farmaceutiche Riunite S.P.A. | Process for preparing gamma-dimethylamino L-beta hydroxy butyric acid |
JPH01287065A (en) * | 1988-05-13 | 1989-11-17 | Kanegafuchi Chem Ind Co Ltd | Production of carnitine |
JP2007246161A (en) * | 2006-03-20 | 2007-09-27 | Mitani Valve Co Ltd | Container with top cap |
Also Published As
Publication number | Publication date |
---|---|
JPS5945670B2 (en) | 1984-11-07 |
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