JPS5728035A - Preparation of gamma-amino-beta-hydroxybutyric acid - Google Patents
Preparation of gamma-amino-beta-hydroxybutyric acidInfo
- Publication number
- JPS5728035A JPS5728035A JP10333180A JP10333180A JPS5728035A JP S5728035 A JPS5728035 A JP S5728035A JP 10333180 A JP10333180 A JP 10333180A JP 10333180 A JP10333180 A JP 10333180A JP S5728035 A JPS5728035 A JP S5728035A
- Authority
- JP
- Japan
- Prior art keywords
- hydroxybutyric acid
- amino
- catalyst
- acid ester
- pref
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To prepare the titled compound useful as an antiepileptic agent, in high yield, without using highly toxic and expensive hydrocyanic acid compound, by the hydrolysis of a γ-chloro-β-hydroxybutyric acid ester in the presence of a catalyst, followed by amination.
CONSTITUTION: γ-Cholo-β-hydroxybutyric acid ester is hydrolyzed in the presence of an acidic catalyst such as hydrochloric acid, sulfuric acid, etc., or a basic catalyst such as alkali metal, etc., at 0W80°C, and the resulted γ-chloro-β-hydroxybutyric acid or its salt is neutralized. The product is concentrated if necessary, and aminated with an aminating agent (e.g. ammonia, ammonium carbonate, etc.) to obtain the objective compound. The amount of the catalyst is 1W100mol%, pref. 2W 50mol%, based on the γ-amino-β-hydroxybutyric acid ester, and that of the aminating agent is 5W100mol, pref. 20W60mol per 1mol of the γ-amino-β-hydroxybutyric acid.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10333180A JPS5950661B2 (en) | 1980-07-28 | 1980-07-28 | Method for producing γ-amino-β-hydroxybutyric acid |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10333180A JPS5950661B2 (en) | 1980-07-28 | 1980-07-28 | Method for producing γ-amino-β-hydroxybutyric acid |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5728035A true JPS5728035A (en) | 1982-02-15 |
JPS5950661B2 JPS5950661B2 (en) | 1984-12-10 |
Family
ID=14351175
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP10333180A Expired JPS5950661B2 (en) | 1980-07-28 | 1980-07-28 | Method for producing γ-amino-β-hydroxybutyric acid |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5950661B2 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59118093A (en) * | 1982-12-06 | 1984-07-07 | シグマ−タウ・インズストリエ・フアルマチエウチケ・リウニテ・エツセ・ピ・ア | Production of l-carnitine and chemical intermediate used therein |
JPH0767674A (en) * | 1982-12-06 | 1995-03-14 | Sigma Tau Ind Farmaceut Riunite Spa | Optically active gamma - substituted beta - hydroxybutyric acid derivative |
-
1980
- 1980-07-28 JP JP10333180A patent/JPS5950661B2/en not_active Expired
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59118093A (en) * | 1982-12-06 | 1984-07-07 | シグマ−タウ・インズストリエ・フアルマチエウチケ・リウニテ・エツセ・ピ・ア | Production of l-carnitine and chemical intermediate used therein |
JPH0767674A (en) * | 1982-12-06 | 1995-03-14 | Sigma Tau Ind Farmaceut Riunite Spa | Optically active gamma - substituted beta - hydroxybutyric acid derivative |
Also Published As
Publication number | Publication date |
---|---|
JPS5950661B2 (en) | 1984-12-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PT92271A (en) | PROCESS FOR OBTAINING EFFERVESCENT PREPARATIONS OF IBUPPHENE | |
KR870005982A (en) | Method for preparing methionine alkali metal salt solution useful as feed additive | |
JPS5728035A (en) | Preparation of gamma-amino-beta-hydroxybutyric acid | |
KR970001305A (en) | Valine Purification Method | |
JPS5668649A (en) | Preparation of gamma-amino-beta-hydroxybutyric acid | |
JPS57158743A (en) | Preparation of alpha-amino acid amide | |
JPS5334716A (en) | Preparation of amide amine amphoteric surface active agent | |
ES8800659A1 (en) | Preparation of 3-amino-4-hydroxybenzoic acids. | |
JPS5459224A (en) | Preparation of ethylenediaminetetraacetates | |
JPS56120662A (en) | Novel nitrosourea derivative and its preparation | |
JPS55164669A (en) | Preparation of cysteine | |
JPS5618963A (en) | Preparation of alpha-halogeno-beta-phthalimide propionitrile | |
JPS56128770A (en) | N-amino-5-fluorouracil and its preparation | |
JPS5692254A (en) | Purification of unsaturated amide aqueous solution | |
JPS5772983A (en) | Preparation of 1,2,3,4,6,7,8,9-octahydrophenazine | |
JPS5616449A (en) | Preparation of p-phenylenediamine | |
JPS5534278A (en) | Material with swelling potential | |
TH12765A (en) | Production of detergent particles with High agility | |
JPS56150034A (en) | Preparation of 3,4,5-trimethoxybenzaldehyde | |
JPS53108983A (en) | Preparation of 5-fluorouracil | |
JPS5492985A (en) | Preparation of cephamycin derivative | |
JPS57197202A (en) | Agent for controlling white fly and thrips | |
JPS5432418A (en) | Preparation of n,n-disubstituted glycol amide | |
JPS55164664A (en) | Preparation of beta-chlorolactonitrile | |
JPS56128769A (en) | Amino-5-fluorouracil derivative and its preparation |