JPS57158743A - Preparation of alpha-amino acid amide - Google Patents
Preparation of alpha-amino acid amideInfo
- Publication number
- JPS57158743A JPS57158743A JP4454581A JP4454581A JPS57158743A JP S57158743 A JPS57158743 A JP S57158743A JP 4454581 A JP4454581 A JP 4454581A JP 4454581 A JP4454581 A JP 4454581A JP S57158743 A JPS57158743 A JP S57158743A
- Authority
- JP
- Japan
- Prior art keywords
- ketone
- amino acid
- acid amide
- reaction
- aminonitrile
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
PURPOSE: To obtain the titled compound useful as a synthetic intermeidate for various industrial chemicals, etc. in high yield in a short time, by hydrolyzing an α-aminonitrile in the presence of a very small amount of a strongly basic substance and a ketone in a high pH region.
CONSTITUTION: An α-aminonitrile is hydrolyzed in the presence of a strongly basic substatnce, e.g. NaOH, and a ketone, e.g. acetone, in an aqueous medium to give an α-amino acid amide. The amount of the base to be used is 0.01mol or less based on one mole αaminonitrile. The ketone is added to the reaction system to give a pH over 14 of the reaction solution, and the reaction is carried out while keeping the pH at 14 or above. The reaction temperature is preferably 40°C or below. The method is characterized by the hydrolytic rate of almost 100% and almost no occurrence of side reactions.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4454581A JPS5817741B2 (en) | 1981-03-26 | 1981-03-26 | Method for producing α-amino acid amide |
DE8282301062T DE3266977D1 (en) | 1981-03-26 | 1982-03-02 | Process for producing alpha-amino acids |
EP82301062A EP0067499B1 (en) | 1981-03-26 | 1982-03-02 | Process for producing alpha-amino acids |
US06/355,142 US4459423A (en) | 1981-03-26 | 1982-03-05 | Process for producing α-amino acids |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4454581A JPS5817741B2 (en) | 1981-03-26 | 1981-03-26 | Method for producing α-amino acid amide |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57158743A true JPS57158743A (en) | 1982-09-30 |
JPS5817741B2 JPS5817741B2 (en) | 1983-04-09 |
Family
ID=12694468
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP4454581A Expired JPS5817741B2 (en) | 1981-03-26 | 1981-03-26 | Method for producing α-amino acid amide |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5817741B2 (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4997985A (en) * | 1987-07-01 | 1991-03-05 | Ciba-Geigy Corporation | Alpha amino acid amide compounds which are useful intermediates in the preparation of herbicides |
JP2001163845A (en) * | 1999-12-13 | 2001-06-19 | Mitsubishi Rayon Co Ltd | Method of producing amino acid amide |
JP2002047260A (en) * | 2000-07-26 | 2002-02-12 | Mitsubishi Gas Chem Co Inc | METHOD FOR STABILIZING alpha-AMINO ACID AMIDE |
JP2004099506A (en) * | 2002-09-09 | 2004-04-02 | Mitsubishi Rayon Co Ltd | Method for producing amino acid amide |
CN102827028A (en) * | 2012-09-17 | 2012-12-19 | 浙江邦成化工有限公司 | Acylation process of cyanoacyl |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2785609B1 (en) * | 1998-11-06 | 2000-12-15 | Rhone Poulenc Nutrition Animal | PROCESS FOR THE PREPARATION OF METHIONINE |
-
1981
- 1981-03-26 JP JP4454581A patent/JPS5817741B2/en not_active Expired
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4997985A (en) * | 1987-07-01 | 1991-03-05 | Ciba-Geigy Corporation | Alpha amino acid amide compounds which are useful intermediates in the preparation of herbicides |
JP2001163845A (en) * | 1999-12-13 | 2001-06-19 | Mitsubishi Rayon Co Ltd | Method of producing amino acid amide |
JP2002047260A (en) * | 2000-07-26 | 2002-02-12 | Mitsubishi Gas Chem Co Inc | METHOD FOR STABILIZING alpha-AMINO ACID AMIDE |
JP2004099506A (en) * | 2002-09-09 | 2004-04-02 | Mitsubishi Rayon Co Ltd | Method for producing amino acid amide |
CN102827028A (en) * | 2012-09-17 | 2012-12-19 | 浙江邦成化工有限公司 | Acylation process of cyanoacyl |
Also Published As
Publication number | Publication date |
---|---|
JPS5817741B2 (en) | 1983-04-09 |
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