JPS57158743A - Preparation of alpha-amino acid amide - Google Patents

Preparation of alpha-amino acid amide

Info

Publication number
JPS57158743A
JPS57158743A JP4454581A JP4454581A JPS57158743A JP S57158743 A JPS57158743 A JP S57158743A JP 4454581 A JP4454581 A JP 4454581A JP 4454581 A JP4454581 A JP 4454581A JP S57158743 A JPS57158743 A JP S57158743A
Authority
JP
Japan
Prior art keywords
ketone
amino acid
acid amide
reaction
aminonitrile
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP4454581A
Other languages
Japanese (ja)
Other versions
JPS5817741B2 (en
Inventor
Masaharu Dotani
Takako Uchiyama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Gas Chemical Co Inc
Original Assignee
Mitsubishi Gas Chemical Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Gas Chemical Co Inc filed Critical Mitsubishi Gas Chemical Co Inc
Priority to JP4454581A priority Critical patent/JPS5817741B2/en
Priority to DE8282301062T priority patent/DE3266977D1/en
Priority to EP82301062A priority patent/EP0067499B1/en
Priority to US06/355,142 priority patent/US4459423A/en
Publication of JPS57158743A publication Critical patent/JPS57158743A/en
Publication of JPS5817741B2 publication Critical patent/JPS5817741B2/en
Expired legal-status Critical Current

Links

Abstract

PURPOSE: To obtain the titled compound useful as a synthetic intermeidate for various industrial chemicals, etc. in high yield in a short time, by hydrolyzing an α-aminonitrile in the presence of a very small amount of a strongly basic substance and a ketone in a high pH region.
CONSTITUTION: An α-aminonitrile is hydrolyzed in the presence of a strongly basic substatnce, e.g. NaOH, and a ketone, e.g. acetone, in an aqueous medium to give an α-amino acid amide. The amount of the base to be used is 0.01mol or less based on one mole αaminonitrile. The ketone is added to the reaction system to give a pH over 14 of the reaction solution, and the reaction is carried out while keeping the pH at 14 or above. The reaction temperature is preferably 40°C or below. The method is characterized by the hydrolytic rate of almost 100% and almost no occurrence of side reactions.
COPYRIGHT: (C)1982,JPO&Japio
JP4454581A 1981-03-26 1981-03-26 Method for producing α-amino acid amide Expired JPS5817741B2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP4454581A JPS5817741B2 (en) 1981-03-26 1981-03-26 Method for producing α-amino acid amide
DE8282301062T DE3266977D1 (en) 1981-03-26 1982-03-02 Process for producing alpha-amino acids
EP82301062A EP0067499B1 (en) 1981-03-26 1982-03-02 Process for producing alpha-amino acids
US06/355,142 US4459423A (en) 1981-03-26 1982-03-05 Process for producing α-amino acids

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4454581A JPS5817741B2 (en) 1981-03-26 1981-03-26 Method for producing α-amino acid amide

Publications (2)

Publication Number Publication Date
JPS57158743A true JPS57158743A (en) 1982-09-30
JPS5817741B2 JPS5817741B2 (en) 1983-04-09

Family

ID=12694468

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4454581A Expired JPS5817741B2 (en) 1981-03-26 1981-03-26 Method for producing α-amino acid amide

Country Status (1)

Country Link
JP (1) JPS5817741B2 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4997985A (en) * 1987-07-01 1991-03-05 Ciba-Geigy Corporation Alpha amino acid amide compounds which are useful intermediates in the preparation of herbicides
JP2001163845A (en) * 1999-12-13 2001-06-19 Mitsubishi Rayon Co Ltd Method of producing amino acid amide
JP2002047260A (en) * 2000-07-26 2002-02-12 Mitsubishi Gas Chem Co Inc METHOD FOR STABILIZING alpha-AMINO ACID AMIDE
JP2004099506A (en) * 2002-09-09 2004-04-02 Mitsubishi Rayon Co Ltd Method for producing amino acid amide
CN102827028A (en) * 2012-09-17 2012-12-19 浙江邦成化工有限公司 Acylation process of cyanoacyl

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2785609B1 (en) * 1998-11-06 2000-12-15 Rhone Poulenc Nutrition Animal PROCESS FOR THE PREPARATION OF METHIONINE

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4997985A (en) * 1987-07-01 1991-03-05 Ciba-Geigy Corporation Alpha amino acid amide compounds which are useful intermediates in the preparation of herbicides
JP2001163845A (en) * 1999-12-13 2001-06-19 Mitsubishi Rayon Co Ltd Method of producing amino acid amide
JP2002047260A (en) * 2000-07-26 2002-02-12 Mitsubishi Gas Chem Co Inc METHOD FOR STABILIZING alpha-AMINO ACID AMIDE
JP2004099506A (en) * 2002-09-09 2004-04-02 Mitsubishi Rayon Co Ltd Method for producing amino acid amide
CN102827028A (en) * 2012-09-17 2012-12-19 浙江邦成化工有限公司 Acylation process of cyanoacyl

Also Published As

Publication number Publication date
JPS5817741B2 (en) 1983-04-09

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