JPS5643288A - Cephalosporin derivative and its preparation - Google Patents

Cephalosporin derivative and its preparation

Info

Publication number
JPS5643288A
JPS5643288A JP11878879A JP11878879A JPS5643288A JP S5643288 A JPS5643288 A JP S5643288A JP 11878879 A JP11878879 A JP 11878879A JP 11878879 A JP11878879 A JP 11878879A JP S5643288 A JPS5643288 A JP S5643288A
Authority
JP
Japan
Prior art keywords
formula
compound shown
compound
gram
reacted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP11878879A
Other languages
English (en)
Inventor
Osamu Makabe
Yasushi Murai
Tsuneo Okonogi
Masahiro Onodera
Yoshiyuki Koyama
Takashi Yoshida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Meiji Seika Kaisha Ltd
Original Assignee
Meiji Seika Kaisha Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meiji Seika Kaisha Ltd filed Critical Meiji Seika Kaisha Ltd
Priority to JP11878879A priority Critical patent/JPS5643288A/ja
Priority to GB8029630A priority patent/GB2058769B/en
Priority to CA000360265A priority patent/CA1148142A/en
Priority to AR282537A priority patent/AR227398A1/es
Priority to FR8020008A priority patent/FR2465739A1/fr
Priority to ES495137A priority patent/ES8200113A1/es
Priority to BE0/202127A priority patent/BE885265A/fr
Priority to IT49684/80A priority patent/IT1145390B/it
Priority to US06/188,417 priority patent/US4393058A/en
Priority to DE3035259A priority patent/DE3035259C2/de
Publication of JPS5643288A publication Critical patent/JPS5643288A/ja
Priority to AR287751A priority patent/AR227452A1/es
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C07D213/85—Nitriles in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP11878879A 1979-09-18 1979-09-18 Cephalosporin derivative and its preparation Pending JPS5643288A (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
JP11878879A JPS5643288A (en) 1979-09-18 1979-09-18 Cephalosporin derivative and its preparation
GB8029630A GB2058769B (en) 1979-09-18 1980-09-12 Cephalosporin compounds and process for preparing same
CA000360265A CA1148142A (en) 1979-09-18 1980-09-12 Cephalosporin compounds and process for preparing the same
AR282537A AR227398A1 (es) 1979-09-18 1980-09-16 Procedimiento para preparar compuesto del acido 7-(6-fenil 1,2-dihidro-2-oxopiridin-3-carbonilamino)-fenilacetamido-3-metil-3-cefem-4-carboxilico y sus sales
ES495137A ES8200113A1 (es) 1979-09-18 1980-09-17 Un procedimiento para la preparacion de derivados de cefalosporina.
FR8020008A FR2465739A1 (fr) 1979-09-18 1980-09-17 Cephalosporines, leurs procedes de preparation et compositions pharmaceutiques en contenant
BE0/202127A BE885265A (fr) 1979-09-18 1980-09-17 Composes de cephalosporine et leur procede de preparation
IT49684/80A IT1145390B (it) 1979-09-18 1980-09-17 Composti di cefalosporina procedimento per prepararli e composizioni che li contengono
US06/188,417 US4393058A (en) 1979-09-18 1980-09-18 Cephalosporin compounds
DE3035259A DE3035259C2 (de) 1979-09-18 1980-09-18 Cephalosporinverbindungen, Verfahren zu deren Herstellung und Arzneimittel, welche diese enthalten
AR287751A AR227452A1 (es) 1979-09-18 1981-12-10 Procedimiento para preparar compuestos del acido 7-(6-fenil-1,2-dihidro-2-oxopiridina-3-carbonilamino)-fenilacetamino-3-metil-3-cefem-4-carboxilico y sus sales

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11878879A JPS5643288A (en) 1979-09-18 1979-09-18 Cephalosporin derivative and its preparation

Publications (1)

Publication Number Publication Date
JPS5643288A true JPS5643288A (en) 1981-04-21

Family

ID=14745096

Family Applications (1)

Application Number Title Priority Date Filing Date
JP11878879A Pending JPS5643288A (en) 1979-09-18 1979-09-18 Cephalosporin derivative and its preparation

Country Status (10)

Country Link
US (1) US4393058A (ja)
JP (1) JPS5643288A (ja)
AR (2) AR227398A1 (ja)
BE (1) BE885265A (ja)
CA (1) CA1148142A (ja)
DE (1) DE3035259C2 (ja)
ES (1) ES8200113A1 (ja)
FR (1) FR2465739A1 (ja)
GB (1) GB2058769B (ja)
IT (1) IT1145390B (ja)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4758557A (en) * 1985-06-26 1988-07-19 Meiji Seika Kaisha, Ltd. Cephalosporin derivatives and bactericides containing the same
US5254571A (en) * 1988-04-21 1993-10-19 Smith Kline & French Laboratories Ltd. Chemical compounds
DE19500760A1 (de) * 1995-01-13 1996-07-18 Basf Ag Substituierte 2-Phenylpyridine
KR20030071311A (ko) * 2002-02-28 2003-09-03 주식회사 엘지생명과학 신규 세팔로스포린 화합물 및 그의 제조방법
JP4046708B2 (ja) * 2004-06-04 2008-02-13 明治製菓株式会社 ３−アルケニルセフェム化合物の製造方法
BR112014004832A2 (pt) * 2011-08-29 2017-04-04 Ptc Therapeutics Inc compostos antibacterianos e métodos para uso
JP2014525453A (ja) 2011-08-29 2014-09-29 ピーティーシー セラピューティクス， インコーポレイテッド 抗菌化合物および使用方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4982687A (ja) * 1972-12-21 1974-08-08
JPS5293790A (en) * 1976-02-02 1977-08-06 Sumitomo Chem Co Ltd 7-(n-acylamino-alpha-arylacetamide) cephalosporins
JPS5344585A (en) * 1976-10-02 1978-04-21 Meiji Seika Kaisha Ltd Cephalosporin derivatives and their preparation

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1074784A (en) * 1974-09-06 1980-04-01 Sumitomo Chemical Company N-ACYLAMINO-.alpha.-ARYLACETAMIDO CEPHALOSPORINS
US4302454A (en) * 1976-03-03 1981-11-24 Sumitomo Chemical Company, Limited Cephalosporins
DE2658905A1 (de) * 1976-12-24 1978-10-19 Bayer Ag Beta-lactam-antibiotica, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
US4101661A (en) * 1977-06-03 1978-07-18 Warner-Lambert Novel antibacterial amide compounds and process means for producing the same
DE2924948A1 (de) * 1979-06-21 1981-01-22 Thomae Gmbh Dr K Neue cephalosporine, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4982687A (ja) * 1972-12-21 1974-08-08
JPS5293790A (en) * 1976-02-02 1977-08-06 Sumitomo Chem Co Ltd 7-(n-acylamino-alpha-arylacetamide) cephalosporins
JPS5344585A (en) * 1976-10-02 1978-04-21 Meiji Seika Kaisha Ltd Cephalosporin derivatives and their preparation

Also Published As

Publication number Publication date
AR227398A1 (es) 1982-10-29
ES495137A0 (es) 1981-10-16
AR227452A1 (es) 1982-10-29
FR2465739B1 (ja) 1983-06-17
ES8200113A1 (es) 1981-10-16
IT1145390B (it) 1986-11-05
US4393058A (en) 1983-07-12
IT8049684A0 (it) 1980-09-17
GB2058769B (en) 1984-04-18
GB2058769A (en) 1981-04-15
BE885265A (fr) 1981-01-16
FR2465739A1 (fr) 1981-03-27
DE3035259A1 (de) 1981-03-19
CA1148142A (en) 1983-06-14
DE3035259C2 (de) 1986-03-13

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