JPS5569549A - Novel substrate for determination of enzyme activity - Google Patents
Novel substrate for determination of enzyme activityInfo
- Publication number
- JPS5569549A JPS5569549A JP14146378A JP14146378A JPS5569549A JP S5569549 A JPS5569549 A JP S5569549A JP 14146378 A JP14146378 A JP 14146378A JP 14146378 A JP14146378 A JP 14146378A JP S5569549 A JPS5569549 A JP S5569549A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- determination
- hydroxyaniline
- gtp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000000694 effects Effects 0.000 title abstract 2
- 239000000758 substrate Substances 0.000 title abstract 2
- 102000004190 Enzymes Human genes 0.000 title 1
- 108090000790 Enzymes Proteins 0.000 title 1
- -1 alkali metal salt Chemical class 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 101000856500 Bacillus subtilis subsp. natto Glutathione hydrolase proenzyme Proteins 0.000 abstract 2
- KBOPZPXVLCULAV-UHFFFAOYSA-N mesalamine Chemical compound NC1=CC=C(O)C(C(O)=O)=C1 KBOPZPXVLCULAV-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 239000007853 buffer solution Substances 0.000 abstract 1
- 238000004737 colorimetric analysis Methods 0.000 abstract 1
- 230000005494 condensation Effects 0.000 abstract 1
- 238000009833 condensation Methods 0.000 abstract 1
- 239000012535 impurity Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 229960004963 mesalazine Drugs 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/91045—Acyltransferases (2.3)
- G01N2333/91074—Aminoacyltransferases (general) (2.3.2)
- G01N2333/9108—Aminoacyltransferases (general) (2.3.2) with definite EC number (2.3.2.-)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14146378A JPS5569549A (en) | 1978-11-16 | 1978-11-16 | Novel substrate for determination of enzyme activity |
GB7916858A GB2034690B (en) | 1978-11-16 | 1979-05-15 | - y - glutamyl - 3 - carboxy - 4-hydroxyanilide and salts thereof |
DE2920292A DE2920292C3 (de) | 1978-11-16 | 1979-05-18 | L-γ -Glutamyl-3-carboxy-4-hydroxyanilid und dessen Säureadditions- oder Alkalisalze, Verfahren zu deren Herstellung und deren Verwendung zur Bestimmung der Aktivität von γ-Glutamyltranspeptidase |
CH477579A CH640826A5 (de) | 1978-11-16 | 1979-05-22 | L-gamma-glutamyl-3-carboxy-4-hydroxyanilid und dessen salze, verfahren zu dessen herstellung und dessen verwendung zur bestimmung der aktivitaet von gamma-glutamyltranspeptidase. |
SE7905009A SE445829B (sv) | 1978-11-16 | 1979-06-08 | Ny l-gamma-glutamyl-3-karboxi-4-hydroxianilid och salter derav |
FR7915353A FR2441609A1 (fr) | 1978-11-16 | 1979-06-15 | Nouveau l-gamma-glutamyl-3-carboxy-4-hydroxyanilide et ses sels et leur application a la determination de l'activite de g-glutamyl-transpeptidase |
US06/094,072 US4281181A (en) | 1978-11-16 | 1979-11-14 | Novel L-γ-glutamyl-3-carboxy-4-hydroxyanilide and salts thereof |
US06/245,817 US4336331A (en) | 1978-11-16 | 1981-03-20 | Method for assaying the activity of γ-glutamyl transpeptidase in serum |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14146378A JPS5569549A (en) | 1978-11-16 | 1978-11-16 | Novel substrate for determination of enzyme activity |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5569549A true JPS5569549A (en) | 1980-05-26 |
JPS5649904B2 JPS5649904B2 (ja) | 1981-11-25 |
Family
ID=15292461
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP14146378A Granted JPS5569549A (en) | 1978-11-16 | 1978-11-16 | Novel substrate for determination of enzyme activity |
Country Status (7)
Country | Link |
---|---|
US (2) | US4281181A (ja) |
JP (1) | JPS5569549A (ja) |
CH (1) | CH640826A5 (ja) |
DE (1) | DE2920292C3 (ja) |
FR (1) | FR2441609A1 (ja) |
GB (1) | GB2034690B (ja) |
SE (1) | SE445829B (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6425749A (en) * | 1987-04-10 | 1989-01-27 | Shino Test Corp | Substrate for measuring enzyme activity and method for measuring enzyme activity using said substrate |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0052296B1 (en) * | 1980-11-12 | 1984-06-27 | Mitsubishi Kasei Corporation | Glutamine derivatives usable for curing immune diseases, methods for their preparation and compositions comprising said derivatives |
DE3176589D1 (en) * | 1980-12-02 | 1988-02-11 | Health Lab Service Board | Method for the estimation of n-acylated primary aromatic amines |
JPS5856695A (ja) * | 1981-09-28 | 1983-04-04 | Nitto Boseki Co Ltd | 新規なトロンビン測定用基質 |
JPS5863399A (ja) * | 1981-10-14 | 1983-04-15 | Nitto Boseki Co Ltd | 新規なプラスミン測定用基質 |
US4588836A (en) * | 1982-09-01 | 1986-05-13 | Toyo Jozo Kabushiki Kaisha | Novel synthetic substrate and assay method using the same |
DE3234478A1 (de) * | 1982-09-17 | 1984-03-22 | Boehringer Mannheim Gmbh, 6800 Mannheim | Reagenz und verfahren zur bestimmung von (gamma)-glutamyltransferase |
JPS60166657A (ja) * | 1984-02-10 | 1985-08-29 | Nitto Boseki Co Ltd | アルギニル−3−カルボキシ−4−ヒドロキシアニリド |
US5116730A (en) * | 1988-06-15 | 1992-05-26 | Board Of Governors Of Wayne State University | Amino acid substituted 4-aminophenazones for measuring enzyme activity |
FR2644697B1 (fr) * | 1989-03-24 | 1992-05-15 | Poudres & Explosifs Ste Nale | Composes anesthesiques a duree d'action controlee et compositions pharmaceutiques les contenant |
IT1244873B (it) * | 1990-09-12 | 1994-09-12 | Depha Team Srl | Derivati dell'acido 5-aminosalicilico (5-asa) per la terapia delle infiammazioni croniche intestinali |
US5474906A (en) * | 1993-03-26 | 1995-12-12 | Eiken Kagaku Kabushiki Kaisha | Reagent for determining γ-glutamyl transpeptidase activity |
US5847192A (en) * | 1994-01-28 | 1998-12-08 | Prolinx, Inc. | Boronic compound complexing reagents and complexes |
US5594151A (en) * | 1994-01-28 | 1997-01-14 | Prolinx, Inc. | Phenylboronic acid complexing reagents derived from aminosalicylic acid |
US5594111A (en) * | 1994-01-28 | 1997-01-14 | Prolinx, Inc. | Phenylboronic acid complexes for bioconjugate preparation |
US5852178A (en) * | 1994-01-28 | 1998-12-22 | Prolinx, Inc. | Phenylboronic acid complexing reagents for conjugating biologically active molecules |
US5777148A (en) * | 1994-01-28 | 1998-07-07 | Prolinx, Inc. | Boronic compound complexing reagents and highly stable complexes |
US5744627A (en) * | 1994-01-28 | 1998-04-28 | Prolinx, Inc. | Boronic compound complexing reagents and complexes |
US5837878A (en) * | 1994-01-28 | 1998-11-17 | Prolinx, Inc. | Boronic compound complexing reagents and highly stable complexes |
US5623055A (en) * | 1994-01-28 | 1997-04-22 | Prolinx, Inc. | Phenylboronic acid complexes derived from aminosalicylic acid for bioconjugate preparation |
US6156884A (en) * | 1996-08-05 | 2000-12-05 | Prolinx, Inc. | Bifunctional boronic compound complexing reagents and complexes |
US6075126A (en) * | 1996-08-05 | 2000-06-13 | Prolinx, Inc. | Phenyldiboronic acid reagents and complexes |
US10391038B2 (en) * | 2008-02-08 | 2019-08-27 | Colgate-Palmolive Company | Tooth sealant |
JP5685941B2 (ja) * | 2008-10-03 | 2015-03-18 | 味の素株式会社 | CaSRアゴニスト |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2891091A (en) * | 1957-06-03 | 1959-06-16 | Canadian Patents Dev | Derivatives of para-aminosalicylic acid |
US3383411A (en) * | 1964-02-17 | 1968-05-14 | Merck & Co Inc | 4-alkanoylphenoxy-alkanoic acids |
US3452086A (en) * | 1966-04-29 | 1969-06-24 | Bristol Myers Co | Substituted tartranilic acid resolving agents |
US3769173A (en) * | 1972-08-21 | 1973-10-30 | Warner Lambert Co | Determination of gamma-glutamyl transpeptidase in biological fluids |
AT331994B (de) * | 1972-12-05 | 1976-09-10 | Boehringer Mannheim Gmbh | Verfahren zur bestimmung von delta-glutamyltranspeptidase |
JPS584560B2 (ja) * | 1976-06-01 | 1983-01-26 | 三共株式会社 | 鉄錯塩を用いた酵素活性測定法 |
JPS53147034A (en) * | 1977-05-30 | 1978-12-21 | Wako Pure Chem Ind Ltd | Gamma-glutamyl-p-aminoanilide derivatives and process for their preparation |
JPS54157691A (en) * | 1978-06-01 | 1979-12-12 | Nitto Boseki Co Ltd | Novel substrate for measuring enzyme activity |
-
1978
- 1978-11-16 JP JP14146378A patent/JPS5569549A/ja active Granted
-
1979
- 1979-05-15 GB GB7916858A patent/GB2034690B/en not_active Expired
- 1979-05-18 DE DE2920292A patent/DE2920292C3/de not_active Expired
- 1979-05-22 CH CH477579A patent/CH640826A5/de not_active IP Right Cessation
- 1979-06-08 SE SE7905009A patent/SE445829B/sv not_active IP Right Cessation
- 1979-06-15 FR FR7915353A patent/FR2441609A1/fr active Granted
- 1979-11-14 US US06/094,072 patent/US4281181A/en not_active Expired - Lifetime
-
1981
- 1981-03-20 US US06/245,817 patent/US4336331A/en not_active Expired - Lifetime
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6425749A (en) * | 1987-04-10 | 1989-01-27 | Shino Test Corp | Substrate for measuring enzyme activity and method for measuring enzyme activity using said substrate |
Also Published As
Publication number | Publication date |
---|---|
DE2920292A1 (de) | 1980-05-22 |
SE445829B (sv) | 1986-07-21 |
SE7905009L (sv) | 1980-05-17 |
US4336331A (en) | 1982-06-22 |
GB2034690A (en) | 1980-06-11 |
DE2920292C3 (de) | 1982-01-28 |
JPS5649904B2 (ja) | 1981-11-25 |
GB2034690B (en) | 1983-01-12 |
US4281181A (en) | 1981-07-28 |
FR2441609A1 (fr) | 1980-06-13 |
DE2920292B2 (de) | 1981-02-19 |
CH640826A5 (de) | 1984-01-31 |
FR2441609B1 (ja) | 1984-05-11 |
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