IT1244873B - Derivati dell'acido 5-aminosalicilico (5-asa) per la terapia delle infiammazioni croniche intestinali - Google Patents
Derivati dell'acido 5-aminosalicilico (5-asa) per la terapia delle infiammazioni croniche intestinaliInfo
- Publication number
- IT1244873B IT1244873B IT02144390A IT2144390A IT1244873B IT 1244873 B IT1244873 B IT 1244873B IT 02144390 A IT02144390 A IT 02144390A IT 2144390 A IT2144390 A IT 2144390A IT 1244873 B IT1244873 B IT 1244873B
- Authority
- IT
- Italy
- Prior art keywords
- aminosalicylic acid
- pct
- asa
- therapy
- derivatives
- Prior art date
Links
- KBOPZPXVLCULAV-UHFFFAOYSA-N mesalamine Chemical class NC1=CC=C(O)C(C(O)=O)=C1 KBOPZPXVLCULAV-UHFFFAOYSA-N 0.000 title abstract 4
- 229960004963 mesalazine Drugs 0.000 title abstract 2
- 206010061218 Inflammation Diseases 0.000 title 1
- 230000001684 chronic effect Effects 0.000 title 1
- 230000000968 intestinal effect Effects 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
- OZDAOHVKBFBBMZ-UHFFFAOYSA-N 2-aminopentanedioic acid;hydrate Chemical compound O.OC(=O)C(N)CCC(O)=O OZDAOHVKBFBBMZ-UHFFFAOYSA-N 0.000 abstract 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 abstract 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 235000003704 aspartic acid Nutrition 0.000 abstract 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 235000013922 glutamic acid Nutrition 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Priority Applications (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT02144390A IT1244873B (it) | 1990-09-12 | 1990-09-12 | Derivati dell'acido 5-aminosalicilico (5-asa) per la terapia delle infiammazioni croniche intestinali |
| CA002091459A CA2091459A1 (en) | 1990-09-12 | 1991-09-10 | 5-aminosalicylic acid derivatives for the therapy of chronic inflammatory bowel diseases |
| PCT/EP1991/001718 WO1992004369A1 (en) | 1990-09-12 | 1991-09-10 | 5-aminosalicylic acid derivatives for the therapy of chronic inflammatory bowel diseases |
| AT91916335T ATE105841T1 (de) | 1990-09-12 | 1991-09-10 | 5-aminosalicylsäurederivate zur therapie chronisch entzündlicher baucherkrankungen. |
| AU85308/91A AU8530891A (en) | 1990-09-12 | 1991-09-10 | 5-aminosalicylic acid derivatives for the therapy of chronic inflammatory bowel diseases |
| DK91916335.2T DK0548177T3 (da) | 1990-09-12 | 1991-09-10 | 5-Aminosalicylsyrederivater til terapi af kroniske inflammatoriske tarmsygdomme |
| US07/984,575 US5424292A (en) | 1990-09-12 | 1991-09-10 | 5-aminosalicylic acid derivatives for the therapy of chronic inflammatory bowel diseases |
| DE69102069T DE69102069T2 (de) | 1990-09-12 | 1991-09-10 | 5-aminosalicylsäurederivate zur therapie chronisch entzündlicher baucherkrankungen. |
| ES91916335T ES2052391T3 (es) | 1990-09-12 | 1991-09-10 | Derivados de acido 5-aminosalicilico para la terapia de enfermedades inflamatorias cronicas del intestino. |
| EP91916335A EP0548177B1 (en) | 1990-09-12 | 1991-09-10 | 5-aminosalicylic acid derivatives for the therapy of chronic inflammatory bowel diseases |
| JP3515457A JPH06500787A (ja) | 1990-09-12 | 1991-09-10 | 慢性炎症性腸疾患治療のための５―アミノサリチル酸誘導体 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT02144390A IT1244873B (it) | 1990-09-12 | 1990-09-12 | Derivati dell'acido 5-aminosalicilico (5-asa) per la terapia delle infiammazioni croniche intestinali |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| IT9021443A0 IT9021443A0 (it) | 1990-09-12 |
| IT9021443A1 IT9021443A1 (it) | 1992-03-12 |
| IT1244873B true IT1244873B (it) | 1994-09-12 |
Family
ID=11181864
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT02144390A IT1244873B (it) | 1990-09-12 | 1990-09-12 | Derivati dell'acido 5-aminosalicilico (5-asa) per la terapia delle infiammazioni croniche intestinali |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5424292A (it) |
| EP (1) | EP0548177B1 (it) |
| JP (1) | JPH06500787A (it) |
| AT (1) | ATE105841T1 (it) |
| AU (1) | AU8530891A (it) |
| CA (1) | CA2091459A1 (it) |
| DE (1) | DE69102069T2 (it) |
| DK (1) | DK0548177T3 (it) |
| ES (1) | ES2052391T3 (it) |
| IT (1) | IT1244873B (it) |
| WO (1) | WO1992004369A1 (it) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5484605A (en) * | 1988-11-25 | 1996-01-16 | Henning Berlin Gmbh Chemie-Und Pharmawerk | Agent for treating chronically inflammatory intestinal diseases |
| US6903075B1 (en) | 1997-05-29 | 2005-06-07 | Merck & Co., Inc. | Heterocyclic amide compounds as cell adhesion inhibitors |
| JP2002512625A (ja) * | 1997-05-29 | 2002-04-23 | メルク エンド カンパニー インコーポレーテッド | 細胞接着阻害薬としての複素環アミド化合物 |
| US6716452B1 (en) * | 2000-08-22 | 2004-04-06 | New River Pharmaceuticals Inc. | Active agent delivery systems and methods for protecting and administering active agents |
| US8394813B2 (en) | 2000-11-14 | 2013-03-12 | Shire Llc | Active agent delivery systems and methods for protecting and administering active agents |
| US20060014697A1 (en) * | 2001-08-22 | 2006-01-19 | Travis Mickle | Pharmaceutical compositions for prevention of overdose or abuse |
| US7169752B2 (en) * | 2003-09-30 | 2007-01-30 | New River Pharmaceuticals Inc. | Compounds and compositions for prevention of overdose of oxycodone |
| ES2380622T5 (es) * | 2003-05-29 | 2018-05-30 | Shire Llc | Compuestos de anfetamina resistentes al abuso |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL7008620A (it) * | 1969-06-25 | 1970-12-29 | ||
| NL7008623A (it) * | 1969-06-25 | 1970-12-29 | ||
| JPS5569549A (en) * | 1978-11-16 | 1980-05-26 | Nitto Boseki Co Ltd | Novel substrate for determination of enzyme activity |
| WO1981002672A1 (en) * | 1980-03-20 | 1981-10-01 | Ferring Farma Lab | Pharmaceutical composition and method for the treatment of colitis ulcerosa and crohn's disease |
| US4505898A (en) * | 1982-04-21 | 1985-03-19 | Marks Robert E | Derivatives of acetylsalicylic acid and substituted phenylacetic acids and compositions containing them |
| IT1196348B (it) * | 1984-11-29 | 1988-11-16 | Italfarmaco Spa | Composti ad attivita'antiinfiammatoria |
| US5120306A (en) * | 1990-03-21 | 1992-06-09 | Gosselin Leon F | Direct delivery of anti-inflammatories to the proximal small bowel |
-
1990
- 1990-09-12 IT IT02144390A patent/IT1244873B/it active IP Right Grant
-
1991
- 1991-09-10 CA CA002091459A patent/CA2091459A1/en not_active Abandoned
- 1991-09-10 EP EP91916335A patent/EP0548177B1/en not_active Expired - Lifetime
- 1991-09-10 US US07/984,575 patent/US5424292A/en not_active Expired - Fee Related
- 1991-09-10 WO PCT/EP1991/001718 patent/WO1992004369A1/en active IP Right Grant
- 1991-09-10 AT AT91916335T patent/ATE105841T1/de not_active IP Right Cessation
- 1991-09-10 AU AU85308/91A patent/AU8530891A/en not_active Abandoned
- 1991-09-10 ES ES91916335T patent/ES2052391T3/es not_active Expired - Lifetime
- 1991-09-10 DK DK91916335.2T patent/DK0548177T3/da active
- 1991-09-10 JP JP3515457A patent/JPH06500787A/ja active Pending
- 1991-09-10 DE DE69102069T patent/DE69102069T2/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0548177A1 (en) | 1993-06-30 |
| CA2091459A1 (en) | 1992-03-13 |
| IT9021443A0 (it) | 1990-09-12 |
| ES2052391T3 (es) | 1994-07-01 |
| WO1992004369A1 (en) | 1992-03-19 |
| DE69102069D1 (de) | 1994-06-23 |
| JPH06500787A (ja) | 1994-01-27 |
| ATE105841T1 (de) | 1994-06-15 |
| US5424292A (en) | 1995-06-13 |
| DK0548177T3 (da) | 1994-08-22 |
| EP0548177B1 (en) | 1994-05-18 |
| AU8530891A (en) | 1992-03-30 |
| DE69102069T2 (de) | 1994-09-01 |
| IT9021443A1 (it) | 1992-03-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted | ||
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19970729 |