JPS55135595A - Preparation of dipeptide - Google Patents

Preparation of dipeptide

Info

Publication number
JPS55135595A
JPS55135595A JP4017079A JP4017079A JPS55135595A JP S55135595 A JPS55135595 A JP S55135595A JP 4017079 A JP4017079 A JP 4017079A JP 4017079 A JP4017079 A JP 4017079A JP S55135595 A JPS55135595 A JP S55135595A
Authority
JP
Japan
Prior art keywords
organic solvent
lower alkyl
water
substituted
fixed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP4017079A
Other languages
English (en)
Japanese (ja)
Other versions
JPS615399B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html
Inventor
Kiyotaka Koyama
Shigetetsu Nishimura
Yuji Nonaka
Tsutomu Hashimoto
Keiichi Kihara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Sagami Chemical Research Institute
Tosoh Corp
Original Assignee
Ajinomoto Co Inc
Sagami Chemical Research Institute
Toyo Soda Manufacturing Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co Inc, Sagami Chemical Research Institute, Toyo Soda Manufacturing Co Ltd filed Critical Ajinomoto Co Inc
Priority to JP4017079A priority Critical patent/JPS55135595A/ja
Priority to CA348,800A priority patent/CA1133841A/en
Priority to US06/136,347 priority patent/US4284721A/en
Priority to DE19803012693 priority patent/DE3012693A1/de
Priority to NL8001902A priority patent/NL8001902A/nl
Priority to IT21154/80A priority patent/IT1147338B/it
Priority to BE0/200093A priority patent/BE882603A/fr
Priority to GB8011159A priority patent/GB2049703B/en
Priority to CH263880A priority patent/CH645341A5/de
Priority to FR8007552A priority patent/FR2453137B1/fr
Publication of JPS55135595A publication Critical patent/JPS55135595A/ja
Publication of JPS615399B2 publication Critical patent/JPS615399B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
    • C07K5/0613—Aspartame

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Peptides Or Proteins (AREA)
JP4017079A 1979-04-03 1979-04-03 Preparation of dipeptide Granted JPS55135595A (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
JP4017079A JPS55135595A (en) 1979-04-03 1979-04-03 Preparation of dipeptide
CA348,800A CA1133841A (en) 1979-04-03 1980-03-27 Method for manufacturing dipeptides
US06/136,347 US4284721A (en) 1979-04-03 1980-04-01 Method for manufacturing dipeptides
DE19803012693 DE3012693A1 (de) 1979-04-03 1980-04-01 Verfahren zur herstellung von dipeptiden
NL8001902A NL8001902A (nl) 1979-04-03 1980-04-01 Werkwijze voor het bereiden van dipeptide.
IT21154/80A IT1147338B (it) 1979-04-03 1980-04-02 Metodo per preparare dipertidi
BE0/200093A BE882603A (fr) 1979-04-03 1980-04-02 Procede de preparation de dipeptides
GB8011159A GB2049703B (en) 1979-04-03 1980-04-02 Dipeptide preparation utilising an insolubilised-metalloproteinase
CH263880A CH645341A5 (de) 1979-04-03 1980-04-03 Verfahren zur herstellung von dipeptiden.
FR8007552A FR2453137B1 (fr) 1979-04-03 1980-04-03 Procede de preparation de dipeptides

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4017079A JPS55135595A (en) 1979-04-03 1979-04-03 Preparation of dipeptide

Publications (2)

Publication Number Publication Date
JPS55135595A true JPS55135595A (en) 1980-10-22
JPS615399B2 JPS615399B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1986-02-18

Family

ID=12573284

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4017079A Granted JPS55135595A (en) 1979-04-03 1979-04-03 Preparation of dipeptide

Country Status (10)

Country Link
US (1) US4284721A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS55135595A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BE (1) BE882603A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1133841A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CH (1) CH645341A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE3012693A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FR (1) FR2453137B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GB (1) GB2049703B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IT (1) IT1147338B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NL (1) NL8001902A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57146595A (en) * 1981-02-02 1982-09-10 Searle & Co Production of amino protected-l- aspartyl-l-phenylalanine alkyl ester
JPH0279993A (ja) * 1987-12-11 1990-03-20 Fan Shun Mou Ii Yuu Shen Kun Tsu Ｌ，ｌ−ジペプチドアスパルテームの製法

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4506011A (en) * 1981-09-05 1985-03-19 Toyo Soda Manufacturing Co., Ltd. Process for preparation of aspartylphenylalanine alkyl esters
DK28283A (da) * 1982-01-26 1983-07-27 Kazutomo Imahori Fremgangsmaade til syntetisering af peptider eller peptidderivater
EP0092228B1 (en) * 1982-04-19 1988-01-20 Nissan Motor Co., Ltd. Method and apparatus for controlling reduction ratio of continuously variable transmission
JPH0724587B2 (ja) * 1982-07-08 1995-03-22 三井東圧化学株式会社 酵素を利用した反応方法
JPS5917997A (ja) * 1982-07-23 1984-01-30 Toyo Soda Mfg Co Ltd ジペプチドエステルとアミノ酸エステルとの付加化合物の製造方法
DE3479214D1 (en) * 1983-04-28 1989-09-07 Ajinomoto Kk Process for the production of l-aspartyl-l-phenylalanine methyl ester or l-aspartyl-l-phenylalanine
DE3690076T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1985-02-15 1987-03-12
US4873359A (en) * 1985-10-21 1989-10-10 W. R. Grace & Co. - Conn. Process for preparing as partyl-phenylalanine dipeptides
US4810817A (en) * 1985-10-21 1989-03-07 W. R. Grace & Co. Aspartyl-beta substituted phenylalanine dipeptides
NZ217813A (en) * 1985-10-21 1991-01-29 Grace W R & Co Dipeptides and process for their preparation using an enzyme coupling agent
FR2589480B1 (fr) * 1985-11-05 1988-09-16 Hoechst France Procede biologique de preparation de n-(n-benzyloxycarbonyl l-aspartyl-1) l-phenylalaninate de methyle
US4935355A (en) * 1986-04-15 1990-06-19 Synthetech, Inc. Preparation of dipeptides
EP0269390B1 (en) * 1986-11-21 1993-08-25 Genencor International, Inc. Enzymatic l-aspartyl-l-phenylalanine alkyl ester production
US4892820A (en) * 1987-06-10 1990-01-09 The Nutrasweet Company Solvent system for enzymatic coupling process
DE68924196T2 (de) * 1988-06-03 1996-05-09 Sharp Kk Elektronische Anordnung mit einer Kalenderfunktion.
US5002872A (en) * 1989-05-10 1991-03-26 W. R. Grace & Co.-Conn. Enzyme mediated coupling reactions
KR930002966B1 (ko) * 1990-11-24 1993-04-16 주식회사 미 원 디펩티드의 제조방법
DE4408534A1 (de) * 1994-03-14 1995-09-28 Hoechst Ag Substituierte N-Ethyl-Glycinderivate zur Herstellung von PNA und PNA-/DNA-Hybriden
US6465650B1 (en) 1995-03-13 2002-10-15 Aventis Pharma Deutschland Gmbh Substituted N-ethylglycine derivatives for preparing PNA and PNA/DNA hybrids
CA2172022A1 (en) * 1995-03-20 1996-09-21 Tsugio Murakami Method for crystallizing alpha-l-aspartyl-l-phenylalanine methyl ester
DE69613305T2 (de) * 1995-10-11 2002-05-02 Holland Sweetener Co. V.O.F., Maastricht Verbesserte enzymatische Kupplungsreaktion von N-geschützte L-Asparaginsäure und Phenylalaninmethylester
EP0768384B1 (en) * 1995-10-11 2001-06-13 Holland Sweetener Company V.o.F. Improved enzymatic coupling reaction of N-protected-L-aspartic acid and phenylalanine methyl ester
US5837483A (en) * 1996-10-15 1998-11-17 Holland Sweetener Company V.O.F. Enzymatic method for producing N-formyl-α-L-aspartyl-L-phenylalanine methyl ester
ES2350722T3 (es) * 1998-06-05 2011-01-26 Wm. Wrigley Jr. Company Método de liberación controlada de derivados n-sustituidos de aspartamo en goma de mascar y goma producida de esta manera.
US6692778B2 (en) * 1998-06-05 2004-02-17 Wm. Wrigley Jr. Company Method of controlling release of N-substituted derivatives of aspartame in chewing gum
CN112301081B (zh) * 2020-10-26 2022-07-22 江南大学 一种酶催化合成苯丙氨酸寡肽-赖氨酸寡肽共聚物的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3972773A (en) * 1975-04-29 1976-08-03 Sagami Chemical Research Center Process for producing peptide
US4119493A (en) * 1975-10-23 1978-10-10 (Zaidanhojin) Sagami Chemical Research Center Process for producing a peptide
DE2857828C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1977-01-27 1990-06-07 Toyo Soda Mfg. Co., Ltd., Shinnanyo, Yamaguchi, Jp

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57146595A (en) * 1981-02-02 1982-09-10 Searle & Co Production of amino protected-l- aspartyl-l-phenylalanine alkyl ester
JPH0279993A (ja) * 1987-12-11 1990-03-20 Fan Shun Mou Ii Yuu Shen Kun Tsu Ｌ，ｌ−ジペプチドアスパルテームの製法

Also Published As

Publication number Publication date
IT8021154A0 (it) 1980-04-02
GB2049703B (en) 1983-01-12
NL8001902A (nl) 1980-10-07
DE3012693A1 (de) 1980-10-16
FR2453137B1 (fr) 1985-06-07
CH645341A5 (de) 1984-09-28
DE3012693C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1990-04-26
CA1133841A (en) 1982-10-19
JPS615399B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1986-02-18
IT1147338B (it) 1986-11-19
GB2049703A (en) 1980-12-31
BE882603A (fr) 1980-10-02
FR2453137A1 (fr) 1980-10-31
US4284721A (en) 1981-08-18

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