JPS54141798A - 44desacetyl vlboo33carboxyhydrazide derivative - Google Patents

44desacetyl vlboo33carboxyhydrazide derivative

Info

Publication number
JPS54141798A
JPS54141798A JP4715279A JP4715279A JPS54141798A JP S54141798 A JPS54141798 A JP S54141798A JP 4715279 A JP4715279 A JP 4715279A JP 4715279 A JP4715279 A JP 4715279A JP S54141798 A JPS54141798 A JP S54141798A
Authority
JP
Japan
Prior art keywords
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP4715279A
Other languages
English (en)
Japanese (ja)
Other versions
JPS6245873B2 (enExample
Inventor
Jiei Kurinan Jiyooji
Geruzon Koruto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of JPS54141798A publication Critical patent/JPS54141798A/ja
Publication of JPS6245873B2 publication Critical patent/JPS6245873B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
JP4715279A 1978-04-20 1979-04-17 44desacetyl vlboo33carboxyhydrazide derivative Granted JPS54141798A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/899,032 US4166810A (en) 1978-04-20 1978-04-20 Derivatives of 4-desacetyl VLB C-3 carboxyhydrazide

Publications (2)

Publication Number Publication Date
JPS54141798A true JPS54141798A (en) 1979-11-05
JPS6245873B2 JPS6245873B2 (enExample) 1987-09-29

Family

ID=25410402

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4715279A Granted JPS54141798A (en) 1978-04-20 1979-04-17 44desacetyl vlboo33carboxyhydrazide derivative

Country Status (32)

Country Link
US (1) US4166810A (enExample)
EP (1) EP0005051B1 (enExample)
JP (1) JPS54141798A (enExample)
AR (1) AR228940A1 (enExample)
AT (1) AT369010B (enExample)
AU (1) AU527109B2 (enExample)
BE (1) BE875652A (enExample)
BG (3) BG33294A3 (enExample)
CA (1) CA1097629A (enExample)
CH (1) CH643269A5 (enExample)
CS (3) CS218585B2 (enExample)
DD (1) DD143075A5 (enExample)
DE (1) DE2964130D1 (enExample)
DK (1) DK147484C (enExample)
EG (1) EG14867A (enExample)
ES (2) ES479754A1 (enExample)
FI (1) FI791286A7 (enExample)
FR (1) FR2423495A1 (enExample)
GB (1) GB2019396B (enExample)
GR (1) GR69987B (enExample)
HU (1) HU181431B (enExample)
IE (1) IE48213B1 (enExample)
IL (1) IL57168A (enExample)
LU (1) LU81166A1 (enExample)
NZ (1) NZ190213A (enExample)
PH (1) PH14163A (enExample)
PL (3) PL119416B1 (enExample)
PT (1) PT69496A (enExample)
RO (3) RO81037A (enExample)
SU (3) SU1225490A3 (enExample)
YU (1) YU93179A (enExample)
ZA (1) ZA791856B (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4322351A (en) * 1980-08-25 1982-03-30 Eli Lilly And Company Antineoplastic 4'-formylamino and 4'-acetylamino VLB, and derivatives thereof
US4596676A (en) * 1983-03-30 1986-06-24 Lilly Industries Limited Bifunctional ester derivatives of 4-desacetyl indole-dihydroindole alkaloids
US4675400A (en) * 1985-06-17 1987-06-23 Eli Lilly And Company Bifunctional derivatives of 4-desacetyl indole-dihydroindole alkaloids
US4667030A (en) * 1985-06-17 1987-05-19 Eli Lilly And Company Hydrazide succinimide derivatives of antineoplastic indole-dihydroindole alkaloids
US4801688A (en) * 1986-05-27 1989-01-31 Eli Lilly And Company Hydrazone immunoglobulin conjugates
US5043340A (en) * 1990-04-03 1991-08-27 Eli Lilly And Company Derivatives of 4-desacetyl VLB C-3 carboxhydrazide
US5043336A (en) * 1990-04-03 1991-08-27 Eli Lilly And Company Cyclic imide derivatives of 4-desacetyl VLB c-3 carboxhydrazide
WO2002085908A1 (en) 2001-04-24 2002-10-31 Purdue Research Foundation Folate mimetics and folate-receptor binding conjugates thereof
CA2484640C (en) * 2002-05-15 2012-01-17 Endocyte, Inc. Vitamin-mitomycin conjugates
JP5576007B2 (ja) 2003-01-27 2014-08-20 エンドサイト・インコーポレイテッド ビタミン受容体結合性薬剤送達結合体
JP5149620B2 (ja) * 2004-07-23 2013-02-20 エンドサイト，インコーポレイテッド ２価リンカーおよびその結合体
WO2006101845A2 (en) * 2005-03-16 2006-09-28 Endocyte, Inc. Synthesis and purification of pteroic acid and conjugates thereof
JP2009504783A (ja) 2005-08-19 2009-02-05 エンドサイト，インコーポレイテッド ビンカアルカロイド、類似体および誘導体のリガンド結合体
EP2374480A3 (en) 2005-08-19 2013-05-01 Endocyte, Inc. Mutli-drug ligand conjugates
US20100087370A1 (en) * 2007-02-14 2010-04-08 The General Hospital Corporation Modulation of nitric oxide signaling to normalize tumor vasculature
US20100104626A1 (en) * 2007-02-16 2010-04-29 Endocyte, Inc. Methods and compositions for treating and diagnosing kidney disease
NZ580132A (en) * 2007-03-14 2012-11-30 Endocyte Inc Binding ligand linked drug delivery conjugates of tubulysins to vitamins
CN104383553A (zh) 2007-06-25 2015-03-04 恩多塞特公司 含有亲水性间隔区接头的共轭物
US9877965B2 (en) 2007-06-25 2018-01-30 Endocyte, Inc. Vitamin receptor drug delivery conjugates for treating inflammation
WO2009055562A1 (en) * 2007-10-25 2009-04-30 Endocyte, Inc. Tubulysins and processes for preparing
ES2574032T3 (es) * 2009-09-07 2016-06-14 Nipro Patch Co., Ltd. Preparación absorbible por vía transdérmica
US10080805B2 (en) 2012-02-24 2018-09-25 Purdue Research Foundation Cholecystokinin B receptor targeting for imaging and therapy
US20140080175A1 (en) 2012-03-29 2014-03-20 Endocyte, Inc. Processes for preparing tubulysin derivatives and conjugates thereof
JP2015536323A (ja) 2012-10-16 2015-12-21 エンドサイト・インコーポレイテッドＥｎｄｏｃｙｔｅ， Ｉｎｃ． 非天然アミノ酸を含む薬物送達結合体および使用方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3097137A (en) * 1960-05-19 1963-07-09 Canadian Patents Dev Vincaleukoblastine
US3205220A (en) * 1961-10-26 1965-09-07 Lilly Co Eli Leurosidine and leurocristine and their production
US3392173A (en) * 1964-03-09 1968-07-09 Lilly Co Eli Novel acyl derivatives of desacetyl-vincaleukoblastine and processes for their preparation
US3370057A (en) * 1964-04-27 1968-02-20 Lilly Co Eli Leurosine
US3387001A (en) * 1964-10-19 1968-06-04 Lilly Co Eli Novel aminoacyl esters of desacetyl vincaleukoblastine
US3887565A (en) * 1974-05-06 1975-06-03 Lilly Co Eli Vincadioline
US3890325A (en) * 1974-05-15 1975-06-17 Lilly Co Eli Leurocolombine
US3954773A (en) * 1974-11-21 1976-05-04 Eli Lilly And Company 4-Desacetoxyvinblastine
US3944554A (en) * 1975-01-09 1976-03-16 Eli Lilly And Company 4-Desacetoxy-3-hydroxyvinblastine
IL48685A (en) 1975-01-09 1980-03-31 Lilly Co Eli Amides of vincadioline and vinblastine
US4029663A (en) * 1975-07-10 1977-06-14 Eli Lilly And Company Dimeric anhydro-vinca derivatives
US4115388A (en) * 1977-03-30 1978-09-19 Eli Lilly And Company 3'-Oxygenated derivatives of 4'-deoxy VLB "A" and "B" and related 1-formyl compounds

Also Published As

Publication number Publication date
SU1225490A3 (ru) 1986-04-15
AR228940A1 (es) 1983-05-13
AU527109B2 (en) 1983-02-17
BE875652A (fr) 1979-10-18
AT369010B (de) 1982-11-25
ZA791856B (en) 1980-11-26
CH643269A5 (fr) 1984-05-30
RO81037B (ro) 1983-01-30
DK160679A (da) 1979-10-21
DD143075A5 (de) 1980-07-30
GR69987B (enExample) 1982-07-22
PL125470B1 (en) 1983-05-31
CS218584B2 (en) 1983-02-25
RO80084A (ro) 1983-02-01
DE2964130D1 (en) 1983-01-05
DK147484B (da) 1984-08-27
BG33297A3 (bg) 1983-01-14
PL215911A1 (enExample) 1980-03-24
PL119416B1 (en) 1981-12-31
FI791286A7 (fi) 1981-01-01
ES479754A1 (es) 1980-08-16
HU181431B (en) 1983-07-28
FR2423495A1 (fr) 1979-11-16
EP0005051B1 (en) 1982-12-01
LU81166A1 (fr) 1979-09-07
SU1061698A3 (ru) 1983-12-15
BG33294A3 (bg) 1983-01-14
IE790795L (en) 1979-10-20
RO80084B (ro) 1983-01-30
RO81037A (ro) 1983-02-01
NZ190213A (en) 1982-12-21
RO81114A (ro) 1983-02-01
ATA291279A (de) 1982-04-15
DK147484C (da) 1985-03-25
YU93179A (en) 1983-01-21
EG14867A (en) 1986-09-30
BG33296A3 (bg) 1983-01-14
CA1097629A (en) 1981-03-17
CS218583B2 (en) 1983-02-25
IE48213B1 (en) 1984-10-31
IL57168A0 (en) 1979-07-25
CS218585B2 (en) 1983-02-25
AU4609779A (en) 1979-10-25
PH14163A (en) 1981-03-19
JPS6245873B2 (enExample) 1987-09-29
ES479753A1 (es) 1980-08-16
FR2423495B1 (enExample) 1983-02-11
EP0005051A1 (en) 1979-10-31
RO81114B (ro) 1983-01-30
GB2019396A (en) 1979-10-31
IL57168A (en) 1983-10-31
GB2019396B (en) 1982-09-15
PT69496A (en) 1979-05-01
SU893135A3 (ru) 1981-12-23
US4166810A (en) 1979-09-04

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