FR2423495B1 - - Google Patents

Info

Publication number
FR2423495B1
FR2423495B1 FR7909874A FR7909874A FR2423495B1 FR 2423495 B1 FR2423495 B1 FR 2423495B1 FR 7909874 A FR7909874 A FR 7909874A FR 7909874 A FR7909874 A FR 7909874A FR 2423495 B1 FR2423495 B1 FR 2423495B1
Authority
FR
France
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR7909874A
Other languages
French (fr)
Other versions
FR2423495A1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of FR2423495A1 publication Critical patent/FR2423495A1/fr
Application granted granted Critical
Publication of FR2423495B1 publication Critical patent/FR2423495B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
FR7909874A 1978-04-20 1979-04-19 Derives anti-tumoraux de carboxhydrazide en c-3 de la 4-desacetyl vincaleublastine Granted FR2423495A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/899,032 US4166810A (en) 1978-04-20 1978-04-20 Derivatives of 4-desacetyl VLB C-3 carboxyhydrazide

Publications (2)

Publication Number Publication Date
FR2423495A1 FR2423495A1 (fr) 1979-11-16
FR2423495B1 true FR2423495B1 (enExample) 1983-02-11

Family

ID=25410402

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7909874A Granted FR2423495A1 (fr) 1978-04-20 1979-04-19 Derives anti-tumoraux de carboxhydrazide en c-3 de la 4-desacetyl vincaleublastine

Country Status (32)

Country Link
US (1) US4166810A (enExample)
EP (1) EP0005051B1 (enExample)
JP (1) JPS54141798A (enExample)
AR (1) AR228940A1 (enExample)
AT (1) AT369010B (enExample)
AU (1) AU527109B2 (enExample)
BE (1) BE875652A (enExample)
BG (3) BG33294A3 (enExample)
CA (1) CA1097629A (enExample)
CH (1) CH643269A5 (enExample)
CS (3) CS218583B2 (enExample)
DD (1) DD143075A5 (enExample)
DE (1) DE2964130D1 (enExample)
DK (1) DK147484C (enExample)
EG (1) EG14867A (enExample)
ES (2) ES479753A1 (enExample)
FI (1) FI791286A7 (enExample)
FR (1) FR2423495A1 (enExample)
GB (1) GB2019396B (enExample)
GR (1) GR69987B (enExample)
HU (1) HU181431B (enExample)
IE (1) IE48213B1 (enExample)
IL (1) IL57168A (enExample)
LU (1) LU81166A1 (enExample)
NZ (1) NZ190213A (enExample)
PH (1) PH14163A (enExample)
PL (3) PL119416B1 (enExample)
PT (1) PT69496A (enExample)
RO (3) RO81114A (enExample)
SU (3) SU893135A3 (enExample)
YU (1) YU93179A (enExample)
ZA (1) ZA791856B (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4322351A (en) * 1980-08-25 1982-03-30 Eli Lilly And Company Antineoplastic 4'-formylamino and 4'-acetylamino VLB, and derivatives thereof
GR79898B (enExample) * 1983-03-30 1984-10-31 Lilly Industries Ltd
US4675400A (en) * 1985-06-17 1987-06-23 Eli Lilly And Company Bifunctional derivatives of 4-desacetyl indole-dihydroindole alkaloids
US4667030A (en) * 1985-06-17 1987-05-19 Eli Lilly And Company Hydrazide succinimide derivatives of antineoplastic indole-dihydroindole alkaloids
US4801688A (en) * 1986-05-27 1989-01-31 Eli Lilly And Company Hydrazone immunoglobulin conjugates
US5043336A (en) * 1990-04-03 1991-08-27 Eli Lilly And Company Cyclic imide derivatives of 4-desacetyl VLB c-3 carboxhydrazide
US5043340A (en) * 1990-04-03 1991-08-27 Eli Lilly And Company Derivatives of 4-desacetyl VLB C-3 carboxhydrazide
DE60231868D1 (de) * 2001-04-24 2009-05-20 Purdue Research Foundation Folat-mimetika und deren folatrezeptorbindende konjugate
DE60326833D1 (de) * 2002-05-15 2009-05-07 Endocyte Inc Vitamin-mitomycin-konjugate
TWI367096B (en) 2003-01-27 2012-07-01 Endocyte Inc Vitamin-receptor binding drug delivery conjugates and pharmaceutical compositions
WO2006012527A1 (en) 2004-07-23 2006-02-02 Endocyte, Inc. Bivalent linkers and conjugates thereof
CN101175757B (zh) * 2005-03-16 2012-11-14 恩多塞特公司 蝶酸及其缀合物的合成和纯化
US8465724B2 (en) 2005-08-19 2013-06-18 Endocyte, Inc. Multi-drug ligand conjugates
WO2007022493A2 (en) 2005-08-19 2007-02-22 Endocyte, Inc. Ligand conjugates of vinca alkaloids, analogs, and derivatives
WO2008100591A2 (en) * 2007-02-14 2008-08-21 The General Hospital Corporation Modulation of nitric oxide signaling to normalize tumor vasculature
WO2008101231A2 (en) 2007-02-16 2008-08-21 Endocyte, Inc. Methods and compositions for treating and diagnosing kidney disease
EP2489372A3 (en) * 2007-03-14 2013-01-02 Endocyte, Inc. Binding ligand linked drug delivery conjugates of tubulysins
RU2523909C2 (ru) * 2007-06-25 2014-07-27 Эндосайт, Инк. Конъюгаты, содержащие гидрофильные спейсеры линкеров
US9877965B2 (en) 2007-06-25 2018-01-30 Endocyte, Inc. Vitamin receptor drug delivery conjugates for treating inflammation
CN101909441B (zh) * 2007-10-25 2015-05-13 恩多塞特公司 微管蛋白抑制剂及其制备方法
PH12012500472A1 (en) * 2009-09-07 2012-10-22 Nipro Patch Co Ltd Transdermally absorbable preparation
WO2013126797A1 (en) 2012-02-24 2013-08-29 Purdue Research Foundation Cholecystokinin b receptor targeting for imaging and therapy
US20140080175A1 (en) 2012-03-29 2014-03-20 Endocyte, Inc. Processes for preparing tubulysin derivatives and conjugates thereof
IN2015DN04147A (enExample) 2012-10-16 2015-10-16 Endocyte Inc

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3097137A (en) * 1960-05-19 1963-07-09 Canadian Patents Dev Vincaleukoblastine
US3205220A (en) * 1961-10-26 1965-09-07 Lilly Co Eli Leurosidine and leurocristine and their production
US3392173A (en) * 1964-03-09 1968-07-09 Lilly Co Eli Novel acyl derivatives of desacetyl-vincaleukoblastine and processes for their preparation
US3370057A (en) * 1964-04-27 1968-02-20 Lilly Co Eli Leurosine
US3387001A (en) * 1964-10-19 1968-06-04 Lilly Co Eli Novel aminoacyl esters of desacetyl vincaleukoblastine
US3887565A (en) * 1974-05-06 1975-06-03 Lilly Co Eli Vincadioline
US3890325A (en) * 1974-05-15 1975-06-17 Lilly Co Eli Leurocolombine
US3954773A (en) * 1974-11-21 1976-05-04 Eli Lilly And Company 4-Desacetoxyvinblastine
US3944554A (en) * 1975-01-09 1976-03-16 Eli Lilly And Company 4-Desacetoxy-3-hydroxyvinblastine
IL48685A (en) * 1975-01-09 1980-03-31 Lilly Co Eli Amides of vincadioline and vinblastine
US4029663A (en) * 1975-07-10 1977-06-14 Eli Lilly And Company Dimeric anhydro-vinca derivatives
US4115388A (en) * 1977-03-30 1978-09-19 Eli Lilly And Company 3'-Oxygenated derivatives of 4'-deoxy VLB "A" and "B" and related 1-formyl compounds

Also Published As

Publication number Publication date
ZA791856B (en) 1980-11-26
BG33296A3 (bg) 1983-01-14
RO81037B (ro) 1983-01-30
CS218585B2 (en) 1983-02-25
GB2019396B (en) 1982-09-15
IE790795L (en) 1979-10-20
ATA291279A (de) 1982-04-15
PL125470B1 (en) 1983-05-31
ES479753A1 (es) 1980-08-16
GB2019396A (en) 1979-10-31
IL57168A0 (en) 1979-07-25
BE875652A (fr) 1979-10-18
AU527109B2 (en) 1983-02-17
DD143075A5 (de) 1980-07-30
AR228940A1 (es) 1983-05-13
PL119416B1 (en) 1981-12-31
FI791286A7 (fi) 1981-01-01
PL215911A1 (enExample) 1980-03-24
BG33294A3 (bg) 1983-01-14
SU893135A3 (ru) 1981-12-23
BG33297A3 (bg) 1983-01-14
DE2964130D1 (en) 1983-01-05
RO81037A (ro) 1983-02-01
HU181431B (en) 1983-07-28
YU93179A (en) 1983-01-21
LU81166A1 (fr) 1979-09-07
AU4609779A (en) 1979-10-25
RO81114A (ro) 1983-02-01
IL57168A (en) 1983-10-31
ES479754A1 (es) 1980-08-16
DK160679A (da) 1979-10-21
SU1225490A3 (ru) 1986-04-15
DK147484B (da) 1984-08-27
NZ190213A (en) 1982-12-21
PH14163A (en) 1981-03-19
US4166810A (en) 1979-09-04
IE48213B1 (en) 1984-10-31
CH643269A5 (fr) 1984-05-30
AT369010B (de) 1982-11-25
JPS6245873B2 (enExample) 1987-09-29
EP0005051B1 (en) 1982-12-01
RO80084A (ro) 1983-02-01
SU1061698A3 (ru) 1983-12-15
JPS54141798A (en) 1979-11-05
GR69987B (enExample) 1982-07-22
FR2423495A1 (fr) 1979-11-16
RO80084B (ro) 1983-01-30
EG14867A (en) 1986-09-30
CS218583B2 (en) 1983-02-25
CA1097629A (en) 1981-03-17
DK147484C (da) 1985-03-25
PT69496A (en) 1979-05-01
CS218584B2 (en) 1983-02-25
EP0005051A1 (en) 1979-10-31
RO81114B (ro) 1983-01-30

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Legal Events

Date Code Title Description
ST Notification of lapse
ST Notification of lapse