JPS54139794A - Method and composite substance for analyzing protein bond - Google Patents

Method and composite substance for analyzing protein bond

Info

Publication number
JPS54139794A
JPS54139794A JP4154779A JP4154779A JPS54139794A JP S54139794 A JPS54139794 A JP S54139794A JP 4154779 A JP4154779 A JP 4154779A JP 4154779 A JP4154779 A JP 4154779A JP S54139794 A JPS54139794 A JP S54139794A
Authority
JP
Japan
Prior art keywords
analyzing protein
composite substance
protein bond
bond
composite
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP4154779A
Other languages
English (en)
Other versions
JPH0114541B2 (ja
Inventor
Jiei Ritoman Deebitsudo
Hareru Jibi
Efu Uruman Edouin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syva Co
Original Assignee
Syva Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/893,650 external-priority patent/US4233402A/en
Priority claimed from US05/964,099 external-priority patent/US4275149A/en
Application filed by Syva Co filed Critical Syva Co
Publication of JPS54139794A publication Critical patent/JPS54139794A/ja
Publication of JPH0114541B2 publication Critical patent/JPH0114541B2/ja
Granted legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/581—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with enzyme label (including co-enzymes, co-factors, enzyme inhibitors or substrates)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP4154779A 1978-04-05 1979-04-05 Method and composite substance for analyzing protein bond Granted JPS54139794A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/893,650 US4233402A (en) 1978-04-05 1978-04-05 Reagents and method employing channeling
US05/964,099 US4275149A (en) 1978-11-24 1978-11-24 Macromolecular environment control in specific receptor assays

Publications (2)

Publication Number Publication Date
JPS54139794A true JPS54139794A (en) 1979-10-30
JPH0114541B2 JPH0114541B2 (ja) 1989-03-13

Family

ID=27129059

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4154779A Granted JPS54139794A (en) 1978-04-05 1979-04-05 Method and composite substance for analyzing protein bond

Country Status (13)

Country Link
EP (1) EP0022768B1 (ja)
JP (1) JPS54139794A (ja)
AU (1) AU531777B2 (ja)
CA (1) CA1140033A (ja)
DE (2) DE2966245D1 (ja)
ES (1) ES479278A1 (ja)
FR (1) FR2435716B1 (ja)
GB (1) GB2019562B (ja)
IL (1) IL57042A (ja)
IT (1) IT1198432B (ja)
NL (1) NL7902663A (ja)
SE (1) SE444086B (ja)
WO (1) WO1979000882A1 (ja)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5692218A (en) * 1979-12-26 1981-07-25 Syva Co Immunoassay
JPS57103055A (en) * 1980-10-30 1982-06-26 Miles Lab Analysis of homogeneous peculiar bond and apparatus used therefor
JPS5862562A (ja) * 1981-09-18 1983-04-14 シバ・カンパニ− 非多孔性表面上での均一系分析法
JPS5877843U (ja) * 1981-11-20 1983-05-26 株式会社三協精機製作所 テ−プレコ−ダ
JPS60179657A (ja) * 1983-12-12 1985-09-13 マイルス・ラボラトリ−ズ・インコ−ポレ−テツド 標識プロ−ブ及び抗−ハイブリツドを用いるハイブリツド形成分析法
JPH01123148A (ja) * 1987-11-07 1989-05-16 Shinotesuto Kenkyusho:Kk 均一系による特異的結合部位を有する物質の測定法
JPH0617909B2 (ja) * 1984-04-23 1994-03-09 ボストン バイオメディカル リサーチ インスティテュート，インコーポレイテッド 双特異性抗体決定子

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4486530A (en) * 1980-08-04 1984-12-04 Hybritech Incorporated Immunometric assays using monoclonal antibodies
US4366241A (en) * 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
IL64574A (en) * 1981-04-27 1986-01-31 Syva Co Method for determining the presence of an analyte by determination of the amount of fluorescence in competitive protein binding assays
US4442218A (en) * 1981-05-27 1984-04-10 Corning Glass Works Method of measuring degree of partitioning
JPS58209994A (ja) * 1982-05-10 1983-12-07 Fujirebio Inc 活性蛋白等固定化物を用いた抗原の測定方法
US4435504A (en) * 1982-07-15 1984-03-06 Syva Company Immunochromatographic assay with support having bound "MIP" and second enzyme
US4687735A (en) * 1983-03-14 1987-08-18 Syntex (U.S.A.) Inc. Enzymatic poly-reactant channeling binding assay
GB2136565B (en) * 1983-03-15 1986-05-08 Boots Celltech Diagnostics Heterogeneous binding assay
GB8307156D0 (en) * 1983-03-15 1983-04-20 Celltech Ltd Heterogeneous binding assays
US4550075A (en) * 1983-06-22 1985-10-29 Kallestad Laboratories, Inc. Method for ligand determination utilizing an immunoassay monitorable by biotin-containing enzymes, and compositions therefor
US4560648A (en) * 1983-09-23 1985-12-24 Syntex (U.S.A.) Inc. Homogeneous enzyme immunoassay for ferritin
US4578350A (en) * 1983-09-23 1986-03-25 Syntex (U.S.A.) Inc. Immunoassays employing protected labels
US4717654A (en) * 1984-06-19 1988-01-05 Akzo N.V. Process for solid phase platelet antibody assay
GB8423227D0 (en) * 1984-09-14 1984-10-17 Unilever Plc Materials for specific binding assays
FR2585836B1 (fr) * 1985-08-02 1987-11-27 Commissariat Energie Atomique Procede homogene de detection et/ou de determination par luminescence d'un analyte dans un milieu susceptible de le contenir
DE3541033A1 (de) * 1985-11-19 1987-05-21 Boehringer Mannheim Gmbh Verfahren zur quantifizierung von zellpopulationen bzw. subpopulationen sowie hierfuer geeignetes reagenz
JPH01500059A (ja) * 1986-05-22 1989-01-12 ユニリーバー・ナームローゼ・ベンノートシヤープ アッセイ
IL85597A (en) * 1987-05-18 1992-08-18 Technicon Instr Immunoassay method and composition using conjugate of analyte and reaction intermediate for analyte capable of mediating signal generation
US4943525A (en) * 1987-11-02 1990-07-24 Bioventures, Inc. Simultaneous immunoassay for the determination of antigens and antibodies
CA2019711A1 (en) * 1989-06-28 1990-12-28 Takashi Ikegami Sensitization of assays
GB2236852B (en) * 1989-09-25 1994-04-06 Scotgen Ltd DNA probe based assays and intermediates useful in the synthesis of cleavable nucleic acids for use in such assays
JPH0534345A (ja) * 1991-02-19 1993-02-09 Tdk Corp 化学発光を利用する抗原・抗体の測定方法
JP2683172B2 (ja) * 1991-10-01 1997-11-26 キヤノン株式会社 検体測定方法及び検体測定装置
USRE38525E1 (en) * 1998-07-03 2004-06-08 Torsana Diabetes Diagnostics A/S Optical sensor for in situ measurement of analytes
GB9814506D0 (en) * 1998-07-03 1998-09-02 Stanley Christopher J Optical sensor for insitu measurement of analytes
EP1542014B1 (en) 1998-07-03 2006-10-18 Precisense A/S Optical sensor for in situ measurement of analytes

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS50894A (ja) * 1973-04-28 1975-01-07
JPS5282723A (en) * 1975-12-02 1977-07-11 Pasteur Institut Production of magnetic gell for preparing immune enzyme

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3169956A (en) * 1962-04-17 1965-02-16 Ferrania Spa Sucrose organo-phosphorus ester and method of preparing it
US3652761A (en) * 1969-09-04 1972-03-28 Corning Glass Works Immunochemical composites and antigen or antibody purification therewith
NL154599B (nl) * 1970-12-28 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen, alsmede testverpakking.
US3690834A (en) * 1971-01-11 1972-09-12 Syva Co Ligand determination with spin labeled compounds by receptor displacement
US4118349A (en) * 1971-05-12 1978-10-03 Behringwerke Aktiengesellschaft Process for the manufacture of polystyrene latex compounds
US3817837A (en) * 1971-05-14 1974-06-18 Syva Corp Enzyme amplification assay
US3852157A (en) * 1971-05-14 1974-12-03 Syva Corp Compounds for enzyme amplification assay
US3853987A (en) * 1971-09-01 1974-12-10 W Dreyer Immunological reagent and radioimmuno assay
US3826613A (en) * 1973-03-06 1974-07-30 Us Navy Detection and titration of viruses and antibodies using latex
DE2440367C2 (de) * 1973-08-30 1984-03-15 General Electric Co., Schenectady, N.Y. Verfahren zum Herstellen multimolekularer Schichten aus immunologisch komplexierten Proteinen auf einem Substrat
US3951748A (en) * 1974-11-11 1976-04-20 Medical Products, Inc. Sensitized matrix for detection of disease
SE388694B (sv) * 1975-01-27 1976-10-11 Kabi Ab Sett att pavisa ett antigen exv i prov av kroppvetskor, med utnyttjande av till porost berarmaterial bundna eller adsorberande antikroppar
IN142734B (ja) * 1975-04-28 1977-08-20 Miles Lab
US4181650A (en) * 1975-08-25 1980-01-01 Maier Charles L Jr Procedure for the assay of pharmacologically immunologically and biochemically active compounds in biological fluids
US4080264A (en) * 1976-03-01 1978-03-21 Massachusetts Institute Of Technology Immunoassay by light scattering spectroscopy
GB1572220A (en) * 1976-10-07 1980-07-30 Mochida Pharm Co Ltd Immunochemical process of measuring physiologically active substances
US4134792A (en) * 1976-12-06 1979-01-16 Miles Laboratories, Inc. Specific binding assay with an enzyme modulator as a labeling substance
US4130462A (en) * 1976-12-16 1978-12-19 Syva Company Receptor steric hindrance immunoassay for receptor determination

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS50894A (ja) * 1973-04-28 1975-01-07
JPS5282723A (en) * 1975-12-02 1977-07-11 Pasteur Institut Production of magnetic gell for preparing immune enzyme

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5692218A (en) * 1979-12-26 1981-07-25 Syva Co Immunoassay
JPS6312260B2 (ja) * 1979-12-26 1988-03-18 Syva Co
JPS57103055A (en) * 1980-10-30 1982-06-26 Miles Lab Analysis of homogeneous peculiar bond and apparatus used therefor
JPH0235261B2 (ja) * 1980-10-30 1990-08-09 Miles Inc
JPS5862562A (ja) * 1981-09-18 1983-04-14 シバ・カンパニ− 非多孔性表面上での均一系分析法
JPH038513B2 (ja) * 1981-09-18 1991-02-06 Syva Co
JPS5877843U (ja) * 1981-11-20 1983-05-26 株式会社三協精機製作所 テ−プレコ−ダ
JPH0210590Y2 (ja) * 1981-11-20 1990-03-15
JPS60179657A (ja) * 1983-12-12 1985-09-13 マイルス・ラボラトリ−ズ・インコ−ポレ−テツド 標識プロ−ブ及び抗−ハイブリツドを用いるハイブリツド形成分析法
JPS60201256A (ja) * 1983-12-12 1985-10-11 マイルス・ラボラトリ−ズ・インコ−ポレ−テツド 特定のポリヌクレオチド配列の検出方法、検出用試薬系及び試験キツト
JPH0617909B2 (ja) * 1984-04-23 1994-03-09 ボストン バイオメディカル リサーチ インスティテュート，インコーポレイテッド 双特異性抗体決定子
JPH01123148A (ja) * 1987-11-07 1989-05-16 Shinotesuto Kenkyusho:Kk 均一系による特異的結合部位を有する物質の測定法

Also Published As

Publication number Publication date
FR2435716A1 (fr) 1980-04-04
IL57042A0 (en) 1979-07-25
EP0022768B1 (en) 1983-10-05
NL7902663A (nl) 1979-10-09
SE444086B (sv) 1986-03-17
GB2019562B (en) 1983-03-30
DE2966245D1 (en) 1983-11-10
ES479278A1 (es) 1979-12-01
GB2019562A (en) 1979-10-31
IT7948641A0 (it) 1979-04-05
SE7910042L (sv) 1979-12-05
CA1140033A (en) 1983-01-25
EP0022768A1 (en) 1981-01-28
JPH0114541B2 (ja) 1989-03-13
WO1979000882A1 (en) 1979-11-01
FR2435716B1 (fr) 1986-02-21
IT1198432B (it) 1988-12-21
DE2913551A1 (de) 1979-10-25
EP0022768A4 (en) 1980-08-18
AU4562979A (en) 1979-10-11
AU531777B2 (en) 1983-09-08
IL57042A (en) 1982-07-30

Similar Documents

Publication Publication Date Title
JPS54139794A (en) Method and composite substance for analyzing protein bond
AU560552B2 (en) Quantitative analysis apparatus and method
JPS5267388A (en) Method and reagent for analyzing specific bonding in nonnuniform system
GB2029012B (en) Method and apparatus for analyzing whole blood samples
DE3377018D1 (en) Method and apparatus for clinical analysis
GB2026430B (en) Method and apparatus for bonding components together
GB2102810B (en) Human interferon-related peptides antigens antibodies and process for preparing the same
JPS5779887A (en) Improved composite substance
JPS5534087A (en) Enzyme composite * method and use
JPS53108904A (en) Reagent for concurrent protein bond analyzing method
JPS5526896A (en) Method and reagent for determining edenosinephosphate
GB2024647B (en) Chromatographic method and appartus
GB2019910B (en) Sliding-clasp fstener stringer and method for its manufacture
JPS54125252A (en) Method and apparatus for blending and injectionnmolding composite resins
JPS55124072A (en) Stable calibrator composite substance and making method thereof
JPS5369824A (en) Analysis for immune composite substance
JPS53130692A (en) Reagent using in concurrent protein bond analyzing method method of preparing same and using method
ES531436A0 (es) Procedimiento de obtener y aislar hibridomas secretores de anticuerpos, procedimiento de obtener anticuerpos y metodo de obtener polipeptidos
JPS57179730A (en) Light-radiation competition protein combining analyzing method
JPS54127396A (en) Method of analyzing sample solution depending on prepared state of sample contained in solution
JPS54163929A (en) Method and apparatus for bonding assembly parts
JPS54132892A (en) Antifriction particle bonding method
JPS54137399A (en) Method and device for analyzing quantity of protein by immunological electrophoresis
JPS5526485A (en) Method and composition for detecting human
EP0104258A4 (en) STICK FOR CHROMATOGRAPHY AND METHOD FOR DEVELOPING A SAMPLE USING THE SAME.