FR2435716A1 - Procede et composition pour le dosage immunologique, a l'aide d'un conjugue particulaire solide dispersable, d'un compose organique ou du recepteur correspondant - Google Patents

Procede et composition pour le dosage immunologique, a l'aide d'un conjugue particulaire solide dispersable, d'un compose organique ou du recepteur correspondant

Info

Publication number
FR2435716A1
FR2435716A1 FR7908534A FR7908534A FR2435716A1 FR 2435716 A1 FR2435716 A1 FR 2435716A1 FR 7908534 A FR7908534 A FR 7908534A FR 7908534 A FR7908534 A FR 7908534A FR 2435716 A1 FR2435716 A1 FR 2435716A1
Authority
FR
France
Prior art keywords
composition
dispersable
solid
organic compound
receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7908534A
Other languages
English (en)
Other versions
FR2435716B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syva Co
Original Assignee
Syva Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/893,650 external-priority patent/US4233402A/en
Priority claimed from US05/964,099 external-priority patent/US4275149A/en
Application filed by Syva Co filed Critical Syva Co
Publication of FR2435716A1 publication Critical patent/FR2435716A1/fr
Application granted granted Critical
Publication of FR2435716B1 publication Critical patent/FR2435716B1/fr
Expired legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/581—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with enzyme label (including co-enzymes, co-factors, enzyme inhibitors or substrates)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Procédé et composition pour le dosage immunologijue, à l'aide d'un conjugué particulaire solide dispersable, d'un ligand et/ou de son récepteur. Le procédé utilise un marqueur conjugué à un membre de la paire homologue (ligand et son récepteur) et une phase discontinue de particules distinctes uniformément dispersées dans une phase aqueuse continue. Les particules créent des micro-environnements permettant une distinction entre le marqueur associé à la particule, en phase discontinue, et le marqueur se trouvant dans la phase continue. Application : dosages spectro-photométriques d'un poly-(amino-acide) comme une gamma-globuline, pour un examen de santé ou l'étude d'un processus physiologique.
FR7908534A 1978-04-05 1979-04-04 Procede et composition pour le dosage immunologique, a l'aide d'un conjugue particulaire solide dispersable, d'un compose organique ou du recepteur correspondant Expired FR2435716B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/893,650 US4233402A (en) 1978-04-05 1978-04-05 Reagents and method employing channeling
US05/964,099 US4275149A (en) 1978-11-24 1978-11-24 Macromolecular environment control in specific receptor assays

Publications (2)

Publication Number Publication Date
FR2435716A1 true FR2435716A1 (fr) 1980-04-04
FR2435716B1 FR2435716B1 (fr) 1986-02-21

Family

ID=27129059

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7908534A Expired FR2435716B1 (fr) 1978-04-05 1979-04-04 Procede et composition pour le dosage immunologique, a l'aide d'un conjugue particulaire solide dispersable, d'un compose organique ou du recepteur correspondant

Country Status (13)

Country Link
EP (1) EP0022768B1 (fr)
JP (1) JPS54139794A (fr)
AU (1) AU531777B2 (fr)
CA (1) CA1140033A (fr)
DE (2) DE2966245D1 (fr)
ES (1) ES479278A1 (fr)
FR (1) FR2435716B1 (fr)
GB (1) GB2019562B (fr)
IL (1) IL57042A (fr)
IT (1) IT1198432B (fr)
NL (1) NL7902663A (fr)
SE (1) SE444086B (fr)
WO (1) WO1979000882A1 (fr)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4299916A (en) * 1979-12-26 1981-11-10 Syva Company Preferential signal production on a surface in immunoassays
US4486530A (en) * 1980-08-04 1984-12-04 Hybritech Incorporated Immunometric assays using monoclonal antibodies
US4366241A (en) * 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
CA1183450A (fr) * 1980-10-30 1985-03-05 Alfred C. Greenquist Dispositif et methode d'essai de liaison specifique homogene
IL64574A (en) * 1981-04-27 1986-01-31 Syva Co Method for determining the presence of an analyte by determination of the amount of fluorescence in competitive protein binding assays
US4442218A (en) * 1981-05-27 1984-04-10 Corning Glass Works Method of measuring degree of partitioning
CA1209889A (fr) * 1981-09-18 1986-08-19 Litai Weng Essai homogene sur une surface non poreuse
JPS5877843U (ja) * 1981-11-20 1983-05-26 株式会社三協精機製作所 テ−プレコ−ダ
JPS58209994A (ja) * 1982-05-10 1983-12-07 Fujirebio Inc 活性蛋白等固定化物を用いた抗原の測定方法
US4435504A (en) * 1982-07-15 1984-03-06 Syva Company Immunochromatographic assay with support having bound "MIP" and second enzyme
US4687735A (en) * 1983-03-14 1987-08-18 Syntex (U.S.A.) Inc. Enzymatic poly-reactant channeling binding assay
GB8307156D0 (en) * 1983-03-15 1983-04-20 Celltech Ltd Heterogeneous binding assays
GB2136565B (en) * 1983-03-15 1986-05-08 Boots Celltech Diagnostics Heterogeneous binding assay
US4550075A (en) * 1983-06-22 1985-10-29 Kallestad Laboratories, Inc. Method for ligand determination utilizing an immunoassay monitorable by biotin-containing enzymes, and compositions therefor
US4578350A (en) * 1983-09-23 1986-03-25 Syntex (U.S.A.) Inc. Immunoassays employing protected labels
US4560648A (en) * 1983-09-23 1985-12-24 Syntex (U.S.A.) Inc. Homogeneous enzyme immunoassay for ferritin
ZA849595B (en) * 1983-12-12 1985-07-31 Miles Lab Hybridization assay employing labeled probe and anti-hybrid
ATE64622T1 (de) * 1984-04-23 1991-07-15 Boston Biomed Res Inst Doppelspezifische antikoerper-determinanten.
US4717654A (en) * 1984-06-19 1988-01-05 Akzo N.V. Process for solid phase platelet antibody assay
GB8423227D0 (en) * 1984-09-14 1984-10-17 Unilever Plc Materials for specific binding assays
FR2585836B1 (fr) * 1985-08-02 1987-11-27 Commissariat Energie Atomique Procede homogene de detection et/ou de determination par luminescence d'un analyte dans un milieu susceptible de le contenir
DE3541033A1 (de) * 1985-11-19 1987-05-21 Boehringer Mannheim Gmbh Verfahren zur quantifizierung von zellpopulationen bzw. subpopulationen sowie hierfuer geeignetes reagenz
JPH01500059A (ja) * 1986-05-22 1989-01-12 ユニリーバー・ナームローゼ・ベンノートシヤープ アッセイ
IL85597A (en) * 1987-05-18 1992-08-18 Technicon Instr Immunoassay method and composition using conjugate of analyte and reaction intermediate for analyte capable of mediating signal generation
US4943525A (en) * 1987-11-02 1990-07-24 Bioventures, Inc. Simultaneous immunoassay for the determination of antigens and antibodies
JP2607102B2 (ja) * 1987-11-07 1997-05-07 株式会社シノテスト 均一系による特異的結合部位を有する物質の測定法
CA2019711A1 (fr) * 1989-06-28 1990-12-28 Takashi Ikegami Sensibilisation des methodes d'essai
GB2236852B (en) * 1989-09-25 1994-04-06 Scotgen Ltd DNA probe based assays and intermediates useful in the synthesis of cleavable nucleic acids for use in such assays
JPH0534345A (ja) * 1991-02-19 1993-02-09 Tdk Corp 化学発光を利用する抗原・抗体の測定方法
JP2683172B2 (ja) * 1991-10-01 1997-11-26 キヤノン株式会社 検体測定方法及び検体測定装置
GB9814506D0 (en) * 1998-07-03 1998-09-02 Stanley Christopher J Optical sensor for insitu measurement of analytes
USRE38525E1 (en) * 1998-07-03 2004-06-08 Torsana Diabetes Diagnostics A/S Optical sensor for in situ measurement of analytes
EP1542014B1 (fr) 1998-07-03 2006-10-18 Precisense A/S Capteur optique pour la mesure in situ d'analytes

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2121723A1 (fr) * 1971-01-11 1972-08-25 Synvar Ass
US3839153A (en) * 1970-12-28 1974-10-01 Akzona Inc Process for the detection and determination of specific binding proteins and their corresponding bindable substances
FR2257259A1 (fr) * 1973-08-30 1975-08-08 Gen Electric
FR2332533A1 (fr) * 1975-04-28 1977-06-17 Miles Lab Composition et procede de fixation specifique pour la detection d'un ligand dans un milieu liquide
GB1502563A (en) * 1975-01-27 1978-03-01 Kabi Ab Diagnostic devices for immuno-chemical quantification

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3169956A (en) * 1962-04-17 1965-02-16 Ferrania Spa Sucrose organo-phosphorus ester and method of preparing it
US3652761A (en) * 1969-09-04 1972-03-28 Corning Glass Works Immunochemical composites and antigen or antibody purification therewith
US4118349A (en) * 1971-05-12 1978-10-03 Behringwerke Aktiengesellschaft Process for the manufacture of polystyrene latex compounds
US3852157A (en) * 1971-05-14 1974-12-03 Syva Corp Compounds for enzyme amplification assay
US3817837A (en) * 1971-05-14 1974-06-18 Syva Corp Enzyme amplification assay
US3853987A (en) * 1971-09-01 1974-12-10 W Dreyer Immunological reagent and radioimmuno assay
US3826613A (en) * 1973-03-06 1974-07-30 Us Navy Detection and titration of viruses and antibodies using latex
JPS50894A (fr) * 1973-04-28 1975-01-07
US3951748A (en) * 1974-11-11 1976-04-20 Medical Products, Inc. Sensitized matrix for detection of disease
US4181650A (en) * 1975-08-25 1980-01-01 Maier Charles L Jr Procedure for the assay of pharmacologically immunologically and biochemically active compounds in biological fluids
FR2334106A1 (fr) * 1975-12-02 1977-07-01 Pasteur Institut Gel magnetique convenant pour dosages immunoenzymatiques
US4080264A (en) * 1976-03-01 1978-03-21 Massachusetts Institute Of Technology Immunoassay by light scattering spectroscopy
GB1572220A (en) * 1976-10-07 1980-07-30 Mochida Pharm Co Ltd Immunochemical process of measuring physiologically active substances
US4134792A (en) * 1976-12-06 1979-01-16 Miles Laboratories, Inc. Specific binding assay with an enzyme modulator as a labeling substance
US4130462A (en) * 1976-12-16 1978-12-19 Syva Company Receptor steric hindrance immunoassay for receptor determination

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3839153A (en) * 1970-12-28 1974-10-01 Akzona Inc Process for the detection and determination of specific binding proteins and their corresponding bindable substances
FR2121723A1 (fr) * 1971-01-11 1972-08-25 Synvar Ass
FR2257259A1 (fr) * 1973-08-30 1975-08-08 Gen Electric
GB1502563A (en) * 1975-01-27 1978-03-01 Kabi Ab Diagnostic devices for immuno-chemical quantification
FR2332533A1 (fr) * 1975-04-28 1977-06-17 Miles Lab Composition et procede de fixation specifique pour la detection d'un ligand dans un milieu liquide

Also Published As

Publication number Publication date
FR2435716B1 (fr) 1986-02-21
IL57042A (en) 1982-07-30
IT7948641A0 (it) 1979-04-05
EP0022768A4 (fr) 1980-08-18
JPS54139794A (en) 1979-10-30
AU531777B2 (en) 1983-09-08
DE2966245D1 (en) 1983-11-10
EP0022768B1 (fr) 1983-10-05
GB2019562B (en) 1983-03-30
DE2913551A1 (de) 1979-10-25
CA1140033A (fr) 1983-01-25
IT1198432B (it) 1988-12-21
GB2019562A (en) 1979-10-31
IL57042A0 (en) 1979-07-25
ES479278A1 (es) 1979-12-01
SE7910042L (sv) 1979-12-05
AU4562979A (en) 1979-10-11
WO1979000882A1 (fr) 1979-11-01
SE444086B (sv) 1986-03-17
JPH0114541B2 (fr) 1989-03-13
EP0022768A1 (fr) 1981-01-28
NL7902663A (nl) 1979-10-09

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