JPS4857993A - - Google Patents

Info

Publication number
JPS4857993A
JPS4857993A JP47115495A JP11549572A JPS4857993A JP S4857993 A JPS4857993 A JP S4857993A JP 47115495 A JP47115495 A JP 47115495A JP 11549572 A JP11549572 A JP 11549572A JP S4857993 A JPS4857993 A JP S4857993A
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP47115495A
Other languages
Japanese (ja)
Other versions
JPS563873B2 (enrdf_load_stackoverflow
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of JPS4857993A publication Critical patent/JPS4857993A/ja
Publication of JPS563873B2 publication Critical patent/JPS563873B2/ja
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP11549572A 1971-11-19 1972-11-17 Expired JPS563873B2 (enrdf_load_stackoverflow)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB5375071A GB1400999A (en) 1971-11-19 1971-11-19 Imidazo-triazine compounds and their use in therapeutic compositions

Publications (2)

Publication Number Publication Date
JPS4857993A true JPS4857993A (enrdf_load_stackoverflow) 1973-08-14
JPS563873B2 JPS563873B2 (enrdf_load_stackoverflow) 1981-01-27

Family

ID=10468856

Family Applications (1)

Application Number Title Priority Date Filing Date
JP11549572A Expired JPS563873B2 (enrdf_load_stackoverflow) 1971-11-19 1972-11-17

Country Status (18)

Country Link
US (1) US3840537A (enrdf_load_stackoverflow)
JP (1) JPS563873B2 (enrdf_load_stackoverflow)
AT (1) AT321923B (enrdf_load_stackoverflow)
AU (1) AU472127B2 (enrdf_load_stackoverflow)
BE (1) BE791025A (enrdf_load_stackoverflow)
CA (1) CA990292A (enrdf_load_stackoverflow)
CH (1) CH594671A5 (enrdf_load_stackoverflow)
DE (1) DE2255172A1 (enrdf_load_stackoverflow)
DK (1) DK138691B (enrdf_load_stackoverflow)
ES (1) ES408736A1 (enrdf_load_stackoverflow)
FR (1) FR2160407B1 (enrdf_load_stackoverflow)
GB (1) GB1400999A (enrdf_load_stackoverflow)
IE (1) IE37046B1 (enrdf_load_stackoverflow)
IL (1) IL40686A (enrdf_load_stackoverflow)
NL (1) NL7215646A (enrdf_load_stackoverflow)
PH (1) PH9669A (enrdf_load_stackoverflow)
SE (1) SE402915B (enrdf_load_stackoverflow)
ZA (1) ZA727532B (enrdf_load_stackoverflow)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017204316A1 (ja) * 2016-05-27 2017-11-30 塩野義製薬株式会社 ５－オキソ－１，２，４－トリアジン誘導体およびその医薬組成物

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1457873A (en) * 1973-01-04 1976-12-08 Allen & Hanburys Ltd Imidazotriazines
DE2314488C3 (de) * 1973-03-23 1979-01-04 C.H. Boehringer Sohn, 6507 Ingelheim 8-(2,6-Dichlorphenyl)-7-(4-chlorphenyl)-5-oxo-233,8-tetrahydro-imidazo [1,2-a] -s-triazin, Verfahren zu dessen Herstellung und dieses enthaltene Arzneimittel
DE2335193A1 (de) * 1973-07-11 1975-01-30 Hoechst Ag Bis-triazinobenzimidazole und ihre herstellung
USRE30511E (en) * 1977-02-03 1981-02-10 American Cyanamid Company Imidazo[1,5-d]-as-triazine-4(3H)-ones and thiones
US4115572A (en) * 1977-02-03 1978-09-19 American Cyanamid Company Imidazo-[1,5-d]-as-triazin-1(2H)-ones and method of ameliorating asthma
US4107307A (en) * 1977-02-03 1978-08-15 American Cyanamid Company Imidazo [1,5-d]-as-triazine-4(3H)-ones and thiones
DK109578A (da) * 1977-03-25 1978-09-26 Allen & Hanburys Ltd Fremgangsmaade til fremstilling af heterocycliske forbindelser
US4107308A (en) * 1977-10-18 1978-08-15 American Cyanamid Company Imidazo[1,5-d]-as-triazines
US4308384A (en) * 1978-09-18 1981-12-29 Glaxo Group Limited Production of triazinones
HU187474B (en) * 1981-11-18 1986-01-28 Gyogyszerkutato Intezet,Hu Process for producing new spiro-pyrazole-square bracket-1,5-d-square bracket closed-square bracket-1,2,4-square bracket closed-triazine derivatives
US4395547A (en) * 1982-02-10 1983-07-26 American Cyanamid Co. Process for preparing 1-substituted-6-n-propyl-8-methylimidazo[1,5-d]-as-triazin-4(3H)-ones
AU622330B2 (en) * 1989-06-23 1992-04-02 Takeda Chemical Industries Ltd. Condensed heterocyclic compounds having a nitrogen atom in the bridgehead for use as fungicides
US6624181B1 (en) * 1997-02-28 2003-09-23 Altana Pharma Ag Synergistic combination
CZ301911B6 (cs) * 1997-11-12 2010-07-28 Bayer Schering Pharma Aktiengesellschaft 2-Fenylsubstituované imidazotriazinony, zpusob jejich výroby, léciva tyto látky obsahující a jejich použití
DE19827640A1 (de) * 1998-06-20 1999-12-23 Bayer Ag 7-Alkyl- und Cycloalkyl-substituierte Imidazotriazinone
AU754379B2 (en) 1998-08-26 2002-11-14 Smithkline Beecham Corporation Therapies for treating pulmonary diseases
JP5038568B2 (ja) * 1999-08-21 2012-10-03 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング 協力剤の組合せ物
EP1392314B1 (de) * 2001-05-09 2006-12-20 Bayer HealthCare AG NEUE VERWENDUNG VON 2-[2-Ethoxy-5-(4-methyl-piperazin-1-sulfonyl)-phenyl]-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-on
GB0113343D0 (en) * 2001-06-01 2001-07-25 Bayer Ag Novel Heterocycles 2
GB0113344D0 (en) * 2001-06-01 2001-07-25 Bayer Ag Novel heterocycles 3
DE10135815A1 (de) 2001-07-23 2003-02-06 Bayer Ag Verwendung von 2-Alkoxyphenyl-substituierten Imidazotriazinonen
DE10232113A1 (de) * 2002-07-16 2004-01-29 Bayer Ag Vardenafil Hydrochlorid Trihydrat enthaltende Arzneimittel
DE602004021363D1 (de) * 2003-04-01 2009-07-16 Smithkline Beecham Corp Imidazotriazin verbindungen zur behandlung von krebserkrankungen
CN1960993A (zh) 2004-04-02 2007-05-09 Osi制药公司 6,6－双环取代的杂双环蛋白激酶抑制剂
DE102005001989A1 (de) * 2005-01-15 2006-07-20 Bayer Healthcare Ag Intravenöse Formulierungen von PDE-Inhibitoren
DE102005009241A1 (de) * 2005-03-01 2006-09-07 Bayer Healthcare Ag Arzneiformen mit kontrollierter Bioverfügbarkeit
DE102005009240A1 (de) * 2005-03-01 2006-09-07 Bayer Healthcare Ag Arzneiformen mit verbesserten pharmakokinetischen Eigenschaften
WO2007039075A2 (en) * 2005-09-29 2007-04-12 Bayer Healthcare Ag Pde inhibitors and combinations thereof for the treatment of urological disorders
RS51843B (en) * 2005-11-17 2012-02-29 Osi Pharmaceuticals Llc. CONDENSED BICYCLIC m TOR INHIBITORS
WO2008151734A1 (en) * 2007-06-13 2008-12-18 Bayer Schering Pharma Aktiengesellschaft Pde inhibitors for the treatment of hearing impairment
WO2010123792A1 (en) 2009-04-20 2010-10-28 Osi Pharmaceuticals, Inc. Preparation of c-pyrazine-methylamines
CN103374002B (zh) * 2012-04-19 2015-07-15 山东轩竹医药科技有限公司 磷酸二酯酶-5抑制剂
JP2018508555A (ja) * 2015-03-16 2018-03-29 大日本住友製薬株式会社 二環性イミダゾロ誘導体
WO2017000276A1 (en) * 2015-07-01 2017-01-05 Merck Sharp & Dohme Corp. Bicyclic heterocyclic compounds as pde2 inhibitors

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017204316A1 (ja) * 2016-05-27 2017-11-30 塩野義製薬株式会社 ５－オキソ－１，２，４－トリアジン誘導体およびその医薬組成物

Also Published As

Publication number Publication date
CH594671A5 (enrdf_load_stackoverflow) 1978-01-13
JPS563873B2 (enrdf_load_stackoverflow) 1981-01-27
AT321923B (de) 1975-04-25
GB1400999A (en) 1975-07-16
PH9669A (en) 1976-02-10
ZA727532B (en) 1973-07-25
ES408736A1 (es) 1976-03-01
FR2160407B1 (enrdf_load_stackoverflow) 1975-10-17
SE402915B (sv) 1978-07-24
IE37046L (en) 1973-05-19
NL7215646A (enrdf_load_stackoverflow) 1973-05-22
IE37046B1 (en) 1977-04-27
AU4819172A (en) 1974-05-16
AU472127B2 (en) 1976-05-20
CA990292A (en) 1976-06-01
IL40686A (en) 1975-12-31
BE791025A (fr) 1973-05-07
DK138691B (da) 1978-10-16
DK138691C (enrdf_load_stackoverflow) 1979-03-26
DE2255172A1 (de) 1973-05-24
IL40686A0 (en) 1972-12-29
FR2160407A1 (enrdf_load_stackoverflow) 1973-06-29
US3840537A (en) 1974-10-08

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