PH9669A - Imidazo-(5,1-f)-as-triazin-4(3h)-ones,their compositions and method of use - Google Patents

Imidazo-(5,1-f)-as-triazin-4(3h)-ones,their compositions and method of use

Info

Publication number
PH9669A
PH9669A PH14090*UA PH14090A PH9669A PH 9669 A PH9669 A PH 9669A PH 14090 A PH14090 A PH 14090A PH 9669 A PH9669 A PH 9669A
Authority
PH
Philippines
Prior art keywords
triazin
imidazo
ones
compositions
Prior art date
Application number
PH14090*UA
Inventor
L Lunts
A Oxford
S Garside
D Hartley
Original Assignee
L Lunts
A Oxford
S Garside
D Hartley
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by L Lunts, A Oxford, S Garside, D Hartley filed Critical L Lunts
Publication of PH9669A publication Critical patent/PH9669A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
PH14090*UA 1971-11-19 1972-11-16 Imidazo-(5,1-f)-as-triazin-4(3h)-ones,their compositions and method of use PH9669A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB5375071A GB1400999A (en) 1971-11-19 1971-11-19 Imidazo-triazine compounds and their use in therapeutic compositions

Publications (1)

Publication Number Publication Date
PH9669A true PH9669A (en) 1976-02-10

Family

ID=10468856

Family Applications (1)

Application Number Title Priority Date Filing Date
PH14090*UA PH9669A (en) 1971-11-19 1972-11-16 Imidazo-(5,1-f)-as-triazin-4(3h)-ones,their compositions and method of use

Country Status (18)

Country Link
US (1) US3840537A (en)
JP (1) JPS563873B2 (en)
AT (1) AT321923B (en)
AU (1) AU472127B2 (en)
BE (1) BE791025A (en)
CA (1) CA990292A (en)
CH (1) CH594671A5 (en)
DE (1) DE2255172A1 (en)
DK (1) DK138691B (en)
ES (1) ES408736A1 (en)
FR (1) FR2160407B1 (en)
GB (1) GB1400999A (en)
IE (1) IE37046B1 (en)
IL (1) IL40686A (en)
NL (1) NL7215646A (en)
PH (1) PH9669A (en)
SE (1) SE402915B (en)
ZA (1) ZA727532B (en)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1457873A (en) * 1973-01-04 1976-12-08 Allen & Hanburys Ltd Imidazotriazines
DE2314488C3 (en) * 1973-03-23 1979-01-04 C.H. Boehringer Sohn, 6507 Ingelheim 8- (2,6-Dichlorophenyl) -7- (4-chlorophenyl) -5-oxo-233,8-tetrahydro-imidazo [1,2-a] -s-triazine, process for its preparation and medicament containing it
DE2335193A1 (en) * 1973-07-11 1975-01-30 Hoechst Ag BIS-TRIAZINOBENZIMIDAZOLE AND THEIR PRODUCTION
US4107307A (en) * 1977-02-03 1978-08-15 American Cyanamid Company Imidazo [1,5-d]-as-triazine-4(3H)-ones and thiones
US4115572A (en) * 1977-02-03 1978-09-19 American Cyanamid Company Imidazo-[1,5-d]-as-triazin-1(2H)-ones and method of ameliorating asthma
USRE30511E (en) * 1977-02-03 1981-02-10 American Cyanamid Company Imidazo[1,5-d]-as-triazine-4(3H)-ones and thiones
DK109578A (en) * 1977-03-25 1978-09-26 Allen & Hanburys Ltd PROCEDURE FOR MAKING HETEROCYCLIC COMPOUNDS
US4107308A (en) * 1977-10-18 1978-08-15 American Cyanamid Company Imidazo[1,5-d]-as-triazines
US4308384A (en) * 1978-09-18 1981-12-29 Glaxo Group Limited Production of triazinones
HU187474B (en) * 1981-11-18 1986-01-28 Gyogyszerkutato Intezet,Hu Process for producing new spiro-pyrazole-square bracket-1,5-d-square bracket closed-square bracket-1,2,4-square bracket closed-triazine derivatives
US4395547A (en) * 1982-02-10 1983-07-26 American Cyanamid Co. Process for preparing 1-substituted-6-n-propyl-8-methylimidazo[1,5-d]-as-triazin-4(3H)-ones
AU622330B2 (en) * 1989-06-23 1992-04-02 Takeda Chemical Industries Ltd. Condensed heterocyclic compounds having a nitrogen atom in the bridgehead for use as fungicides
US6624181B1 (en) * 1997-02-28 2003-09-23 Altana Pharma Ag Synergistic combination
ATE213246T1 (en) * 1997-11-12 2002-02-15 2-PHENYL-SUBSTITUTED IMIDAZOTRIAZINONES AS PHOSPHODIESTERASE INHIBITORS
DE19827640A1 (en) * 1998-06-20 1999-12-23 Bayer Ag New imidazotriazine derivatives useful as smooth muscle relaxants for treating e.g. cardiovascular disorders, cerebrovascular disorders, or erectile dysfunction
IL141335A0 (en) 1998-08-26 2002-03-10 Smithkline Beecham Corp Therapies for treating pulmonary diseases
EA006685B1 (en) 1999-08-21 2006-02-24 Алтана Фарма Аг Synergistic combination
DK1392314T3 (en) * 2001-05-09 2007-03-12 Bayer Healthcare Ag Hitherto unknown use of 2- [2-ethoxy-5- (4-methyl-piperazine-1-sulfonyl) -phenyl] -5-methyl-7-propyl-3H-imidazo [5,1-f] [1,2 , 4] triazin-4-one
GB0113343D0 (en) * 2001-06-01 2001-07-25 Bayer Ag Novel Heterocycles 2
GB0113344D0 (en) * 2001-06-01 2001-07-25 Bayer Ag Novel heterocycles 3
DE10135815A1 (en) 2001-07-23 2003-02-06 Bayer Ag Use of imidazo-triazinone derivative phosphodiesterase 5 inhibitors e.g. for treatment of cardiac insufficiency, psoriasis, diabetes, cancer, glaucoma, bladder disease, Parkinson's disease or pain
DE10232113A1 (en) * 2002-07-16 2004-01-29 Bayer Ag Medicinal products containing vardenafil hydrochloride trihydrate
ES2326808T3 (en) * 2003-04-01 2009-10-20 Smithkline Beecham Corporation IMIDAZOTRIAZINE COMPOUNDS FOR THE TREATMENT OF CANCER DISEASES.
EP2168968B1 (en) 2004-04-02 2017-08-23 OSI Pharmaceuticals, LLC 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors
DE102005001989A1 (en) * 2005-01-15 2006-07-20 Bayer Healthcare Ag Intravenous formulations of PDE inhibitors
DE102005009240A1 (en) * 2005-03-01 2006-09-07 Bayer Healthcare Ag Dosage forms with improved pharmacokinetic properties
DE102005009241A1 (en) * 2005-03-01 2006-09-07 Bayer Healthcare Ag Dosage forms with controlled bioavailability
BRPI0616633A2 (en) * 2005-09-29 2011-06-28 Bayer Healthcare Ag pde inhibitors and combinations thereof for the treatment of urological disorders
EP1951724B1 (en) * 2005-11-17 2011-04-27 OSI Pharmaceuticals, Inc. FUSED BICYCLIC mTOR INHIBITORS
KR20100029762A (en) * 2007-06-13 2010-03-17 바이엘 쉐링 파마 악티엔게젤샤프트 Pde inhibitors for the treatment of hearing impairment
CN102405214A (en) 2009-04-20 2012-04-04 Osi药物有限责任公司 Preparation of c-pyrazine-methylamines
CN103374002B (en) * 2012-04-19 2015-07-15 山东轩竹医药科技有限公司 Phosphodiesterase-5 inhibitor
US20180044343A1 (en) * 2015-03-16 2018-02-15 Sumitomo Dainippon Pharma Co., Ltd. Bicyclic imidazolo derivative
WO2017000276A1 (en) * 2015-07-01 2017-01-05 Merck Sharp & Dohme Corp. Bicyclic heterocyclic compounds as pde2 inhibitors
WO2017204316A1 (en) * 2016-05-27 2017-11-30 塩野義製薬株式会社 5-oxo-1,2,4-triazine derivative, and pharmaceutical composition thereof

Also Published As

Publication number Publication date
FR2160407B1 (en) 1975-10-17
DK138691C (en) 1979-03-26
AU472127B2 (en) 1976-05-20
US3840537A (en) 1974-10-08
DK138691B (en) 1978-10-16
AU4819172A (en) 1974-05-16
ZA727532B (en) 1973-07-25
CH594671A5 (en) 1978-01-13
GB1400999A (en) 1975-07-16
ES408736A1 (en) 1976-03-01
IE37046L (en) 1973-05-19
AT321923B (en) 1975-04-25
IL40686A0 (en) 1972-12-29
DE2255172A1 (en) 1973-05-24
IL40686A (en) 1975-12-31
SE402915B (en) 1978-07-24
JPS563873B2 (en) 1981-01-27
BE791025A (en) 1973-05-07
CA990292A (en) 1976-06-01
NL7215646A (en) 1973-05-22
JPS4857993A (en) 1973-08-14
IE37046B1 (en) 1977-04-27
FR2160407A1 (en) 1973-06-29

Similar Documents

Publication Publication Date Title
PH9669A (en) Imidazo-(5,1-f)-as-triazin-4(3h)-ones,their compositions and method of use
CA966828A (en) 1.alpha.-HYDROXYCHOLECALCIFEROL AND PROCESS OF MAKING SAME
IL36045A (en) 3,20-dioxo-17alpha,21-dimethyl-19-norpregna-4,9 diene and process of preparation
PH9765A (en) Aminophenylamidines and cycloamidines,compositions containing them and method of use
ZA728566B (en) Method and compositions for the treatment of human hair
CA954536A (en) Ceramic composition and process of making the same
JPS5718699A (en) Manufacture of 17,21-dihydroxy-20-ketopregnanes
ZA725203B (en) Novel phthalazone derivatives and process for their manufacturere
IL35894A (en) The preparation of 1,2,4-triazine-5-ones and certain novel intermediates being 5-imino-1,2,4-triazine derivatives
ZA716382B (en) Process for the preparation of 21-chloro-6,6,9d-trifluoro-11b,16d,17d-trihydroxy-1,4-pregnadien-3,20-dione 16,17-ketals and selected intermediates
IL28020A (en) 3,5-diketals of 4,5-seco-estrane-3,5,17-triones and process of preparation
ZA725870B (en) Fungicidal composition and process
GB1407478A (en) 11beta-alkoxy-estra-1,3,5-10-trienes and processes for their preparation
IL38361A0 (en) 3-sulphoalkyl-6-hydroxypyrid-(2)-ones,their manufacture and use
PH9777A (en) 3-alkyl-7-phenylpyrimido-(1,2-a)(1,4)benzodiazepin-1(5h)ones and process of preparation
AU4775772A (en) Compositions and processes
PH9928A (en) 30(-hydroxy-19-nor-50(-pregnane-11,20-dione and compositions containing them
IL39221A0 (en) The preparation of 5-benzyl-pyrimidines and certain novel 5-benzyl-pyrimidines
GB1401723A (en) Quinazolines process for producing them and compositions containing them
CA951328A (en) Method of producing 2,2,6-trichlorocylohexanone and composition thereof
ZA721516B (en) Cleaning and treating compositions
IL35278A (en) Process for the preparation of 4,5,6,7-tetrahydrocyclopenta-1,3-dioxinones-(4) and some novel tetrahydrocyclopenta-1,3-dioxinones
PH9608A (en) 1,5-disubstituted-4-nitropyrazoles,compositions and method of use
ZA713078B (en) 4,5-oxido-bufa-dienolido-3-(rhamnosido-2',3'-dialkylorthocarbonates)and process for their manufacture
MY7700158A (en) 1,4-methano-and ethano-tetrahydronaphthyl-oxypropanols and process for their preparation