CA990292A - Imidazo-triazinones - Google Patents

Imidazo-triazinones

Info

Publication number
CA990292A
CA990292A CA155,720A CA155720A CA990292A CA 990292 A CA990292 A CA 990292A CA 155720 A CA155720 A CA 155720A CA 990292 A CA990292 A CA 990292A
Authority
CA
Canada
Prior art keywords
triazinones
imidazo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA155,720A
Other versions
CA155720S (en
Inventor
David Hartley
Susan C. Garside
Lawrence H.C. Lunts
Alexander W. Oxford
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allen and Hanburys Ltd
Original Assignee
GARSIDE, SUSAN C.
Allen and Hanburys Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to GB5375071A priority Critical patent/GB1400999A/en
Application filed by GARSIDE, SUSAN C., Allen and Hanburys Ltd filed Critical GARSIDE, SUSAN C.
Application granted granted Critical
Publication of CA990292A publication Critical patent/CA990292A/en
Application status is Expired legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D253/00Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/061,2,4-Triazines
    • C07D253/0651,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/071,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075Two hetero atoms, in positions 3 and 5
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D253/00Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/061,2,4-Triazines
CA155,720A 1971-11-19 1972-11-01 Imidazo-triazinones Expired CA990292A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB5375071A GB1400999A (en) 1971-11-19 1971-11-19 Imidazo-triazine compounds and their use in therapeutic compositions

Publications (1)

Publication Number Publication Date
CA990292A true CA990292A (en) 1976-06-01

Family

ID=10468856

Family Applications (1)

Application Number Title Priority Date Filing Date
CA155,720A Expired CA990292A (en) 1971-11-19 1972-11-01 Imidazo-triazinones

Country Status (18)

Country Link
US (1) US3840537A (en)
JP (1) JPS563873B2 (en)
AT (1) AT321923B (en)
AU (1) AU472127B2 (en)
BE (1) BE791025A (en)
CA (1) CA990292A (en)
CH (1) CH594671A5 (en)
DE (1) DE2255172A1 (en)
DK (1) DK138691C (en)
ES (1) ES408736A1 (en)
FR (1) FR2160407B1 (en)
GB (1) GB1400999A (en)
IE (1) IE37046B1 (en)
IL (1) IL40686A (en)
NL (1) NL7215646A (en)
PH (1) PH9669A (en)
SE (1) SE402915B (en)
ZA (1) ZA7207532B (en)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1457873A (en) * 1973-01-04 1976-12-08 Allen & Hanburys Ltd Imidazotriazines
DE2314488C3 (en) * 1973-03-23 1979-01-04 C.H. Boehringer Sohn, 6507 Ingelheim
DE2335193A1 (en) * 1973-07-11 1975-01-30 Hoechst Ag Until triazinobenzimidazole and their production
US4115572A (en) * 1977-02-03 1978-09-19 American Cyanamid Company Imidazo-[1,5-d]-as-triazin-1(2H)-ones and method of ameliorating asthma
US4107307A (en) * 1977-02-03 1978-08-15 American Cyanamid Company Imidazo [1,5-d]-as-triazine-4(3H)-ones and thiones
USRE30511E (en) * 1977-02-03 1981-02-10 American Cyanamid Company Imidazo[1,5-d]-as-triazine-4(3H)-ones and thiones
DK109578A (en) * 1977-03-25 1978-09-26 Allen & Hanburys Ltd Process for the preparation of heterocyclic compounds
US4107308A (en) * 1977-10-18 1978-08-15 American Cyanamid Company Imidazo[1,5-d]-as-triazines
US4308384A (en) * 1978-09-18 1981-12-29 Glaxo Group Limited Production of triazinones
HU187474B (en) * 1981-11-18 1986-01-28 Gyogyszerkutato Intezet,Hu Process for producing new spiro-pyrazole-square bracket-1,5-d-square bracket closed-square bracket-1,2,4-square bracket closed-triazine derivatives
US4395547A (en) * 1982-02-10 1983-07-26 American Cyanamid Co. Process for preparing 1-substituted-6-n-propyl-8-methylimidazo[1,5-d]-as-triazin-4(3H)-ones
AU622330B2 (en) * 1989-06-23 1992-04-02 Takeda Chemical Industries Ltd. Condensed heterocyclic compounds having a nitrogen atom in the bridgehead for use as fungicides
US6624181B1 (en) * 1997-02-28 2003-09-23 Altana Pharma Ag Synergistic combination
AT213246T (en) 1997-11-12 2002-02-15 2-phenyl-substituted imidazotriazinones as phosphodiesterase inhibitors
DE19827640A1 (en) * 1998-06-20 1999-12-23 Bayer Ag New imidazotriazine derivatives useful as smooth muscle relaxants for treating e.g. cardiovascular disorders, cerebrovascular disorders, or erectile dysfunction
CN1314811A (en) 1998-08-26 2001-09-26 史密丝克莱恩比彻姆公司 Therapies for treating pulmonary diseases
SK287231B6 (en) * 1999-08-21 2010-04-07 Nycomed Gmbh Medicament comprising a PDE inhibitor and a beta2 adrenoreceptor agonist
KR100701904B1 (en) 1999-08-21 2007-04-02 알타나 파마 아게 Synergistic combination of pde inhibitors and beta 2 adrenoceptor agonist
CA2449163C (en) * 2001-05-09 2010-07-13 Bayer Healthcare Ag New use of 2-phenyl-substituted imidazotriazinones
GB0113344D0 (en) * 2001-06-01 2001-07-25 Bayer Ag Novel heterocycles 3
GB0113343D0 (en) * 2001-06-01 2001-07-25 Bayer Ag Novel Heterocycles 2
DE10135815A1 (en) 2001-07-23 2003-02-06 Bayer Ag Use of imidazo-triazinone derivative phosphodiesterase 5 inhibitors e.g. for treatment of cardiac insufficiency, psoriasis, diabetes, cancer, glaucoma, bladder disease, Parkinson's disease or pain
DE10232113A1 (en) * 2002-07-16 2004-01-29 Bayer Ag Vardenafil hydrochloride trihydrate medicaments containing
AT432936T (en) * 2003-04-01 2009-06-15 Smithkline Beecham Corp Imidazotriazin compounds for treatment of cancers
AU2005230818B2 (en) 2004-04-02 2010-11-25 Osi Pharmaceuticals, Inc. 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors
DE102005001989A1 (en) * 2005-01-15 2006-07-20 Bayer Healthcare Ag Intravenous formulations of PDE inhibitors
DE102005009241A1 (en) * 2005-03-01 2006-09-07 Bayer Healthcare Ag Dosage forms with controlled bioavailability
DE102005009240A1 (en) * 2005-03-01 2006-09-07 Bayer Healthcare Ag Dosage forms with improved pharmacokinetic properties
EP1931797A2 (en) * 2005-09-29 2008-06-18 Bayer HealthCare AG Pde inhibitors and combinations thereof for the treatment of urological disorders
PT2385053E (en) 2005-11-17 2013-12-17 Osi Pharm Inc Intermediates for the preparation of fused bicyclic mtor inhibitors
KR20100029762A (en) * 2007-06-13 2010-03-17 바이엘 쉐링 파마 악티엔게젤샤프트 Pde inhibitors for the treatment of hearing impairment
WO2010123792A1 (en) 2009-04-20 2010-10-28 Osi Pharmaceuticals, Inc. Preparation of c-pyrazine-methylamines
CN103374002B (en) * 2012-04-19 2015-07-15 山东轩竹医药科技有限公司 Phosphodiesterase-5 inhibitor
TW201639851A (en) * 2015-03-16 2016-11-16 Sumitomo Dainippon Pharma Co Ltd Bicyclic imidazolo derivative
WO2017000276A1 (en) * 2015-07-01 2017-01-05 Merck Sharp & Dohme Corp. Bicyclic heterocyclic compounds as pde2 inhibitors
WO2017204316A1 (en) * 2016-05-27 2017-11-30 塩野義製薬株式会社 5-oxo-1,2,4-triazine derivative, and pharmaceutical composition thereof

Also Published As

Publication number Publication date
CH594671A5 (en) 1978-01-13
AT321923B (en) 1975-04-25
AU4819172A (en) 1974-05-16
IL40686A (en) 1975-12-31
BE791025A (en) 1973-05-07
DK138691B (en) 1978-10-16
ZA7207532B (en) 1973-07-25
FR2160407A1 (en) 1973-06-29
AU472127B2 (en) 1976-05-20
DE2255172A1 (en) 1973-05-24
IE37046L (en) 1973-05-19
JPS4857993A (en) 1973-08-14
ES408736A1 (en) 1976-03-01
SE402915B (en) 1978-07-24
IE37046B1 (en) 1977-04-27
JPS563873B2 (en) 1981-01-27
BE791025A1 (en)
NL7215646A (en) 1973-05-22
PH9669A (en) 1976-02-10
GB1400999A (en) 1975-07-16
DK138691C (en) 1979-03-26
US3840537A (en) 1974-10-08
CA990292A1 (en)
IL40686D0 (en) 1972-12-29
FR2160407B1 (en) 1975-10-17

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