JPH11511196A - 喘息を治療するための方法及び組成物 - Google Patents
喘息を治療するための方法及び組成物Info
- Publication number
- JPH11511196A JPH11511196A JP9509428A JP50942897A JPH11511196A JP H11511196 A JPH11511196 A JP H11511196A JP 9509428 A JP9509428 A JP 9509428A JP 50942897 A JP50942897 A JP 50942897A JP H11511196 A JPH11511196 A JP H11511196A
- Authority
- JP
- Japan
- Prior art keywords
- composition
- ulmwh
- antigen
- molecular weight
- patient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/727—Heparin; Heparan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dispersion Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Otolaryngology (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.喘息を誘発する抗原によって攻撃され、抗原誘発された喘息にかかった患 者を治療するための方法であって、前記方法が、各投与量中に患者の体重1kg 当たり約0.05〜約1.0mgの超低分子量ヘパリン(ULMWH)を含有す る医薬組成物を患者に気管支内投与することを含み、前記ULMWHが3,00 0ダルトン以下の平均分子量を有することを特徴とする、抗原誘発された喘息に かかった患者の治療方法。 2.前記ULMWHが2,500ダルトン以下の平均分子量を有することを特 徴とする請求項1記載の方法。 3.前記組成物が、一回の投与量当たり約0.075〜約0.75mg/kg のULMWHを含有することを特徴とする請求項1記載の方法。 4.前記組成物が、該組成物1ml当たり約1.0〜約20.0mgのULM WHを含有することを特徴とする請求項1記載の方法。 5.前記ULMWHが、実質的に抗凝血活性を有しないことを特徴とする請求 項1記載の方法。 6.前記ULMWHのそれぞれが、二糖類、三糖類、四糖類又は五糖類を含む ことを特徴とする請求項1記載の方法。 7.前記組成物が、水性で製薬学的に受容可能な吸入賦形剤中にあるULMW H溶液から成ることを特徴とする請求項1記載の方法。 8.前記賦形剤が、等張性の生理食塩水又は静菌性の水であることを特徴とす る請求項7記載の方法。 9.前記組成物が、ポンプ又は圧搾作動噴霧器を用いて投与されることを特徴 とする請求項7記載の方法。 10.前記組成物が、更にエアロゾル推進剤を含み、しかも、計量エアロゾル投 与吸入器を経て投与されることを特徴とする請求項7記載の方法。 11.前記組成物が、気管支内投与可能な不活性粉末と混合されたULMWHの 粉末状製剤を含むことを特徴とする請求項1記載の方法。 12.前記不活性粉末がラクトースであることを特徴とする請求項11記載の方法 。 13.前記組成物が、エアロゾル投薬器を経て投与されることを特徴とする請求 項11記載の方法。 14.前記組成物が、崩壊可能なカプセルで投与されることを特徴とする請求項 11記載の方法。 15.気道過応答性を減少させ抑制させることにより、喘息にかかった患者を治 療するための方法であって、前記方法が、各投与量中に患者の体重1kg当たり 約0.05〜約1.0mgの超低分子量ヘパリン(ULMWH)を含有する医薬 組成物を、患者に対して慢性主薬と同時に気管支内投与することを含み、前記U LMWHが3,000ダルトン以下の平均分子量を有することを特徴とする、喘 息にかかった患者の治療方法。 16.前記ULMWHが2,500ダルトン以下の平均分子量を有することを特 徴とする請求項15記載の方法。 17.前記組成物が、一回の投与量当たり約0.075〜約0.75mg/kg のULMWHを含有することを特徴とする請求項15記載の方法。 18.前記組成物が、該組成物1ml当たり約1.0〜約20.0mgのULM WHを含有することを特徴とする請求項15記載の方法。 19.前記ULMWHが、実質的に抗凝血活性を有しないことを特徴とする請求 項15記載の方法。 20.前記ULMWHのそれぞれが、二糖類、三糖類、四糖類又は五糖類を含む ことを特徴とする請求項15記載の方法。 21.抗原誘発された喘息にかかった患者を治療するための医薬組成物であって 、前記組成物が、製薬学的に受容可能な吸入賦形剤において、各投与量中に患者 の体重1kg当たり約0.05〜約1.0mgのULMWHを含有しており、前 記ULMWHが3,000ダルトン以下の平均分子量を有することを特徴とする 、抗原誘発された喘息にかかった患者の治療用医薬組成物。 22.前記ULMWHが2,500ダルトン以下の平均分子量を有することを特 徴とする請求項21記載の組成物。 23.前記組成物が、一回の投与量当たり約0.075〜約0.75mg/kg のULMWHを含有することを特徴とする請求項21記載の組成物。 24.前記組成物が、該組成物1ml当たり約1.0〜約20.0mgのULM WHを含有することを特徴とする請求項21記載の組成物。 25.前記ULMWHが、実質的に抗凝血活性を有しないことを特徴とする請求 項21記載の組成物。 26.前記ULMWHのそれぞれが、二糖類、三糖類、四糖類又は五糖類を含む ことを特徴とする請求項21記載の組成物。 27.前記組成物が、水性で製薬学的に受容可能な吸入賦形剤中にあるULMW H溶液から成ることを特徴とする請求項21記載の組成物。 28.前記賦形剤が、等張性の生理食塩水又は静菌性の水であることを特徴とす る請求項27記載の組成物。 29.前記組成物が、ポンプ又は圧搾作動噴霧器を用いて投与するのに適したも のであることを特徴とする請求項27記載の組成物。 30.前記組成物が、更にエアロゾル推進剤を含み、しかも、計量エアロゾル投 与吸入器を経て投与するのに適したものであることを特徴とする請求項27記載の 組成物。 31.前記組成物が、気管支内投与可能な不活性粉末と混合されたULMWHの 粉末状製剤を含むことを特徴とする請求項27記載の組成物。 32.前記不活性粉末がラクトースであることを特徴とする請求項31記載の組成 物。 33.前記組成物が、エアロゾル投薬器を経て投与されることを特徴とする請求 項31記載の組成物。 34.前記組成物が、崩壊可能なカプセルで投与されることを特徴とする請求項 31記載の組成物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/516,786 | 1995-08-18 | ||
US516,786 | 1995-08-18 | ||
US08/516,786 US5690910A (en) | 1995-08-18 | 1995-08-18 | Method for treating asthma |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH11511196A true JPH11511196A (ja) | 1999-09-28 |
JP3263723B2 JP3263723B2 (ja) | 2002-03-11 |
Family
ID=24057086
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP50942897A Expired - Lifetime JP3263723B2 (ja) | 1995-08-18 | 1996-08-13 | 喘息を治療するための組成物、及び喘息にかかった患者を治療するための気管支内薬物の製造における超低分子量ヘパリンの使用 |
Country Status (22)
Country | Link |
---|---|
US (1) | US5690910A (ja) |
EP (1) | EP0844869B1 (ja) |
JP (1) | JP3263723B2 (ja) |
KR (1) | KR100451901B1 (ja) |
AR (1) | AR003271A1 (ja) |
AT (1) | ATE300938T1 (ja) |
AU (1) | AU701691B2 (ja) |
CA (1) | CA2229060A1 (ja) |
CZ (1) | CZ292134B6 (ja) |
DE (1) | DE69635023T2 (ja) |
DK (1) | DK0844869T3 (ja) |
ES (1) | ES2244974T3 (ja) |
HK (1) | HK1007060A1 (ja) |
HU (1) | HUP9901614A3 (ja) |
IL (1) | IL123166A (ja) |
NZ (2) | NZ315275A (ja) |
PL (1) | PL186912B1 (ja) |
PT (1) | PT844869E (ja) |
SK (1) | SK282759B6 (ja) |
UA (1) | UA62919C2 (ja) |
WO (1) | WO1997006783A1 (ja) |
ZA (1) | ZA966838B (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007505830A (ja) * | 2003-09-15 | 2007-03-15 | ベクトゥラ・リミテッド | 肺疾患を治療するための粘液活性剤 |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5980865A (en) * | 1995-08-18 | 1999-11-09 | Baker Norton Pharmaceuticals, Inc. | Method for treating late phase allergic reactions and inflammatory diseases |
US7056504B1 (en) | 1998-08-27 | 2006-06-06 | Massachusetts Institute Of Technology | Rationally designed heparinases derived from heparinase I and II |
US6235725B1 (en) * | 1998-10-30 | 2001-05-22 | Baker Norton Pharmaceuticals, Inc. | Methods and compositions for the prevention of tolerance to medications |
EP1462148A3 (en) * | 1998-10-30 | 2010-03-17 | Ivax Research, Inc. | Methods and compositions for the prevention of tolerance to bronchodilators |
US9006175B2 (en) | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
AU4351201A (en) | 2000-03-08 | 2001-09-17 | Massachusetts Inst Technology | Heparinase iii and uses thereof |
WO2001093846A2 (en) * | 2000-05-23 | 2001-12-13 | The Trustees Of Columbia University In The City Of New York | Method for treating respiratory disorders associated with pulmonary elastic fiber injury comprising the use of clycosaminoglycans |
WO2002023190A2 (en) | 2000-09-12 | 2002-03-21 | Massachusetts Institute Of Technology | Methods and products related to low molecular weight heparin |
AU2002224408B2 (en) * | 2000-10-18 | 2007-08-23 | Massachusetts Institute Of Technology | Methods and products related to pulmonary delivery of polysaccharides |
EP1894591B1 (en) | 2002-03-20 | 2013-06-26 | MannKind Corporation | Cartridge for an inhalation apparatus |
US20040171819A1 (en) | 2002-10-10 | 2004-09-02 | Aventis Pharma S.A. | Mixtures of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them |
US20040152694A1 (en) * | 2003-02-04 | 2004-08-05 | Istvan Kurucz | Methods and compositions for treating inflammatory disorders of the airways |
PL1786784T3 (pl) | 2004-08-20 | 2011-04-29 | Mannkind Corp | Kataliza syntezy diketopiperazyn |
CN101027057B (zh) | 2004-08-23 | 2017-04-12 | 曼金德公司 | 用于药物输送的二酮哌嗪盐、二酮吗啉盐或二酮二氧杂环己烷盐 |
KR101241434B1 (ko) | 2004-09-10 | 2013-03-12 | 파마오리진 에이피에스 | 국소 기관, 기관지 또는 폐포의 출혈 또는 객혈의 치료방법 |
EP1928423B1 (en) | 2005-09-14 | 2015-12-09 | Mannkind Corporation | Method of drug formulation based on increasing the affinity of active agents for crystalline microparticle surfaces |
ES2647080T3 (es) | 2006-02-22 | 2017-12-19 | Mannkind Corporation | Un método para mejorar las propiedades farmacéuticas de micropartículas que comprenden dicetopiperazina y un agente activo |
WO2009059284A2 (en) * | 2007-11-02 | 2009-05-07 | Momenta Pharmaceuticals, Inc. | Non-anticoagulant polysaccharide compositions |
US8569262B2 (en) * | 2007-11-02 | 2013-10-29 | Momenta Pharmaceuticals, Inc. | Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization |
US8592393B2 (en) * | 2007-11-02 | 2013-11-26 | Momenta Pharmaceuticals, Inc. | Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization |
US8485180B2 (en) | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
EP2567723B1 (en) | 2008-06-13 | 2021-01-20 | MannKind Corporation | A dry powder inhaler and system for drug delivery |
ES2421385T3 (es) | 2008-06-20 | 2013-09-02 | Mannkind Corp | Aparato interactivo y procedimiento para establecer el perfil, en tiempo real, de esfuerzos de inhalación |
TWI532497B (zh) | 2008-08-11 | 2016-05-11 | 曼凱公司 | 超快起作用胰島素之用途 |
US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
EP2676695A3 (en) | 2009-03-11 | 2017-03-01 | MannKind Corporation | Apparatus, system and method for measuring resistance of an inhaler |
KR20210027546A (ko) | 2009-06-12 | 2021-03-10 | 맨카인드 코포레이션 | 한정된 비표면적을 갖는 디케토피페라진 마이크로입자 |
CA2778698A1 (en) | 2009-11-03 | 2011-05-12 | Mannkind Corporation | An apparatus and method for simulating inhalation efforts |
WO2011068721A1 (en) * | 2009-12-03 | 2011-06-09 | Opko Health, Inc. | Hypersulfated disaccharide formulations |
WO2011130697A2 (en) | 2010-04-16 | 2011-10-20 | Momenta Pharmaceuticals, Inc. | Tissue targeting |
CA2795868A1 (en) | 2010-06-17 | 2011-12-22 | Momenta Pharmaceuticals, Inc. | Methods and compositions for modulating hair growth |
KR20130117755A (ko) | 2010-06-21 | 2013-10-28 | 맨카인드 코포레이션 | 건조 분말 약물 운반 시스템 및 방법 |
RU2528093C2 (ru) * | 2010-07-21 | 2014-09-10 | Олег Ильич Эпштейн | Фармацевтическая композиция и способ лечения острых и хронических заболевания дыхательной системы и синдрома кашля |
CN103269585B (zh) * | 2010-10-29 | 2016-12-21 | Opko健康公司 | 治疗弹性蛋白酶相关病症的超硫酸化双糖 |
EP2694402B1 (en) | 2011-04-01 | 2017-03-22 | MannKind Corporation | Blister package for pharmaceutical cartridges |
WO2012174472A1 (en) | 2011-06-17 | 2012-12-20 | Mannkind Corporation | High capacity diketopiperazine microparticles |
US9233159B2 (en) | 2011-10-24 | 2016-01-12 | Mannkind Corporation | Methods and compositions for treating pain |
AU2013289957B2 (en) | 2012-07-12 | 2017-02-23 | Mannkind Corporation | Dry powder drug delivery systems and methods |
EP2911690A1 (en) | 2012-10-26 | 2015-09-02 | MannKind Corporation | Inhalable influenza vaccine compositions and methods |
MX369136B (es) | 2013-03-15 | 2019-10-30 | Mannkind Corp | Composiciones de dicetopiperazina microcristalina y metodos. |
JP2016520613A (ja) | 2013-05-28 | 2016-07-14 | モメンタ ファーマシューティカルズ インコーポレイテッド | 薬学的組成物 |
KR102465025B1 (ko) | 2013-07-18 | 2022-11-09 | 맨카인드 코포레이션 | 열-안정성 건조 분말 약제학적 조성물 및 방법 |
US11446127B2 (en) | 2013-08-05 | 2022-09-20 | Mannkind Corporation | Insufflation apparatus and methods |
US10307464B2 (en) | 2014-03-28 | 2019-06-04 | Mannkind Corporation | Use of ultrarapid acting insulin |
US10561806B2 (en) | 2014-10-02 | 2020-02-18 | Mannkind Corporation | Mouthpiece cover for an inhaler |
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Publication number | Priority date | Publication date | Assignee | Title |
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US5474759A (en) * | 1991-06-10 | 1995-12-12 | Schering Corporation | Non-chlorofluorocarbon aerosol formulations |
WO1993019734A1 (en) * | 1992-04-02 | 1993-10-14 | Baker Norton Pharmaceuticals, Inc. | Method and composition for treating antigen-induced and exercise-induced asthma |
-
1995
- 1995-08-18 US US08/516,786 patent/US5690910A/en not_active Expired - Fee Related
-
1996
- 1996-08-13 HU HU9901614A patent/HUP9901614A3/hu unknown
- 1996-08-13 PL PL96324970A patent/PL186912B1/pl unknown
- 1996-08-13 ES ES96926952T patent/ES2244974T3/es not_active Expired - Lifetime
- 1996-08-13 PT PT96926952T patent/PT844869E/pt unknown
- 1996-08-13 NZ NZ315275A patent/NZ315275A/xx not_active IP Right Cessation
- 1996-08-13 IL IL12316696A patent/IL123166A/en not_active IP Right Cessation
- 1996-08-13 DK DK96926952T patent/DK0844869T3/da active
- 1996-08-13 UA UA98020876A patent/UA62919C2/uk unknown
- 1996-08-13 DE DE69635023T patent/DE69635023T2/de not_active Expired - Lifetime
- 1996-08-13 AU AU66945/96A patent/AU701691B2/en not_active Expired
- 1996-08-13 ZA ZA9606838A patent/ZA966838B/xx unknown
- 1996-08-13 CA CA002229060A patent/CA2229060A1/en not_active Abandoned
- 1996-08-13 CZ CZ1998481A patent/CZ292134B6/cs not_active IP Right Cessation
- 1996-08-13 WO PCT/US1996/013133 patent/WO1997006783A1/en active IP Right Grant
- 1996-08-13 EP EP96926952A patent/EP0844869B1/en not_active Expired - Lifetime
- 1996-08-13 KR KR10-1998-0701167A patent/KR100451901B1/ko not_active IP Right Cessation
- 1996-08-13 SK SK172-98A patent/SK282759B6/sk not_active IP Right Cessation
- 1996-08-13 JP JP50942897A patent/JP3263723B2/ja not_active Expired - Lifetime
- 1996-08-13 AT AT96926952T patent/ATE300938T1/de active
- 1996-08-15 AR ARP960103997A patent/AR003271A1/es not_active Application Discontinuation
-
1998
- 1998-06-24 HK HK98106409A patent/HK1007060A1/xx not_active IP Right Cessation
-
1999
- 1999-09-23 NZ NZ337996A patent/NZ337996A/en not_active IP Right Cessation
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007505830A (ja) * | 2003-09-15 | 2007-03-15 | ベクトゥラ・リミテッド | 肺疾患を治療するための粘液活性剤 |
JP2012031204A (ja) * | 2003-09-15 | 2012-02-16 | Vectura Group Plc | 肺疾患を治療するための粘液活性剤 |
Also Published As
Publication number | Publication date |
---|---|
AR003271A1 (es) | 1998-07-08 |
UA62919C2 (en) | 2004-01-15 |
KR19990037688A (ko) | 1999-05-25 |
ES2244974T3 (es) | 2005-12-16 |
DE69635023T2 (de) | 2006-05-24 |
NZ315275A (en) | 2000-01-28 |
PL324970A1 (en) | 1998-06-22 |
AU6694596A (en) | 1997-03-12 |
US5690910A (en) | 1997-11-25 |
IL123166A (en) | 2002-07-25 |
HK1007060A1 (en) | 1999-04-01 |
DK0844869T3 (da) | 2005-12-12 |
JP3263723B2 (ja) | 2002-03-11 |
PL186912B1 (pl) | 2004-03-31 |
HUP9901614A2 (hu) | 1999-09-28 |
ZA966838B (en) | 1997-02-19 |
ATE300938T1 (de) | 2005-08-15 |
CZ48198A3 (cs) | 1998-11-11 |
WO1997006783A1 (en) | 1997-02-27 |
CZ292134B6 (cs) | 2003-08-13 |
AU701691B2 (en) | 1999-02-04 |
SK282759B6 (sk) | 2002-12-03 |
PT844869E (pt) | 2005-10-31 |
EP0844869A1 (en) | 1998-06-03 |
EP0844869A4 (en) | 2003-04-09 |
DE69635023D1 (de) | 2005-09-08 |
IL123166A0 (en) | 1998-09-24 |
KR100451901B1 (ko) | 2005-09-12 |
EP0844869B1 (en) | 2005-08-03 |
CA2229060A1 (en) | 1997-02-27 |
SK17298A3 (en) | 1998-09-09 |
HUP9901614A3 (en) | 2000-04-28 |
MX9801165A (es) | 1998-07-31 |
NZ337996A (en) | 2001-04-27 |
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