AR003271A1 - Una composicion farmaceutica para el tratamiento del asma inducido por un antigeno y uso de la heparina de peso molecular ultra bajo para la preparación de dicha composicón farmacéutica. - Google Patents

Una composicion farmaceutica para el tratamiento del asma inducido por un antigeno y uso de la heparina de peso molecular ultra bajo para la preparación de dicha composicón farmacéutica.

Info

Publication number
AR003271A1
AR003271A1 ARP960103997A AR10399796A AR003271A1 AR 003271 A1 AR003271 A1 AR 003271A1 AR P960103997 A ARP960103997 A AR P960103997A AR 10399796 A AR10399796 A AR 10399796A AR 003271 A1 AR003271 A1 AR 003271A1
Authority
AR
Argentina
Prior art keywords
pharmaceutical composition
asthma
molecular weight
low molecular
preparation
Prior art date
Application number
ARP960103997A
Other languages
English (en)
Original Assignee
Ivax Research Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ivax Research Inc filed Critical Ivax Research Inc
Publication of AR003271A1 publication Critical patent/AR003271A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Un método para el tratamiento de un paciente afectado de asma inducida por antígeno, que ha sido estimulado con un antígeno inductor de asma, quecomprende la administración intrabronquial al paciente de una composición farmacéutica quecontien e entre 0,05 mg aproximadamente y 1,0 mgaproximadamente de heparinas de peso molecular ultrabajo (en inglés ULMWH) por kilogramo de peso del paciente, en cada dosis; dicha ULMWH tiene un pesomolecular promedio de 3.000 daltons ó menos.
ARP960103997A 1995-08-18 1996-08-15 Una composicion farmaceutica para el tratamiento del asma inducido por un antigeno y uso de la heparina de peso molecular ultra bajo para la preparación de dicha composicón farmacéutica. AR003271A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/516,786 US5690910A (en) 1995-08-18 1995-08-18 Method for treating asthma

Publications (1)

Publication Number Publication Date
AR003271A1 true AR003271A1 (es) 1998-07-08

Family

ID=24057086

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP960103997A AR003271A1 (es) 1995-08-18 1996-08-15 Una composicion farmaceutica para el tratamiento del asma inducido por un antigeno y uso de la heparina de peso molecular ultra bajo para la preparación de dicha composicón farmacéutica.

Country Status (22)

Country Link
US (1) US5690910A (es)
EP (1) EP0844869B1 (es)
JP (1) JP3263723B2 (es)
KR (1) KR100451901B1 (es)
AR (1) AR003271A1 (es)
AT (1) ATE300938T1 (es)
AU (1) AU701691B2 (es)
CA (1) CA2229060A1 (es)
CZ (1) CZ292134B6 (es)
DE (1) DE69635023T2 (es)
DK (1) DK0844869T3 (es)
ES (1) ES2244974T3 (es)
HK (1) HK1007060A1 (es)
HU (1) HUP9901614A3 (es)
IL (1) IL123166A (es)
NZ (2) NZ315275A (es)
PL (1) PL186912B1 (es)
PT (1) PT844869E (es)
SK (1) SK282759B6 (es)
UA (1) UA62919C2 (es)
WO (1) WO1997006783A1 (es)
ZA (1) ZA966838B (es)

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US7056504B1 (en) 1998-08-27 2006-06-06 Massachusetts Institute Of Technology Rationally designed heparinases derived from heparinase I and II
US6235725B1 (en) * 1998-10-30 2001-05-22 Baker Norton Pharmaceuticals, Inc. Methods and compositions for the prevention of tolerance to medications
EP1462148A3 (en) * 1998-10-30 2010-03-17 Ivax Research, Inc. Methods and compositions for the prevention of tolerance to bronchodilators
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
EP1266013B1 (en) 2000-03-08 2014-10-15 Massachusetts Institute Of Technology Heparinase iii and uses thereof
JP2004513071A (ja) * 2000-05-23 2004-04-30 ザ・トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク 肺の弾性繊維損傷に関連した呼吸器疾患の治療方法
US7083937B2 (en) 2000-09-12 2006-08-01 Massachusetts Institute Of Technology Methods and products related to the analysis of polysaccarides
US7709461B2 (en) * 2000-10-18 2010-05-04 Massachusetts Institute Of Technology Methods and products related to pulmonary delivery of polysaccharides
SI1494732T1 (sl) 2002-03-20 2008-08-31 Mannking Corp Inhalacijski aparat
US20040171819A1 (en) 2002-10-10 2004-09-02 Aventis Pharma S.A. Mixtures of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
US20040152694A1 (en) * 2003-02-04 2004-08-05 Istvan Kurucz Methods and compositions for treating inflammatory disorders of the airways
GB0327723D0 (en) * 2003-09-15 2003-12-31 Vectura Ltd Pharmaceutical compositions
EP1786784B1 (en) 2004-08-20 2010-10-27 MannKind Corporation Catalysis of diketopiperazine synthesis
KR101306384B1 (ko) 2004-08-23 2013-09-09 맨카인드 코포레이션 약물 전달용 디케토피페라진염, 디케토모르포린염 또는디케토디옥산염
EP1791555B1 (en) * 2004-09-10 2013-03-13 Pharmaorigin ApS Methods for treating local tracheal, bronchial or alveolar bleeding or hemoptysis
AU2006290227B2 (en) 2005-09-14 2012-08-02 Mannkind Corporation Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents
RU2403059C2 (ru) 2006-02-22 2010-11-10 Маннкайнд Корпорейшн Способ улучшения фармацевтических свойств микрочастиц, содержащих дикетопиперазин и активный агент
US8592393B2 (en) 2007-11-02 2013-11-26 Momenta Pharmaceuticals, Inc. Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization
US8569262B2 (en) * 2007-11-02 2013-10-29 Momenta Pharmaceuticals, Inc. Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization
WO2009059284A2 (en) * 2007-11-02 2009-05-07 Momenta Pharmaceuticals, Inc. Non-anticoagulant polysaccharide compositions
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
KR101629154B1 (ko) 2008-06-13 2016-06-21 맨카인드 코포레이션 건조 분말 흡입기 및 약물 투여 시스템
DK2300083T3 (da) 2008-06-20 2013-07-22 Mannkind Corp Interaktivt apparat og fremgangsmåde til realtids-profilering af inhalationsforsøg
TWI614024B (zh) 2008-08-11 2018-02-11 曼凱公司 超快起作用胰島素之用途
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
MX2011009512A (es) 2009-03-11 2011-11-29 Mannkind Corp Aparato, sistema y metodo para medir la resistencia de un inhalador.
SG176738A1 (en) 2009-06-12 2012-01-30 Mannkind Corp Diketopiperazine microparticles with defined specific surface areas
CA2778698A1 (en) 2009-11-03 2011-05-12 Mannkind Corporation An apparatus and method for simulating inhalation efforts
EP2506711B1 (en) * 2009-12-03 2019-04-03 OPKO Health, Inc. Hypersulfated disaccharide formulations
BR112012026542A2 (pt) 2010-04-16 2016-07-12 Momenta Pharmaceuticals Inc abordagem seletiva de tecido
EP2582355A2 (en) 2010-06-17 2013-04-24 Momenta Pharmaceuticals, Inc. Methods and compositions for promoting hair growth
BR112012033060A2 (pt) 2010-06-21 2018-02-27 Mannkind Corp métodos de sistema de liberação de fármaco em pó seco
RU2528093C2 (ru) * 2010-07-21 2014-09-10 Олег Ильич Эпштейн Фармацевтическая композиция и способ лечения острых и хронических заболевания дыхательной системы и синдрома кашля
JP2014500863A (ja) * 2010-10-29 2014-01-16 オプコ ヘルス インコーポレイテッド エラスターゼ関連障害を治療するための高硫酸化二糖
CN105667994B (zh) 2011-04-01 2018-04-06 曼金德公司 用于药物药盒的泡罩包装
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
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SG10201605800UA (en) 2012-07-12 2016-09-29 Mannkind Corp Dry powder drug delivery system and methods
EP2911690A1 (en) 2012-10-26 2015-09-02 MannKind Corporation Inhalable influenza vaccine compositions and methods
JP6523247B2 (ja) 2013-03-15 2019-05-29 マンカインド コーポレイション 微結晶性ジケトピペラジン粒子の製造方法および乾燥粉末組成物の製造方法
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ATE203902T1 (de) * 1991-06-10 2001-08-15 Schering Corp Fluorchlorkohlenwasserstofffreie aerosolformulierungen
WO1993019734A1 (en) * 1992-04-02 1993-10-14 Baker Norton Pharmaceuticals, Inc. Method and composition for treating antigen-induced and exercise-induced asthma

Also Published As

Publication number Publication date
PL324970A1 (en) 1998-06-22
EP0844869B1 (en) 2005-08-03
ES2244974T3 (es) 2005-12-16
IL123166A0 (en) 1998-09-24
US5690910A (en) 1997-11-25
EP0844869A4 (en) 2003-04-09
HUP9901614A3 (en) 2000-04-28
DE69635023D1 (de) 2005-09-08
KR19990037688A (ko) 1999-05-25
IL123166A (en) 2002-07-25
AU701691B2 (en) 1999-02-04
SK17298A3 (en) 1998-09-09
DK0844869T3 (da) 2005-12-12
CZ292134B6 (cs) 2003-08-13
MX9801165A (es) 1998-07-31
AU6694596A (en) 1997-03-12
HK1007060A1 (en) 1999-04-01
WO1997006783A1 (en) 1997-02-27
ZA966838B (en) 1997-02-19
PT844869E (pt) 2005-10-31
CA2229060A1 (en) 1997-02-27
EP0844869A1 (en) 1998-06-03
NZ337996A (en) 2001-04-27
JPH11511196A (ja) 1999-09-28
CZ48198A3 (cs) 1998-11-11
HUP9901614A2 (hu) 1999-09-28
UA62919C2 (en) 2004-01-15
JP3263723B2 (ja) 2002-03-11
NZ315275A (en) 2000-01-28
SK282759B6 (sk) 2002-12-03
DE69635023T2 (de) 2006-05-24
KR100451901B1 (ko) 2005-09-12
PL186912B1 (pl) 2004-03-31
ATE300938T1 (de) 2005-08-15

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