JPH11511171A - α▲下V▼β▲下5▼仲介血管形成の阻止に有効な方法及び組成物 - Google Patents
α▲下V▼β▲下5▼仲介血管形成の阻止に有効な方法及び組成物Info
- Publication number
- JPH11511171A JPH11511171A JP9509460A JP50946097A JPH11511171A JP H11511171 A JPH11511171 A JP H11511171A JP 9509460 A JP9509460 A JP 9509460A JP 50946097 A JP50946097 A JP 50946097A JP H11511171 A JPH11511171 A JP H11511171A
- Authority
- JP
- Japan
- Prior art keywords
- angiogenesis
- tissue
- compound
- tumor
- antagonist
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.αvβ5含有組織において血管形成を阻止する方法であって、αvβ5拮抗体の 血管形成阻止量を含む組成物を前記組織に投与することを特徴とする方法。 2.前記αvβ5拮抗体が、αvβ5に免疫特異的であるがαvβ1、αvβ3又はαII b β3に免疫特異的でないモノクローナル抗体である請求項1記載の方法。 3.前記モノクローナル抗体が、P1F6と称するモノクローナル抗体の免疫反 応特性を有する請求項2記載の方法。 4.前記αvβ5拮抗体がRGD含有ポリペプチドである請求項1記載の方法。 5.前記ポリペプチドが、シクロ(Arg-Gly-Asp-D-Phe-Val)(配列番号4)、シク ロ(Gly-D-Arg-Gly-Asp-Phe-Val)(配列番号6)、シクロ(Arg-Gly-Asp-Phe-D-Val) (配列番号7)、Tyr-Thr-Ala-Glu-Cys-Lys-Pro-Gln-Val-Thr-Arg-Gly-Asp-Val-Ph e(配列番号8)及びシクロ(Arg-Gly-Asp-D-Phe-Asn-MeVal(配列番号9)及びその 塩からなる群より選ばれる請求項4記載の方法。 6.前記塩が塩酸塩である請求項5記載の方法。 7.前記組織が炎症組織であり、前記血管形成が炎症組織血管形成である請求項 1記載の方法。 8.前記組織が関節炎である請求項7記載の方法。 9.前記関節炎組織が、リウマチ様関節炎に罹った哺乳動物に存在する請求項8 記載の方法。 10.前記血管形成が、糖尿病性網膜症、老人性黄斑変性症、推定眼ヒストプラズ マ症、未熟児網膜症及び血管新生緑内障からなる眼疾患群より選ばれた眼疾患を もつ患者に存在する請求項1記載の方法。 11.前記血管形成が、角膜移植、ヘルペス性角膜炎、梅毒性角膜炎、翼状片及び コンタクトレンズ装用に伴う血管新生パンヌスからなる障害群より選ばれた角膜 血管新生障害をもつ患者に存在する請求項1記載の方法。 12.前記組織が血管腫である請求項1記載の方法。 13.前記組織が充実性腫瘍又は充実性腫瘍転移であり、前記血管形成が腫瘍血管 形成である請求項1記載の方法。 14.前記血管形成がサイトカインによって誘導される請求項1記載の方法。 15.前記サイトカインが、血管内皮細胞増殖因子、トランスフォーミング増殖因 子−α及び表皮増殖因子からなる群より選ばれる請求項14記載の方法。 16.前記サイトカインが血管内皮細胞増殖因子であり、前記血管形成が網膜血管 形成、角膜血管形成、腫瘍血管形成及び炎症組織血管形成からなる群より選ばれ る請求項15記載の方法。 17.前記血管形成阻止量が約2μM〜5mMである請求項1記載の方法。 18.前記投与が眼内、静脈内、経皮、滑液嚢内、筋肉内又は経口投与を含む請求 項1記載の方法。 19.前記投与が化学療法と共に行われる請求項1記載の方法。 20.前記投与が1回の静脈内投与を含む請求項1記載の方法。 21.前記αvβ5拮抗体が有機擬似体である請求項1記載の方法。 22.前記有機擬似体が下記構造によって表される請求項21記載の方法。 23.前記有機擬似体が下記構造によって表される請求項21記載の方法。 24.前記有機擬似体が下記構造によって表される請求項21記載の方法。 25.前記有機擬似体が下記構造によって表される請求項21記載の方法。 26.前記有機擬似体が下記構造によって表される請求項21記載の方法。 27.前記有機擬似体が下記構造によって表される請求項21記載の方法。 28.前記有機擬似体が下記構造によって表される請求項21記載の方法。 29.前記有機擬似体が下記構造によって表される請求項21記載の方法。 30.前記有機擬似体が下記構造によって表される請求項21記載の方法。
Applications Claiming Priority (3)
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US51479995A | 1995-08-14 | 1995-08-14 | |
US08/514,799 | 1995-08-14 | ||
PCT/US1996/013194 WO1997006791A1 (en) | 1995-08-14 | 1996-08-13 | METHODS AND COMPOSITIONS USEFUL FOR INHIBITION OF αvβ5 MEDIATED ANGIOGENESIS |
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JP2007112625A Division JP4544639B2 (ja) | 1995-08-14 | 2007-04-23 | αVβ5仲介血管形成の阻止に有効な方法及び組成物 |
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JPH11511171A true JPH11511171A (ja) | 1999-09-28 |
JP4903921B2 JP4903921B2 (ja) | 2012-03-28 |
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JP50946097A Expired - Fee Related JP4903921B2 (ja) | 1995-08-14 | 1996-08-13 | αVβ5仲介血管形成の阻止に有効な方法及び組成物 |
JP2007112625A Expired - Fee Related JP4544639B2 (ja) | 1995-08-14 | 2007-04-23 | αVβ5仲介血管形成の阻止に有効な方法及び組成物 |
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JP (2) | JP4903921B2 (ja) |
KR (1) | KR100516322B1 (ja) |
CN (2) | CN101053561A (ja) |
AT (1) | ATE308981T1 (ja) |
AU (1) | AU726793B2 (ja) |
CA (2) | CA2754102C (ja) |
CZ (1) | CZ40998A3 (ja) |
DE (1) | DE69635417T2 (ja) |
DK (1) | DK0844874T3 (ja) |
ES (1) | ES2250996T3 (ja) |
HU (1) | HUP9802675A3 (ja) |
MX (1) | MX9801228A (ja) |
NO (1) | NO319264B1 (ja) |
RU (1) | RU2214268C2 (ja) |
SK (1) | SK18898A3 (ja) |
UA (1) | UA84665C2 (ja) |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2013028611A (ja) * | 2004-04-02 | 2013-02-07 | Regents Of The Univ Of California | avβ5インテグリンに関連のある疾患を治療および予防するための方法および組成物 |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CZ380098A3 (cs) * | 1996-05-31 | 1999-05-12 | The Scripps Research Institute | Způsoby, výrobky, farmaceutické látky a alfa v beta5 antagonisté, vhodní pro inhibici angiogeneze řízené alfa v beta5 |
AU5596298A (en) * | 1996-12-09 | 1998-07-03 | Cor Therapeutics, Inc. | Integrin antagonists |
US6245809B1 (en) | 1996-12-09 | 2001-06-12 | Cor Therapeutics Inc. | Integrin antagonists |
US6228985B1 (en) | 1998-05-21 | 2001-05-08 | Schering Corporation | Derivatives of aminobenzoic and aminobiphenylcarboxylic acids useful as anti-cancer agents |
GB9812019D0 (en) * | 1998-06-05 | 1998-07-29 | Zeneca Ltd | Chemical compounds |
CA2333332A1 (en) | 1998-06-05 | 1999-12-16 | Astrazeneca Ab | Oxazolidinone derivatives, process for their preparation and pharmaceutical compositions containing them |
US6759047B1 (en) | 1998-06-17 | 2004-07-06 | Beth Israel Deaconess Hospital Corp. | Anti-angiogenic proteins and methods of use thereof |
US7387779B2 (en) | 1998-06-17 | 2008-06-17 | Beth Israel Deaconess Medical Center | Anti-angiogenic proteins and fragments and methods of use thereof |
US6962974B1 (en) | 1998-06-17 | 2005-11-08 | Beth Israel Deaconess Medical Center | Anti-angiogenic proteins and fragments and methods of use thereof |
US6235877B1 (en) | 1999-08-04 | 2001-05-22 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Peptido-mimetic compounds containing RGD sequence useful as integrin inhibitors |
US6160099A (en) | 1998-11-24 | 2000-12-12 | Jonak; Zdenka Ludmila | Anti-human αv β3 and αv β5 antibodies |
US6344484B1 (en) | 1999-02-12 | 2002-02-05 | 3-Dimensional Pharmaceuticals, Inc. | Tyrosine alkoxyguanidines as integrin inhibitors |
EP1028114A1 (en) | 1999-02-13 | 2000-08-16 | Aventis Pharma Deutschland GmbH | Novel guanidine derivatives as inhibitors of cell adhesion |
US6429214B1 (en) | 1999-07-21 | 2002-08-06 | Wyeth | Bicyclic antagonists selective for the αvβ3 integrin |
CZ20011872A3 (cs) | 1999-09-29 | 2002-03-13 | Ortho-Mcneil Pharmaceutical, Inc. | Isonipekotamidy pro léčbu onemocnění zprostředkovaných integriny |
GB9928568D0 (en) | 1999-12-03 | 2000-02-02 | Zeneca Ltd | Chemical compounds |
JP5043271B2 (ja) | 2000-04-12 | 2012-10-10 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | ペプチドベースの化合物 |
GB0009803D0 (en) | 2000-04-25 | 2000-06-07 | Astrazeneca Ab | Chemical compounds |
US6486174B2 (en) | 2000-08-07 | 2002-11-26 | 3-Dimensional Pharmaceuticals, Inc. | Tetrahydroisoquinoline-3-carboxylic acid alkoxyguanidines as integrin antagonists |
US7163681B2 (en) | 2000-08-07 | 2007-01-16 | Centocor, Inc. | Anti-integrin antibodies, compositions, methods and uses |
US7288390B2 (en) | 2000-08-07 | 2007-10-30 | Centocor, Inc. | Anti-dual integrin antibodies, compositions, methods and uses |
NO20004795D0 (no) | 2000-09-26 | 2000-09-26 | Nycomed Imaging As | Peptidbaserte forbindelser |
JP4615826B2 (ja) | 2001-01-29 | 2011-01-19 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | 置換インドールおよびインテグリンアンタゴニストとしてのそれらの使用 |
EP1389205B1 (en) | 2001-04-09 | 2005-12-21 | Ortho-McNeil Pharmaceutical Research Inc. | Quinazoline and quinazoline-like compounds for the treatment of integrin-mediated disorders |
US6872730B2 (en) | 2001-04-27 | 2005-03-29 | 3-Dimensional Pharmaceuticals, Inc. | Substituted benzofurans and benzothiophenes, methods of making and methods of use as integrin antagonists |
IL159310A0 (en) | 2001-07-10 | 2004-06-01 | Amersham Health As | Peptide-based compounds |
CN1536998A (zh) * | 2001-08-01 | 2004-10-13 | Ĭ��ר������˾ | 用于治疗眼病的整联蛋白抑制剂 |
WO2005053683A1 (en) | 2003-11-26 | 2005-06-16 | Duke University | A method of preventing or treating glaucoma |
AU2012216372B2 (en) * | 2004-04-02 | 2015-01-22 | The Regents Of The University Of California | Methods and compositions for treating and preventing disease associated with alphaVbeta5 integrin |
JP2012513589A (ja) | 2008-12-23 | 2012-06-14 | ジーイー・ヘルスケア・リミテッド | 骨髄イメージング剤としての99mTc−ペプチド系化合物の応用 |
WO2013132485A1 (en) | 2012-03-05 | 2013-09-12 | Ramot At Tel-Aviv University Ltd. | Polymers having therapeutically active agents conjugated thereto, processes of preparing same and uses thereof |
KR101597327B1 (ko) * | 2014-04-24 | 2016-02-24 | 동아에스티 주식회사 | 옥사졸리딘계 화합물 및 이를 포함하는 선택적 안드로겐 수용체 효능제 |
WO2017145164A1 (en) | 2016-02-24 | 2017-08-31 | Ramot At Tel-Aviv University Ltd. | Polymeric conjugates and uses thereof |
RU2646125C1 (ru) * | 2016-09-20 | 2018-03-01 | Константин Николаевич Руссков | Способ профилактики рецидива птеригиума |
RU2653814C1 (ru) * | 2017-06-01 | 2018-05-14 | Федеральное государственное автономное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова" Министерства здравоохранения Российской Федерации | Способ профилактики рецидивов птеригиума после хирургического лечения |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5135919A (en) * | 1988-01-19 | 1992-08-04 | Children's Medical Center Corporation | Method and a pharmaceutical composition for the inhibition of angiogenesis |
US5235919A (en) * | 1991-07-01 | 1993-08-17 | Robuck Norman F | Picnic table and flying insect control apparatus |
UA43823C2 (uk) * | 1992-07-06 | 2002-01-15 | Мерк Патент Геселлшафт Міт Бесшренктер Хафтунг | ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ ДЛЯ ІНГІБУВАННЯ ІНТЕГРИН <font face="Symbol">a</font><sub>V</sub><font face="Symbol">b</font><sub>3</sub>-ОПОСЕРЕДКОВАНОЇ КЛІТИННОЇ АДГЕЗІЇ КЛІТИН ССАВЦІВ, СПОСІБ ЛІКУВАННЯ ТА ПРОФІЛАКТИКИ ЗАХВОРЮВАННЯ, АСОЦІЙОВАНОГО З ПОРУШЕННЯМ АДГЕЗІЇ КЛІТИН, СПОСІБ БЛОКУВАННЯ ЗВ'ЯЗУВАННЯ ФІБРИНОГЕНОМ ІНТЕГРИНУ, КОМПОЗИЦІЯ ДЛЯ ЗАГОЄННЯ РАН |
US5981478A (en) * | 1993-11-24 | 1999-11-09 | La Jolla Cancer Research Foundation | Integrin-binding peptides |
US5753230A (en) * | 1994-03-18 | 1998-05-19 | The Scripps Research Institute | Methods and compositions useful for inhibition of angiogenesis |
SK163598A3 (en) * | 1996-05-31 | 1999-06-11 | Scripps Research Inst | Methods and compositions useful for inhibition of angiogenesis |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2013028611A (ja) * | 2004-04-02 | 2013-02-07 | Regents Of The Univ Of California | avβ5インテグリンに関連のある疾患を治療および予防するための方法および組成物 |
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UA84665C2 (ru) | 2008-11-25 |
ATE308981T1 (de) | 2005-11-15 |
NO980622L (no) | 1998-04-07 |
WO1997006791A1 (en) | 1997-02-27 |
CN1313146C (zh) | 2007-05-02 |
EP0844874A4 (en) | 2001-02-14 |
NO980622D0 (no) | 1998-02-13 |
RU2214268C2 (ru) | 2003-10-20 |
CA2227265A1 (en) | 1997-02-27 |
ES2250996T3 (es) | 2006-04-16 |
JP4903921B2 (ja) | 2012-03-28 |
CA2754102C (en) | 2012-12-18 |
JP4544639B2 (ja) | 2010-09-15 |
KR19990036426A (ko) | 1999-05-25 |
EP0844874B1 (en) | 2005-11-09 |
CA2754102A1 (en) | 1997-02-27 |
SK18898A3 (en) | 1998-07-08 |
NO319264B1 (no) | 2005-07-11 |
DE69635417T2 (de) | 2006-07-13 |
CA2227265C (en) | 2012-01-03 |
CZ40998A3 (cs) | 1998-09-16 |
MX9801228A (es) | 1998-05-31 |
JP2007262073A (ja) | 2007-10-11 |
CN101053561A (zh) | 2007-10-17 |
CN1198667A (zh) | 1998-11-11 |
DK0844874T3 (da) | 2006-01-16 |
HUP9802675A3 (en) | 2000-09-28 |
HUP9802675A2 (hu) | 1999-03-29 |
AU726793B2 (en) | 2000-11-23 |
AU6846696A (en) | 1997-03-12 |
KR100516322B1 (ko) | 2005-12-26 |
DE69635417D1 (de) | 2005-12-15 |
ZA966886B (en) | 1997-04-24 |
EP0844874A1 (en) | 1998-06-03 |
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