UA84665C2 - Способ ингибирования опосредствованного ангиогенеза в ткани у пациента с неоваскулярным заболеванием роговицы - Google Patents
Способ ингибирования опосредствованного ангиогенеза в ткани у пациента с неоваскулярным заболеванием роговицыInfo
- Publication number
- UA84665C2 UA84665C2 UA98031297A UA98031297A UA84665C2 UA 84665 C2 UA84665 C2 UA 84665C2 UA 98031297 A UA98031297 A UA 98031297A UA 98031297 A UA98031297 A UA 98031297A UA 84665 C2 UA84665 C2 UA 84665C2
- Authority
- UA
- Ukraine
- Prior art keywords
- inhibiting
- mediated angiogenesis
- neovascular diseases
- cornea
- tissue
- Prior art date
Links
- 230000033115 angiogenesis Effects 0.000 title abstract 4
- 230000001404 mediated effect Effects 0.000 title abstract 3
- 201000010099 disease Diseases 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- 230000002401 inhibitory effect Effects 0.000 title abstract 2
- 210000004087 cornea Anatomy 0.000 title 1
- 108090000695 Cytokines Proteins 0.000 abstract 1
- 102000004127 Cytokines Human genes 0.000 abstract 1
- 102000009024 Epidermal Growth Factor Human genes 0.000 abstract 1
- 101800003838 Epidermal growth factor Proteins 0.000 abstract 1
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 abstract 1
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 abstract 1
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 abstract 1
- 230000002596 correlated effect Effects 0.000 abstract 1
- 230000003511 endothelial effect Effects 0.000 abstract 1
- 229940116977 epidermal growth factor Drugs 0.000 abstract 1
- 230000012010 growth Effects 0.000 abstract 1
- 230000004968 inflammatory condition Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 230000001131 transforming effect Effects 0.000 abstract 1
- 230000004614 tumor growth Effects 0.000 abstract 1
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 abstract 1
- 230000002792 vascular Effects 0.000 abstract 1
Classifications
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/03—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C311/06—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms to acyclic carbon atoms of hydrocarbon radicals substituted by carboxyl groups
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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- A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
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- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/08—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by singly-bound oxygen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/10—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of a saturated carbon skeleton containing rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
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- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms
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- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
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- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
- C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
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- Ophthalmology & Optometry (AREA)
- Gastroenterology & Hepatology (AREA)
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- Physical Education & Sports Medicine (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Abstract
Изобретение относится к отрасли медицины, в частности к способу ингибирования опосредствованного αβангиогенеза, где указанный ангиогенез имеет место у пациента с неоваскулярным нарушением роговицы, выбранным из группы нарушений, которая состоит из трансплантации роговицы, герпесного кератита, люэтического кератита, птеригиума и неоваскулярного паннуса, связанного с ношением контактных линз, который включает введение указанному пациенту композиции, содержащей ингибирующее ангиогенез количество антагониста αβ, являющегося RGD-содержащим полипептид.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US51479995A | 1995-08-14 | 1995-08-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
UA84665C2 true UA84665C2 (ru) | 2008-11-25 |
Family
ID=24048748
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UA98031297A UA84665C2 (ru) | 1995-08-14 | 1996-08-13 | Способ ингибирования опосредствованного ангиогенеза в ткани у пациента с неоваскулярным заболеванием роговицы |
Country Status (19)
Country | Link |
---|---|
EP (1) | EP0844874B1 (ru) |
JP (2) | JP4903921B2 (ru) |
KR (1) | KR100516322B1 (ru) |
CN (2) | CN1313146C (ru) |
AT (1) | ATE308981T1 (ru) |
AU (1) | AU726793B2 (ru) |
CA (2) | CA2754102C (ru) |
CZ (1) | CZ40998A3 (ru) |
DE (1) | DE69635417T2 (ru) |
DK (1) | DK0844874T3 (ru) |
ES (1) | ES2250996T3 (ru) |
HU (1) | HUP9802675A3 (ru) |
MX (1) | MX9801228A (ru) |
NO (1) | NO319264B1 (ru) |
RU (1) | RU2214268C2 (ru) |
SK (1) | SK18898A3 (ru) |
UA (1) | UA84665C2 (ru) |
WO (1) | WO1997006791A1 (ru) |
ZA (1) | ZA966886B (ru) |
Families Citing this family (36)
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BR9709514A (pt) * | 1996-05-31 | 1999-08-10 | Scripps Research Inst | Processo e composições úteis para a inibição de angiogénese mediada por alfa beta |
US6245809B1 (en) | 1996-12-09 | 2001-06-12 | Cor Therapeutics Inc. | Integrin antagonists |
AU5596298A (en) * | 1996-12-09 | 1998-07-03 | Cor Therapeutics, Inc. | Integrin antagonists |
US6228985B1 (en) | 1998-05-21 | 2001-05-08 | Schering Corporation | Derivatives of aminobenzoic and aminobiphenylcarboxylic acids useful as anti-cancer agents |
AU753988B2 (en) | 1998-06-05 | 2002-10-31 | Astrazeneca Ab | Oxazolidinone derivatives, process for their preparation and pharmaceutical compositions containing them |
GB9812019D0 (en) * | 1998-06-05 | 1998-07-29 | Zeneca Ltd | Chemical compounds |
US6759047B1 (en) | 1998-06-17 | 2004-07-06 | Beth Israel Deaconess Hospital Corp. | Anti-angiogenic proteins and methods of use thereof |
US7387779B2 (en) | 1998-06-17 | 2008-06-17 | Beth Israel Deaconess Medical Center | Anti-angiogenic proteins and fragments and methods of use thereof |
US6962974B1 (en) | 1998-06-17 | 2005-11-08 | Beth Israel Deaconess Medical Center | Anti-angiogenic proteins and fragments and methods of use thereof |
US6235877B1 (en) | 1999-08-04 | 2001-05-22 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Peptido-mimetic compounds containing RGD sequence useful as integrin inhibitors |
US6160099A (en) * | 1998-11-24 | 2000-12-12 | Jonak; Zdenka Ludmila | Anti-human αv β3 and αv β5 antibodies |
US6344484B1 (en) | 1999-02-12 | 2002-02-05 | 3-Dimensional Pharmaceuticals, Inc. | Tyrosine alkoxyguanidines as integrin inhibitors |
EP1028114A1 (en) | 1999-02-13 | 2000-08-16 | Aventis Pharma Deutschland GmbH | Novel guanidine derivatives as inhibitors of cell adhesion |
CA2378860A1 (en) | 1999-07-21 | 2001-02-01 | American Home Products Corporation | Bicyclic antagonists selective for the .alpha.v.beta.3 integrin |
CA2352957A1 (en) | 1999-09-29 | 2001-04-05 | Ortho-Mcneil Pharmaceutical, Inc. | Isonipecotamides for the treatment of integrin-mediated disorders |
GB9928568D0 (en) | 1999-12-03 | 2000-02-02 | Zeneca Ltd | Chemical compounds |
KR100866666B1 (ko) | 2000-04-12 | 2008-11-04 | 지이 헬스케어 에이에스 | 펩티드 기재 화합물 |
GB0009803D0 (en) | 2000-04-25 | 2000-06-07 | Astrazeneca Ab | Chemical compounds |
US7163681B2 (en) | 2000-08-07 | 2007-01-16 | Centocor, Inc. | Anti-integrin antibodies, compositions, methods and uses |
US6486174B2 (en) | 2000-08-07 | 2002-11-26 | 3-Dimensional Pharmaceuticals, Inc. | Tetrahydroisoquinoline-3-carboxylic acid alkoxyguanidines as integrin antagonists |
US7288390B2 (en) | 2000-08-07 | 2007-10-30 | Centocor, Inc. | Anti-dual integrin antibodies, compositions, methods and uses |
NO20004795D0 (no) | 2000-09-26 | 2000-09-26 | Nycomed Imaging As | Peptidbaserte forbindelser |
KR100854424B1 (ko) | 2001-01-29 | 2008-08-27 | 3-디멘져널 파마슈티칼즈 인코오포레이티드 | 치환된 인돌 및 인테그린 길항제로서의 이들의 용도 |
EP1389205B1 (en) | 2001-04-09 | 2005-12-21 | Ortho-McNeil Pharmaceutical Research Inc. | Quinazoline and quinazoline-like compounds for the treatment of integrin-mediated disorders |
US6872730B2 (en) | 2001-04-27 | 2005-03-29 | 3-Dimensional Pharmaceuticals, Inc. | Substituted benzofurans and benzothiophenes, methods of making and methods of use as integrin antagonists |
EP1404371B1 (en) | 2001-07-10 | 2019-03-13 | GE Healthcare UK Limited | Peptide-based compounds for targeting intergin receptors |
HUP0401605A3 (en) * | 2001-08-01 | 2012-09-28 | Merck Patent Gmbh | Integrin inhibitors for the treatment of eye diseases |
US8415364B2 (en) | 2003-11-26 | 2013-04-09 | Duke University | Method of preventing or treating glaucoma |
AU2012216372B2 (en) * | 2004-04-02 | 2015-01-22 | The Regents Of The University Of California | Methods and compositions for treating and preventing disease associated with alphaVbeta5 integrin |
JP5223072B2 (ja) * | 2004-04-02 | 2013-06-26 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | avβ5インテグリンに関連のある疾患を治療および予防するための方法および組成物 |
CN102265158A (zh) | 2008-12-23 | 2011-11-30 | 通用电气健康护理有限公司 | 99mTc肽基化合物作为骨髓成像剂的应用 |
EP2822598A4 (en) | 2012-03-05 | 2016-04-13 | Univ Ramot | POLYMERS HAVING THERAPEUTICALLY ACTIVE AGENTS CONJUGATED THERETO, METHODS FOR THE PREPARATION OF SAID POLYMERS AND USES THEREOF |
KR101597327B1 (ko) * | 2014-04-24 | 2016-02-24 | 동아에스티 주식회사 | 옥사졸리딘계 화합물 및 이를 포함하는 선택적 안드로겐 수용체 효능제 |
WO2017145164A1 (en) | 2016-02-24 | 2017-08-31 | Ramot At Tel-Aviv University Ltd. | Polymeric conjugates and uses thereof |
RU2646125C1 (ru) * | 2016-09-20 | 2018-03-01 | Константин Николаевич Руссков | Способ профилактики рецидива птеригиума |
RU2653814C1 (ru) * | 2017-06-01 | 2018-05-14 | Федеральное государственное автономное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова" Министерства здравоохранения Российской Федерации | Способ профилактики рецидивов птеригиума после хирургического лечения |
Family Cites Families (6)
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US5135919A (en) * | 1988-01-19 | 1992-08-04 | Children's Medical Center Corporation | Method and a pharmaceutical composition for the inhibition of angiogenesis |
US5235919A (en) * | 1991-07-01 | 1993-08-17 | Robuck Norman F | Picnic table and flying insect control apparatus |
UA43823C2 (uk) * | 1992-07-06 | 2002-01-15 | Мерк Патент Геселлшафт Міт Бесшренктер Хафтунг | ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ ДЛЯ ІНГІБУВАННЯ ІНТЕГРИН <font face="Symbol">a</font><sub>V</sub><font face="Symbol">b</font><sub>3</sub>-ОПОСЕРЕДКОВАНОЇ КЛІТИННОЇ АДГЕЗІЇ КЛІТИН ССАВЦІВ, СПОСІБ ЛІКУВАННЯ ТА ПРОФІЛАКТИКИ ЗАХВОРЮВАННЯ, АСОЦІЙОВАНОГО З ПОРУШЕННЯМ АДГЕЗІЇ КЛІТИН, СПОСІБ БЛОКУВАННЯ ЗВ'ЯЗУВАННЯ ФІБРИНОГЕНОМ ІНТЕГРИНУ, КОМПОЗИЦІЯ ДЛЯ ЗАГОЄННЯ РАН |
US5981478A (en) * | 1993-11-24 | 1999-11-09 | La Jolla Cancer Research Foundation | Integrin-binding peptides |
US5753230A (en) * | 1994-03-18 | 1998-05-19 | The Scripps Research Institute | Methods and compositions useful for inhibition of angiogenesis |
AU733303C (en) * | 1996-05-31 | 2002-08-08 | Scripps Research Institute, The | Methods and compositions useful for inhibition of angiogenesis |
-
1996
- 1996-08-13 DE DE69635417T patent/DE69635417T2/de not_active Expired - Lifetime
- 1996-08-13 UA UA98031297A patent/UA84665C2/ru unknown
- 1996-08-13 EP EP96928868A patent/EP0844874B1/en not_active Expired - Lifetime
- 1996-08-13 KR KR10-1998-0701095A patent/KR100516322B1/ko not_active IP Right Cessation
- 1996-08-13 CA CA2754102A patent/CA2754102C/en not_active Expired - Fee Related
- 1996-08-13 MX MX9801228A patent/MX9801228A/es active IP Right Grant
- 1996-08-13 DK DK96928868T patent/DK0844874T3/da active
- 1996-08-13 AT AT96928868T patent/ATE308981T1/de active
- 1996-08-13 ES ES96928868T patent/ES2250996T3/es not_active Expired - Lifetime
- 1996-08-13 CN CNB96197429XA patent/CN1313146C/zh not_active Expired - Fee Related
- 1996-08-13 HU HU9802675A patent/HUP9802675A3/hu not_active Application Discontinuation
- 1996-08-13 AU AU68466/96A patent/AU726793B2/en not_active Ceased
- 1996-08-13 JP JP50946097A patent/JP4903921B2/ja not_active Expired - Fee Related
- 1996-08-13 RU RU98104128/14A patent/RU2214268C2/ru not_active IP Right Cessation
- 1996-08-13 CN CNA2007100863044A patent/CN101053561A/zh active Pending
- 1996-08-13 WO PCT/US1996/013194 patent/WO1997006791A1/en not_active Application Discontinuation
- 1996-08-13 CZ CZ98409A patent/CZ40998A3/cs unknown
- 1996-08-13 SK SK188-98A patent/SK18898A3/sk unknown
- 1996-08-13 CA CA2227265A patent/CA2227265C/en not_active Expired - Fee Related
- 1996-08-14 ZA ZA966886A patent/ZA966886B/xx unknown
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1998
- 1998-02-13 NO NO19980622A patent/NO319264B1/no unknown
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2007
- 2007-04-23 JP JP2007112625A patent/JP4544639B2/ja not_active Expired - Fee Related
Also Published As
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EP0844874A1 (en) | 1998-06-03 |
HUP9802675A3 (en) | 2000-09-28 |
CN1313146C (zh) | 2007-05-02 |
SK18898A3 (en) | 1998-07-08 |
CA2754102A1 (en) | 1997-02-27 |
JP2007262073A (ja) | 2007-10-11 |
DE69635417T2 (de) | 2006-07-13 |
CN101053561A (zh) | 2007-10-17 |
DK0844874T3 (da) | 2006-01-16 |
MX9801228A (es) | 1998-05-31 |
NO980622L (no) | 1998-04-07 |
JPH11511171A (ja) | 1999-09-28 |
KR100516322B1 (ko) | 2005-12-26 |
KR19990036426A (ko) | 1999-05-25 |
EP0844874A4 (en) | 2001-02-14 |
CA2754102C (en) | 2012-12-18 |
ES2250996T3 (es) | 2006-04-16 |
HUP9802675A2 (hu) | 1999-03-29 |
CA2227265C (en) | 2012-01-03 |
CZ40998A3 (cs) | 1998-09-16 |
RU2214268C2 (ru) | 2003-10-20 |
AU726793B2 (en) | 2000-11-23 |
JP4544639B2 (ja) | 2010-09-15 |
NO980622D0 (no) | 1998-02-13 |
CA2227265A1 (en) | 1997-02-27 |
ATE308981T1 (de) | 2005-11-15 |
JP4903921B2 (ja) | 2012-03-28 |
ZA966886B (en) | 1997-04-24 |
DE69635417D1 (de) | 2005-12-15 |
NO319264B1 (no) | 2005-07-11 |
CN1198667A (zh) | 1998-11-11 |
EP0844874B1 (en) | 2005-11-09 |
AU6846696A (en) | 1997-03-12 |
WO1997006791A1 (en) | 1997-02-27 |
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