JPH11510479A - タモキシフェン類似体による心臓血管疾病の予防及び治療 - Google Patents
タモキシフェン類似体による心臓血管疾病の予防及び治療Info
- Publication number
- JPH11510479A JPH11510479A JP9502239A JP50223997A JPH11510479A JP H11510479 A JPH11510479 A JP H11510479A JP 9502239 A JP9502239 A JP 9502239A JP 50223997 A JP50223997 A JP 50223997A JP H11510479 A JPH11510479 A JP H11510479A
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- Prior art keywords
- tgf
- beta
- compound
- pharmaceutically acceptable
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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Landscapes
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US08/477,393 | 1995-06-07 | ||
| US08/486,334 | 1995-06-07 | ||
| US08/478,936 | 1995-06-07 | ||
| US08/486,334 US5770609A (en) | 1993-01-28 | 1995-06-07 | Prevention and treatment of cardiovascular pathologies |
| US08/476,735 | 1995-06-07 | ||
| US08/476,735 US5595722A (en) | 1993-01-28 | 1995-06-07 | Method for identifying an agent which increases TGF-beta levels |
| PCT/US1996/010211 WO1996040098A2 (en) | 1995-06-07 | 1996-06-07 | Prevention and treatment of cardiovascular pathologies with tamoxifen analogues |
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| JPH11510479A true JPH11510479A (ja) | 1999-09-14 |
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| EP (1) | EP0833624B1 (enExample) |
| JP (1) | JPH11510479A (enExample) |
| AT (1) | ATE377418T1 (enExample) |
| AU (1) | AU6277396A (enExample) |
| CA (1) | CA2223595C (enExample) |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8263661B2 (en) | 2003-10-21 | 2012-09-11 | The Regents Of The University Of California | Development of new selective estrogen receptor modulators |
| JP2019532026A (ja) * | 2016-08-19 | 2019-11-07 | ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ | 選択的エストロゲン受容体モジュレーター（ｓｅｒｍ）は、光受容体の変性に対する保護を付与する |
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| GB9824207D0 (en) * | 1998-11-04 | 1998-12-30 | Zeneca Ltd | Neurological disorders |
| GB9827121D0 (en) * | 1998-12-09 | 1999-02-03 | Orion Corp | Agent for lowering endothelin levels |
| CA2697598A1 (en) | 1999-01-12 | 2000-07-20 | Cambridge Enterprise Limited | Compounds and methods to inhibit or augment an inflammatory response |
| US7112409B2 (en) | 1999-01-29 | 2006-09-26 | Center For Molecular Medicine And Immunology | Method of determining cytokine dosage for myelosuppressive state |
| US6649352B1 (en) * | 1999-01-29 | 2003-11-18 | Center For Molecular Medicine And Immunology | Method of evaluating myelosuppressive state |
| US7220782B1 (en) * | 1999-02-26 | 2007-05-22 | University Of Iowa Research Foundation | Methods to reduce the sensitivity of endothelially-compromised vascular smooth muscle |
| US7393864B2 (en) * | 1999-02-26 | 2008-07-01 | University Of Iowa Research Foundation | Use of ClC3 chloride channel blockers to modulate vascular tone |
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| US9522217B2 (en) | 2000-03-15 | 2016-12-20 | Orbusneich Medical, Inc. | Medical device with coating for capturing genetically-altered cells and methods for using same |
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| WO2003014727A1 (fr) * | 2001-08-08 | 2003-02-20 | Chugai Seiyaku Kabushiki Kaisha | Medicaments pour maladies cardiaque |
| US20030032676A1 (en) * | 2001-08-09 | 2003-02-13 | Kimelberg Harold K. | Drugs for treatment of cerebral injury and methods of use thereof |
| US6908460B2 (en) | 2001-08-28 | 2005-06-21 | Joseph Distefano | Apparatus for conveying a light source to an intravenous needle to kill blood pathogens |
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| JP3990972B2 (ja) * | 2001-11-20 | 2007-10-17 | 有限会社 キック | 血管再狭窄防止薬及び該防止薬がコーティングされた血管内埋め込み器具 |
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| US5521191A (en) | 1994-10-17 | 1996-05-28 | Washington University | Method for treatment of arterial stenosis |
| US5516807A (en) | 1994-10-25 | 1996-05-14 | Warner-Lambert Company | Method for treating vascular proliferative disorders following balloon angioplasty |
| US5498775A (en) | 1994-11-07 | 1996-03-12 | American Home Products Corporation | Polyanionic benzylglycosides as inhibitors of smooth muscle cell proliferation |
| US5489587A (en) | 1995-01-20 | 1996-02-06 | Eli Lilly And Company | Benzofurans used to inhibit bone loss |
| US5484808A (en) | 1995-02-09 | 1996-01-16 | Eli Lilly And Company | Methods of inhibiting cell-cell adhesion |
| US5510357A (en) | 1995-02-28 | 1996-04-23 | Eli Lilly And Company | Benzothiophene compounds as anti-estrogenic agents |
| US5563054A (en) | 1995-03-31 | 1996-10-08 | Eli Lilly And Company | Process for preparation of benzo[B]thiophene glucuronides |
| US5622975A (en) | 1995-06-01 | 1997-04-22 | Eli Lilly And Company | Methods for inhibiting vascular smooth muscle cell migration |
| US5639274A (en) | 1995-06-02 | 1997-06-17 | Fischell; Robert E. | Integrated catheter system for balloon angioplasty and stent delivery |
| US5726186A (en) | 1995-09-08 | 1998-03-10 | Eli Lilly And Company | Pentacyclic compounds, intermediates, processes, compositions, and methods |
| AU6959898A (en) * | 1997-04-11 | 1998-11-11 | David J. Grainger | Compounds and therapies for the prevention of vascular and non-vascular pathol ogies |
-
1996
- 1996-06-07 CA CA002223595A patent/CA2223595C/en not_active Expired - Fee Related
- 1996-06-07 AU AU62773/96A patent/AU6277396A/en not_active Abandoned
- 1996-06-07 US US08/973,570 patent/US6197789B1/en not_active Expired - Lifetime
- 1996-06-07 AT AT96921577T patent/ATE377418T1/de not_active IP Right Cessation
- 1996-06-07 JP JP9502239A patent/JPH11510479A/ja active Pending
- 1996-06-07 EP EP96921577A patent/EP0833624B1/en not_active Expired - Lifetime
- 1996-06-07 WO PCT/US1996/010211 patent/WO1996040098A2/en not_active Ceased
-
2001
- 2001-01-04 US US09/754,775 patent/US20020068731A1/en not_active Abandoned
-
2003
- 2003-12-05 US US10/729,056 patent/US20060135560A1/en not_active Abandoned
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8263661B2 (en) | 2003-10-21 | 2012-09-11 | The Regents Of The University Of California | Development of new selective estrogen receptor modulators |
| JP2019532026A (ja) * | 2016-08-19 | 2019-11-07 | ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ | 選択的エストロゲン受容体モジュレーター（ｓｅｒｍ）は、光受容体の変性に対する保護を付与する |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2223595C (en) | 2008-08-05 |
| WO1996040098A2 (en) | 1996-12-19 |
| US6197789B1 (en) | 2001-03-06 |
| US20060135560A1 (en) | 2006-06-22 |
| EP0833624B1 (en) | 2007-11-07 |
| AU6277396A (en) | 1996-12-30 |
| WO1996040098A3 (en) | 1997-06-19 |
| US20020068731A1 (en) | 2002-06-06 |
| EP0833624A2 (en) | 1998-04-08 |
| ATE377418T1 (de) | 2007-11-15 |
| CA2223595A1 (en) | 1996-12-19 |
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