JPH10513363A - 細胞の増殖基質としての粘膜下組織 - Google Patents
細胞の増殖基質としての粘膜下組織Info
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- JPH10513363A JPH10513363A JP8524477A JP52447796A JPH10513363A JP H10513363 A JPH10513363 A JP H10513363A JP 8524477 A JP8524477 A JP 8524477A JP 52447796 A JP52447796 A JP 52447796A JP H10513363 A JPH10513363 A JP H10513363A
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0655—Chondrocytes; Cartilage
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/34—Internal compartments or partitions
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
- C12M25/02—Membranes; Filters
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- C—CHEMISTRY; METALLURGY
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0068—General culture methods using substrates
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0679—Cells of the gastro-intestinal tract
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/32—Amino acids
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/38—Vitamins
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue
- C12N2533/92—Amnion; Decellularised dermis or mucosa
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
- Y10S623/915—Method or apparatus for preparing biological material
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
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- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Sustainable Development (AREA)
- Rheumatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Clinical Laboratory Science (AREA)
- Immunology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Materials For Medical Uses (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.真核細胞の in vitro 増殖及び分化を促進する方法であって、前記細胞の 増殖を誘導する条件下で、前記細胞と温血脊椎動物の粘膜下組織を含む細胞増殖 基質とを in vitro 接触させる段階を含む方法。 2.粘膜下組織が筋層から分離した粘膜下層、少なくとも筋層の内腔部分を含 んでなる脳粘膜下組織である請求の範囲第1項記載の方法。 3.細胞を細胞増殖基質と接触させる段階が、流動状粘膜下組織で被覆した培 養器具上に細胞を培養することを含んでなる請求の範囲第1項記載の方法。 4.細胞を細胞増殖基質と接触させる段階が、流動状粘膜下組織を液体細胞培 養培地に加えることを含んでなる請求の範囲第1項記載の方法。 5.細胞集団の増殖を促進する培養培地組成物であって、温血脊椎動物の粘膜 下組織と、前記細胞集団の増殖を促進する栄養とを含む培養培地組成物。 6.粘膜下組織が、筋層から分離した粘膜下層、少なくとも筋層の内腔部分か らなる腸粘膜下組織である請求の範囲第5項記載の組成物。 7.粘膜下組織が流動状粘膜下組織である請求の範囲第5項記載の組成物。 8.粘膜下組織を、前記組織を可溶化するのに十分な時間プロテアーゼで消化 し、実質上均質な溶液が提供される請求の範囲第5項記載の組成物。 9.温血脊椎動物の粘膜下組織と;前記細胞集団の増殖を促進する栄養と;あ らかじめ選択した細胞型の増殖集団とを含む細胞培養組成物。 10.粘膜下組織が腸粘膜下組織である請求の範囲第9項記載の細胞培養組成 物。 11.あらかじめ選択した細胞型が、線維芽細胞過剰増殖を実質上伴わない島 細胞である請求の範囲第9項記載の細胞培養組成物。 12.温血脊椎動物の粘膜下組織の、移植または注入組織グラフト材料として の機能的特性を高める方法であって、グラフト材料を宿主に移植または注入する 前に、粘膜下組織にあらかじめ選択した細胞型を接種する段階を含む方法。 13.グラフト材料を宿主に移植または注入する前に、そのグラフト材料を、 あらかじめ選択した細胞型の増殖を誘導する条件にさらし、前記細胞を増殖させ る段階をさらに含む請求の範囲第12項記載の方法。 14.In vitro で線維芽細胞の同時増殖なしに島細胞を増殖させる方法であ って、前記細胞の増殖を誘導する条件下で、島細胞を温血脊椎動物の粘膜下組織 を含む細胞増殖基質と in vitro 接触させる段階を含む方法。 15.種々の腫瘍細胞増殖条件のもとで腫瘍細胞の増殖特性を in vitro 分析 する方法であって、前記腫瘍細胞を、温血脊椎動物の粘膜下組織を含む細胞増殖 基質上に接種し、前記細胞の増殖に必要な栄養を含む培養培地を作り;種々の細 胞増殖条件を選択し;腫瘍細胞を、選択した条件下で前記栄養培地中の前記基質 上に培養し;粘膜組織基質及び前記基質上の腫瘍細胞集団を組織学的に検査する 諸段階からなる方法。 16.選択する増殖条件が、栄養培地中の腫瘍細胞増殖改変化合物の存在また は濃度である請求の範囲第15項記載の方法。 17.選択する増殖条件が電磁放射量である請求の範囲第15項記載の方法。 18.細胞外基質の腫瘍侵襲を in vitro 分析する方法であって、前記腫瘍細 胞を温血脊椎動物の粘膜下組織を含む細胞増殖基質上に接種し;前記基質上の腫 瘍細胞を真核細胞の増殖を誘導する条件下で培養し;粘膜組織基質及び前記基質 の腫瘍細胞集団を組織学的に検査する諸段階からなる方法。 19.1つ以上の増殖条件を変えて、その変化が腫瘍細胞の増殖特性に与える 影響を調べる段階をさらに含む請求の範囲第18項記載の方法。 20.1つ以上の増殖条件を変える段階が腫瘍細胞増殖改変化合物の添加また は濃度変化を含んでなる請求の範囲第19項記載の方法。 21.1つ以上の増殖条件を変える段階が、腫瘍細胞を或る量の電磁放射にさ らすことを含んでなる請求の範囲第19項記載の方法。 22.細胞の in vitro 侵襲性増殖特性を研究する装置であって、第1チェン バーを輪郭づける上方体部と;第2チェンバーを輪郭づけるベースと;前記第1 及び第2チェンバーを分離する基質界面と;上方体部をベースの方にバイアスし 、前記基質を上方体部とベースとの間に保持する手段とを含んでなり、基質界面 は温血脊椎動物の粘膜下組織を含んでなる装置。 23.基質界面が実質上粘膜下組織からなる請求の範囲第22記載の装置。 24.基質界面が粘膜下組織被覆フィルターからなる請求の範囲第22項記載 の装置。 25.第1及び第2チェンバーが栄養培地で満たされる請求の範囲第22項記 載の装置。 26.前記上方体部は、軸方向に延びる突出部をもち、軸方向に延びる突出部 を突き抜ける穴が、その突出部に平行にあいており、軸方向に延びる突出部は第 1の環状面を提供し;前記ベースは第2チェンバーへの開口部を限定する末端壁 を含み、末端壁は第2の環状面を提供し、前記第1及び第2環状面は実質的に相 補的な形をもち;第1環状面を第2環状面の方にバイアスをかけ、前記基質界面 を前記第1及び第2環状面の間に保持する手段をもつ請求の範囲第22記載の装 置。 27.粘膜下組織層が実質上粘膜下組織からなる請求の範囲第26項記載の侵 襲チェンバー。 28.粘膜下組織層が粘膜下組織被覆された多孔性支持体を構成する請求の範 囲第26項記載の侵襲チェンバー。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/386,452 | 1995-02-10 | ||
US08/386,452 US5695998A (en) | 1995-02-10 | 1995-02-10 | Submucosa as a growth substrate for islet cells |
PCT/US1996/001842 WO1996024661A1 (en) | 1995-02-10 | 1996-02-09 | Submucosa as a growth substrate for cells |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2006186890A Division JP4054352B2 (ja) | 1995-02-10 | 2006-07-06 | 細胞の増殖基質としての粘膜下組織 |
Publications (2)
Publication Number | Publication Date |
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JPH10513363A true JPH10513363A (ja) | 1998-12-22 |
JP4054059B2 JP4054059B2 (ja) | 2008-02-27 |
Family
ID=23525638
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP52447796A Expired - Fee Related JP4054059B2 (ja) | 1995-02-10 | 1996-02-09 | 細胞の増殖基質としての粘膜下組織 |
JP2006186890A Expired - Fee Related JP4054352B2 (ja) | 1995-02-10 | 2006-07-06 | 細胞の増殖基質としての粘膜下組織 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2006186890A Expired - Fee Related JP4054352B2 (ja) | 1995-02-10 | 2006-07-06 | 細胞の増殖基質としての粘膜下組織 |
Country Status (8)
Country | Link |
---|---|
US (4) | US5695998A (ja) |
EP (2) | EP1449916B1 (ja) |
JP (2) | JP4054059B2 (ja) |
AR (1) | AR000921A1 (ja) |
AU (1) | AU719160B2 (ja) |
CA (1) | CA2212704A1 (ja) |
DE (2) | DE69638369D1 (ja) |
WO (1) | WO1996024661A1 (ja) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2010507584A (ja) * | 2006-10-20 | 2010-03-11 | ユニバーシティ オブ ノートル ダム | 細胞外マトリックス癌ワクチンアジュバント |
JP2010516763A (ja) * | 2007-01-30 | 2010-05-20 | ユニバーシティ オブ ノートル ダム | 感染性病原体又は毒素に関連する疾患のためのワクチンアジュバントとしての細胞外マトリックス物質 |
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US6506599B1 (en) * | 1999-10-15 | 2003-01-14 | Tai-Wook Yoon | Method for culturing langerhans islets and islet autotransplantation islet regeneration |
BR9915476A (pt) * | 1998-11-19 | 2002-01-02 | Organogenesis Inc | Construtos de tecidos feitos por bioengenharia e métodos para a sua produção e utilização |
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US6918396B1 (en) | 1998-12-01 | 2005-07-19 | Purdue Research Foundation | Method for vocal cord reconstruction |
US6303355B1 (en) | 1999-03-22 | 2001-10-16 | Duke University | Method of culturing, cryopreserving and encapsulating pancreatic islet cells |
US6365385B1 (en) | 1999-03-22 | 2002-04-02 | Duke University | Methods of culturing and encapsulating pancreatic islet cells |
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Cited By (2)
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JP2010507584A (ja) * | 2006-10-20 | 2010-03-11 | ユニバーシティ オブ ノートル ダム | 細胞外マトリックス癌ワクチンアジュバント |
JP2010516763A (ja) * | 2007-01-30 | 2010-05-20 | ユニバーシティ オブ ノートル ダム | 感染性病原体又は毒素に関連する疾患のためのワクチンアジュバントとしての細胞外マトリックス物質 |
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US5753267A (en) | 1998-05-19 |
CA2212704A1 (en) | 1996-08-15 |
EP0809691A4 (en) | 2000-06-21 |
DE69638369D1 (de) | 2011-06-16 |
EP0809691A1 (en) | 1997-12-03 |
AU4921096A (en) | 1996-08-27 |
WO1996024661A1 (en) | 1996-08-15 |
JP4054059B2 (ja) | 2008-02-27 |
JP2007105031A (ja) | 2007-04-26 |
US5695998A (en) | 1997-12-09 |
DE69630206D1 (de) | 2003-11-06 |
JP4054352B2 (ja) | 2008-02-27 |
EP1449916B1 (en) | 2011-05-04 |
US5866414A (en) | 1999-02-02 |
EP1449916A2 (en) | 2004-08-25 |
EP0809691B1 (en) | 2003-10-01 |
US6087157A (en) | 2000-07-11 |
AU719160B2 (en) | 2000-05-04 |
AR000921A1 (es) | 1997-08-27 |
EP1449916A3 (en) | 2004-12-22 |
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