JPH10512551A - 準冷却溶融生成物からの活性物質経皮吸収剤 - Google Patents
準冷却溶融生成物からの活性物質経皮吸収剤Info
- Publication number
- JPH10512551A JPH10512551A JP8520180A JP52018096A JPH10512551A JP H10512551 A JPH10512551 A JP H10512551A JP 8520180 A JP8520180 A JP 8520180A JP 52018096 A JP52018096 A JP 52018096A JP H10512551 A JPH10512551 A JP H10512551A
- Authority
- JP
- Japan
- Prior art keywords
- drug
- absorption
- subcooled
- active substance
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.吸収増進補助剤を含む皮膚への薬剤の放散のための薬であって、前記補助物 質が、準冷却溶融生成物を構成する物質であることを特徴とする薬。 2.前記薬剤が、ブプレノルフィン塩基(buprenorphine base)であることを特徴 とする請求項1に記載の薬。 3.前記吸収増進補助剤が、準冷却溶融性のレブリン酸(levulic acid)であるこ とを特徴とする請求項1に記載の薬。 4.前記吸収増進補助剤が準冷却溶融性のドデカノールであることを特徴とする 請求項1に記載の薬。 5.前記薬剤が、ブプレノルフィン塩基であり、前記吸収増進補助剤が、準冷却 溶融性のレブリン酸であることを特徴とする請求項1に記載の薬。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4446600A DE4446600A1 (de) | 1994-12-24 | 1994-12-24 | Transdermale Resorption von Wirkstoffen aus unterkühlten Schmelzen |
DE4446600.5 | 1994-12-24 | ||
PCT/EP1995/005006 WO1996019975A1 (de) | 1994-12-24 | 1995-12-18 | Transdermale resorption von wirkstoffen aus unterkühlten schmelzen |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH10512551A true JPH10512551A (ja) | 1998-12-02 |
JP3549207B2 JP3549207B2 (ja) | 2004-08-04 |
Family
ID=6537122
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP52018096A Expired - Lifetime JP3549207B2 (ja) | 1994-12-24 | 1995-12-18 | 準冷却溶融生成物からの活性物質経皮吸収剤 |
Country Status (12)
Country | Link |
---|---|
US (1) | US6264980B1 (ja) |
EP (1) | EP0792145B1 (ja) |
JP (1) | JP3549207B2 (ja) |
AT (1) | ATE172640T1 (ja) |
AU (1) | AU4387196A (ja) |
DE (2) | DE4446600A1 (ja) |
DK (1) | DK0792145T3 (ja) |
ES (1) | ES2125678T3 (ja) |
IL (1) | IL116452A0 (ja) |
SI (1) | SI0792145T1 (ja) |
WO (1) | WO1996019975A1 (ja) |
ZA (1) | ZA9510876B (ja) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2015500329A (ja) * | 2011-12-12 | 2015-01-05 | エルテーエス ローマン テラピー−ジステーメ アーゲー | ブプレノルフィンを含む経皮送達システム |
JP2015526480A (ja) * | 2012-08-24 | 2015-09-10 | インテグアールエックス セラピューティクス, エルエルシーIntegurx Therapeutics, Llc | 治療剤の経皮送達を増強するための化学組成物および方法 |
JP2016503802A (ja) * | 2012-12-21 | 2016-02-08 | テイコク ファーマ ユーエスエー インコーポレーテッド | ホルモン及びその他の薬剤を経皮送達するための組成物及び方法 |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5968547A (en) | 1997-02-24 | 1999-10-19 | Euro-Celtique, S.A. | Method of providing sustained analgesia with buprenorphine |
IL151058A0 (en) | 2000-02-08 | 2003-04-10 | Euro Celtique Sa | Controlled-release compositions containing opioid agonist and antagonist |
JP4659943B2 (ja) | 2000-02-25 | 2011-03-30 | 帝三製薬株式会社 | 塩酸ブプレノルフィン含有貼付剤 |
US7018649B2 (en) | 2000-10-23 | 2006-03-28 | Euro-Celtique, S.A. | Felodipine transdermal device and methods |
EP1335689B1 (en) | 2000-10-23 | 2010-03-17 | Euro-Celtique S.A. | Loratadine transdermal administration system and use thereof |
JP2004525960A (ja) * | 2001-02-16 | 2004-08-26 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 尿失禁、特に切迫尿失禁の治療用経皮デリバリーディバイスの製造にブプレノルフィンを使用する方法 |
CA2438339C (en) * | 2001-02-16 | 2010-12-14 | Grunenthal Gmbh | Use of buprenorphine for treatment of urinary incontinence |
EP1323421A1 (en) * | 2001-12-20 | 2003-07-02 | Grünenthal GmbH | Use of buprenorphine for the manufacture of a transdermal delivery device for the treatment of urinary incontinence, especially urge incontinence |
EA009024B1 (ru) | 2002-06-25 | 2007-10-26 | АКРУКС ДиДиЭс ПиТиУай ЭлТиДи | Фармацевтическая композиция для чрескожной доставки активного агента (варианты) |
US20050191340A1 (en) * | 2002-08-09 | 2005-09-01 | Gruenenthal Gmbh | Opioid-receptor antagonists in transdermal systems having buprenorphine |
WO2004039317A2 (en) | 2002-10-25 | 2004-05-13 | Euro-Celtique S.A. | Analogs and prodrugs of buprenorphine |
DE10305137A1 (de) * | 2003-02-07 | 2004-08-26 | Novosis Ag | Transdermale therapeutische Abgabesysteme mit einem Butenolid |
WO2005081825A2 (en) | 2004-02-23 | 2005-09-09 | Euro-Celtique S.A. | Abuse resistance opioid transdermal delivery device |
EP1743638A1 (en) | 2005-07-15 | 2007-01-17 | Laboratorios Del Dr. Esteve, S.A. | Pharmaceutical formulations of substituted pyrazoline compounds |
JP5448814B2 (ja) * | 2006-07-21 | 2014-03-19 | バイオデリバリー サイエンシーズ インターナショナル インコーポレイティッド | 取り込みを増強する経粘膜送達装置 |
DE102006054732B4 (de) | 2006-11-21 | 2010-12-30 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System mit Ionenpaar-Mikroreservoiren |
DE102006054731B4 (de) * | 2006-11-21 | 2013-02-28 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System zur Verabreichung des Wirkstoffs Buprenorphin und Verwendung desselben in der Schmerztherapie |
KR20150036825A (ko) | 2010-04-13 | 2015-04-07 | 나지브 바불 | 1-메틸-2''-6''-피페콜옥실리디드의 피부 약제학적 조성물 및 사용 방법 |
US9844515B2 (en) | 2010-11-17 | 2017-12-19 | Hexal Ag | Transdermal therapeutic system comprising buprenorphine |
DE102011076653A1 (de) | 2011-05-27 | 2012-11-29 | Acino Ag | Transdermales therapeutisches System enthaltend Buprenorphin und eine alpha-Hydroxysäure |
HRP20211377T1 (hr) | 2011-11-23 | 2022-01-07 | Therapeuticsmd, Inc. | Prirodne kombinirane hormonske supstitucijske formulacije i terapije |
US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
US9901539B2 (en) | 2011-12-21 | 2018-02-27 | Biodelivery Sciences International, Inc. | Transmucosal drug delivery devices for use in chronic pain relief |
US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
CN104955516B (zh) | 2012-12-28 | 2019-01-22 | 帝国制药美国公司 | 延长丁丙诺啡经皮递送组合物及其使用方法 |
EP2810646B1 (en) | 2013-06-04 | 2016-07-27 | LTS LOHMANN Therapie-Systeme AG | Transdermal delivery system |
EP3145489A1 (en) | 2014-05-22 | 2017-03-29 | TherapeuticsMD, Inc. | Natural combination hormone replacement formulations and therapies |
DE102014013448A1 (de) | 2014-09-16 | 2016-03-17 | Alfred E. Tiefenbacher (Gmbh & Co. Kg) | Transdermales Therapeutisches System umfassend Buprenorphin |
US9656441B2 (en) | 2015-01-08 | 2017-05-23 | Alfred E. Tiefenbacher ( Gmbh & Co. Kg) | Transdermal patch |
CA3104099A1 (en) | 2015-03-10 | 2016-09-15 | Rhodes Technologies | Acetate salt of buprenorphine and methods for preparing buprenorphine |
EP3067050A1 (en) | 2015-03-13 | 2016-09-14 | Acino AG | Transdermal therapeutic system with an overtape comprising two adhesive layers |
US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
AR102214A1 (es) | 2015-10-08 | 2017-02-15 | Amarin Tech S A | Un dispositivo para la administración transdermal de buprenorfina |
WO2017173071A1 (en) | 2016-04-01 | 2017-10-05 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical composition |
US10286077B2 (en) | 2016-04-01 | 2019-05-14 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
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US3598122A (en) | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
US4900730A (en) * | 1981-01-14 | 1990-02-13 | Toyo Jozo Co., Ltd. | Preparation which promotes the absorption of peptides |
JPS58124711A (ja) * | 1982-01-21 | 1983-07-25 | Kanebo Ltd | 皮膚化粧料 |
DE3315272C2 (de) | 1983-04-27 | 1986-03-27 | Lohmann Gmbh & Co Kg, 5450 Neuwied | Pharmazeutisches Produkt und Verfahren zu seiner Herstellung |
CA2002299A1 (en) * | 1988-11-10 | 1990-05-10 | Eugene G. Drust | Compositions for the transdermal delivery of buprenorphine salts |
GB8921710D0 (en) * | 1989-09-26 | 1989-11-08 | Mentholatum Co Ltd | Ibuprofen triturates and topical compositions containing same |
US5240711A (en) * | 1989-11-29 | 1993-08-31 | Lts Lohmann Therapie-Systeme Gmbh & Co. Kg | Transdermal therapeutic system comprising as active component buprenorphine |
DE3939376C1 (ja) * | 1989-11-29 | 1991-05-08 | Lts Lohmann Therapie-Systeme Gmbh & Co. Kg, 5450 Neuwied, De | |
US5069909A (en) * | 1990-06-20 | 1991-12-03 | Cygnus Therapeutic Systems | Transdermal administration of buprenorphine |
DE4238223C1 (de) * | 1992-11-12 | 1994-05-26 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System zur Verabreichung von Physostigmin an die Haut und Verfahren zu dessen Herstellung |
-
1994
- 1994-12-24 DE DE4446600A patent/DE4446600A1/de not_active Withdrawn
-
1995
- 1995-12-18 SI SI9530197T patent/SI0792145T1/xx unknown
- 1995-12-18 DK DK95942687T patent/DK0792145T3/da active
- 1995-12-18 US US08/860,961 patent/US6264980B1/en not_active Expired - Lifetime
- 1995-12-18 WO PCT/EP1995/005006 patent/WO1996019975A1/de active IP Right Grant
- 1995-12-18 AU AU43871/96A patent/AU4387196A/en not_active Abandoned
- 1995-12-18 AT AT95942687T patent/ATE172640T1/de active
- 1995-12-18 ES ES95942687T patent/ES2125678T3/es not_active Expired - Lifetime
- 1995-12-18 DE DE59504097T patent/DE59504097D1/de not_active Expired - Lifetime
- 1995-12-18 EP EP95942687A patent/EP0792145B1/de not_active Expired - Lifetime
- 1995-12-18 JP JP52018096A patent/JP3549207B2/ja not_active Expired - Lifetime
- 1995-12-19 IL IL11645295A patent/IL116452A0/xx unknown
- 1995-12-21 ZA ZA9510876A patent/ZA9510876B/xx unknown
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2015500329A (ja) * | 2011-12-12 | 2015-01-05 | エルテーエス ローマン テラピー−ジステーメ アーゲー | ブプレノルフィンを含む経皮送達システム |
JP2017036304A (ja) * | 2011-12-12 | 2017-02-16 | エルテーエス ローマン テラピー−ジステーメ アーゲー | ブプレノルフィンを含む経皮送達システム |
JP2015526480A (ja) * | 2012-08-24 | 2015-09-10 | インテグアールエックス セラピューティクス, エルエルシーIntegurx Therapeutics, Llc | 治療剤の経皮送達を増強するための化学組成物および方法 |
JP2016503802A (ja) * | 2012-12-21 | 2016-02-08 | テイコク ファーマ ユーエスエー インコーポレーテッド | ホルモン及びその他の薬剤を経皮送達するための組成物及び方法 |
Also Published As
Publication number | Publication date |
---|---|
DK0792145T3 (da) | 1999-07-12 |
EP0792145B1 (de) | 1998-10-28 |
EP0792145A1 (de) | 1997-09-03 |
AU4387196A (en) | 1996-07-19 |
DE59504097D1 (de) | 1998-12-03 |
ATE172640T1 (de) | 1998-11-15 |
US6264980B1 (en) | 2001-07-24 |
ES2125678T3 (es) | 1999-03-01 |
DE4446600A1 (de) | 1996-06-27 |
SI0792145T1 (en) | 1999-10-31 |
WO1996019975A1 (de) | 1996-07-04 |
ZA9510876B (en) | 1996-05-10 |
JP3549207B2 (ja) | 2004-08-04 |
IL116452A0 (en) | 1996-03-31 |
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