JPH08512299A - ５ｈｔ▲下２ｃ▼アンタゴニストとしてのインドリン誘導体 - Google Patents

５ｈｔ▲下２ｃ▼アンタゴニストとしてのインドリン誘導体

Info

Publication number
JPH08512299A
JPH08512299A JP7503812A JP50381295A JPH08512299A JP H08512299 A JPH08512299 A JP H08512299A JP 7503812 A JP7503812 A JP 7503812A JP 50381295 A JP50381295 A JP 50381295A JP H08512299 A JPH08512299 A JP H08512299A
Authority
JP
Japan
Prior art keywords
indoline
pyridylcarbamoyl
chloro
methyl
nmr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP7503812A
Other languages
English (en)
Japanese (ja)
Inventor
ハム，ピーター
ジョーンズ，グレアム・エルジン
フォーブズ，イアン・トムソン
Original Assignee
スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー filed Critical スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー
Publication of JPH08512299A publication Critical patent/JPH08512299A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Eyeglasses (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP7503812A 1993-07-06 1994-06-30 ５ｈｔ▲下２ｃ▼アンタゴニストとしてのインドリン誘導体 Pending JPH08512299A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB939313913A GB9313913D0 (en) 1993-07-06 1993-07-06 Novel compounds
GB9313913.7 1993-07-06
PCT/EP1994/002148 WO1995001976A1 (en) 1993-07-06 1994-06-30 Indoline derivatives as 5ht2c antagonists

Publications (1)

Publication Number Publication Date
JPH08512299A true JPH08512299A (ja) 1996-12-24

Family

ID=10738344

Family Applications (1)

Application Number Title Priority Date Filing Date
JP7503812A Pending JPH08512299A (ja) 1993-07-06 1994-06-30 ５ｈｔ▲下２ｃ▼アンタゴニストとしてのインドリン誘導体

Country Status (15)

Country Link
US (1) US5834494A (cg-RX-API-DMAC7.html)
EP (1) EP0707581B1 (cg-RX-API-DMAC7.html)
JP (1) JPH08512299A (cg-RX-API-DMAC7.html)
CN (1) CN1129937A (cg-RX-API-DMAC7.html)
AP (1) AP463A (cg-RX-API-DMAC7.html)
AT (1) ATE149163T1 (cg-RX-API-DMAC7.html)
AU (1) AU7228394A (cg-RX-API-DMAC7.html)
CA (1) CA2166624A1 (cg-RX-API-DMAC7.html)
DE (1) DE69401823T2 (cg-RX-API-DMAC7.html)
GB (1) GB9313913D0 (cg-RX-API-DMAC7.html)
IL (1) IL110204A0 (cg-RX-API-DMAC7.html)
MA (1) MA23254A1 (cg-RX-API-DMAC7.html)
TW (1) TW297023B (cg-RX-API-DMAC7.html)
WO (1) WO1995001976A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA944807B (cg-RX-API-DMAC7.html)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5618824A (en) * 1994-03-09 1997-04-08 Merrell Pharmaceuticals Inc. Treatment of obsessive-compulsive disorders with 5-HT2 antagonists
GB9414139D0 (en) * 1994-07-13 1994-08-31 Smithkline Beecham Plc Novel compounds
GB9420521D0 (en) * 1994-10-12 1994-11-30 Smithkline Beecham Plc Novel compounds
BR9607016A (pt) * 1995-02-02 1997-10-28 Smithkline Beecham Plc Derivados de indol como antagonísta de receptor 5-ht
WO1996023769A2 (en) * 1995-02-02 1996-08-08 Smithkline Beecham Plc Heterocyclic compounds possessing 5ht2c receptor antagonist activity
GB9517559D0 (en) * 1995-08-26 1995-10-25 Smithkline Beecham Plc Novel compounds
CA2253941A1 (en) * 1996-05-16 1997-11-20 Sumanas Rakhit Thiophene- and furan-tryptamine derivatives
GB9612883D0 (en) * 1996-06-20 1996-08-21 Smithkline Beecham Plc Novel compounds
GB9612885D0 (en) * 1996-06-20 1996-08-21 Smithkline Beecham Plc Novel compounds
US6362009B1 (en) 1997-11-21 2002-03-26 Merck & Co., Inc. Solid phase synthesis of heterocycles
FR2778662B1 (fr) * 1998-05-12 2000-06-16 Adir Nouveaux composes cycliques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP1122252A4 (en) * 1998-10-16 2002-06-26 Takeda Chemical Industries Ltd CONDENSED HEREROCYCLIC NITROGEN COMPOUNDS; MANUFACTURING PROCESS AND AGENTS CONTAINING THEM
US6453357B1 (en) 1999-01-07 2002-09-17 Cisco Technology, Inc. Method and system for processing fragments and their out-of-order delivery during address translation
US6465467B1 (en) 1999-05-21 2002-10-15 Biovitrum Ab Certain aryl-aliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases
ES2252004T3 (es) * 1999-05-21 2006-05-16 Biovitrum Ab Nuevos compuestos, su uso y preparacion.
UA77650C2 (en) 1999-12-06 2007-01-15 Lundbeck & Co As H Use of serotonin reuptake inhibitor in combination with deramcyclane
FR2810979B1 (fr) * 2000-06-29 2002-08-23 Adir Nouveaux derives de diphenyluree, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
GB0019950D0 (en) * 2000-08-12 2000-09-27 Smithkline Beecham Plc Compounds
SE0004245D0 (sv) 2000-11-20 2000-11-20 Pharmacia Ab Novel compounds and their use
EP1304589A1 (en) * 2001-07-09 2003-04-23 Alcatel Connector for optical fibers
US6861440B2 (en) 2001-10-26 2005-03-01 Hoffmann-La Roche Inc. DPP IV inhibitors
FR2837823B1 (fr) * 2002-03-27 2005-04-08 Servier Lab Nouveaux derives d'indoline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
NZ536664A (en) 2002-06-19 2007-07-27 Biovitrum Ab Piperazinylpyrazine derivative compounds, their use and preparation
BRPI0411509A (pt) 2003-06-20 2006-07-25 Hoffmann La Roche compostos, processo para a sua manufatura, composições farmacêuticas que compreendem os mesmos, método para tratamento e/ou profilaxia de enfermidades que estão associadas com dpp-iv e sua utilização
EA009591B1 (ru) 2003-06-20 2008-02-28 Ф.Хоффманн-Ля Рош Аг Производные пиридо[2,1-а]изохинолина в качестве ингибиторов dpp-iv
AR058040A1 (es) * 2005-09-13 2008-01-23 Bayer Cropscience Ag Derivados plaguicidas de fenilamidina sustituida con feniloxi
US8293100B2 (en) 2009-03-13 2012-10-23 Terrasep, Llc Methods and apparatus for centrifugal liquid chromatography
CN106278987A (zh) * 2016-08-16 2017-01-04 都创(上海)医药科技有限公司 吲哚啉类化合物的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4428881A (en) * 1977-12-23 1984-01-31 Gulf Oil Corporation Control of unwanted vegetation with N-carbamylindolines
KR930702334A (ko) * 1990-09-13 1993-09-08 데이비드 로버트 5 하이드록시트립타민 수용체 길항제로서의 인돌우레아
CA2142721A1 (en) * 1992-08-20 1994-03-03 Ian T. Forbes Condensed indole derivatives as 5ht and 5ht antagonists

Also Published As

Publication number Publication date
DE69401823D1 (de) 1997-04-03
EP0707581A1 (en) 1996-04-24
TW297023B (cg-RX-API-DMAC7.html) 1997-02-01
AP9400653A0 (en) 1994-07-31
ATE149163T1 (de) 1997-03-15
WO1995001976A1 (en) 1995-01-19
AU7228394A (en) 1995-02-06
US5834494A (en) 1998-11-10
IL110204A0 (en) 1995-01-24
CA2166624A1 (en) 1995-01-19
GB9313913D0 (en) 1993-08-18
DE69401823T2 (de) 1997-08-28
ZA944807B (en) 1996-01-04
EP0707581B1 (en) 1997-02-26
CN1129937A (zh) 1996-08-28
AP463A (en) 1996-02-19
MA23254A1 (fr) 1995-04-01

Similar Documents

Publication Publication Date Title
JPH08512299A (ja) ５ｈｔ▲下２ｃ▼アンタゴニストとしてのインドリン誘導体
EP1278741B1 (en) Muscarinic agonists
EP0690843B1 (en) Formyl- or cyano- substituted indole derivatives having dopaminergic activity
JP2005527463A (ja) Ｃｎｓ疾患を治療するための５−ｈｔ６受容体アフィニティーを有する３−アリールスルホニル−７−ピペラジニル−インドール、−ベンゾフランおよび−ベンゾチオフェン
JPH07504429A (ja) ５ＨＴ↓１ｃアンタゴニストとしてのインドール誘導体
JPH08508289A (ja) 抗精神病ベンゾイミダゾール誘導体
JP2001526643A (ja) ５ｈｔ１ａ、５ｈｔ１ｂおよび５ｈｔ１ｄ受容体アンタゴニスト活性を合わせ持つ化合物を含む二環式アリールまたは二環式複素環
AU6538294A (en) Indole derivatives as 5-ht1a and/or 5-ht2 ligands
JPH08511515A (ja) アセチルコリンエステラーゼの阻害剤としての１−置換イサチンおよびオキシンドール誘導体
JP3157179B2 (ja) ３−アリールカルボニル−１−アミノアルキル−１ｈ−インドール含有抗緑内障組成物
KR100221158B1 (ko) 6-헤테로사이클릭-4-아미노-1,3,4,5-테트라하이드로벤즈(cd)인돌
HUP0002843A2 (hu) Új béta-karbolin-származékok, eljárás előállításukra és az ezeket tartalmazó gyógyszerkészítmények
JPH069618A (ja) ヒドロキシキノロン誘導体
JP2001521529A (ja) 置換へテロ芳香環５−ｈｔ▲下１ｆ▼アゴニスト
JP2001512727A (ja) ５ｈｔ−１受容体のリガンドとしてのニ環式化合物
JP3174382B2 (ja) ６−複素環−４−アミノ−１，２，２ａ，３，４，５−ヘキサヒドロベンズ［ｃｄ］インドール類
JP2961023B2 (ja) 置換ピリジニルアミノ−１Ｈ−インドール、１Ｈ−インダゾール、２Ｈ−インダゾール、ベンゾ〔ｂ〕チオフェンおよび１，２−ベンズイソチアゾール
HU203350B (en) Process for producing antiinflammatory tricyclic oxindole derivatives
JPH06211655A (ja) 乗物酔いおよび嘔吐症の処置用６−ヘテロ環−４−アミノ−１，３，４，５−テトラヒドロベンズ［ｃｄ］インドール類
JP2000508299A (ja) 抗ウイルス作用を有する置換キノリン誘導体
US8114899B2 (en) 2H- or 3H-benzo[e]indazol-1-yl carbamate derivatives, the preparation and therapeutic use thereof
JPH09512025A (ja) ５ｈｔ▲下２ｃ▼および５ｈｔ▲下２ｂ▼アンタゴニストとしての三環式誘導体
JP2000512306A (ja) ５―ｈｔ―２ｃ受容体アンタゴニストとして有用なインドリン誘導体
JP2003518112A (ja) 置換型ピロール
JP2001526674A (ja) ５ｈｔ２ｃ受容体アンタゴニストとしてのインドリン誘導体